Faculty Profile

Robert E. Strecker, PhD


Associate Professor of Psychiatry, Harvard Medical School
Associate Professor, Department of Psychiatry, VA Boston Healthcare System

Other Affiliation(s)

Department of Psychology, Stonehill College

See publications


Society Memberships

Society for Neuroscience
Sleep Research Society
American Association for the Advancement of Science

Research Unit(s)

Director, Section of Behavioral Neuroscience, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System

Research Interests

Dr. Strecker's research uses animal models to study how the brain controls behavior, especially that of sleep and wakefulness. His early work examined the physiology and neuropharmacology of monoamine neurotransmitter systems in the mammalian brain in relation to sleep, drug abuse, Parkinson's disease, and the potential use of neural transplantation to treat neurological disorders.
Since joining the faculty of Harvard Medical School his work has focused on the brain circuitry involved in the control of REM sleep, and non-REM sleep (also known as slow wave sleep). Several publications describe brainstem mechanisms controlling REM sleep, in particular the promotion of REM sleep by reticular cholinergic activity and the inhibition of REM sleep by increases in monoaminergic neurotransmission. In the control of non-REM sleep are a unique set of anterior hypothalamic neurons (ventrolateral preoptic area; VLPO) that is selectively activated during non-REM sleep and has been found in all mammals studied to date. It was proposed that these neurons are important in the maintenance of non-REM sleep, whereas the inhibition of wakefulness promoting neurotransmitter systems by adenosine is responsible for the sleepiness associated with long periods of wakefulness.
Cortically projecting and wakefulness promoting cholinergic neurons are found throughout the basal forebrain region, an area that is a potent site for the sleep inducing properties of endogenous adenosine. The cumulative data indicate that adenosine, acting via A1 receptors, inhibits the cortically projecting cholinergic neuronal arousal system found in this basal forebrain region. These published studies were among those funded by Dr. Strecker's first VA merit award (1999-2004) and this work led directly to his currently funded studies investigating the role of adenosine and the basal forebrain in the pathological sleepiness associated with obstructive sleep apnea (OSA). Thus, in early 2002, Dr. Strecker initiated a new line of research to investigate the behavioral and neurobiological consequences of OSA using a rat model. These projects are now funded by the VA and by NIH/NHLBI.
 Despite an understanding of the causes of OSA and the availability of treatment options, the investigation of the consequences/symptoms of OSA remains important because up to 85% of patients with OSA are undiagnosed, spending many years with the disorder. In addition, OSA therapy (e.g., CPAP) does not fully resolve the symptoms in many OSA patients. Thus, the consequences of chronic OSA are an important public health concern that has been little investigated, due, in part, to the relative lack of animal models of OSA. Indeed, recent findings that intermittent hypoxia (IH), by itself, produces cell death in brain regions associated with cognition underscores the importance of studying the consequences of OSA. The primary characteristics of OSA are intermittent hypoxia (IH) and sleep interruption (SI) (fragmentation), and are thought to produce symptoms/signs associated with OSA including excessive daytime sleepiness and various cognitive/attentional impairments. However, it has remained unknown which symptoms/signs of OSA are attributable to SI, and which to IH, because these characteristics are difficult to separate in humans.
The overarching hypothesis is that the inhibitory neuromodulator adenosine (AD) mediates the sleepiness associated with OSA. Previous findings by Dr. Strecker supported the hypothesis that AD is a mediator of sleepiness following short (6h) periods of sleep loss, a role in which its inhibitory action on the basal forebrain (BF) wakefulness-promoting neurons appears especially important. Dr. Strecker developed 2 paradigms in which the OSA characteristics of IH and SI can be separated in the rat, and a third paradigm in which these two conditions are presented simultaneously to best mimic the clinical disorder. A variety of neurobiological and behavioral measures are obtained in these animal models. Dr. Strecker's lab is now uniquely able to assess the effects of sleep loss, SI, and IH on the following behavioral dimensions: learning and memory, vigilance/attention, motor coordination, executive function, and anxiety/emotion.
Recent publications describe the following findings: 1. Rats exposed to 24h of SI have impaired spatial learning and memory in the water maze task. 24h of SI also blocks hippocampal synaptic plasticity (i.e., long term potentiation) which is necessary for spatial memory formation.  2. Rats exposed to 24 h of SI are also impaired in a attentional set shifting, as shown by their an impaired ability to learn new rules in a behavioral test designed to assess executive function (intradimensionl/extradimensional set shifting task, which is analagous to the Wisconsin card sorting test used in human studies). 3. Rats that have undergone as little as 7 h of total sleep deprivation have impaired performance in an operant test of attention. This task is analogous the psychomotor vigilance test (PVT) used in human studies of sleepiness. 4. SI, but not IH, elevates sleepiness and basal forebrain adenosine levels, supporting out hypothesis that SI is responsible for the excessive daytime sleepiness of OSA and not IH.


