Faculty Profile

John W. Winkelman, MD, PhD


Professor in Psychiatry, Harvard Medical School
Associate Physician, Sleep Medicine, Department of Psychiatry, Massachusetts General Hospital

Administrative Title(s)

Chief, Sleep Disorders Clinical Research Program
Department of Psychiatry
Massachusetts General Hospital

See publications


Address

1 Bowdoin Square, 9th floor
Boston, MA 02114
USA

Phone 617-643-9101
Fax 617-783-1458

Society Memberships

American Academy of Sleep Medicine

Brief Biosketch
Dr. Winkelman received his PhD in Psychobiology from Harvard University, an MD from Harvard Medical School and then completed both a residency in Psychiatry and a fellowship in Sleep Medicine at Massachusetts General Hospital. He was Medical Director of the Sleep Program at McLean Hospital and subsequently Medical Director of the sleep laboratory at Brigham and Women's Hospital.  He is currently a Professor of Psychiatry at Harvard Medical School and chief of the Sleep Disorders Clinical Research Program in the Department of Psychiatry at Massachusetts General Hospital.

Research and Publication Contributions
Dr. Winkelman's research has primarily focused in two areas: 1) epidemiology, physiology, cardiovascular consequences and treatment of restless legs syndrome, and 2) neurobiology and treatment of insomnia. He has lectured in and directed post-graduate medical education courses in sleep disorders nationally and internationally. Dr. Winkelman serves on the editorial boards of Sleep Medicine and CNS Drugs. He has published more than 150 articles, reviews and book chapters and is also the editor of the textbook Foundations of Psychiatric Sleep Medicine, Cambridge University Press (2011).

Research Funding

GlaxoSmithKline, UCB Pharma, NIMH

Selected Publications

Original Articles

Yang MS, Montplaisir J, Desautels A, Winkelman JW, Cramer Bornemann MA, Earley CJ, Allen RP. Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording.
Sleep Med. 2014 Jan;15(1):132-7. [PMID:24332046]

Li Y, Zhang X, Winkelman JW, Redline S, Hu FB, Stampfer M, Ma J, Gao X. The Association between Insomnia Symptoms and Mortality: A Prospective Study of US Men.
Circulation. 2013 Nov 15. [PMID: 24226807]

Spiegelhalder K, Regen W, Baglioni C, Riemann D, Winkelman JW. Neuroimaging studies in insomnia.
Curr Psychiatry Rep. 2013 Nov;15(11):405. [PMID: 24057158]

Winkelman JW, Gagnon A, Clair AG. Sensory symptoms in restless legs syndrome: the enigma of pain.
Sleep Med. 2013 Oct;14(10):934-42. [PMID: 23948222]

Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Högl B, Manconi M, Montplaisir J, Inoue Y, Allen RP. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group.
Sleep Med. 2013 Jul;14(7):675-84. [PMID: 23859128]

Winkelman JW, Plante DT, Schoerning L, Benson K, Buxton OM, O'Connor SP, Jensen JE, Renshaw PF, Gonenc A. Increased Rostral Anterior Cingulate Cortex Volume in Chronic Primary Insomnia. Sleep. 2013 Jul 1;36(7):991-998. [PMID: 23814335]

Li Y, Wang W, Winkelman JW, Malhotra A, Ma J, Gao X. Prospective study of restless legs syndrome and mortality among men.
Neurology. 2013 Jul 2;81(1):52-9. [PMID: 23761622]

Mackie S, Winkelman JW. Normal ferritin in a patient with iron deficiency and RLS.
J Clin Sleep Med. 2013 May 15;9(5):511-3. [PMID: 23674944]

Winkelman JW. Is restless legs syndrome a sleep disorder?
Neurology. 2013 May  28;80(22):2006-7. [PMID: 23624567]

Harper DG, Plante DT, Jensen JE, Ravichandran C, Buxton OM, Benson KL, O'Connor SP, Renshaw PF, Winkelman JW. Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla.
Sleep. 2013 Apr 1;36(4):493-500.[PMID: 23564996]

Deak MC, Winkelman JW. Insomnia.
Neurol Clin. 2012 Nov;30(4):1045-66. [PMID: 23099129]

Li Y, Walters AS, Chiuve SE, Rimm EB, Winkelman JW, Gao X. Prospective study of restless legs syndrome and coronary heart disease among women.
Circulation. 2012 Oct 2;126(14):1689-94. [PMID: 22967852]

Li Y, Mirzaei F, O'Reilly EJ, Winkelman J, Malhotra A, Okereke OI, Ascherio A, Gao X. Prospective study of restless legs syndrome and risk of depression in women.
Am J Epidemiol. 2012 Aug 15;176(4):279-88.[PMID: 22805376]

