Faculty Profile

Hadine Joffe, MD, MSc

Hadine joffe 20180322
Paula A. Johnson Endowed Associate Professor of Psychiatry in the Field of Women’s Health, Harvard Medical School
Associate Professor, Connors Center for Women’s Health and Gender Biology, Department of Psychiatry, Brigham and Women's Hospital

Administrative Title(s)

Executive Director, Brigham and Women’s Hospital
Mary Horrigan Connors Center for Women’s Health
Vice Chair for Research, Brigham and Women’s Hospital Department of Psychiatry



See publications


Address

Brigham and Women's Hospital
75 Francis Street, Thorn 1111
Boston, MA 02115
USA

Phone 617-732-4906
Fax 617-525-7746

Email hjoffe@bwh.harvard.edu

Society Memberships

American College of Neuropsychopharmacology
American Psychiatric Association
American Psychosocial Oncology Society
Endocrine Society
International Marcé Society for Perinatal Mental Health
Massachusetts Psychiatric Association
North American Menopause Society
North American Society for Psychosocial Obstetrics and Gynecology

Research Unit(s)

Center for Women’s Mental Health (also called Perinatal and Reproductive Psychiatry Clinical Research Program)

Research Interests

Dr. Joffe’s current research focuses on the mechanisms underlying, consequences of, and treatment approaches to neuropsychological manifestations of female reproductive hormone changes in the brain (mood, sleep, and vasomotor symptom disturbance) in midlife women and breast cancer survivors. Her work involves experimental paradigms with use of both hormone- and sleep-manipulation to isolate the causal pathways linking hormonal changes and neural processes with vasomotor symptoms, sleep and mood disturbance, as well as the impact of reproductive transition physiology on metabolic and behavioral indices of body fat gain in women. She also conducts randomized trials to demonstrate the efficacy of therapies directed at vasomotor, sleep, and mood disturbance in midlife women and breast cancer survivors, as well as clinical and community-based epidemiologic studies of symptom burden in these populations. Her research has been continuously funded by the NIH for the past 20 years, as well as through foundation, pharmaceutical industry, and philanthropic sources.

Dr. Joffe directs this research in her role as Director of the Women’s Hormone and Aging Research Program in the BWH Department of Psychiatry, which is affiliated with the DFCI Breast Oncology Program. She is also the Executive Director of the BWH Connors Center for Women’s Health and Gender Biology, where she leads a team of investigators on a series of investigations related to sex-differences and women’s health more broadly, including in relation to women’s aging health, brain health, stress, and the advancement and expansion of female-specific knowledge of noveltherapeutics (drugs, devices, digital innovations) for women.

Trainees

Deborah Kim, MD, 2005 - 2006
Rodrigo Dias, MD, 2006–2013
M. Pia Rogines-Velo-Sardi, MD PhD, 2007–2008
Jennifer L. Payne, MD, 2007 - 2009
Sanam Dhaliwal, MSc, MS, 2009 - 2010
Sara E. Dolan Looby, PhD, ANP-BC, FAAN, 2009 - 2013
Katherine Sharkey, MD, PhD, 2010 - 2013
Snezana Milanovic, MD MSc, 2010 - 2013
H. Irene Su, MD, MSCE, 2011 - 2013
Fremonta Meyer, MD, 2013 - 2017
Geena Athappilly, MD, 2013 - 2017
Leena Mittal, MD, 2013 - date
David Wolfe, MD, 2013 - 2018
Deborah Knudson Gonzales, MD, 2013 - 2017
Marley Doyle, MD, 2014 - 2015
Whitney Peters, MD, 2014 - 2016
Suzie Bertisch, MD, MPH, 2014 - 2018
Margo Nathan, MD 2017 - 2019
Shadab Rahman, PhD, 2017 - date
Jessica Harder, MD, 2017 - date
Hanneke Poort, PhD, 2017 - date
Miryam Yusufov. PhD, 2017 - date
Jamie Coborn, PhD 2019 - 2020

Research Funding

Current funding:

NIH
"Menopausal Sleep Fragmentation: Impact on Body Fat Gain Biomarkers in Women"
Role:  Principal Investigator

Merck Investigator Studies Program
"A Double-Blind, Randomized, Placebo-Controlled Study to Determine the Efficacy of
Suvorexant in the Treatment of Hot Flash-Associated Insomnia in Midlife Women"
Role: Principal Investigator

Pfizer ASPIRE Oncology Research Award
"Incidence, Course and Predictors of Fatigue Developing on Palbociclib in Advanced HR+ HER2- Breast Cancer"
Role: Principle Investigator

IH
"Study of Women’s Health Across the Nation IV"
Role: Co-Investigator

NIH
"MsFLASH:  Living a Healthy Menopause"
Role: Co-Investigator

NIH
"A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer Survivors"
Role: Co-Investigator

BWH Women’s Brain Initiative Donor Fund
"Clinical and Biological Predictors of Cognitive Outcome in Postmenopausal Women with Major Depression"
Role: Co-Investigator

V Foundation BRCA 1,2 Research Collaborative Grant
"Development of Effective Hormonal Chemoprevention for BRCA2 Carriers"
Role: Co-Investigator


Teaching

Harvard Longwood Psychiatry Residency Program
Reproductive Hormone Effects on Mood, Hormone/Psychiatric Medication Interactions, Mood Disturbance and Reproductive Transitions

Selected Publications

Otte JL, Bakoyannis G, Rand KL, Ensrud KE, Guthrie KA, Joffe H, McCurry SM, Newton
KM, Carpenter JS (accepted 02-20-2019). Confirmatory factor analysis of the Insomnia Severity Index (ISI) and invariance across race: A pooled analysis of MsFLASH data. Menopause 2019 (in press). PMCID in progress.

Matthews KA, Hall MH, Lee L, Kravitz HM, Chang Y, Appelhans BM, Swanson LM, Neal-Perry GS, Joffe H. Racial/ethnic disparities in women's sleep duration, continuity, and quality,and their statistical mediators: Study of Women's Health Across the Nation. Sleep 2019 Feb 18. pii: zsz042. doi: 10.1093/sleep/zsz042. [Epub ahead of print] PMCID in progress.

Crawford SL, Crandall CJ, Derby CA, El Khoudary SR, Waetjen LE, Fischer M, Joffe H. Menopausal hormone therapy trends before versus after 2002: impact of the Women’s Health Initiative study results. Menopause 2018 Dec 21. doi: 10.1097/GME.0000000000001282.
[Epub ahead of print] PMCID in progress.

