Trainee Profile

J. Qian, PhD


Postdoctoral Research Fellow, Harvard Medical School
Research Fellow, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

See publications


Address

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, BWH
221 Longwood Avenue (BLI-040)
Boston, MA 02115
USA

Phone 617-525-7423

Email Jqian@bwh.harvard.edu

Society Memberships

Sleep Research Society,
American Diabetes Association,
Society for Research on Biological Rhythms



Research Unit(s)

Medical Chronobiology Program,
Division of Sleep and Circadian Disorders,
Brigham and Women's Hospital

Research Interests

The common MTNR1B (melatonin receptor 1B) risk SNP is associated with the pathogenesis of type 2 diabetes. The risk genotype has a significant adverse influence on the glucose tolerance and insulin secretion over time. The goal of my research is to determine the effect of circulating melatonin on glucose control, and their interactions with MTNR1B genotype. The mechanistic understanding of the role of melatonin and MTNR1B in glucose metabolism will provide insight into the interventions to prevent and treat type 2 diabetes.  

Trainees



Mentor(s)


Research Funding

American Diabetes Association (#1-17-PDF-103), J. Qian, Interaction of Melatonin and MTNR1B Genotype on Glucose Control

Selected Publications

Original reports:
Qian, J.*, Morris, C. J., Caputo, R., Garaulet, M., & Scheer, F. A. (2018). Ghrelin is Impacted by the Endogenous Circadian System and by Circadian Misalignment in Humans. International Journal of Obesity.

Qian, J.*, Dalla Man, C., Morris, C. J., Cobelli, C., & Scheer, F. A. (2018). Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes, Obesity and Metabolism. [PMID: 29862620]

Rakshit, K., Qian, J.*, Gaonkar, K. S., Dhawan, S., Colwell, C. S., & Matveyenko, A. V. (2018). Postnatal Ontogenesis of the Islet Circadian Clock Plays a Contributory Role in β-Cell Maturation Process. Diabetes, db170850. [PMID: 29500314]

Qian, J.*, Thomas, A. P., Schroeder, A. M., Rakshit, K., Colwell, C. S., & Matveyenko, A. V. (2017). Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus. American Journal of Physiology-Endocrinology and Metabolism, 313(2), E213-E221. [PMID: 28465284]

Rakshit, K., Qian, J.*, Ernst, J., & Matveyenko, A. (2016). Circadian variation of the pancreatic islet transcriptome. Physiological Genomics, physiolgenomics-00019. [PMID: 27495157]

Qian, J.*, Yeh, B., Rakshit, K., Colwell, C. S., & Matveyenko, A. V. (2015). Circadian Disruption and Diet-Induced Obesity Synergize to Promote Development of β-Cell Failure and Diabetes in Male Rats. Endocrinology, 156(12), 4426-4436. [PMID: 26348474]

Qian, J.*, Block, G. D., Colwell, C. S., & Matveyenko, A. V. (2013). Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes, 62(10), 3469-3478. [PMID: 23775768]

Gale, J. E., Cox, H. I., Qian, J.*, Block, G. D., Colwell, C. S., & Matveyenko, A. V. (2011). Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. Journal of Biological Rhythms, 26(5), 423-433. [PMID: 21921296]

Jin, K., Xue, C., Qian, J.*, Zhu, Y., Wu, X., Yang, Z., Yonezawa, T. M., Crabbe, J.C., Cao, Y., Hasegawa, M., & Zheng, Y. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS ONE 2011; 6(7):e22602. [PMID: 21818345]

Reviews:
Qian, J.*, & Scheer, F. A. (2016). Circadian System and Glucose Metabolism: Implications for Physiology and Disease. Trends in Endocrinology & Metabolism, 27(5), 282-293. [PMID: 27079518]

Rakshit, K., Qian, J.*, Colwell, C. S., & Matveyenko, A. V. (2015). The islet circadian clock: entrainment mechanisms, function and role in glucose homeostasis. Diabetes, Obesity and Metabolism, 17(S1), 115-122. [PMID: 26332976]

Site Map | Contact Us | © 2017 by the President and Fellows of Harvard College