Faculty Profile

Hadine Joffe, MD, MSc

Hadine joffe 20180322
Associate Professor, Harvard Medical School
Associate Professor, Brigham and Women's Hospital

Administrative Title(s)

Director, Women’s Hormone and Aging Research Program
Director of Research Development, Department of Psychiatry
Director, Division of Women's Mental Health
Brigham and Women’s Hospital
Director, Psycho-Oncology Research
Department of Psychosocial Oncology and Palliative Care
Dana Farber Cancer Institute 

See publications


Simches Research Building
185 Cambridge Street, Suite 2000
Boston, MA 02114

Phone 617-724-1849
Fax 617-643-3080

Email hjoffe@partners.org

Society Memberships

American Psychiatric Association
Endocrine Society
North American Menopause Society

Research Unit(s)

Center for Women’s Mental Health (also called Perinatal and Reproductive Psychiatry Clinical Research Program)

Research Interests

I am a psychiatrist who conducts clinical and translational research focused on women’s mental health, specifically on the interface between reproductive endocrinology, sleep medicine, and psychiatric illness, especially depression.  My work focuses on the biologic mechanisms, inter-relationships, and treatment of menopausal symptoms of hot flashes, depression, sleep disturbance, and cognitive difficulties.  Ongoing work involves an examination of the impact of estrogen deprivation and hot flashes on sleep staging and sleep continuity, as well as mood and well-being, in women.  

My work primarily involves intervention studies using hormone manipulation to dissect specific causal pathways among menopause-related symptoms.  I currently have an R01 grant from the NIMH that includes two projects.  One protocol investigates the effects of induced hot flashes on sleep staging and continuity measures using a GnRH agonist model in healthy volunteers.  The other protocol using estrogen therapy to determine if depression is a result of changes in estradiol and other reproductive hormones or whether hot flashes are a mediating factor in postmenopausal women with depression.  

I am also a PI on an NIA U01 grant (MsFLASH) that involves a multicenter clinical trial network for treatment of hot flashes and other menopause-related symptoms, including sleep disturbance.  I am a co-I on a multicenter epidemiologic study of midlife women’s health (SWAN) that includes multiple subjectively measured sleep parameters.  

Each of the studies that I am involved in include measures of sleep (PSG, actigraphy, sleep diaries, and perceived sleep quality).  In addition, I am part of a larger research group at MGH that investigates the course of psychiatric illness across pregnancy and the postpartum.


Rodrigo Dias, MD, Reserach Fellow, 2006–2007
M Pia Rogines-Velo-Sardi, MD PhD, Research Fellow, 2007–2008

Research Funding

Current funding:
“Defining the Mechanisms of Menopause-Associated Sleep and Mood Disturbance”
Role:  Principal Investigator

 "Ms-FLASH: Relative Efficacy of Hormonal and Non-Hormonal Interventions for VMS "
 Role: Principal Investigator

"(SWAN) Study of Women's Health Across the Nation III"
Role: Co-Investigator

Completed funding:
"Physiology of Estrogen’s Mood Effects in Menopausal Women"
Role: PI

"Predictors of Antenatal and Postpartum Depression"
Role: Consultant

Endocrine Society Bridge Funds
“Defining the Mechanisms of Menopause-Associated Sleep and Mood Disturbance”
Role:  PI

NARSAD (National Alliance for Research on Schizophrenia and Depression) Young Investigator Award
"Stabilizing Estrogen and Progesterone Levels with the Oral-Contraceptive Pill to Treat Premenstrual Worsening Depression"
Role: PI

MGH Claflin Distinguished Scholar Award
"Hot Flushes in Menopause and Breast Cancer Treatment: Developing the Optimal Experimental Model"
Role: PI

HMS Center of Excellence Fund for Women's Health Research Award
"Mechanisms of Hot Flushes in Women with Breast Cancer: Neuroimaging of the Hormonal Changes Caused by Anti-Estrogen Therapies"
Role: PI