Trainees

Alvhild Alette Bjorkum, PhD, 1995-1997
James Timothy McKenna, PhD, 2001-2006
Christopher Peyton Ward, PhD, 2003-2006
Jaime Tartar, PhD, 2004-2006
John McCoy, PhD, 2004-2006
Michael Christie, PhD, 2005-2006
Youngsoo Kim, PhD, 2006-2010

Mentor(s)


Research Funding

Current Funding

Department of Veterans Affairs, Merit Review Grant Strecker (PI) 10/1/98-9/30/11
Adenosine and the Basal Forebrain in the Control of Behavioral State
The goal of this research is to use a rat model to investigate the behavioral/physiological consequences of chronic sleep restriction.

R01 MH39683 McCarley (PI) 3/31/09-12/31/13
Synaptic Basis of Sleep Cycle Control
The goal of this project is to investigate the cholinergic and nitrergic mechanisms of sleep-wakefulness control. 

T32 HL07901 Czeisler (PI) 2009-2014
Harvard Medical School Training Program in Sleep, Circadian, and Respiratory Neurobiology
Role: Dr. Strecker is a full preceptor on this training grant and has mentored 5 postdocs from 2002-present.

P01HL095491 Saper (PI) 3/1/10-2/28/2015
Mechanisms of Arousal in Sleep and Sleep Apnea
The goal of this project is to understand the neural circuits that underlie pathological arousals from sleep in obstructive sleep apnea.
Role: co-PI of Project #4 “Neuronal Control Mechanism of the Ascending Sleep Arousal Pathway”. Kocsis (PI).

Department of Veterans Affairs, Research Career Scientist Award  Strecker (PI) 2011-2016
This is a competitive salary award which covers Dr. Strecker’s full time research salary for 5 years. This basic research program investigates endogenous sleep factors & the neural control of sleep/wakefulness in order to provide a rational basis for the development of treatments for sleep disorders that affect veterans.

Past Funding

Veterans Administration Merit Review (R01 equivalent in VA) Strecker (PI) 2004-2009
Adenosine and the Basal Forebrain in the Control of Behavioral State
Rat model of obstructive sleep apnea using concurrent exposure to intermittent hypoxia and sleep interruption.

NHLB (2 P50 HLO60292 White (PI) 2003-2008
Harvard Center on Sleep Neurobiology and Sleep Apnea

NIH/NIMH (R37 MH39683 McCarley (PI) Investigator 2002-2007
Synaptic Basis of Sleep Cycle Control (MERIT Award, renewed over 20yr)
Cholinergic and adenosinergic mechanisms of sleep. Animal models

Teaching

Harvard Medical School Graduate School courses
1995- Neuroscience Basics of Pyschopharmacology , Invited Lecturer
2002 Led a 3 day workshop on "Sleep and Depression" at the Sleep Workshop of the Multi-site Training Program for Basic Sleep Research, held in Lake Arrowhead, California, (PI = Dr. Michael Chase), entitled "Interactions and Intersections between Sleep and Other Disciplines".

Teaching leadership:
2005- Creator/director of PC343, Research in Biopsychology, a research internship program, for undergraduates at Stonehill College, including a 1h/wk research seminar. Enrollment ~10 students/semester.

Selected Publications

McCoy JG, Strecker RE. The cognitive cost of sleep lost.
Neurobiol Learn Mem. 2011 Aug 22. [PMID: 21875679]

Tartar JL, McKenna JT, Ward CP, McCarley RW, Strecker RE, Brown RE. Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine.
Neurosci Lett 2010; 469: 1-5. [PMID: 19914331]

McCoy JG, McKenna JT, Connolly NP, Poeta DL, Ling L, McCarley RW, Strecker RE. One week of exposure to intermittent hypoxia impairs attentional set-shifting in rats.
Behav Brain Res 2010; 210:123-6. Epub 2010 Feb 1. [PMID: 20122971]

Christie MA, McCarley RW, Strecker RE. Twenty-four hours, or five days, of continuous sleep deprivation or experimental sleep fragmentation do not alter thirst or motivation for water reward in rats.
Behav Brain Res 2010; 214:180-6. [PMID: 20493906]