Bertisch SM**, Wiley A, McCormick K, Muresan C, Camuso J, Albert K, Crawford SL, Newhouse P, Taylor JA*, Joffe H*. Cardiovascular reactivity and psychological hyperarousal in hot-flash associated insomnia disorder.  Menopause 2019. Jan 21. doi:
10.1097/GME.0000000000001298. [Epub ahead of print]. PMCID not applicable.

Bromberger JT, Schott L, Avis NE, Crawford S, Harlow S, Joffe H, Kravitz HM, Matthews KA. Psychosocial and health-related risk factors for depressive symptom trajectories among midlife women over 15 years: Study of Women’s Health Across the Nation (SWAN). Psych Med 2019 Jan;49(2):250-259. doi: 10.1017/S0033291718000703. [Epub ahead of print]. PMCID in progress.

Chung HF, Pandeya N, Dobson AJ, Kuh D, Brunner EJ, Crawford SL, Avis NE, Gold EB, Mitchell ES, Woods NF, Bromberger JT, Thurston RC, Joffe H, Yoshizawa T, Anderson D, Mishra GD. The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium.  Psych Med 2018 Nov;48(15):2550-2561. doi: 10.1017/S0033291718000168.  
[PMCID: PMC6087679]

Looby SE*, Psaros C*, Raggio GA, Rivard C, Smeaton L, Joffe H. Longitudinal assessment of menopause and mood symptoms in perimenopausal women with HIV. Menopause 2018 Jun;25(6):648-656. doi: 10.1097/GME.0000000000001058.  [PMCID: PMC5970016]

Katherine A. Guthrie KA, Larson JC, Ensrud KE, Anderson GL, Carpenter JS, Freeman EW, Joffe H, LaCroix AZ, Manson JE, Morin CM, Newton KM, Otte J, Reed SR, McCurry SM. Effects of pharmacologic and nonpharmacologic interventions on insomnia symptoms and subjective sleep quality in women with hot flashes: A pooled analysis of individual participant data from 4 MsFLASH trials.  Sleep 2018 Jan 1;41(1). doi: 10.1093/sleep/zsx190. [PMCID: PMC6380606]

Marsh WK, Bromberger JT, Crawford SL, Leung K, Kravitz HM, Randolph JF, Joffe H, Soares CN.  Lifelong estradiol exposure and risk of depressive symptoms during the transition to menopause and postmenopause. Menopause 2017 Dec;24(12):1351-1359. doi:
10.1097/GME.0000000000000929.  [PMCID: PMC5860642]

Peters W, Freeman MP, Kim S, Cohen LS, Joffe H. Treatment of premenstrual breakthrough of depression with adjunctive oral contraceptive pills compared to placebo. J Clin Psychopharm 2017; 37(5):609-614. PMCID not applicable.

Kravitz HM, Janssen I, Bromberger JT, Matthews KA, Hall MH, Ruppert K, Joffe H. Sleep trajectories before and after the final menstrual period in the Study of Women’s Health Across the Nation (SWAN).  Current Sleep Med Reports 2017; 3:235–250. [PMCID:  PMC5604858]

Mitchell CM, Srinivasan S, Zhan X, Wu MC, Reed SD, Guthrie KA, LaCroix AZ,  Fiedler T, Munch M, Liu C, Hoffman NG, Blair IA, Newton K, Freeman EW, Joffe H, Cohen L, Fredricks DN. Vaginal microbiota and genitourinary menopausal symptoms: A cross sectionalanalysis. Menopause 2018 May;25(5):500-507. doi: 10.1097/GME.0000000000001037. [PMCID PMC5898977]

Buchanan DT, Landis CA, Hohensee C, Guthrie KA, Otte JL, Paudel M, Anderson GL, Caan B, Freeman EW, Joffe H, LaCroix AZ, Newton KM, Reed SD, Ensrud KE.  Effects of yoga and aerobic exercise on actigraphic sleep parameters in menopausal women with hot flashes. JClin Sleep Med 2017; 13(1): 11-18.  [PMID: 22707450]

Joffe H, Crawford S, Freeman MP, White DP, Bianchi MT, Kim S, Economou N, Camuso J, Hall JE,* Cohen LS.* Independent contributions of nocturnal hot flashes and sleep disturbance to depression in estrogen-deprived women. J Clin Endocrinol Metab 2016; 101: 3847–3855. [PMCID: PMC5052351]

Carpenter JS, Woods NF, Otte JL, Guthrie KA, Hohensee C, Newton KM, Joffe H, Cohen LS, Sternfeld B, Lau RJ, Reed, SD, LaCroix AZ.  MsFLASH participants’ priorities for alleviating menopausal symptoms. Climacteric 2015;18(6):859-66. doi:
10.3109/13697137.2015.1083003.   [PMCID: PMC4732703]

Galvan T,** Camuso J, Sullivan K, Kim S, White DP, Redline S, Joffe H. Association of estradiol with sleep apnea in menopause:  a preliminary study. Menopause 2017
Jan;24(1):112-117. doi: 10.1097/GME.0000000000000737.  [PMCID: PMC5177515].

Hickey M, Schoenaker DA, Joffe H, Mishra G. Depressive symptoms across the menopause transition: Findings from a large population based cohort study. Menopause 2016
Dec;23(12):1287-1293. Exempt from PMCID; not NIH funded.

