Faculty Profile

Monika Haack, PhD

Monika Haack, PhD profile photo
Associate Professor of Neurology, Harvard Medical School
Associate Professor of Neurology, Department of Neurology, Beth Israel Deaconess Medical Center

See publications


Address

330 Brookline Avenue
Dana 779
Boston, MA 02215
USA

Inter-office Mail Address

Beth Israel Deaconess Medical Center East Campus, Dana 779

Phone 617-667-5234

Email mhaack@bidmc.harvard.edu

Society Memberships

Sleep Research Society (SRS)
Psychoneuroimmunology Research Society (PNIRS)
German Sleep Society (DGSM)
American Pain Society (APS)


Research Unit(s)

Human Sleep & Inflammatory Systems Laboratory
Systems Neurobiology Group (Saper)

Research Interests

My research goals are directed at discovering the mechanisms underlying the relationship between sleep deficiency and pain processing, with a focus on inflammatory networks.  My long term goal is to identify key inflammatory pathways or signatures affected by sleep deficiency that serve the development of interventions to prevent inflammatory alterations and related abnormalities in pain processing when exposed to sleep deficiency. I have developed and implemented complex and lengthy experimental models of sleep deficiency in order to mimic sleep patterns that are highly common in society, such as the repeated exposure to restricting sleep on weekdays and catching-up on sleep over the weekend, or patterns of recurrent sleep disruption. Testing the effects of more chronic (rather than acute) forms of sleep deficiency allows to determine to which degree the immune and other biological systems can adapt to sleep deficiency, which is critical information in understanding how sleep deficiency in the long term affects health, and in particular increases chronic pain vulnerability. In addition, my work further focuses on recovery options, such as how much recovery sleep is needed to reinstate inflammatory balance.

Trainees

Norah Simpson PhD, 2009-11
Francieli Ruiz PhD, 2010
Lea Michaels, 2011-12
Laura Dieppa-Perea BS, 2012 
Samantha Floam DMD, 2012-14
Edith Laryea BS, 2012
Sana Sajjad, 2012-13
Eric Zigon, 2013
Hanna Heck BS, 2013
Moussa Diolombi BS, 2013-14
John Smith BS, 2014
Christopher Villongco BS, 2015
Assem Jabri BS, 2016
Alisha Wilkins BS, 2016-17
Keeyon Olia BS, 2016-18
Caitlin Sullivan, 2016-17
Jaime Devine PhD, 2015-17
Victoria Molina BS, 2017
Hannah Alaimo, 2017-18
Erin Wright, 2017-18
Luciana Besedovsky PhD, 2017-18
Rasha Nadheer, 2018-19

Mentor(s)


Research Funding

NIH/NINDS R01 NS091177
PI Monika Haack
Pain sensitization and habituation in a model of experimentally induced insomnia symptoms

NIH/NHLBI R01 HL136310
PI Monika Haack
Patterns of sleep restriction and recovery: The inflammatory resolution pathways

NIH/NHLBI R01 HL125379
PI Janet Mulllington
Mechanisms underlying the blood pressure lowering effect of sleep extension



Selected Publications

Peer reviewed publications in print or other media

Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiological Reviews. In press.

Devine JK, Bertisch SM, Yang H, Scott-Sutherland J, Wilkins A, Molina V, Henrikson K, Haack M. Glucocorticoid and Inflammatory Reactivity to a Repeated Physiological Stressor in Insomnia Disorder. Neurobiology of Sleep and Circadian Rhythms. In press.

Alkozei A, Killgore WD, Smith R, Dailey NS, Bajaj S, Haack M. Chronic sleep restriction differentially affects implicit biases toward food among men and women:  Preliminary evidence. J of Sleep Research. In press. [PMID:29094414]

Simpson N, Scott-Sutherland J, Gautam S, Sethna N, Haack M. Chronic exposure to insufficient sleep alters processes related to pain habituation and sensitization. Pain. 2018;159(1):33-40. [PMID:28891869].
Selected as Editor’s Choice article.
Alkozei A, Killgore WD, Smith R, Dailey NS, Haack M. Chronic sleep restriction increases negative implicit attitudes toward Arab Muslims. Scientific Reports, 2017;7:article number 4285. [PMID:28655901]
Featured in: You Are Not So Smart: https://youarenotsosmart.com/2017/09/11/yanss-110-how-sleep-deprivation-dulls-our-minds-and-unleashes-our-biases/