McKenna JT, Cordeira JW, Jeffrey BA, Ward CP, Winston S, McCarley RW, Strecker RE. c-Fos protein expression is increased in cholinergic neurons of the rodent basal forebrain during spontaneous and induced wakefulness.
Brain Res Bull. 2009 Dec 16;80(6):382-8. Epub 2009 Aug 28. [PMID: 19716862]

Ward CP, McCoy JG, McKenna JT, Connolly NP, McCarley RW, Strecker RE. Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apnea.
Brain Res. 2009 Oct 19;1294:128-37. Epub 2009 Jul 28. [PMID: 19643093]

Ward CP, McCarley RW, Strecker RE. Experimental sleep fragmentation impairs spatial reference but not working memory in Fischer/Brown Norway rats.
J Sleep Res. 2009 Jun;18(2):238-44. [PMID: 19645967]

Tartar JL, Ward CP, Cordeira JW, Legare SL, Blanchette AJ, McCarley RW, Strecker RE. Experimental sleep fragmentation and sleep deprivation in rats increases exploration in an open field test of anxiety while increasing plasma corticosterone levels.
Behav Brain Res. 2009 Feb 11;197(2):450-3. Epub 2008 Sep 2. [PMID: 18805441]

McKenna JT, Cordeira JW, Christie MA, Tartar JL, McCoy JG, Lee E, McCarley RW, Strecker RE. Assessing sleepiness in the rat: a multiple sleep latencies test compared to polysomnographic measures of sleepiness.
J Sleep Res. 2008 Dec;17(4):365-75. Epub 2008 Sep 13. [PMID: 18823428]

Christie MA, McKenna JT, Connolly NP, McCarley RW, Strecker RE. 24 hours of sleep deprivation in the rat increases sleepiness and decreases vigilance: introduction of the rat-psychomotor vigilance task. J Sleep Res. 2008 Dec;17(4):376-84. Epub 2008 Oct 6. Erratum in: J Sleep Res. 2009 Mar;18(1):143. [PMID: 19021853]

McGuire M, Tartar JL, Cao Y, McCarley RW, White DP, Strecker RE, Ling L. Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors.
J Physiol. 2008 Nov 1;586(Pt 21):5215-29. Epub 2008 Sep 11. [PMID: 18787037]

Christie MA, Bolortuya Y, Chen LC, McKenna JT, McCarley RW, Strecker RE. Microdialysis elevation of adenosine in the basal forebrain produces vigilance impairments in the rat psychomotor vigilance task.
Sleep. 2008 Oct 1;31(10):1393-8. [PMID: 18853936]

McKenna JT, Tartar JL, Ward CP, Thakkar MM, Cordeira JW, McCarley RW, Strecker RE. Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness.
Neuroscience. 2007 Jun 8;146(4):1462-73. Epub 2007 Apr 18. [PMID: 17442498]

McCoy JG, Tartar JL, Bebis AC, Ward CP, McKenna JT, Baxter MG, McGaughy J, McCarley RW, Strecker RE. Experimental sleep fragmentation impairs attentional set-shifting in rats. Sleep. 2007 Jan 1;30(1):52-60. [PMID: 17310865]

Tao R, Ma Z, McKenna JT, Thakkar MM, Winston S, Strecker RE, McCarley RW. Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats.
Neuroscience. 2006 Sep 1;141(3):1101-5. Epub 2006 Jul 3. [PMID: 16820265]

Tartar JL, Ward CP, McKenna JT, Thakkar M, Arrigoni E, McCarley RW, Brown RE, Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci. 2006 May;23(10):2739-48. [PMID: 16817877]

Strecker RE, Basheer R, McKenna JT, McCarley RW. Another chapter in the adenosine story.
Sleep. 2006 Apr 1;29(4):426-8. [PMID: 16676774]

Córdova CA, Said BO, McCarley RW, Baxter MG, Chiba AA, Strecker RE. Sleep deprivation in rats produces attentional impairments on a 5-choice serial reaction time task. Sleep. 2006 Jan 1;29(1):69-76. [PMID: 16453983]

Ma Z, Strecker RE, McKenna JT, Thakkar MM, McCarley RW, Tao R. Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats. Neuroscience. 2005;135(3):949-58. Epub 2005 Sep 8. [PMID: 16154286]

Lo CC, Chou T, Penzel T, Scammell TE, Strecker RE, Stanley HE, Ivanov PCh. Common scale-invariant patterns of sleep-wake transitions across mammalian species.
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17545-8. Epub 2004 Dec 6. [PMID: 15583127]

Ramesh V, Thakkar MM, Strecker RE, Basheer R, McCarley RW. Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats.
Behav Brain Res. 2004 Jul 9;152(2):271-8. [PMID: 15196795]

Bjorkum AA, Strecker RE, Portas CM, Porkka-Heiskanen T, Thakkar M, McCarley RW. Perfusion of a 5-HT1A antagonist in the cat DRN increases wakefulness and extracellular 5-HT level in DRN.
Sleep Research Online. 2003; 5: 149-154.