Bromberger JT, Kravitz HM, Youk A, Schott LL, Joffe H. Patterns of depressive disorders across 13 years and their determinants among midlife women: SWAN Mental Health Study. J Aff Disord 2016 Jul 5;206:31-40. doi: 10.1016/j.jad.2016.07.005. [PMCID: PMC5077630]

Jackson EA, El Khoudary SR, Crawford SL, Matthews K, Joffe H, Chae C, Thurston RC. Hot flash frequency and blood pressure: data from the Study of Women’s Health Across the Nation (SWAN). J Women’s Health (Larchmt). 2016 Dec;25(12):1204-1209. [PMCID: PMC5175429]

Reed SD, Newton KM, Larson JC, Booth-LaForce C, Woods NF, Landis CA, Tolentino E, Carpenter JS, Freeman EW, Joffe H, Anawalt BD, Guthrie KA. Daily salivary cortisol patterns in midlife women with hot flashes. Clin Endocrinol (Oxf). 2016 May;84(5):672-9. doi: 10.1111/cen.12995. [PMCID: PMC5106033]

Tepper PG, Brooks MM, Randolph JF, Crawford SL, El Khoudary SR, Gold EB, Lasley BL, Jones B, Joffe H, Hess R, Avis NE, Harlow S, McConnell DS, Bromberger JT, Zheng H, Ruppert K, Thurston RC.  Characterizing the trajectories of vasomotor symptoms across the menopausal transition. Menopause 2016 Oct;23(10):1067-74. doi:
10.1097/GME.0000000000000676.  [PMCID: PMC5028150]

Taylor AP, Lee H, Webb ML, Joffe H, Finkelstein JS.  Effects of testosterone and estradiol deficiency on vasomotor symptoms in hypogonadal men. J Clin Endocrinol Metab 2016
Sep;101(9):3479-86. doi: 10.1210/jc.2016-1612. [PMCID: PMC5010571]

McCurry SM, Guthrie KA, Morin CM, Woods NF, Landis CA, Ensrud KE, Larson JC, Joffe H, Cohen LS, Hunt JR, Newton KM, Otte JL, Reed SD, Sternfeld B, Tinker LF, LaCroix AZ. Telephone delivered cognitive-behavior therapy for insomnia in midlife women with vasomotor symptoms: an MsFLASH randomized trial.  JAMA Int Med 2016 2016 Jul 1;176(7):913-20. doi: 10.1001/jamainternmed.2016.1795.  [PMCID:  PMC4935624]

Bianchi MT,* Kim S,* ** Galvan T, White DP, Joffe H.  Nocturnal hot flashes: relationship to objective awakenings and sleep stage transitions.  J Clin Sleep Med 2016 Jul 15;12(7):1003-9.  doi: 10.5664/jcsm.5936. [PMCID: PMC4918982]

Thurston RC, El Khoudary SR, Tepper PG, Jackson EA, Joffe H, Chen H, Matthews KA. Trajectories of vasomotor symptoms and carotid intima media thickness in the Study of Women's Health Across the Nation. Stroke 2016 Jan;47(1):12-7. doi:
10.1161/STROKEAHA.115.010600. [PMCID: PMC496910]

Guthrie KA, LaCroix AZ, Ensrud KE, Joffe H, Newton KM, Reed SD, Caan B, Carpenter JS, Cohen LS, Freeman EW, Larson JC, Manson JE, Rexrode K, Skaar TC, Sternfeld B, Anderson GL.  Pooled analysis of six pharmacologic and nonpharmacologic interventions for vasomotor symptoms.  Obstet Gynecol 2015 Aug;126(2):413-22. doi: 10.1097/AOG.0000000000000927. [PMCID: PMC4526122]

Woods NF, Hohensee C, Carpenter J, Cohen L, Ensrud K, Freeman EW, Guthrie KA, Joffe H, LaCroix AZ, Otte JL, Cochrane B. Symptom clusters among MsFLASH clinical trial participants.  Menopause 2016 Feb;23(2):158-65. doi: 10.1097/GME.0000000000000516.
[PMCID: PMC4731298]

Meyer F,** Freeman M, Petrillo L, Barsky M, Galvan T, Kim S, Cohen L, Joffe H. Armodafinil for fatigue associated with menopause: an open-label trial. Menopause 2016 Feb;23(2):209-14. doi: 10.1097/GME.0000000000000505. Exempt from PMCID; not NIH funded.

Caan B, LaCroix AZ, Joffe H, Guthrie KA, Larson JC, Carpenter JS, Cohen LS, Freeman EW, Manson JE, Newton K, Reed S, Rexrode K, Shifren J, Sternfeld B, Ensrud K. Effects of estrogen and venlafaxine on menopause-related quality of life in healthy postmenopausal women with hot flashes: a placebo-controlled randomized trial. Menopause 2015
Jun;22(6):607-15. doi: 10.1097/GME.0000000000000364. [PMCID: PMC4610378]

Freeman EW, Ensrud K, Larson J, Guthrie KA, Carpenter J, Joffe H, Newton K, Sternfeld B, LaCroix AZ. Placebo Improvement in Pharmacologic Treatment of Menopausal Hot Flashes: Time Course, Duration and Predictors.  Psychosom Med 2015 Feb-Mar;77(2):167-75. doi: 10.1097/PSY.0000000000000143. [PMCID: PMC4333078]

Bromberger JT, Schott L, Kravitz HM, Joffe H.  Risk factors for major depression during midlife among a community sample of women with and without prior major depression: Are they the same or different? Psychol Med 2015 June;45(8): 1653-1664. [PMCID: PMC4414245]


Joffe H, Guthrie KA, LaCroix AZ, Reed SD, Ensrud KE, Manson JE, Newton KM, Freeman
EW, Anderson GL, Larson JC, Hunt JR, Shifren J, Rexrode KM, Caan B, Sternfeld B,
Carpenter JS, Cohen LS. Randomized controlled trial of low-dose estradiol and the SNRI
venlafaxine for vasomotor symptoms. JAMA Int Med 2014 May 26. doi:
10.1001/jamainternmed.2014.1891. [PMCID: PMC4179877]

Avis NE, Crawford SL, Greendale G, Bromberger JT, Everson-Rose SA, Gold EB, Hess R, Joffe H, Kravitz HM, Tepper PG, Thurston RC. Duration of menopausal vasomotor symptoms over the menopause transition.  JAMA Int Med 2015 Apr;175(4):531-9. doi:
10.1001/jamainternmed.2014.8063. [PMCID: PMC4433164]

Manson JE, Ames JM, Shapiro M, Gass ML, Shifren JL, Stuenkel CA, Pinkerton JV, Kaunitz AM, Pace DT, Kagan R, Schnatz PF, Kingsberg SA, Liu JH, Joffe H, Richard-Davis G, Goldstein SR, Schiff I, Utian WH.  Algorithm and mobile app for menopausal symptom management and hormonal/non-hormonal therapy decision making: a clinical decision-support tool from The North American Menopause Society.  Menopause 2015 Mar;22(3):247-53. doi: 10.1097/GME.0000000000000373]  Exempt from PMCID.

