Faculty Profile

Heinrich S. Gompf, PhD


Instructor in Neurology, Harvard Medical School

See publications


Address

3 Blackfan Circle
CLS -717
Boston, MA 02115
USA

Fax 617-735-3249

Email hgompf@bidmc.harvard.edu

Society Memberships

Society for Neuroscience
Sleep Research Society

Research Unit(s)

Systems Neurobiology Group

Research Interests

My primary research interests are the mechanisms by which external stimuli and the internal clock activate arousal systems.  My approach has involved in vitro whole-cell patch-clamp and in vivo single unit neurophysiology, neuroanatomy and EEG monitoring of sleep and wakefulness in rats and mice.

Prior to joining the Division of Sleep Medicine, I described a role for hypothalamic orexin neurons in the regulation of locus coeruleus circadian activity and the effects of inhaled anesthetics.  Currently, I am using novel social and environmental stimuli to study how arousal areas can override the circadian and homeostatic sleep drive.


Mentor(s)

Clifford B. Saper, MD, PhD
Gary Aston-Jones, PhD
Charles Allen, PhD


Research Funding

NIH, PI: Heinrich S Gompf, PhD, Circadian light entrainment following genetic ablation of retinal glutamate transmission

Selected Publications

Gompf H, Chen J, Sun Y, Yanagisawa M, Aston-Jones G, Kelz MB. Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents. Anesthesiology. 2009 Oct 5. [Epub ahead of print] [PubMed PMID:19809293]

Aston-Jones G, Gonzalez M, Gompf H.  Brain norepinephrine and control of sleep-wake circadian rhythms.  Manuscript in press, Frontiers in Neuroscience.

Gompf HS, Aston-Jones G. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. Brain Res. 2008 Jun 3. [PMID: 18614159]

Gompf HS, Irwin RP, Allen CN. Retrograde suppression of GABAergic currents in a subset of SCN neurons. Eur J Neurosci. 2006 Jun;23(12):3209-16. [PMID: 16820011]

Gompf HS, Moldavan MG, Irwin RP, Allen CN. Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic signaling in the suprachiasmatic nucleus (SCN). Neuroscience. 2005;132(4):955-65. [PMID: 15857701]

Gompf HS, Allen CN. GABAergic synapses of the suprachiasmatic nucleus exhibit a diurnal rhythm of short-term synaptic plasticity. Eur J Neurosci. 2004 May;19(10):2791-8. [PMID: 15147312]

Ikeda M, Sugiyama T, Wallace CS, Gompf HS, Yoshioka T, Miyawaki A, Allen CN. Circadian dynamics of cytosolic and nuclear Ca2+ in single suprachiasmatic nucleus neurons.
Neuron. 2003 Apr 24;38(2):253-63. [PMID: 12718859]

Gompf H, Luft FC, Morano I. Nitric oxide synthase upregulation and the predelivery blood pressure decrease in spontaneously hypertensive rats. J Hypertens. 2002 Feb;20(2):255-61. [PMID: 11821710]

Nelson CS, Ikeda M, Gompf HS, Robinson ML, Fuchs NK, Yoshioka T, Neve KA, Allen CN. Regulation of melatonin 1a receptor signaling and trafficking by asparagine-124. Mol Endocrinol. 2001 Aug;15(8):1306-17. [PMID: 11463855]




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