McKenna JT, Dauphin, LJ, Mulkern KJ, Stronge AM, McCarley RW, Strecker RE. Nocturnal elevation of extracellular adenosine in the rat basal forebrain.
Sleep Research Online. 2003; 5: 155-160.

Thakkar MM, Delgiacco RA, Strecker RE, McCarley RW. Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats.
Neuroscience. 2003;122(4):1107-13. [PMID: 14643776]

Gaus SE, Strecker RE, Tate BA, Parker RA, Saper CB. Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species.
Neuroscience. 2002;115(1):285-94. [PMID: 12401341]

Thakkar MM, Strecker RE, McCarley RW. Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons. Brain Res. 2002 Aug 2;945(2):276-80. [PMID: 12126890]

Strecker RE, Nalwalk J, Dauphin LJ, Thakkar MM, Chen Y, Ramesh V, Hough LB, McCarley RW. Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study.
Neuroscience. 2002;113(3):663-70. [PMID:12150786]

Thakkar MM, Ramesh V, Strecker RE, McCarley RW. Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.
Arch Ital Biol. 2001 Apr;139(3):313-28. [PMID: 11330208]

Strecker RE, Morairty S, Thakkar MM, Porkka-Heiskanen T, Basheer R, Dauphin LJ, Rainnie DG, Portas CM, Greene RW, McCarley RW. Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav
Brain Res. 2000 Nov;115(2):183-204. [PMID: 11000420]

Porkka-Heiskanen T, Strecker RE, McCarley RW. Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study.
Neuroscience. 2000;99(3):507-17. [PMID: 11029542]

Thakkar MM, Ramesh V, Cape EG, Winston S, Strecker RE, McCarley RW. REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation.
Sleep Res Online. 1999;2(4):112-20. [PMID: 11382892]

Strecker RE, Thakkar MM, Porkka-Heiskanen T, Dauphin LJ, Bjørkum AA, McCarley RW. Behavioral state-related changes of extracellular serotonin concentration in the pedunculopontine tegmental nucleus: a microdialysis study in freely moving animals.
Sleep Res Online. 1999;2(2):21-7. [PMID: 11421239]

Liu X, Strecker RE, Brener J. A comparison of the effects of amphetamine and low doses of apomorphine on operant force production, inter-response times and response duration in rat.
Psychopharmacology (Berl). 1999 Aug;145(4):351-9. [PMID: 10460311]

Thakkar MM, Strecker RE, McCarley RW. Behavioral state control through differential serotonergic inhibition in the mesopontine cholinergic nuclei: a simultaneous unit recording and microdialysis study.
J Neurosci. 1998 Jul 15;18(14):5490-7. [PMID: 9651229]

Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA, Greene RW, McCarley RW. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness.
Science. 1997 May 23;276(5316):1265-8. [PMID: 9157887]

Kurata K, Ashby CR Jr, Oberlender R, Tanii Y, Kurachi M, Rini NJ, Strecker RE. The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study.
Synapse. 1996 Dec;24(4):313-21. [PMID: 10638822]

Clark RN, Ashby CR Jr, Dewey SL, Ramachandran PV, Strecker RE. Effect of acute and chronic fluoxetine on extracellular dopamine levels in the caudate-putamen and nucleus accumbens of rat.
Synapse. 1996 Jul;23(3):125-31. [PMID: 8807740]

Liu X, Strecker RE, Brener JM. Low doses of apomorphine suppress operant motor performance in rats.
Pharmacol Biochem Behav. 1996 Feb;53(2):335-40. [PMID: 8808141]

Strecker RE, Eberle WF, Ashby CR Jr. Extracellular dopamine and its metabolites in the nucleus accumbens of Fischer and Lewis rats: basal levels and cocaine-induced changes. Life Sci. 1995;56(6):PL135-41. [PMID: 7530315]