Ensrud KE, Guthrie KA, Hohensee C, Caan B, Carpenter JS, Freeman EW, LaCroix AZ, Landis CA, Manson J, Newton KM, Otte J, Reed SD, Shifren JL, Sternfeld B, Woods NF, Joffe H. Effects of estradiol and venlafaxine on insomnia symptoms and sleep quality in women with hot flashes. Sleep 2015 Jan 1;38(1):97-108. doi: 10.5665/sleep.4332. [PMCID: PMC3382013]

Reed SD, Mitchell CM, Joffe H, Cohen L, Shifren JL, Newton KM, Freeman EW, Larson JC, Manson JE, LaCroix AZ, Guthrie KA. Sexual function in women on estradiol or venlafaxine for hot flushes: a randomized controlled trial.  Obstet Gynecol 2014 Aug;124 (2 Pt 1):233-41. doi: 10.1097/AOG.0000000000000386. [PMCID: PMC4113909]

Diem S, Joffe H, Larson J, Tsai J, Guthrie K, LaCroix A, Ensrud K, Freeman E, Leder B. Effects of escitalopram on markers of bone turnover: a randomized clinical trial. J Clin Endocrinol Metabol 2014 Sep;99(9):E1732-7. doi: 10.1210/jc.2014-2288. [PMCID: PMC4154080]

Pinkerton JV, Joffe H, Kazempour K, Mekonnen H, Sailaja B, Lippman J. Low-dose paroxetine (7.5mg) improves sleep in women with vasomotor symptoms associated with menopause. Menopause 2015 Jan;22(1):50-8. doi: 10.1097/GME.0000000000000311. Exempt from PMCID requirements; not NIH funded

Kravitz HM, Schott LL, Joffe H, Cyranowski JM, Bromberger JT.  Do anxiety symptoms predict major depressive disorder in midlife women?  The SWAN Mental Health Study. Psychol Med 2014 Sep;44(12):2593-602. doi: 10.1017/S0033291714000075. [PMCID: PMC4135380]

Joffe H, Guthrie KA, LaCroix AZ, Reed SD, Ensrud KE, Manson JE, Newton KM, Freeman EW, Anderson GL, Larson JC, Hunt JR, Shifren J, Rexrode KM, Caan B, Sternfeld B, Carpenter JS, Cohen LS.   Randomized controlled trial of low-dose estradiol and the SNRI venlafaxine for vasomotor symptoms.  JAMA Int Med 2014 May 26. doi:
10.1001/jamainternmed.2014.1891. [PMCID:  PMC4179877]

Sharkey KM,** Crawford SL, Kim S, Joffe H.  Objective sleep interruption and reproductive hormone dynamics in the menstrual cycle.  Sleep Med 2014 Mar 6. pii: S1389-9457(14)00081-1.   doi: 10.1016/j.sleep.2014.02.003.  [PMCID:  PMC4098663]

Reed SD, Guthrie KA, Newton KM, Anderson GL, Booth-LaForce C, Caan B, Carpenter JS, Cohen LS, Dunn AL, Ensrud KE, Freeman EW, Hunt JR, Joffe H, Larson JC, Learman LA, Rothenberg R, Sequin RA, Sherman KJ, Sternfeld BS, LaCroix AZ.  Menopausal quality of life: a RCT of yoga, exercise and omega-3 supplements.  Am J Obstets Gynecol 2014
Mar;210(3):244.e1-11. doi: 10.1016/j.ajog.2013.11.016. [PMCID: PMC3976276]

Su HI,* ** Maas K,* ** Sluss P, Chang RJ, Hall JE, Joffe H. The impact of depot GnRH agonist on AMH levels in healthy reproductive-aged women.  J Clin Endocrinol Metab 2013;
Dec;98(12):E1961-6. doi: 10.1210/jc.2013-2410.[ PMCID: PMC3849679]

Sternfeld B,  Guthrie KA, Ensrud KE, LaCroix AZ, Larson JC, Dunn AL, Anderson GL, Sequin RA, Carpenter JS, Newton K, Reed SD, Freeman EW, Cohen LS, Joffe H, Roberts M, Caan B.  Efficacy of exercise for menopausal symptoms: a randomized controlled trial Menopause 2014; 21(4):330-338. [PMCID: PMC3858421]

Cohen LS, Joffe H, Guthrie KA, Ensrud KE, Freeman M, Carpenter JS, Learman LA, Newton K, Reed SD, Manson JE, Sternfeld B, Caan B, Freeman EW, LaCroix AZ, Tinker LF, Booth-LaForce C, Larson JC, Anderson GL.  Efficacy of omega-3 treatment for vasomotor symptoms: a randomized controlled trial.  Menopause 2014; 21(4):347-54. [PMCID: PMC4072122]

Newton K, Reed SD, Guthrie KA, Sherman KJ, Booth-LaForce C, Caan B, Sternfeld B, Carpenter JS, Learman LA, Freeman EW, Cohen LS, Joffe H, Anderson GL, Larson JC, Hunt JR, Ensrud KE, LaCroix AZ. Efficacy of yoga for vasomotor symptoms: a randomized controlled trial.  Menopause 2013; September 16. [PMCID: PMC3871975]

Looby SE,** Shifren J, Corless I, Rope A, Pedersen MC, Joffe H,* Grinspoon S.*  Increased hot flash severity and related interference in perimenopausal HIV-infected women. Menopause 2014 Apr;21(4):403-9. doi: 10.1097/GME.0b013e31829d4c4c. [PMCID: PMC3819412]

Newton KN, Carpenter JS, Guthrie KA, Anderson GL, Caan B, Cohen LS, Ensrud KE, Freeman EW, Joffe H, Sternfeld B, Reed SD, Sherman S, Sammel MD, Kroenke K, Larson JC, LaCroix AZ.  Methods for the design of vasomotor symptom trials: the MsFLASH network.  Menopause 2014 Jan;21(1):45-58. doi: 10.1097/GME.0b013e31829337a4. [PMCID: PMC3796184]

Joffe H, Crawford S, Economou N, Kim S, Regan S, Hall JE,* White DP.* A gonadotropin-releasing hormone agonist model demonstrates that nocturnal hot flashes interrupt objective sleep.  Sleep 2013 Dec 1;36(12):1977-85. doi: 10.5665/sleep.3244.  [PMCID: PMC3825449]

Freeman MP, Hirschberg AM, Wang B, Petrillo LF, Connors S, Regan S, Joffe H*, Cohen LS*.  Duloxetine for major depressive disorder and daytime and nighttime hot flashes associated with the menopausal transition. Maturitas 2013 June: 75(2):170-4.  Exempt from PMCID requirements; not NIH funded