Yang H, Haack M, Gautam S, Meier-Ewert H, and Mullington J. Repetitive exposure to shortened sleep leads to blunted sleep-associated blood pressure dipping. J Hypertension. 2017;35(6):1187-94. [PMID: 28169885]

Simpson, NS, Diolombi, M, Scott-Sutherland, J, Yang, H, Bhatt, V, Gautam, S, Mullington, J, Haack, M. Repeating patterns of sleep restriction and recovery: Do we get used to it? Brain Behav Immun. 2016;58:142-151. [PMID:27263430]

Mullington, JM, Abbott, SM, Carroll, JE, Davis, CJ, Dijk, DJ, Dinges, DF, Gehrman, PR, Ginsburg, GS, Gozal, D, Haack, M, Lim, DC, Macrea, M, Pack, AI, Plante, DT, Teske, JA, Zee, PC. Developing biomarker arrays predicting sleep and circadian-coupled risks to health. Sleep. 2016;39:727-36. [PMID:26951388]

Floam S, Simpson N, Nemeth E, Scott-Sutherland J, Gautam S, Haack M. Sleep characteristics as predictor variables of stress systems markers in insomnia disorder. J Sleep Research. 2015;24:296-304. [PMID:25524529]

Haack M, Serrador J, Cohen D, Simpson N, Meier-Ewert H, Mullington JM. Increasing sleep duration to lower beat-to-beat blood pressure – a pilot study. J Sleep Res. 2013;22:295-304. [PMID:23171375]

Haack M, Scott-Sutherland J, Santangelo G, Simpson N, Sethna N, Mullington JM. Pain sensitivity and modulation in primary insomnia. Euro J Pain. 2012;16:522-533. [PMID:22396081]

Mullington JM, Simpson NS, Meier-Ewert H, Haack M. Sleep loss and inflammation.  Best Practice & Research Clinical Endocrinology & Metabolism. 2010;24:775-784.

[PMID:21112025]
Haack M, Lee E, Cohen AD, Mullington JM. Activation of the prostaglandin system in response to sleep loss in healthy humans: Potential mediator of increased spontaneous pain. Pain. 2009;145:136-141. [PMID:19560866]

Mullington JM, Haack M, Toth M, Serrador J, Meier-Ewert HK. Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation. Progress in Cardiovascular Diseases. 2009;51:294-302. [PMID:19110131]

Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep. 2007;30:1145-52. [PMID:17910386]

Schuld A, Birkmann S., Beitinger P., Haack M., Kraus T., Dalal M.A., Holsboer F., Pollmächer T. Low doses of dexamethasone affect immune parameters in the absence of immunological stimulation.  Exp Clin Endocrinol Diabetes. 2006;114(6):322-8. [PMID:16868892]

Haack M, Mullington JM. Sustained sleep restriction reduces emotional and physical well-being. Pain. 2005;119:56-64. [PMID:15380398]
Himmerich H, Schuld A, Haack M, Kaufmann C, Pollmächer T. Early prediction of changes in weight during six weeks of treatment with antidepressants. J Psychiatr Res. 2004;38:485-9. [PMID:15380398]

Haack M, Pollmächer T, Mullington J. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers.  Brain Behav Immun. 2004;18(4):361-7. [PMID: 15157953]

Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone. J Psychiatr Res. 2003;37:463-70. [PMID:14563377]

Straub RH, Schuld A, Mullington J, Haack M, Scholmerich J, Pollmächer T. The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects. J Endocrinol. 2002;175:467-74. [PMID:12429044]

Reichenberg A, Kraus T, Haack M, Schuld A, Pollmächer T, Yirmiya R. Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-a and IL-6 secretion. Psychoneuroendocrinology. 2002;27:945-56. [PMID:12383455]

Pollmächer T, Haack M, Schuld A, Reichenberg A, Yirmiya R. Low levels of circulating inflammatory cytokines - Do they affect human brain functions? Brain Behav Immun. 2002;16:525-32. [PMID: 12401466]

Kraus T, Haack M, Schuld A, Hinze-Selch D, Koethe D, Pollmächer T. Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine. Pharmacopsychiatry. 2002;35:220-5. [PMID:12518269]

Haack M, Schuld A, Pollmächer T. Immune activation: Effects on mood and cognition. Psychotherapie in Psychiatrie, Psychotherapeutischer Medizin und Klinischer Psychologie. 2002;7:210-8.