Plante DT, Jensen JE, Winkelman JW. The role of GABA in primary insomnia.
Sleep. 2012 Jun 1;35(6):741-2. [PMID: 22654187]

Plante DT, Jensen JE, Schoerning L, Winkelman JW. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
Neuropsychopharmacology. 2012 May;37(6):1548-57. [PMID: 22318195]

García-Borreguero D, Högl B, Ferini-Strambi L, Winkelman J, Hill-Zabala C, Asgharian A, Allen R. Systematic evaluation of augmentation during treatment with ropinirole in restless legs syndrome (Willis-Ekbom disease): results from a prospective, multicenter study over 66 weeks.
Mov Disord. 2012 Feb;27(2):277-83.  [PMID: 22328464]

Batool-Anwar S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X. Restless legs syndrome and hypertension in middle-aged women.
Hypertension. 2011 Nov;58(5):791-6. Epub 2011 Oct 10. [PMID: 21986505]

Winkelman JW, Bogan RK, Schmidt MH, Hudson JD, DeRossett SE, Hill-Zabala CE. Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndrome.
Mov Disord. 2011 Sep;26(11):2065-72. [PMID: 21611981]

Duffy JF, Lowe AS, Silva EJ, Winkelman JW. Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night.
Sleep Med. 2011 Jan;12(1):83-8. Epub 2010 Nov 18. [PMID: 21093364]

Yang C, Winkelman JW. Clinical and polysomnographic characteristics of high frequency leg movements.
J Clin Sleep Med. 2010 Oct 15;6(5):431-8. [PMID: 20957842]

Hening WA, Allen RP, Ondo WG, Walters AS, Winkelman JW, Becker P, Bogan R, Fry
M, Kudrow DB, Lesh KW, Fichtner A, Schollmayer E; SP792 Study Group. Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States.
Mov Disord. 2010 Aug 15;25(11):1675-83. [PMID: 20629075]

Winkelman JW, Benson KL, Buxton OM, Lyoo IK, Yoon S, O'Connor S, Renshaw PF. Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla.
Sleep Med. 2010 Jun;11(6):576-82. Epub 2010 May 13. [PMID: 20466585]

Winkelman JW. The diagnosis and work-up of insomnia.
CNS Spectr. 2009 Dec;14(12 Suppl 13):4-6. [PMID: 20448511]

Winkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ. Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study.
Sleep. 2009 Jun;32(6):772-8. [PMID: 19544754]

Winkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ. Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study. Sleep. 2009 Jun 1;32(6):772-8. [PMID: 19544754]

Winkelman JW, Buxton OM, Jensen JE, Benson KL, O'Connor SP, Wang W, Renshaw PF. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS).
Sleep. 2008 Nov 1;31(11):1499-506. [PMID: 19014069]

Winkelman JW, Shahar E, Sharief I, Gottlieb DJ. Association of restless legs
syndrome and cardiovascular disease in the Sleep Heart Health Study.
Neurology. 2008 Jan 1;70(1):35-42. [PMID: 18166705]

Winkelman JW. Periodic limb movements in sleep--endophenotype for restless legs syndrome?
N Engl J Med. 2007 Aug 16;357(7):703-5. Epub 2007 Jul 18. [PMID: 17634452]

Garcia-Borreguero D, Winkelman J, Adams A, Ellis A, Morris M, Lamb J, Layton G, Versavel M; Sumanirole in RLS Study Group. Efficacy and tolerability of sumanirole in restless legs syndrome: a phase II,randomized, double-blind, placebo-controlled, dose-response study.
Sleep Med. 2007 Mar;8(2):119-27. Epub 2007 Jan 18. [PMID: 17239657]

Winkelman JW. A better future for patients with restless legs syndrome.
Am J Med. 2007 Jan;120(1 Suppl 1):S28-9. [PMID: 17198768]

Winkelman JW. Sleep-related eating disorder and night eating syndrome: sleep disorders, eating disorders, or both?
Sleep 2006; 29(7):876-877. [PMID: 16895252]

Winkelman JW, Sethi KD, Kushida CA, Becker PM, Koester J, Cappola JJ et al. Efficacy and safety of pramipexole in restless legs syndrome.
Neurology 2006; 67(6):1034-1039. [PMID: 16931507]

Winkelman JW. Considering the causes of RLS.
Eur J Neurol 2006; 13 Suppl 3:8-14. [PMID: 16930377]

Winkelman JW, Finn L, Young T. Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort.
Sleep Med 2006; 7(7):545-552. [PMID: 16740407]