Friends of Dana-Farber
"Mechanisms of Hot Flushes in Women with Breast Cancer: Neuroimaging of the Hormonal Changes Caused by Anti-Estrogen Therapies"
Role: Co-Investigator

Sepracor Investigator Initiated Trial
"Treatment of Insomnia in Symptomatic Peri- and Postmenopausal Women"
Role: Co-Investigator

Susan B. Komen Breast Cancer Foundation
"Targeting Insomnia to Optimize Hot-Flush Therapy in Women with Breast Cancer"
Role: PI

Bayer Investigator Initiated Trial
"Oral Contraceptive Pill for the Treatment of Premenstrual Worsening of Depression"
Role: Co-PI

Selected Publications

Joffe H, Petrillo L, Viguera A, Koukopoulos A, Silver-Heilman K, Farrell A, Yu G, Silver M,  Cohen LS.  Eszopiclone improves insomnia, depressive and anxious symptoms in  perimenopausal and postmenopausal women with hot flashes:  a randomized, double-blinded, placebo-controlled cross-over trial. 
Am J Obstet Gynecol 2010;202(2):171.e1.e11.  [PMID: 20035910]

Joffe H, Partridge A, Giobbie-Hurder A, Li X, Habin K, Goss P, Winer E, Garber J. Augmentation of venlafaxine and SSRI’s with zolpidem improves sleep and quality-of-life in  breast cancer patients with hot flashes:  a randomized double-blind placebo-controlled trial.  Menopause 2010 (in press).

Thurston RC, Sowers MR, Sternfeld B, Gold EB, Bromberger J, Chang Y, Joffe H, Crandall CJ, Waetjen LE, Matthews KA. Gains in body fat and vasomotor symptom reporting over the menopausal transition: the study of women's health across the nation. 
Am J Epidemiol. 2009 Sep 15;170(6):766-74. Epub 2009 Aug 12. [PMID:19675142]

Joffe H, Soares CN, Thurston RC, White DP, Cohen LS, Hall JE. Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with vasomotor symptoms. 
Menopause. 2009 Jul-Aug;16(4):671-9. [PMID: 19197217]
Harlow BL, Joffe H. Interpreting incidence of hospitalization for postpartum psychotic and bipolar episodes study. 
Arch Gen Psychiatry. 2009 Mar;66(3):332. [PMID: 19255383]

Joffe H, Greenfield SF. Introduction: women's mental health: new research findings. 
Harv Rev Psychiatry. 2009;17(2):69-71. [PMID: 19373616]

Thurston RC, Bromberger JT, Joffe H, Avis NE, Hess R, Crandall CJ, Chang Y, Green R, Matthews KA. Beyond frequency: who is most bothered by vasomotor symptoms?
 Menopause. 2008 Sep-Oct;15(5):841-7. [PMID: 18521049]

Soares CN, Joffe H, Viguera AC, Petrillo L, Rydzewski M, Yehezkel R, Somley B, Cohen LS. Paroxetine versus placebo for women in midlife after hormone therapy discontinuation.
Am J Med. 2008 Feb;121(2):159-162.e1. [PMID: 18261506]

Joffe H, Petrillo LF, Viguera AC, Gottshcall H, Soares CN, Hall JE, Cohen LS. Treatment of premenstrual worsening of depression with adjunctive oral contraceptive pills: a preliminary report.
J Clin Psychiatry. 2007 Dec;68(12):1954-62. [PMID: 18162029]

Gold EB, Lasley B, Crawford SL, McConnell D, Joffe H, Greendale GA. Relation of daily urinary hormone patterns to vasomotor symptoms in a racially/ethnically diverse sample of midlife women: study of women's health across the nation.
Reprod Sci. 2007 Dec;14(8):786-97. [PMID: 18089597]

Harlow BL, Vitonis AF, Sparen P, Cnattingius S, Joffe H, Hultman CM. Incidence of hospitalization for postpartum psychotic and bipolar episodes in women with and without prior prepregnancy or prenatal psychiatric hospitalizations.
Arch Gen Psychiatry. 2007 Jan;64(1):42-8. [PMID: 17199053]

