Faculty Profile

Christopher Paul Landrigan, MD, MPH

Christopher Landrigan, MD
Professor of Pediatrics, Harvard Medical School
Physician, General Pediatrics, Department of Medicine, Children's Hospital Boston
Director, Sleep and Patient Safety Program, Sleep Medicine, Departments of Medicine and Neurology, Brigham and Women's Hospital

Administrative Title(s)

Research and Fellowship Director, Inpatient Pediatrics Service

See publications


Address

Boston Children's Hospital
Division of General Pediatrics, Enders 1
Boston, MA 02115
USA

Inter-office Mail Address

Boston Children’s Hospital, Division of General Pediatrics, Enders 1

Phone 17-355-2568
Phone 617-525-7310

Email christopher.landrigan@childrens.harvard.edu

Society Memberships

American Pediatric Society
American Society for Clinical Investigation
Sleep Research Society
Ambulatory Pediatrics Association
Society of Hospital Medicine
Society for Pediatric Research

Research Unit(s)

Division of Seep Medicine, Brigham and Women's Hospital
Harvard Work Hours, Health, and Safety Group
I-PASS Study Group
Pediatric Research in Inpatient Settigns (PRIS) Network

Research Interests

I am the Research Director of the Inpatient Pediatrics Service at Boston Children’s Hospital, Director of the Sleep and Patient Safety Program at Brigham and Women’s Hospital, and Professor of Pediatrics at Harvard Medical School. In addition, I was the founding chair and am currently an Executive Council Member of the Pediatric Research in Inpatient Settings (PRIS) Network, a collaboration of over 100 pediatric hospitals, which has conducted a series of major multi-center research and improvement projects.

My work has been focused on studying the epidemiology of medical errors and adverse events, and interventions designed to reduce their incidence.   My most important work has been focused on developing reliable patient safety measurement tools, and improving the organization of residency programs and academic medical centers.  A major focus of this effort has been studying the relationship between resident work hours, sleep, and patient safety.  More recently, concerned with improving communication in hospitals, I led the development of I-PASS, a multi-faceted teamwork and handoff improvement program that has been widely implemented in the United States and beyond.

Trainees


Supinda Bunyavanich, MD,  2001-2004
Colleen Sabaitini, MD, MPH 2001-2004
Sarah McBride, MD, 2002-2004
John Cronin, MD, 2002-2004
Kathleen Walsh, MD, MSc 2002-2007
Kshitij Mistry, MD, MPH, 2002-2007
Amy Fahrenkopf, MD, MPH, 2003-2008
Patrick Conway, MD, 2003-2007
Sarah Edwards, BA, 2004-2006
Michael Gaies, MD, MPH 2004-2006
Carl Eriksson, MD, 2007-2009
Adam Levine, MD, 2007-2009
Josna Adusumilli, MD, 2008-2010
Ejike Okoro, BA, 2008
Mary  Beth Gordon, MD, MPH 2008-2010
Peter Matos, MD, 2008-2010
Amy Jost Starmer, MD, 2008-present
Kao-Ping Chua, MD, 2009-present
Maireade McSweeney, MD, 2009-2014
Derek Williams, MD, 2010-present
Akindele Majekodunmi, MD, 2010-2013
Christopher Guidry, MD, 2011
Angela Feraco, MD, 2011-2015
Dev Kevat, MBBS, 2012-present
Alisa Khan, MD, MPH, 2012-present
Patrick Brady, MD, 2013-present
Jenni Baird, RN, PhD, 2014-2016
Arabella Simpkin, MBBS, MEd, 2014-present
Ariel Winn, MD, 2014-present
Katherine Freund, MD, 2015-present
Carolyn Marcus, MD, 2015-present
Sarah A. Smith, RN, MSN, 2016-present

Mentor(s)


Research Funding

I have been the Principal Investigator on numerous multi-center research studies evaluating rates of medical errors in hospitals; the effects of sleep deprivation and work schedule redesign on patient safety; and the effects of communication improvement programs on patient safety.  Grants have been funded by the federal government (AHRQ, NIH, PCORI, DHHS) as well as by CRICO (Harvard Risk Management Foundation) and numerous additional foundations.

Selected Publications

Khan A, Furtak SL, Melvin P, Rogers JE, Schuster MA, Landrigan CP.
Parent-Provider Miscommunications in Hospitalized Children. Hosp Pediatr. 2017
Sep;7(9):505-515. doi: 10.1542/hpeds.2016-0190. Epub 2017 Aug 2.
PMID:28768684; PMCID: PMC5614475.

Starmer AJ, Schnock KO, Lyons A, Hehn RS, Graham DA, Keohane C, Landrigan CP.
Effects of the I-PASS Nursing Handoff Bundle on communication quality and
workflow. BMJ Qual Saf. 2017 Jul 5. pii: bmjqs-2016-006224. doi:
10.1136/bmjqs-2016-006224. [Epub ahead of print] PMID: 28679836.