Joffe H, White DP, Crawford SL, McCurnin KE, Economou N, Connors S, Hall JE.  Adverse effects of induced hot flashes on objectively recorded and subjectively reported sleep:  results of a gonadotropin-releasing hormone agonist experimental protocol.  Menopause 2013 Sep; 20(9):905-14.  [PMCID: PMC3687015]

Harlow BL, MacLehose RF, Smolenski DJ, Soares CN, Otto MW, Joffe H, Cohen LS. Disparate rates of new onset depression during the menopausal transition in two community-based populations: real, or really wrong? Am J Epidemiol. 2013 May 15;177(10):1148-56. doi: 10.1093/aje/kws365. [PMCID: PMC3649637]

Joffe H, Guthrie KA, Larson J, Cohen LS, Carpenter JS, LaCroix AZ, Freeman EW.  Relapse of vasomotor symptoms after discontinuation of the SSRI escitalopram:  results from the MsFLASH research network.  Menopause 2013 Mar;20(3):261-8. doi:
10.1097/GME.0b013e31826d3108. [PMCID: PMC3561495]

Krystal AD, McCall WV, Fava M, Joffe H, Soares CN, Huang H, Grinell T, Zummo J, Spalding W, Marshall R. Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity.  Prim Care Companion CNS Disord 2012;14(4). doi:pii: PCC.11m01296. [PMCID: PMC3505126]

Cyranowski JM, Schott LL, Kravitz HM, Brown C, Thurston RC, Joffe H, Matthews KA, Bromberger JT.  Psychosocial features associated with lifetime comorbidity of major depression and anxiety disorders among a community sample of mid-life women: the SWAN Mental Health Study.  Depress Anxiety. 2012 Aug 28. doi: 10.1002/da.21990. [PMCID: PMC3592574]

Thurston RC, El Khoudary SR, Sutton-Tyrrell K, Crandall CJ, Sternfeld B, Joffe H, Gold EB, Selzer F, Matthews KA.  Vasomotor symptoms and insulin resistance in the Study of Women’s Health Across the Nation.  J Clin Endocrinol Metab 2012;  Oct;97(10):3487-94.
[PMCID: PMC3462945]

Tepper PG, Randolph JF, McConnell DS, Crawford SL, El Khoudary SR, Joffe H, Gold EB, Zheng H, Bromberger JT, Sutton-Tyrrell K.  Trajectory Clustering of Estradiol and Follicle Stimulating Hormone during the Menopausal Transition among Women in the Study of Women's Health Across the Nation (SWAN).  J Clin Endo Metabol 2012;  Aug;97(8):2872-80.   
[PMCID: PMC341026]

Joffe H, Deckersbach T, Lin NU, Makris N, Skaar TC, Rauch SL, Dougherty DD, Hall JE. Metabolic activity in the insular cortex and hypothalamus predicts hot flashes:  an FDG-PET study.  J Clin Endo Metab 2012;  Sep;97(9):3207-15.  [PMID:  22723326] [PMCID: PMC3791433]

Bromberger JT, Schott LL, Matthews KA, Kravitz HM, Randolph JF, Harlow S,  Crawford S, Green R, Joffe H. Association of past and recent major depression and menstrual characteristics in midlife: Study of Women’s Health Across the Nation.  Menopause 2012 Sep;19(9):959-66. [PMCID: PMC340421]

Ensrud KE, Joffe H, Guthrie KA, Larson JC, Reed SD, Newton KM, Sternfeld B, LaCroix AZ, Landis CA, Woods NF, Freeman EW.  Effect of escitalopram on insomnia symptoms and subjective sleep quality in healthy menopausal women with hot flashes: a randomized controlled trial.  Menopause 2012 Aug;19(8):848-55. [PMCID: PMC3382013]

Carpenter JS, Newton KM, Sternfeld B, Joffe H, Reed SD, Ensrud KE, Milata JL.  Laboratory and ambulatory evaluation of vasomotor symptom monitors from the MsFLASH Network. Menopause 2012 Jun;19(6):664-71. [PMCID: PMC3326209]

Carpenter JS, Guthrie KA, Larson JC, Freeman EW, Joffe H, Reed SD, Ensrud KE, Lacroix AZ.  Effect of escitalopram on hot flash interference: a randomized, controlled trial.  Fertil Steril 2012 Jun;97(6):1399-1404.e1.  [PMID:  22480818] [PMCID: PMC3367120]

Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW+10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging.  Climacteric 2012 Apr;15(2):105-14. [PMID: 22338612] [PMCID: PMC3580996]

Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW + 10 Collaborative Group.  Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging.  Fertil Steril 2012 Apr;97(4):843-51.  [PMID: 22341880] [PMCID: PMC3340904]

Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW 10 Collaborative Group.  Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause 2012 Apr;19(4):387-95. [PMID: 22343510] [PMCID: PMC3340903]

Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ; STRAW + 10 Collaborative Group. Executive summary of the stages of reproductive aging workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 2012 Apr;97(4):1159-68. [PMID: 22344196] [PMCID: PMC3319184]

Joffe H, Chang Y, Dhaliwal S, Hess R, Thurston R, Gold E, Matthews KA, Bromberger JT. Lifetime history of depression and anxiety disorders predicts low quality-of-life in midlife women in the absence of current illness episodes.  Arch Gen Psych 2012;2;69(5):484-492.
[PMCID: PMC3584338]

Gibson C, Joffe H, Bromberger J, Thurston R, Lewis T, Khalil N, Matthews K.  Mood symptoms following natural menopause and hysterectomy with and without bilateral oöphorectomy among midlife women:  Study of Women’s Health across the Nation.  Obstet Gynecol 2012 May;119(5):935-41. [PMCID: PMC3339661]

Sardi P,** Heberle A, Joffe H.  Effect of medroxyprogesterone on depressive symptoms in depressed and non-depressed perimenopausal and postmenopausal women following discontinuation of transdermal estradiol therapy.  Menopause 2012 Apr;19(4):471-5.
[PMCID: PMC3433046]

Thurston RC, El Khoudary SR, Sutton-Tyrrell K, Crandall CJ, Gold EB, Sternfeld B, Joffe H, Selzer F, Matthews KA. Vasomotor symptoms and lipid profiles in women transitioning through menopause.  Obstet Gynecol 2012 Apr;119(4):753-761. [PMCID: PMC3343636]