Winkelman JW. Efficacy and tolerability of open-label topiramate in the treatment of sleep-related eating disorder: a retrospective case series.
J Clin Psychiatry 2006; 67(11):1729-1734. [PMID: 17196052]

Plante DT, Winkelman JW. Parasomnias.
Psychiatr Clin North Am 2006; 29(4):969-987. [PMID: 17118277]

Yang CK, Jordan AS, White DP, Winkelman JW. Heart rate response to respiratory events with or without leg movements.
Sleep. 2006 Apr 1;29(4):553-6. [PMID: 16676789]

Yang C, Winkelman JW. Clinical significance of sleep EEG abnormalities in chronic schizophrenia.
Schizophr Res. 2006 Feb 28;82(2-3):251-60. Epub 2005 Dec 27. [PMID: 16377158]

Yang CK, White DP, Winkelman JW. Antidepressants and Periodic Leg Movements of Sleep.
Biological Psychiatry, 2005, 58:510-514.

Yang CK, White DP, Winkelman JW. Antidepressants and Periodic Leg Movements of Sleep.
Biological Psychiatry, 2005, 58:510-14.

Picchietti D, Winkelman J. Restless legs syndrome, periodic leg movements in sleep, and depression.
Sleep, 2005, 28:891-898.

Winkelman JW, Pies R. Current patterns and future directions in the treatment of insomnia.
Annals of Clinical Psychiatry, 2005, 17:31-40.

Winkelman JW. Designing a sleep disorder curriculum for psychiatry residents.
Harvard Review of Psychiatry, 2005, 13:54-6.

Winkelman JW, James L. Serotonergic antidepressants are associated with REM sleep without atonia.
Sleep, 2004, 27:317-321.

Winkelman JW, Johnston L. Augmentation and tolerance with long-term pramipexole treatment of restless legs syndrome (RLS).
Sleep Medicine, 2004, 5:9-14.

Winkelman JW. Treatment of nocturnal and sleep-related eating with topiramate.
Sleep Medicine, 2003, 4:243-246.

Winkelman JW. Schizophrenia, obesity and obstructive sleep apnea.
Journal of Clinical Psychiatry, 2001;61:8-11.

Gliklich RE, Tagihizadeh F, Winkelman JW. Health status in patients with disturbed sleep and obstructive sleep apnea.
Otolaryngology-Head and Neck Surgery, 2000;122:542-546.

Winkelman JW, Herzog DB, Fava, M. The prevalence of sleep-related eating disorder in psychiatric and non-psychiatric populations.
Psychological Medicine,1999;29:1461-6.

Winkelman JW. The evoked heart rate response to periodic leg movements of sleep.
Sleep, 1999;22:575-580.

Winkelman JW. Clinical and polysomnographic features of sleep-related eating disorder.
Journal of Clinical Psychiatry, 1998;59:14-19.

Winkelman JW, Chertow G. Restless Legs Syndrome.
Seminars in Dialysis, 1997;10:183-184.

Winkelman JW, Chertow G, Lazarus JM. Restless legs syndrome in end-stage renal disease.
American Journal of Kidney Diseases, 1996;28:372-8.

Cunningham SL, Winkelman JW, Dorsey CM, Lukas SE, Richardson GS, Sholar MB. An electromyographic marker for neuroleptic-induced akathisia: preliminary measures of sensitivity and specificity.
Clinical Neuropsychopharmacology, 1996;19:321-332.

Dorsey CM, Lukas SE, Teicher MH, Harper D, Cunningham SL, Taylor JF, Winkelman JW, Satlin A. Effects of passive body heating on sleep of older female insomniacs.
Journal of Geriatric Psychiatry and Neurology, 1996;9:83-90.

Winkelman JW, Goldman H, Piscatelli N, Lukas S, Dorsey CM, Cunningham S. Are thyroid function tests necessary in patients with suspected sleep apnea?
Sleep, 1996;19:790-3.

Pradhan P, Gliklich R, Winkelman JW. Rates of obstructive sleep apnea in patients referred for evaluation of snoring.
Laryngoscope, 1996;106:1393-7.

McCarley RW, Winkelman JW & Duffy FH. Human cerebral potentials associated with REM sleep rapid eye movements: Links to PGO waves and waking potentials.
Brain Research, 1983;274:359-364.

Solomon PR, Crider A, Winkelman JW. Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: Relationship to schizophrenic attention disorder.
Biological Psychiatry, 1981;16:519-537.