La Gamma EF, Strecker RE, Lenn NJ, DeCristofaro JD, Weisinger G. Dopaminergic regulation of a transfected preproenkephalin promoter in primary rat astrocytes in vitro and in vivo.
Exp Neurol. 1994 Dec;130(2):304-10. [PMID: 7867759]

Strecker RE, Moneta ME. Electrical stimulation of the kindled hippocampus briefly increases extracellular dopamine in the nucleus accumbens.
Neurosci Lett. 1994 Aug 1;176(2):173-7. [PMID: 7830940]

Spector DH, Boss BD, Strecker RE. A model three-dimensional culture system for mammalian dopaminergic precursor cells: application for functional intracerebral transplantation. Exp Neurol. 1993 Dec;124(2):253-64. [PMID: 7904568]

McNeish CS, Svingos AL, Hitzemann R, Strecker RE. The 5-HT3 antagonist zacopride attenuates cocaine-induced increases in extracellular dopamine in rat nucleus accumbens. Pharmacol Biochem Behav. 1993 Aug;45(4):759-63. [PMID: 8415815]

LaGamma EF, Weisinger G, Lenn NJ, Strecker RE. Genetically modified primary astrocytes as cellular vehicles for gene therapy in the brain.
Cell Transplantation. 1993; 2: 207-214.

Basso MA, Strecker RE, Evinger C. Midbrain 6-hydroxydopamine lesions modulate blink reflex excitability.
Exp Brain Res. 1993;94(1):88-96. [PMID: 8101493]

La Gamma EF, Weisinger G, Lenn NJ, Strecker RE. Genetically modified striatal astrocytes grafted to the brain: pharmacological control of an inducible promoter.
J. Neural Transplantation Plasticity. 1992; 3: 244-245.

Freeman TB, Spence MS, Boss BD, Spector DH, Strecker RE, Olanow CW, Kordower JH. Development of dopaminergic neurons in the human substantia nigra.
Exp Neurol. 1991 Sep;113(3):344-53. [PMID: 1680741]

Doucet G, Brundin P, Seth S, Murata Y, Strecker RE, Triarhou LC, Ghetti B, Björklund A. Degeneration and graft-induced restoration of dopamine innervation in the weaver mouse neostriatum: a quantitative radioautographic study of [3H]dopamine uptake.
Exp Brain Res. 1989;77(3):552-68. [PMID: 2572446]

Huffaker TK, Boss BD, Morgan AS, Neff NT, Strecker RE, Spence MS, Miao R. Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease.
Exp Brain Res. 1989;77(2):329-36. [PMID: 2571515]

Strecker RE, Miao R, Loring JF. Survival and function of aggregate cultures of rat fetal dopamine neurons grafted in a rat model of Parkinson's disease.
Exp Brain Res. 1989;76(2):315-22. [PMID: 2569985]

Daszuta A, Kalén P, Strecker RE, Brundin P, Björklund A. Serotonin neurons grafted to the adult rat hippocampus. II. 5-HT release as studied by intracerebral microdialysis.
Brain Res. 1989 Oct 2;498(2):323-32. [PMID: 2477113]

Kalén P, Strecker RE, Rosengren E, Björklund A. Regulation of striatal serotonin release by the lateral habenula-dorsal raphe pathway in the rat as demonstrated by in vivo microdialysis: role of excitatory amino acids and GABA.
Brain Res. 1989 Jul 17;492(1-2):187-202. [PMID: 2473826]

Forni C, Brundin P, Strecker RE, el Ganouni S, Björklund A, Nieoullon A. Time-course of recovery of dopamine neuron activity during reinnervation of the denervated striatum by fetal mesencephalic grafts as assessed by in vivo voltammetry.
Exp Brain Res. 1989;76(1):75-87. [PMID: 2502425]

Brundin P, Widner H, Nilsson OG, Strecker RE, Björklund A. Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier.
Exp Brain Res. 1989;75(1):195-207. [PMID: 2495977]

Kalén P, Strecker RE, Rosengren E, Björklund A. Endogenous release of neuronal serotonin and 5-hydroxyindoleacetic acid in the caudate-putamen of the rat as revealed by intracerebral dialysis coupled to high-performance liquid chromatography with fluorimetric detection.
J Neurochem. 1988 Nov;51(5):1422-35. [PMID: 2459309]

Daszuta A, Strecker RE, Brundin P, Björklund A. Serotonin neurons grafted to the adult rat hippocampus. I. Time course of growth as studied by immunohistochemistry and biochemistry.
Brain Res. 1988 Aug 16;458(1):1-19. [PMID: 2463040]