Reed SD, Guthrie KA, Joffe H, Shifren JL, Seguin RA, Freeman EW.  Sexual function among non-depressed women in escitalopram trial for vasomotor symptoms: MsFLASH network. Obstet Gynecol 2012; Mar;119(3):527-38. [PMCID: PMC3345186]

Joffe H, Petrillo L, Koukopoulos A, Viguera AC, Hirschberg A, Nonacs R, Somley B, Pasciullo E, White DP, Hall JE,* Cohen LS.*  Increased estradiol and improved sleep, but not hot flashes, predict enhanced mood during the menopausal transition.  J Clin Endo Metab 2011 Jul;96(7):E1044-54. [PMCID: PMC3135198]

Dias RS,** Lafer B, Russo C, DelDebbio A, Nierenberg AA, Sachs GS, Joffe H. Longitudinal follow-up of bipolar disorder in women with premenstrual exacerbation: findings from STEP-BD.  Am J Psychiatry 2011;168(4):386-94. [PMID:2132495]

Freeman EW, Guthrie KA, Caan B, Sternfeld B, Cohen LS, Joffe H, Carpenter JS, Anderson GL, Larson JC, Ensrud KE, Reed S, Newton KM, Sherman S, Sammel MD, La Croix AZ.Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.  JAMA 2011;305(3):267-274. [PMCID: PMC3129746]

Freeman MP, Hibbeln JR, Silver M, Hirschberg A, Wang B, Yule AM, Petrillo LF,  Pascuilla E, Economou NI, Joffe H ,* Cohen LS.* Omega-3 fatty acids for major depressive disorder associated with the menopausal transition:  a preliminary open trial.  Menopause
2011;18(3):279-84. [PMCID: PMC3195360]

Joffe H, Partridge A, Giobbie-Hurder A, Li X, Habin K, Goss P, Winer E, Garber J. Augmentation of venlafaxine and SSRI’s with zolpidem improves sleep and quality-of-life in breast cancer patients with hot flashes:  a randomized double-blind placebo-controlled trial. Menopause 2010;17(5):908-16. Exempt from PMCID requirements; not NIH funded

Greendale GA, Wight R, Huang M, Avis N, Gold EB, Joffe H, Seeman T, Vuga M, Karlamangla AS.  Menopause associated symptoms and measured cognitive performance during the menopause transition: results from the Study of Women’s Health Across the Nation.  Am J Epidemiol 2010;171(11):1214-24. [PMCID: PMC2915492]

Joffe H, Petrillo L, Viguera A, Koukopoulos A, Silver-Heilman K, Farrell A, Yu G, Silver M, Cohen LS.  Eszopiclone improves insomnia, depressive and anxious symptoms in perimenopausal and postmenopausal women with hot flashes:  a randomized, double-blinded, placebo-controlled cross-over trial.  Am J Obstet Gynecol 2010;202(2):171.e1.e11. Exempt from PMCID requirements; not NIH funded

Thurston RC, Sowers MFR, Sternfeld B, Gold EB, Bromberger J, Chang Y, Joffe H, Crandall CJ, Waetjen LE, Matthews KA.  Gains in body fat and vasomotor symptom reporting over the menopausal transition: The Study of Women’s Health Across the Nation.  Am J Epidemiol 2009;170(6):766-74. [PMCID: PMC2768523]

Joffe H, Soares CN, Thurston RC, White DP, Cohen LS,* Hall JE.*  Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with VMS.  Menopause 2009;16(4):671-9. [PMCID: PMC3405549]

Harlow BL, Joffe H.  Interpreting incidence of hospitalization for postpartum psychotic and bipolar episodes study.  Arch Gen Psych 2009;66(3):332. Exempt from PMCID requirements; response to letter about ms accepted before 4/8/08

Thurston RC, Bromberger JT, Joffe H, Nancy E. Avis NE, Hess R, Crandall CJ, Chang Y, Green R, Matthews KA. Beyond frequency: who is most bothered by vasomotor symptoms?Menopause 2008;15(5):841-847. [PMCID: PMC2866103]

Soares CN,* Joffe H,* Viguera AC, Petrillo LF, Rydzewski M, Yehezkel R, Somley B, Cohen LS.  Paroxetine versus placebo for women in midlife after hormone therapy discontinuation. Am J Med 2008;121(2):159-162. Exempt from PMCID requirements; ms accepted before
4/8/08

Gold EB, Lasley B, Crawford SL, McConnell D, Joffe H, Greendale GA.  Relation of daily urinary hormone patterns to vasomotor symptoms in a multi-ethnic sample of midlife women: Study of Women’s Health Across the Nation (SWAN) Daily Hormone Study (DHS).  Repro Sciences 2007;14(8):786-797. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Gottschall H, Petrillo L, Soares CN, Viguera AC, Hall JE,* Cohen LS.*  Treatment of premenstrual worsening of depression with adjunctive oral-contraceptive pills.  J ClinPsychiatry 2007;68(12):1954-1962. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H,* Soares CN,* Somley B, Koch J, Petrillo L, Viguera A, Cohen LS.  Treatment of depression and menopause-related symptoms with the serotonin-norepinephrine reuptake inhibitor duloxetine.  J Clin Psychiatry 2007; 68(6):943-950. Exempt from PMCID requirements; ms accepted before 4/8/08

Harlow BL, Vitonis AF, Sparen P, Cnattingius S, Joffe H,* Hultman CM.*  Incidence of hospitalization for postpartum psychotic and bipolar episodes in women with and without prior pre-pregnancy or prenatal psychiatric hospitalizations.  Arch Gen Psych 2007; 64(1):42-48. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Cohen LS, Suppes T, Hwang CH, Molay FJ, Adams JM, McLaughlin WL, Sachs GS,* Hall JE.*  Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features.  Biol Psych 2006; 60(12):1378-1381. Exempt from PMCID requirements; ms accepted before 4/8/08

Soares CN, Joffe H, Rubens R, Caron J, Roth T, Cohen L.  Eszopiclone in patients with insomnia during perimenopause and early postmenopause:  a randomized controlled trial. Obstet Gynecol 2006; 108(6):1402-1410. Exempt from PMCID requirements; ms accepted before 4/8/08

