Trainee Profile

Jingyi Qian, PhD


Postdoctoral Research Fellow, Harvard Medical School
Postdoctoral Research Fellow, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

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Address

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, BWH
221 Longwood Avenue (BLI-040)
Boston, MA 02115
USA

Phone 617-525-7423

Email Jqian5@partners.org



Research Unit(s)


Research Interests

The common MTNR1B (melatonin receptor 1B) risk SNP is associated with the pathogenesis of type 2 diabetes. The risk genotype has a significant adverse influence on the glucose tolerance and insulin secretion over time. The goal of my research is to determine the effect of circulating melatonin on glucose control, and their interactions with MTNR1B genotype. The mechanistic understanding of the role of melatonin and MTNR1B in glucose metabolism will provide insight into the interventions to prevent and treat type 2 diabetes.  

Trainees



Mentor(s)


Selected Publications

Qian J, Yeh B, Rakshit K, Colwell CS, Matveyenko AV. Circadian disruption and
diet-induced obesity synergize to promote development of beta cell failure and
diabetes in male rats. Endocrinology. 2015 Sep 8:en20151516. [Epub ahead of
print] [PMID: 26348474]

Rakshit K, Qian J, Colwell CS, Matveyenko AV. The islet circadian clock:
entrainment mechanisms, function and role in glucose homeostasis. Diabetes Obes
Metab. 2015 Sep;17 Suppl 1:115-22. doi: 10.1111/dom.12523. [PMID: 26332976]

Qian J, Block GD, Colwell CS, Matveyenko AV. Consequences of exposure to light
at night on the pancreatic islet circadian clock and function in rats. Diabetes.
2013 Oct;62(10):3469-78. doi: 10.2337/db12-1543. Epub 2013 Jun 17. [PMID: 23775768]

Gale JE, Cox HI, Qian J, Block GD, Colwell CS, Matveyenko AV. Disruption of
circadian rhythms accelerates development of diabetes through pancreatic
beta-cell loss and dysfunction. J Biol Rhythms. 2011 Oct;26(5):423-33. doi:
10.1177/0748730411416341. [PMID: 21921296]

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