Trainee Profile

Jacqueline M. Lane, PhD

Jackie Lane 2017
Postdoctoral Research Fellow, Harvard Medical School
Postdoctoral Research Fellow, Center for Geonomic Medicine, Massachusetts General Hospital
Postdoctoral Research Fellow, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital

See publications


Email jlane@broadinstitute.org

Research Interests

I am interested in the probing the genetics underlying sleep and circadian rhythms in order to elucidate novel genes and pathways underlying circadian regulation.  These findings will open potential new avenues of therapeutics for rare circadian rhythms disorders, increase our understanding of the basic mechanisms of circadian biology, and open new avenues for treatment of more common circadian rhythm associated chronic diseases.  

Mentor(s)


Research Funding

NRSA F32, NIH T32, Broad Institute Next10 Award

Selected Publications

Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 2017 Feb;49(2):274-281. doi: 10.1038/ng.3749. Epub 2016 Dec 19. PubMed PMID: 27992416.
 
Cade BE, Chen H, Stilp AM, Gleason KJ, Sofer T, Ancoli-Israel S, Arens R, Bell GI, Below JE, Bjonnes AC, Chun S, Conomos MP, Evans DS, Johnson WC, Frazier-Wood AC, Lane JM, Larkin EK, Loredo JS, Post WS, Ramos AR, Rice K, Rotter JI, Shah NA, Stone KL, Taylor KD, Thornton TA, Tranah GJ, Wang C, Zee PC, Hanis CL, Sunyaev SR, Patel SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S. Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. Am J Respir Crit Care Med. 2016 Oct 1;194(7):886-897. PubMed PMID: 26977737; PubMed Central PMCID: PMC5074655.

Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R. Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 Jun;65(6):1741-51. doi: 10.2337/db15-0999. Epub 2016 Feb 11. PubMed PMID: 26868293; PubMed Central PMCID: PMC4878414.
 
Eichler FS, Li J, Guo Y, Caruso PA, Bjonnes AC, Pan J, Booker JK, Lane JM, Tare A, Vlasac I, Hakonarson H, Gusella JF, Zhang J, Keating BJ, Saxena R. CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids. Brain. 2016 Jun;139(Pt 6):1666-72. doi: 10.1093/brain/aww066. Epub 2016 May 5. PubMed PMID: 27190017; PubMed Central PMCID: PMC4892751.

Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R. Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun. 2016 Mar 9;7:10889. doi: 10.1038/ncomms10889. PubMed PMID: 26955885; PubMed Central PMCID: PMC4786869.

Saxena R, Bjonnes A, Prescott J, Dib P, Natt P, Lane J, Lerner M, Cooper JA, Ye Y, Li KW, Maubaret CG, Codd V, Brackett D, Mirabello L, Kraft P, Dinney CP, Stowell D, Peyton M, Ralhan S, Wander GS, Mehra NK, Salpea KD, Gu J, Wu X, Mangino M, Hunter DJ, De Vivo I, Humphries SE, Samani NJ, Spector TD, Savage SA, Sanghera DK. Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. Circ Cardiovasc Genet. 2014 Jun;7(3):287-95. doi: 10.1161/CIRCGENETICS.113.000412. Epub 2014 May 3. PubMed PMID: 24795349; PubMed Central PMCID: PMC4106467.

Tare A, Lane JM, Cade BE, Grant SF, Chen TH, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes. Diabetologia. 2014 Feb;57(2):339-46. doi: 10.1007/s00125-013-3110-y. Epub 2013 Nov 27. PubMed PMID: 24280871; PubMed Central PMCID: PMC4006271.
 
Lane JM, Doyle JR, Fortin JP, Kopin AS, Ordovás JM. Development of an OP9 derived cell line as a robust model to rapidly study adipocyte differentiation. PLoS One. 2014 Nov 19;9(11):e112123. doi: 10.1371/journal.pone.0112123. eCollection 2014. PubMed PMID: 25409310; PubMed Central PMCID: PMC4237323.

Lane JM, Tare A, Cade BE, Chen TH, Punjabi NM, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Common variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study. Biol Psychiatry. 2013 Dec 15;74(12):e33-5. doi: 10.1016/j.biopsych.2013.06.006. Epub 2013 Jul 17. PubMed PMID: 23871470; PubMed Central PMCID: PMC4157567.

Doyle JR, Lane JM, Beinborn M, Kopin AS. Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition. J Lipid Res. 2013 Mar;54(3):823-30. doi: 10.1194/jlr.M034660. Epub 2012 Dec 24. PubMed PMID: 23268337; PubMed Central PMCID: PMC3617956.

Junyent M, Tucker KL, Smith CE, Lane JM, Mattei J, Lai CQ, Parnell LD, Ordovas JM. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican Health Study. Nutr Metab Cardiovasc Dis. 2010 Oct;20(8):558-66. doi: 10.1016/j.numecd.2009.05.005. Epub 2009 Aug 18. PubMed PMID: 19692220; PubMed Central PMCID: PMC4038034.
 
Sims HI, Lane JM, Ulyanova NP, Schnitzler GR. Human SWI/SNF drives sequence-directed repositioning of nucleosomes on C-myc promoter DNA minicircles. Biochemistry. 2007 Oct 9;46(40):11377-88. Epub 2007 Sep 18. PubMed PMID: 17877373; PubMed Central PMCID: PMC2526049.
 
Zivelin A, Ogawa T, Bulvik S, Landau M, Toomey JR, Lane J, Seligsohn U, Gailani D. Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): a cross-reactive material positive variant defective in factor IX activation. J Thromb Haemost. 2004 Oct;2(10):1782-9. PubMed PMID: 15456490.

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