Clarke DJ, Brundin P, Strecker RE, Nilsson OG, Björklund A, Lindvall O. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry.
Exp Brain Res. 1988;73(1):115-26. [PMID: 3145209]

Nilsson OG, Brundin P, Widner H, Strecker RE, Björklund A. Human fetal basal forebrain neurons grafted to the denervated rat hippocampus produce an organotypic cholinergic reinnervation pattern.
Brain Res. 1988 Jul 19;456(1):193-8. [PMID: 3409035]

Nilsson OG, Strecker RE, Daszuta A, Björklund A. Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat.
Brain Res. 1988 Jun 21;453(1-2):235-46. [PMID: 3401761]

Brundin P, Barbin G, Strecker RE, Isacson O, Prochiantz A, Björklund A. Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro.
Brain Res. 1988 Apr 1;467(2):233-43. [PMID: 3378172]

Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, Astedt B, Lindvall O, Björklund A. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release.
Exp Brain Res. 1988;70(1):192-208. [PMID: 3402564]

Brundin P, Strecker RE, Londos E, Björklund A. Dopamine neurons grafted unilaterally to the nucleus accumbens affect drug-induced circling and locomotion.
Exp Brain Res. 1987;69(1):183-94. [PMID: 3125059]

Strecker RE, Sharp T, Brundin P, Zetterström T, Ungerstedt U, Björklund A. Autoregulation of dopamine release and metabolism by intrastriatal nigral grafts as revealed by intracerebral dialysis.
Neuroscience. 1987 Jul;22(1):169-78. [PMID: 2819773]

Brundin P, Nilsson OG, Strecker RE, Lindvall O, Astedt B, Björklund A. Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease.
Exp Brain Res. 1986;65(1):235-40. [PMID: 3542544]

Rasmussen K, Strecker RE, Jacobs BL. Single unit response of noradrenergic, serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuli.
Brain Res. 1986 Mar 26;369(1-2):336-40. [PMID: 3697750]

Strecker RE, Jacobs BL. Substantia nigra dopaminergic unit activity in behaving cats: effect of arousal on spontaneous discharge and sensory evoked activity.
Brain Res. 1985 Dec 30;361(1-2):339-50. [PMID: 4084803]

Strecker RE, Steinfels GF, Abercrombie ED, Jacobs BL. Caudate unit activity in freely moving cats: effects of phasic auditory and visual stimuli.
Brain Res. 1985 Mar 11;329(1-2):350-3. [PMID: 3978457]

Steinfels GF, Heym J, Strecker RE, Jacobs BL. Raphe unit activity in freely moving cats is altered by manipulations of central but not peripheral motor systems.
Brain Res. 1983 Nov 21;279(1-2):77-84. [PMID: 6315184]

Steinfels GF, Heym J, Strecker RE, Jacobs BL. Response of dopaminergic neurons in cat to auditory stimuli presented across the sleep-waking cycle.
Brain Res. 1983 Oct 24;277(1):150-4. [PMID: 6640288]

Strecker RE, Steinfels GF, Jacobs BL. Dopaminergic unit activity in freely moving cats: lack of relationship to feeding, satiety, and glucose injections.
Brain Res. 1983 Feb 7;260(2):317-21. [PMID: 6831204]

Steinfels GF, Heym J, Strecker RE, Jacobs BL. Behavioral correlates of dopaminergic unit activity in freely moving cats.
Brain Res. 1983 Jan 10;258(2):217-28. [PMID: 6824912]

Strecker RE, Roberts DC, Koob GF. Apomorphine-induced facilitation of intracranial self-stimulation following dopamine denervation of the nucleus accumbens.
Pharmacol Biochem Behav. 1982 Nov;17(5):1015-8. [PMID: 6817349]

Joyce EM, Koob GF, Strecker R, Iversen SD, Bloom FE. The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
Brain Res. 1981 Sep 28;221(2):359-70. [PMID: 7025963]

Koob GF, Strecker RE, Bloom FE. Effects of naloxone on the anticonflict properties of alcohol and chlordiazepoxide.
Subst Alcohol Actions Misuse. 1980;1(5-6):447-57. [PMID: 7302793]

Reviews

Basheer R, Porkka-Heiskanen T, Strecker RE, Thakkar MM, McCarley RW. Adenosine as a biological signal mediating sleepiness following prolonged wakefulness.
Biol Signals Recept. 2000 Nov-Dec;9(6):319-27. Review. [PMID: 11025338]

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