Trainee Profile

Kirsi-Marja Zitting, PhD

Research Fellow, Harvard Medical School
Postdoctoral Research Fellow, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

See publications


221 Longwood Avenue, RF386
Boston, MA 02115

Inter-office Mail Address

BWH Division of Sleep Medicine

Phone 617-525-8339
Fax 617-730-2877


Society Memberships

Society for Neuroscience
European Sleep Research Society
Sleep Research Society

Research Interests

My research interests focus on understanding the effects of aging on circadian and homeostatic regulation of sleep and performance. My previous research sought to understand the age-related changes in the molecular mechanisms regulating sleep homeostasis. My current research goals include studying the impact sleep quality on subsequent alertness and performance in both young and older adults.


Research Funding

Finnish Cultural Foundation: Sleep-Wake Homeostasis in Aging (2013-2014)

Selected Publications

Original Articles (under the name Rytkönen)

Rytkönen KM, Zitting J, Porkka-Heiskanen T. Automated sleep scoring in rats and mice using the naive Bayes classifier.
Journal of Neuroscience Methods 2011;202(1):60-4. [PMID: 21884727]

Wigren HK, Rytkönen KM, Porkka-Heiskanen T. Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging.
Journal of Neuroscience 2009;29(37):11698-707. [PMID: 19759316]

Rytkönen KM, Wigren HK, Kostin A, Porkka-Heiskanen T, Kalinchuk AV. Nitric oxide mediated recovery sleep is attenuated with aging.
Neurobiology of Aging 2010;31(11):2011-9. [PMID: 19058880]

Savelyev SA, Rantamäki T, Rytkönen KM, Castren E, Porkka-Heiskanen T. Sleep homeostasis and depression: studies with the rat clomipramine model of depression.
Neuroscience 2012;212:149-58. [PMID: 22516018]

Reviews (under the name Zitting)

Porkka-Heiskanen T. Zitting KM, Wigren HK. Sleep, its regulation and possible mechanisms of sleep disturbances.
Acta Physiol (Oxf). 2013 Aug;208(4):311-28. [PMID: 23746394]

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