Soares CN, Arsenio H, Joffe H, Bankier B, Cassano P, Petrillo LF, Cohen LS.  Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri and postmenopausal women: impact on depression, vasomotor symptoms, sleep and quality of life.  Menopause 2006; 13(5):780-786. Exempt from PMCID requirements; ms accepted before 4/8/08

Thurston R, Joffe H, Soares CN, Harlow BL.  Physical activity associated with decreased risk of vasomotor symptoms among women with a history of depression.  Menopause
2006;13(4):553-560. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Cohen LS, Suppes T, McLaughlin WL, Lavori P, Adams JM, Hwang CH, Hall JE,* Sachs GS.*  Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder.  Biol Psych 2006;59(11):1078-1086. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Hall JE, Gruber SA, Sarmiento IA, Cohen LS, Yurgulen-Todd D,* Martin KA.* Estrogen therapy selectively enhances prefrontal cognitive processes:  a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women.  Menopause 2006;13(3):411-422. Exempt from PMCID requirements; ms accepted before 4/8/08

Rich-Edwards J, Kleinman K, Abrams A, Harlow BL, McLaughlin TJ, Joffe H, Gillman MW. Sociodemographic predictors of antenatal and postpartum depressive symptoms among women in a large group medical practice.  J Epidemiol Community Health 2006; 60(3):221-
227.   [PMCID: PMC2465548]

Joffe H, Kim D, Foris JM, Baldessano C, Gyulai L, Hwang CH, McLaughlin WL, Thase M, Sachs GS, Harlow BL, Cohen LS.  Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controls.  J Clin Psychiatry 2006; 67(2):297-304. Exempt from PMCID requirements; ms accepted before 4/8/08

Baldassano CF, Marangell L, Ghaemi N, Joffe H, Kim DR, Sagduyu K, Gyulai L, Wisniewski S, Sachs GS, Cohen LS.  Gender differences in the course of bipolar disorder:  retrospective data from the first 500 STEP-BD participants.  Bipolar Disorders 2005; 7(5):465-470. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Cohen LS, Harlow BL.  Impact of oral contraceptive pill use on premenstrual mood: predictors of improvement and deterioration.  Am J Obstet Gynecol 2003 Dec; 189(6):1523-1530. Exempt from PMCID requirements; ms accepted before 4/8/08

Soares CN, Joffe H, Cohen LS, Almeida OP.  Efficacy of 17-estradiol on depression:  is estrogen deficiency really necessary?  J Clin Psychiatry 2002; 63:451. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Hall JE, Soares CN, Hennen J, Reilly CJ, Carlson KJ, Cohen LS. Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care. Menopause 2002; 9:392-398. Exempt from PMCID requirements; ms accepted before 4/8/08

Soares CN, Almeida OP, Joffe H, Cohen LS. Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry 2001; 58: 529-534. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Groninger H, Soares CN, Nonacs R, Cohen LS. An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy clinic. J Womens Health Gen Based Med 2001; 10:999-1004. Exempt from PMCID requirements; ms accepted before 4/8/08

Joffe H, Georgakopoulos D, Sullivan ID, Celermajer DS, Deanfield JE.  Late ventricular arrhythmia is rare after early repair of tetralogy of fallot.  J Am Coll Cardiology 1994;
23:1146-1150. Exempt from PMCID requirements; ms accepted before 4/8/08

indicates co-first or co-senior authorship; ** indicates paper first authored by mentee

Reviews

Maki PM, Kornstein SG, Joffe H, Bromberger JT, Freeman EW, Athappilly G, Bobo WV,
Rubin LH, Koleva HK, Cohen LS, Soares CN. Board of Trustees for The North American
Menopause Society (NAMS) and the Women and Mood Disorders Task Force of the
National Network of Depression Centers. Guidelines for the evaluation and treatment of
perimenopausal depression: summary and recommendations. Menopause 2018
Oct;25(10):1069-1085. doi: 10.1097/GME.0000000000001174. Exempt from PMCID requirements; not NIH funded.

Maki PM, Kornstein SG, Joffe H, Bromberger JT, Freeman EW, Athappilly G, Bobo WV,Rubin LH, Koleva HK, Cohen LS, Soares CN. Guidelines for the evaluation and treatment of
perimenopausal depression: summary and recommendations. J Womens Health (Larchmt) 2019 Feb;28(2):117-134. doi: 10.1089/jwh.2018.27099.mensocrec. Exempt from PMCID requirements; not NIH funded.

Kravitz HM, Kazlauskaite R, Joffe H. Sleep, health, and metabolism in midlife women and menopause: food for thought. Obstetrics and Gynecology Clinics 2018 Dec; 2018 Dec;45(4):679-694. doi: 10.1016/j.ogc.2018.07.008.

Brindis CD, Freund KM, Baecher-Lind L, Bairey Merz CN, Carnes M, Gulati M, Joffe H,Klein WS, Mazure CM, Pace LE, Regensteiner JG, Redberg RF, Wenger NK, Younger L. The risk of remaining silent: addressing the current threats to women's health. Womens
Health Issues. 2017 Nov - Dec;27(6):621-624. doi: 10.1016/j.whi.2017.10.006.

Joffe H, Hickey M Should hormone therapy be used to prevent depressive symptoms during
the menopause transition? JAMA Psychiatry. 2018 Feb 1;75(2):125-126. doi: 10.1001/jamapsychiatry.2017.3945.

Joffe H, Bromberger JT. Shifting paradigms about hormonal risk factors for postmenopausal
depression: age at menopause as an indicator of cumulative lifetime exposure to female reproductive hormones. JAMA Psychiatry 2016 Feb 1;73(2):111-2. doi:
10.1001/jamapsychiatry.2015.2701.

Gordon JL, Girdler SS, Meltzer-Brody SE, Stika CS, Thurston RC, Clark CT, Prairie BA,
Moses-Kolko E, Joffe H,* Wisner KL. Response to Eskola et al. Am J Psychiatry. 2015 Aug
1;172(8):797. doi: 10.1176/appi.ajp.2015.15030377r.

Gordon JL, Girdler SS, Meltzer-Brody SE, Stika CS, Thurston RC, Clark CT, Prairie BA,
Moses-Kolko E, Joffe H,* Wisner KL.* Ovarian Hormone Fluctuation, Neurosteroids, and
HPA Axis Dysregulation in Perimenopausal Depression: A Novel Heuristic Model. Am J
Psychiatry 2015 Aug 1;172(8):797. doi: 10.1176/appi.ajp.2015.15030377r.