Reviews, Chapters, and Editorials

Lin WC, Winkelman JW. Obstructive sleep apnea and severe mental illness: evolution and consequences.
Curr Psychiatry Rep. 2012 Oct;14(5):503-10. Review. [PMID: 22872493]

Winkelman JW, Johnson EA, Richards LM. Sleep-related eating disorder.
Handb Clin Neurol. 2011;98:577-85. Review. [PMID: 21056212]

Plante DT, Winkelman JW. Sleep disturbance in bipolar disorder: therapeutic
implications.
Am J Psychiatry. 2008 Jul;165(7):830-43. Epub 2008 May 15. Review.  [PMID: 18483132]

Winkelman JW, Allen RP, Tenzer P, Hening W. Restless legs syndrome:
nonpharmacologic and pharmacologic treatments.
Geriatrics. 2007 Oct;62(10):13-6.  Review. [PMID: 17922563]

Hening W, Allen RP, Tenzer P, Winkelman JW. Restless legs syndrome: demographics, presentation, and differential diagnosis.
Geriatrics. 2007 Sep;62(9):26-9. Review. [PMID: 17824723]

Winkelman JW. Restless Legs Syndrome.
In: Sleep Disorders and Psychiatry (Review of Psychiatry Series, Volume 24, Number 2; Oldham JM and Riba, series editors), Buysse DJ, editor, 1st edition, 2005. p.139-162.

Winkelman JW. Parasomnias.
In: Sleep Disorders and Psychiatry (Review of Psychiatry Series, Volume 24, Number 2; Oldham JM and Riba, series editors), Buysse DJ, editor, 1st edition, 2005. p.163-183.

Yang CK,Winkleman JW. Antidepressant and Antipsychotic Drugs and Sleep.
In: SRS Basics of Sleep Guide. ed. M.R. Opp. Sleep Research Society, Westchester, IL, 2005. pp. 167-174

Winkelman JW. Sleep disorders comes of age. Guest editorial.
In: Primary Psychiatry; 2005;12:8-10.

Czeisler CA, Winkelman JW, Richardson GS. Sleep Disorders.
In: Harrison's Principles of Internal Medicine, Kasper DL, Braunwald E, Fauci A, , Hauser SL, Longo DL, Jameson JL, eds., 16th edition, 2005; pp. 153-162.

Winkelman JW, Fogel RB. Sleep disorders.
In: Manual of Neurologic Therapeutics, Seventh Edition, Samuels MA, Ed., Lippincott Williams & Wilkins, 2004.

Weilburg J, Winkelman JW. Sleep Disorders.
In: Consultation-Liason Psychiatry, Wise M, Rundell J editors., 2nd Ed. Washington: American Psychiatric Press; 2002. pp. 495-518.

Fogel RB, Winkelman JW. Parasomnias.
In: Neurologic Therapeutics, Principles and Practice, Noseworthy JH., editor, 2003; pp 1310-1312.

Malhotra A, Fogel RB, Pillar G, Winkelman JW. Non-Respiratory Sleep Disorders.
In: Pulmonary and Critical Update Online; 1999;Volume14, Lesson 4.

Winkelman JW. Parkinson's disease.
In: Encyclopedia of Sleep and Dreaming. Carskadon M, editor. New York: Macmillan; 1992. p. 437-438.

Books

Winkelman JW. Improving Sleep: A Guide to Getting a Good Night's Rest.
Harvard Medical School Publications. 2001;1-43.

Clinical Communications

Picchietti D, Winkelman J. Treatment of depression in patients with restless legs syndrome: What is evidence-based?
Sleep Medicine, in press.

Winkelman JW. Restless Legs Syndrome: Common, unpleasant, and treatable.
Mayo Clinic Proceedings, 2004; 79: S2-3.

Ancoli-Israel S, Benca RM, Edinger JD, Krystal AD, Mendelson W, Moldofsky H, Petrie J,Roth T, Walsh JK, Winkelman J; Special Issues Board Panel Members. Panel discussion: changing how we think about insomnia.
Journal of Clinical Psychiatry; 2004;65 Suppl 8:44-46.

Winkelman JW. High rates of periodic leg movements of sleep in REM-sleep behavior disorder raise more questions about the relationship between sleep-related movement disorders. Article reviewed: M.L. Fantini, M. Michaud, N. Gosselin, G. Lavigne, J. Montplaisir, Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation
Neurology, 59 (2002) 1889-1894. Sleep Medicine; 4:261-262.

Winkelman JW. Restless Legs Syndrome in ESRD.
Nephrology News and Insight 1999;13:27-32.

Winkelman JW. Diagnosis and Treatment of Insomnia.
Psychiatric Times July 1994, p. 37-8.

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