Starmer AJ, Spector ND, West DC, Srivastava R, Sectish TC, Landrigan CP;
I-PASS Study Group. Integrating Research, Quality Improvement, and Medical
Education for Better Handoffs and Safer Care: Disseminating, Adapting, and
Implementing the I-PASS Program. Jt Comm J Qual Patient Saf. 2017
Jul;43(7):319-329. doi: 10.1016/j.jcjq.2017.04.001. Epub 2017 Jun 1.
PMID: 28648217.

Coffey M, Thomson K, Li SA, Bismilla Z, Starmer AJ, O'Toole JK, Blankenburg
RL, Rosenbluth G, Cole FS, Yu CE, Hepps JH, Sectish TC, Spector ND, Srivastava R,
Allen AD, Mahant S, Landrigan CP. Resident Experiences With Implementation of the
I-PASS Handoff Bundle. J Grad Med Educ. 2017 Jun;9(3):313-320. doi:
10.4300/JGME-D-16-00616.1. PMID: 28638509; PMCID: PMC5476380.

Destino LA, Valentine M, Sheikhi FH, Starmer AJ, Landrigan CP, Sanders L.
Inpatient Hospital Factors and Resident Time With Patients and Families.
Pediatrics. 2017 May;139(5). pii: e20163011. doi: 10.1542/peds.2016-3011.
PMID: 28557735.

Geva A, Landrigan CP, van der Velden MG, Randolph AG. Simulation of a Novel
Schedule for Intensivist Staffing to Improve Continuity of Patient Care and
Reduce Physician Burnout. Crit Care Med. 2017 Jul;45(7):1138-1144. doi:
10.1097/CCM.0000000000002319. PMID: 28362643;
PMCID: PMC5474184.

Khan A, Coffey M, Litterer KP, Baird JD, Furtak SL, Garcia BM, Ashland MA,
Calaman S, Kuzma NC, O'Toole JK, Patel A, Rosenbluth G, Destino LA, Everhart JL,
Good BP, Hepps JH, Dalal AK, Lipsitz SR, Yoon CS, Zigmont KR, Srivastava R,
Starmer AJ, Sectish TC, Spector ND, West DC, Landrigan CP; and the Patient and
Family Centered I-PASS Study Group, Allair BK, Alminde C, Alvarado-Little W,
Atsatt M, Aylor ME, Bale JF Jr, Balmer D, Barton KT, Beck C, Bismilla Z,
Blankenberg RL, Chandler D, Choudhary A, Christensen E, Coghlan-McDonald S, Cole
FS, Corless E, Cray S, Da Silva R, Dahale D, Dreyer B, Growdon AS, Gubler L,
Guiot A, Harris R, Haskell H, Kocolas I, Kruvand E, Lane MM, Langrish K, Ledford
CJ, Lewis K, Lopreiato JO, Maloney CG, Mangan A, Markle P, Mendoza F, Micalizzi
DA, Mittal V, Obermeyer M, O'Donnell KA, Ottolini M, Patel SJ, Pickler R, Rogers
JE, Sanders LM, Sauder K, Shah SS, Sharma M, Simpkin A, Subramony A, Thompson ED
Jr, Trueman L, Trujillo T, Turmelle MP, Warnick C, Welch C, White AJ, Wien MF,
Winn AS, Wintch S, Wolf M, Yin HS, Yu CE. Families as Partners in Hospital Error
and Adverse Event Surveillance. JAMA Pediatr. 2017 Apr 1;171(4):372-381. doi:
10.1001/jamapediatrics.2016.4812. PMID: 28241211; PMCID: PMC5526631.

Khan A, Baird J, Rogers JE, Furtak SL, Williams KA, Allair B, Litterer KP,
Sharma M, Smith A, Schuster MA, Landrigan CP. Parent and Provider Experience and
Shared Understanding After a Family-Centered Nighttime Communication
Intervention. Acad Pediatr. 2017 May - Jun;17(4):389-402. doi:
10.1016/j.acap.2017.01.012. Epub 2017 Jan 29. PMID: 28143793; PMCID: PMC5438159.

Klerman EB, Beckett SA, Landrigan CP. Applying mathematical models to predict
resident physician performance and alertness on traditional and novel work
schedules. BMC Med Educ. 2016 Sep 13;16(1):239. doi: 10.1186/s12909-016-0751-9.
PMID: 27623842; PMCID: PMC5022151.

Landrigan CP, Stockwell D, Toomey SL, Loren S, Tracy M, Jang J, Quinn JA,
Ashrafzadeh S, Wang M, Sharek PJ, Parry G, Schuster MA. Performance of the Global
Assessment of Pediatric Patient Safety (GAPPS) Tool. Pediatrics. 2016 Jun;137(6).
pii: e20154076. doi: 10.1542/peds.2015-4076. PMID: 27221286.

Khan A, Rogers JE, Forster CS, Furtak SL, Schuster MA, Landrigan CP.
Communication and Shared Understanding Between Parents and Resident-Physicians at
Night. Hosp Pediatr. 2016 Jun;6(6):319-29. doi: 10.1542/hpeds.2015-0224.
PMID: 27188189;  PMCID: PMC5336324.

