Faculty Profile

Sat Bir Singh Khalsa, PhD

Sat Bir S. Khalsa, PhD
Assistant Professor of Medicine, Harvard Medical School
Associate Neuroscientist, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

See publications


Sleep Disorders Program
Brigham and Women's Hospital, 221 Longwood Avenue
Boston, MA 02115

Inter-office Mail Address

Sleep Disorders Research Program
221 Longwood Avenue
Boston, MA 02115

Phone 617-732-7994

Society Memberships

International Association of Yoga Therapists

Research Unit(s)

Sleep Disorders Program

Research Interests

The major focus of my research interest lies in the field of Mind-Body Medicine. Specifically, I am interested in the evaluation of the clinical effectiveness and basic psychophysiological mechanisms underlying the practice of yoga and meditation techniques. These behavioral techniques include specific manipulations of respiratory frequency and tidal volume, maintenance of body postures and stretching exercises, and meditation, which involves relaxed control of attention in a manner that precludes ruminative thought.

Specific areas of interest include the evaluation of the benefits of yoga practice in the public school settings, and efficacy studies of yoga for insomnia, chronic stress, PTSD, and anxiety disorders.


Aretoula Fullam, PhD, 2005-2006
Jessica Noggle, PhD, 2009-
Bethany Butzer, PhD, 2012-


Research Funding

NIH/NIDA (PI: Khalsa)
"Evaluation of Yoga for Substance Use Risk Factors in the High School Setting"

Kripalu Center for Yoga and Heatlh (PI: Khalsa)
"Evaluation of Yoga in Public Schools"


Mind Body Medicine, elective course Harvard Medical School

Selected Publications

Quilty MT, Saper RB, Goldstein R, Khalsa SBS. Yoga in the real world: Perceptions, motivators, barriers, and patterns of use.
Global Advances in Health and Medicine (in press) 2012.

Conboy LA, Noggle JJ, Frey JL, Kudesia RS, Khalsa SBS. Qualitative evaluation of a high school yoga program: Feasibility and perceived benefits.
Explore: The Journal of Science & Healing, (in press) 2012.

Khalsa SBS, Butzer B, Shorter SM, Reinhardt KM, Cope S. Yoga reduces performance anxiety in adolescent musicians.
Alternative Therapies in Health and Medicine (in press) 2012.

Moliver N, Mika EM, Chartrand MS, Haussmann RE, Khalsa SBS. Yoga Experience as a Predictor of Psychological Wellness in Women Over 45 Years.
International Journal of Yoga (in press) 2012.

Hartfiel N, Burton C, Rycroft-Malone J, Clarke G, Havenhand J, Khalsa SB, Edwards RT. Yoga for reducing perceived stress and back pain at work.
Occup Med (Lond). 2012 Dec;62(8):606-12. [PMID: 23012344]

Rüger M, St Hilaire MA, Brainard G, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a single 6.5-h pulse of short-wavelength light.
J Physiol. 2012 Nov 26. [PMID: 23090946]

Stern JR, Khalsa SB, Hofmann SG. A yoga intervention for music performance anxiety in conservatory students.
Med Probl Perform Art. 2012 Sep;27(3):123-8. [PMID: 22983129]

St Hilaire MA, Gooley JJ, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a 1 h pulse of bright white light.
J Physiol. 2012  Jul 1;590(Pt 13):3035-45. [PMID: 22547633]

Noggle JJ, Steiner NJ, Minami T, Khalsa SB. Benefits of yoga for psychosocial  well-being in a US high school curriculum: a preliminary randomized controlled trial.
J Dev Behav Pediatr. 2012 Apr;33(3):193-201. [PMID: 22343481]

Büssing A, Hedtstück A, Khalsa SB, Ostermann T, Heusser P. Development of Specific Aspects of Spirituality during a 6-Month Intensive Yoga Practice.
Evid Based Complement Alternat Med. 2012;2012:981523. [PMID: 22852023]

Silverthorne C, Khalsa SB, Gueth R, Deavilla N, Pansini J. Respiratory, Physical, and Psychological Benefits of Breath-Focused Yoga for Adults with Severe Traumatic Brain Injury (TBI): A Brief Pilot Study Report.
Int J Yoga Therap. 2012;(22):47-52. [PMID: 23070671]