Haack M, Kraus T, Schuld A, Dalal M, Koethe D, Pollmächer T. Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures. Psychoneuroendocrinology. 2002;27:921-31. [PMID:12383453]

Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D. On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine receptors. Fortschr Neurol Psychiatr. 2001;69 (Suppl 2):S65-74. [PMID:11533853]

Schuld A, Kraus T, Haack M, Hinze-Selch D, Zobel AW, Holsboer F, Pollmächer T. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients. Psychoneuroendocrinology. 2001;26:65-76. [PMID:11070335]

Kraus T, Zimmermann U, Schuld A, Haack M, Hinze-Selch D, Pollmächer T. The pathophysiology of weight regulation during treatment with psychotropic drugs. Forschr Neurol Psychiatr. 2001;69: 116-37. [PMID:11305122]

Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmächer T. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry. 2001;58:445-52. [PMID:11343523]

Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmächer T. Low leptin levels, but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology. 2001;73:243-7. [PMID:11340338]

Haack M, Schuld A, Kraus T, Pollmächer T. Effects of sleep on endotoxin-induced host responses in healthy men. Psychosom Med. 2001;63:568-78. [PMID:11485110]

Dalal MA, Schuld A, Haack M, Uhr M, Geisler P, Eisensehr I, Noachtar S, Pollmächer T. Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients. Neurology. 2001;56:1749-51. [PMID:11425946]

Schuld A, Blum WF, Uhr M, Haack M, Kraus T , Holsboer F, Pollmächer T. Reduced leptin levels in human narcolepsy. Neuroendocrinology. 2000;72:195-8. [PMID:11070422]

Schuld A, Kraus T, Hinze-Selch D, Haack M, Pollmächer T. Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. Acta Psychiatr Scand. 2000;102:153-5. [PMID:10937789]

Pollmächer T, Haack M, Schuld A, Kraus T, Hinze-Selch D. Effects of antipsychotic drugs on cytokine networks. J Psychiatr Res. 2000;34:369-82. [PMID:11165304]

Hinze-Selch D, Schuld A, Kraus T, Kühn M, Uhr M, Haack M, Pollmächer T. Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: a longitudinal study in patients treated with amitriptyline or paroxetine. Neuropsychopharmacology. 2000;23:13-9. [PMID:10869882]

Schuld A, Kraus, T, Haack M, Hinze-Selch D, Kühn M, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors during treatment with olanzapine. Schizophr Res. 2000;43:164-6. [PMID:11001592]

Haack M, Reichenberg A, Kraus T, Schuld A, Yirmiya R, Pollmächer T. Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men. Cytokine. 2000;12:694-8. [PMID:10843747]

Schuld A, Kühn M, Haack M, Kraus T, Hinze-Selch S, Lechner C, Pollmächer T. A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia. Pharmacopsychiatry. 2000:33:109-11. [PMID:10855462]

Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullingon J. Experimental immunomodulation, sleep, and sleepiness in humans. Ann N Y Acad Sci. 2000;917:488-99. [PMID:11268376]

Schuld A, Kraus T, Haack M, Hinze-Selch D, Pollmächer T. Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. J Sleep Res. 1999;8:321-2. [PMID:10646174]

Pollmächer T, Kraus T, Haack M, Uhr M, Mullington J. Salmonella abortus equi endotoxin does not affect leptin plasma levels in healthy humans. J Infect Dis. 1999;179:1047-8. [PMID:10068609]

Kraus T, Haack M, Schuld A, Hinze-Selch D, Kühn M, Uhr M, Pollmächer T. Body weight and leptin plasma levels during treatment with antipsychotic drugs. Am J Psychiatry. 1999;156:312-4. [PMID:9989571]

Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kühn M, Schuld A, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J Psychiatr Res. 1999;33:407-18. [PMID:10504009]

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