Joffe H, Soares CN, Somley B, Koch J, Petrillo L, Viguera A, Cohen LS. Treatment of
depression and menopause-related symptoms with the serotonin-norepinephrine reuptake
inhibitor duloxetine.
J Clin Psychiatry. 2007; 68(6):943-950. [PMID: 17592922]

Joffe H, Cohen LS, Suppes T, Hwang CH, Molay F, Adams JM, Sachs GS, Hall JE. Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary report.
Biol Psychiatry. 2006 Dec 15;60(12):1378-81. Epub 2006 Sep 1. [PMID:16950230]

Thurston RC, Joffe H, Soares CN, Harlow BL. Physical activity and risk of vasomotor symptoms in women with and without a history of depression: results from the Harvard Study of Moods and Cycles.
Menopause. 2006 Jul-Aug;13(4):553-60. [PMID: 16837876]

Joffe H, Cohen LS, Suppes T, McLaughlin WL, Lavori P, Adams JM, Hwang CH, Hall JE, Sachs GS. Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder.
Biol Psychiatry. 2006 Jun 1;59(11):1078-86. Epub 2006 Jan 31. [PMID: 16448626]

Joffe H, Hall JE, Gruber S, Sarmiento IA, Cohen LS, Yurgelun-Todd D, Martin KA. Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women.
Menopause. 2006 May-Jun;13(3):411-22. [PMID: 16735938]

Rich-Edwards JW, Kleinman K, Abrams A, Harlow BL, McLaughlin TJ, Joffe H, Gillman MW. Sociodemographic predictors of antenatal and postpartum depressive symptoms among women in a medical group practice.
J Epidemiol Community Health. 2006 Mar;60(3):221-7. [PMID: 16476752]

Joffe H, Kim DR, Foris JM, Baldassano CF, Gyulai L, Hwang CH, McLaughlin WL, Sachs GS, Thase ME, Harlow BL, Cohen LS. Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controls.
J Clin Psychiatry. 2006 Feb;67(2):297-304. [PMID: 16566627]

Soares CN, Arsenio H, Joffe H, Bankier B, Cassano P, Petrillo LF, Cohen LS. Escitalopram
versus ethinyl estradiol and norethindrone acetate for symptomatic peri and postmenopausal
women: impact on depression, vasomotor symptoms, sleep and quality of life.
Menopause. 2006; 13(5):780-6. [PMID: 16894334]

Soares CN, Joffe H, Rubens R, Caron J, Roth T, Cohen L. Eszopiclone in patients with
insomnia during perimenopause and early postmenopause: a randomized controlled trial.
Obstet Gynecol. 2006; 108(6):1402-1410. [PMID: 17138773]


Joffe H, Massler A, Sharkey KM.  Evaluation and management of sleep disturbance during the menopause transition. 
Semin Reprod Endocrinol 2010 (in press).

Payne JL, Palmer JT, Joffe H. A reproductive subtype of depression: conceptualizing models and moving toward etiology.
Harv Rev Psychiatry. 2009;17(2):72-86. Review. [PMID: 19373617]

Hickey M, Saunders C, Partridge A, Santoro N, Joffe H, Stearns V. Practical clinical guidelines for assessing and managing menopausal symptoms after breast cancer.
Ann Oncol. 2008 Oct;19(10):1669-80. Epub 2008 Jun 2. Review. [PMID: 18522932]

Joffe H, Hayes FJ. Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents.
Ann N Y Acad Sci. 2008;1135:219-29. Review. [PMID: 18574228]

Joffe H. Reproductive biology and psychotropic treatments in premenopausal women with bipolar disorder.
J Clin Psychiatry. 2007;68 Suppl 9:10-5. Review. [PMID: 17764379]

Additional Publications

Joffe H, McCurnin KE, Hall JE. Hormone dynamics and sleep consequences of experimentally induced hot flashes. Endocrine Society 89th Annual Meeting, Toronto, Ontario, Canada, June 2007

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