Trainee Profile

Christa J. Van Dort, PhD

Christa Van Dort, PhD
Research Fellow in Anaesthesia, Harvard Medical School
Postdoctoral Research Fellow, Department of Anesthesia, Massachusetts General Hospital

Other Affiliation(s)

Research Affiliate, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology

See publications


MGH/MIT Bldg 46 Rm 5227
43 Vassar St
Cambridge, MA 02139


Society Memberships

Sleep Research Society
Society for Neuroscience
Sigma Xi
Association for Women in Science

Research Unit(s)

Division of Sleep Medicine
Neuroscience Statistics Research Laboratory

Research Interests

My research investigates the mechanism of loss of consciousness during sleep and general anesthesia. I use in vivo multisite single unit electrophysiology and optogenetics to probe the neuronal circuits involved in the regulation of these states.


Selected Publications

Original Articles

Van Dort CJ, Baghdoyan HA, Lydic R. Adenosine A1 and A2A Receptors in Mouse Prefrontal  Cortex Modulate Acetylcholine Release and Behavioral Arousal.
J Neurosci 29: 871-881, 2009. [PMID: 19158311]

Buchwalter A, Van Dort CJ, Schultz S, Smith R, Le IP, Abbott JL, Oosterhouse E, Johnson AE, Hansen-Smith F, Burnatowska-Hledin M. Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype.
Microvasc Res 75: 155-168, 2008. [PMID: 17950367]

Stanley KT, VanDort C, Motyl C, Endres J, Fox DA. Immunocompetent properties of human osteoblasts: interactions with T lymphocytes.
J Bone Miner Res 21: 29-36, 2006. [PMID: 16355271]

Burnatowska-Hledin MA, Kossoris JB, Van Dort CJ, Shearer RL, Zhao P, Murrey DA, Abbott JL, Kan CE, Barney CC. T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene.
Biochem Biophys Res Commun 319: 817-825, 2004. [PMID: 15184056]

Van Dort CJ, Zhao P, Parmelee K, Capps B, Poel A, Listenberger L, Kossoris J, Wasilevich B, Murrey D, Clare P, Burnatowska-Hledin M. VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways.
Am J Physiol Cell Physiol 285: C1386-C1396, 2003. [PMID: 12917106]

Reviews, Books, & Chapters

Brown EN, Purdon PL, Van Dort CJ. General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis.
Ann Rev Neurosc 34: In Press, 2011.

Van Dort CJ, Baghdoyan HA, Lydic R. Neurochemical Modulators of Sleep and Anesthetic States.
Int Anesthesiol Clin 46: 75-104, 2008. [PMID: 18617819]

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