Khalsa SB, Hickey-Schultz L, Cohen D, Steiner N, Cope S. Evaluation of the mental health benefits of yoga in a secondary school: a preliminary randomized controlled trial.
J Behav Health Serv Res. 2012 Jan;39(1):80-90. [PMID: 21647811]

Moliver N, Mika E, Chartrand M, Burrus S, Haussmann R, Khalsa S. Increased Hatha yoga experience predicts lower body mass index and reduced medication use in women over 45 years.
Int J Yoga. 2011 Jul;4(2):77-86. doi: 10.4103/0973-6131.85490. [PMID: 22022126]

Gooley JJ, Chamberlain K, Smith KA, Khalsa SB, Rajaratnam SM, Van Reen E, Zeitzer JM, Czeisler CA, Lockley SW. Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans.
J Clin Endocrinol Metab. 2011 Mar;96(3):E463-72. [PMID: 21193540]

Hartfiel N, Havenhand J, Khalsa SB, Clarke G, Krayer A. The effectiveness of yoga for the improvement of well-being and resilience to stress in the workplace.
Scand J Work Environ Health. 2011 Jan;37(1):70-6. Epub 2010 Apr 6. [PMID: 20369218]

Cain SW, Dennison CF, Zeitzer JM, Guzik AM, Khalsa SB, Santhi N, Schoen MW,
Czeisler CA, Duffy JF. Sex differences in phase angle of entrainment and melatonin amplitude in humans.
J Biol Rhythms. 2010 Aug;25(4):288-96. [PMID: 20679498]

Jung CM, Khalsa SB, Scheer FA, Cajochen C, Lockley SW, Czeisler CA, Wright KP
Jr. Acute effects of bright light exposure on cortisol levels.
J Biol Rhythms. 2010 Jun;25(3):208-16.[PMID: 20484692]

Khalsa SB, Shorter SM, Cope S, Wyshak G, Sklar E. Yoga Ameliorates Performance Anxiety and Mood Disturbance in Young Professional Musicians.
Appl Psychophysiol Biofeedback. 2009 Aug 6. [Epub ahead of print] [PMID: 19657730]

Khalsa SB, Khalsa GS, Khalsa HK, Khalsa MK. Evaluation of a residential Kundalini yoga lifestyle pilot program for addiction in India.
J Ethn Subst Abuse. 2008;7(1):67-79. [PMID: 19842301]

St Hilaire MA, Klerman EB, Khalsa SB, Wright KP Jr, Czeisler CA, Kronauer RE. Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker.
J Theor Biol. 2007 Aug 21;247(4):583-99. Epub 2007 Apr 4. [PMID: 17531270]

Khalsa SB, Cope S. Effects of a yoga lifestyle intervention on performance-related characteristics of musicians: a preliminary study.
Med Sci Monit. 2006 Aug;12(8):CR325-31. Epub 2006 Jul 12. [PMID: 16865063]

Zeitzer JM, Khalsa SB, Boivin DB, Duffy JF, Shanahan TL, Kronauer RE, Czeisler CA. Temporal dynamics of late-night photic stimulation of the human circadian timing system.
Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R839-44. Epub 2005 May 12. [PMID: 15890792]

Khalsa SB. Treatment of chronic insomnia with yoga: a preliminary study with sleep-wake diaries.
Appl Psychophysiol Biofeedback. 2004 Dec;29(4):269-78. [PMID: 15707256]

Reviews and editorials

Khalsa SB. Author Response to manuscript: "Religious Behavior, Sleep Quantity, Sleep Quality, and Sleep Disorders in American Adults".
J Behav Health Serv Res. 2012 Nov 28. [PMID: 23188488]

Hagins M, Khalsa SB. Bridging yoga therapy and scientific research.
Int J Yoga Therap. 2012;(22):5-6. [PMID: 23070666]

Büssing A, Michalsen A, Khalsa SB, Telles S, Sherman KJ. Effects of yoga on mental and physical health: a short summary of reviews.
Evid Based Complement Alternat Med. 2012;2012:165410. [PMID: 23008738]

Khalsa SB. Yoga as a therapeutic intervention: a bibliometric analysis of published research studies.
Indian J Physiol Pharmacol. 2004 Jul;48(3):269-85. Review. [PMID: 15648399]

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