Shifren JL, Gass ML; NAMS Recommendations for Clinical Care of Midlife Women Working Group. The North American Menopause Society recommendations for clinical care of midlife women. Menopause. 2014 Oct;21(10):1038-62. doi:
10.1097/GME.0000000000000319.

Athappilly G,** Joffe H. Depression rates around natural menopause. First to Know (editorial), The North American Menopause Society (NAMS) e-newsletter, December 2013.

Athappilly G,** Joffe H. Cognition, estradiol, and proximity to menopause tested again. First to Know (editorial), The North American Menopause Society (NAMS) e-newsletter,
December 2013.

Ajmal A, Joffe H, Nachtigall LB. Psychosomatics 2014 Jan-Feb;55(1):29-36. doi: 10.1016/j.psym.2013.08.008. Exempt from PMCID requirements; not NIH funded.

Freeman MP, Joffe H, Cohen LS. Postpartum Depression: Detection and Treatment, Curr Psychiatry 2013: in press. Exempt from PMCID requirements; not NIH funded

Joffe H. Antidepressant use after discontinuation of hormone therapy: what can one infer about post-hormone therapy depression? Menopause 2013 Feb;20(2):123-5. doi:
10.1097/gme.0b013e31828059d4.

Kravitz HM, Joffe H. Sleep during the perimenopause: a SWAN story. Obstet Gynecol Clin North Am 2011; 38(3):567-86. PMCID: PMC3185248

Thurston RC, Joffe H. Vasomotor symptoms and menopause: findings from the study of women’s health across the nation. Obstet Gynecol Clin North Am 2011; 38(3):489-501.
PMCID: PMC3185243

Wroolie T, Joffe H. Psychological symptoms. In: Menopause Practice: A Clinician’s Guide. North American Menopause Society, 2010.

Thurston RC, Joffe H. Vasomotor symptoms and menopause: findings from the study of women’s health across the nation. Obstet Gynecol Clin North Am 2011; 38(3):489-501.
PMCID: PMC3185243

Wroolie T, Joffe H. Psychological symptoms. In: Menopause Practice: A Clinician’s Guide. North American Menopause Society, 2010.

Joffe H, Connors S. “Eszopiclone improves insomnia, depressive and anxious symptoms in perimenopausal and postmenopausal women with hot flashes: a randomized, double-blinded,
placebo-controlled cross-over trial.” In Best of Sleep Medicine 2011 (Volume 2): An Annual Collection of Scientific Literature, edited by Teofilo Lee-Chiong.

Joffe H, Massler A, Sharkey KM. Evaluation and management of sleep disturbance during
the menopause transition. Semin Reprod Endocrinol 2010; 28(5):404-421.
[PMCID:PMC3736837]

Joffe H, Greenfield SF. Women’s Mental Health: New Research Findings. Harv Rev Psychiatry 2009; 17 (2):69-71.

Payne JL,** Teitelbaum-Palmer J, Joffe H. A reproductive subtype of depression: conceptualizing models and moving towards etiology. Harv Rev Psychiatry 2009; 17(2):72-86. [PMCID: PMC3741092]

Hickey M, Saunders C, Partridge A, Santoro N, Joffe H,* Stearns V.* Practical clinical guidelines for assessing and managing menopausal symptoms after breast cancer. Ann Oncol2008; 19(10):1669-1680. Exempt from PMCID requirements; not NIH funded

Joffe H, Hayes FJ. Menstrual-cycle dysfunction associated with neurological and psychiatric
disorders and their treatment in adolescents. Ann N Y Acad Sci 2008; 1135:219-229.

Santoro N, Sherman SS, Joffe H, Newton K, Grady D, Freeman E, Schmidt P, Stearns V; Endicott J, Ganz P, Low Dog T, Monroe S, Shames D, Weber A, Zeitlian G. New intervention strategies for menopausal symptoms. Executive Summary of NIH meeting
November 2006, posted at: http://www.nia.nih.gov/NR/rdonlyres/8F7AA845-03B4-4181-
B43BCDFBC3BC1091/0/NIMSIIExecutiveSummary.pdf in August 2007.

Joffe H. Reproductive biology and psychotropic treatments in women with bipolar disorder.
J Clin Psychiatry 2007; 68 (suppl 9):10-15.

Kim DR,** Joffe H. The use of antidepressants during perimenopause. Women’s Health
2006; 2(4):627-637.

Cohen LS, Soares CN, Joffe H. Diagnosis and management of mood disorders during the
menopausal transition. Am J Medicine 2005; 118 (12 Suppl 2) 93-97.

Soares CN, Joffe H, Steiner M. Menopause and Mood. Clin Obstet Gynecol 2004; 47:576-
591.

Joffe H, Soares CN, Cohen LS. Assessment and treatment of hot flushes and menopausal
mood disturbance. Psychiatr Clin N Am 2003; 26:563-580.

Joffe H, Hall JE, Cohen LS, Taylor AE, Baldessarini RJ. A putative relationship between valproic acid and polycystic ovarian syndrome: implications for treatment of women with bipolar disorder. Harv Rev Psychiatry 2003; 11:99-108.

Joffe H, Taylor AE, Hall JE. Polycystic ovarian syndrome—relationship to epilepsy and
antiepileptic drug therapy. J Clin Endocrinol Metab 2001; 86:2946-2949.

Joffe H, Cohen LS. Estrogen, serotonin, and mood disturbance: where is the therapeutic
bridge? Biol Psychiatry 1998; 44:798-811.


Additional Publications

Joffe H, McCurnin KE, Hall JE. Hormone dynamics and sleep consequences of experimentally induced hot flashes. Endocrine Society 89th Annual Meeting, Toronto, Ontario, Canada, June 2007

Textbooks

Miller LJ, Athappilly G, Avni-Barron O, Carusi D, Joffe H. Depression and Gynecologic
Conditions. In A Barsky & D Silbersweig (Eds.), Depression in Medical Illness, 2016. New
York: McGraw-Hill Education.

Almeida M, Brown K, Mittal L, Nathan M, Joffe H. Women’s Mental Health and
Reproductive Psychiatry. In Summergrad P, Silbersweig D, Muskin PR, Querques J (Eds.),
Medical Psychiatry, 2019. Washington DC: American Psychiatric Association Publishing.


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