Feraco AM, Starmer AJ, Sectish TC, Spector ND, West DC, Landrigan CP.
Reliability of Verbal Handoff Assessment and Handoff Quality Before and After
Implementation of a Resident Handoff Bundle. Acad Pediatr. 2016 Aug;16(6):524-31.
doi: 10.1016/j.acap.2016.04.002. Epub 2016 Apr 16. PMID: 27090858; PMCID: PMC5504880.

Khan A, Furtak SL, Melvin P, Rogers JE, Schuster MA, Landrigan CP.
Parent-Reported Errors and Adverse Events in Hospitalized Children. JAMA Pediatr.
2016 Apr;170(4):e154608. doi: 10.1001/jamapediatrics.2015.4608. Epub 2016 Apr 4.
PubMed PMID: 26928413; PubMed Central PMCID: PMC5336322.

Schondelmeyer AC, Brady PW, Landrigan CP. Alarm fatigue: Clearing the air. J
Hosp Med. 2016 Feb;11(2):153-4. doi: 10.1002/jhm.2521. Epub 2015 Dec 14. PubMed
PMID: 26662376.

Khan A, Rogers JE, Melvin P, Furtak SL, Faboyede GM, Schuster MA, Landrigan
CP. Physician and Nurse Nighttime Communication and Parents' Hospital Experience.
Pediatrics. 2015 Nov;136(5):e1249-58. doi: 10.1542/peds.2015-2391. PMID:
26504131; PMCID: PMC5439977.

Starmer AJ, Destino L, Yoon CS, Landrigan CP. Intern and Resident Workflow
Patterns on Pediatric Inpatient Units: A Multicenter Time-Motion Study. JAMA
Pediatr. 2015 Dec;169(12):1175-7. doi: 10.1001/jamapediatrics.2015.2471.
PMID: 26501753.

Rosenbluth G, Landrigan CP; I-PASS Study Education Executive Committee. The
authors reply "Variation in printed handoff documents: Results and
recommendations from a multicenter needs assessment". J Hosp Med. 2016
Jan;11(1):81-2. doi: 10.1002/jhm.2503. Epub 2015 Oct 23. PMID: 26496516.

Rajaratnam SM, Landrigan CP, Czeisler CA. Graduated Driver-Licensing: The
Authors Reply. Health Aff (Millwood). 2015 Sep;34(9):1610. doi:
10.1377/hlthaff.2015.0852. PMID: 26355070.

Calaman S, Hepps JH, Bismilla Z, Carraccio C, Englander R, Feraco A,
Landrigan CP, Lopreiato JO, Sectish TC, Starmer AJ, Yu CE, Spector ND, West DC;
I-PASS Study Education Executive Committee. The Creation of Standard-Setting
Videos to Support Faculty Observations of Learner Performance and Entrustment
Decisions. Acad Med. 2016 Feb;91(2):204-9. doi: 10.1097/ACM.0000000000000853.
Review. PMID: 26266461.

Rajaratnam SM, Landrigan CP, Wang W, Kaprielian R, Moore RT, Czeisler CA.
Teen Crashes Declined After Massachusetts Raised Penalties For Graduated
Licensing Law Restricting Night Driving. Health Aff (Millwood). 2015
Jun;34(6):963-70. doi: 10.1377/hlthaff.2014.0928. PMID: 26056201.

Rosenbluth G, Bale JF, Starmer AJ, Spector ND, Srivastava R, West DC, Sectish
TC, Landrigan CP; I-PASS Study Education Executive Committee. Variation in
printed handoff documents: Results and recommendations from a multicenter needs
assessment. J Hosp Med. 2015 Aug;10(8):517-24. doi: 10.1002/jhm.2380. Epub 2015
May 26. PMID: 26014471.

Stockwell DC, Bisarya H, Classen DC, Kirkendall ES, Landrigan CP, Lemon V,
Tham E, Hyman D, Lehman SM, Searles E, Hall M, Muething SE, Schuster MA, Sharek
PJ. A trigger tool to detect harm in pediatric inpatient settings. Pediatrics.
2015 Jun;135(6):1036-42. doi: 10.1542/peds.2014-2152. Epub 2015 May 18.
PMID: 25986015.

Landrigan CP. Crying wolf: False alarms and patient safety. J Hosp Med. 2015
Jun;10(6):409-10. doi: 10.1002/jhm.2355. Epub 2015 Apr 15. PMID: 25879176.

Starmer AJ, Landrigan CP; I-PASS Study Group. Changes in medical errors with
a handoff program. N Engl J Med. 2015 Jan 29;372(5):490-1. doi:
10.1056/NEJMc1414788. PMID: 25629753.

Starmer AJ, Spector ND, Srivastava R, West DC, Rosenbluth G, Allen AD, Noble
EL, Tse LL, Dalal AK, Keohane CA, Lipsitz SR, Rothschild JM, Wien MF, Yoon CS,
Zigmont KR, Wilson KM, O'Toole JK, Solan LG, Aylor M, Bismilla Z, Coffey M,
Mahant S, Blankenburg RL, Destino LA, Everhart JL, Patel SJ, Bale JF Jr, Spackman
JB, Stevenson AT, Calaman S, Cole FS, Balmer DF, Hepps JH, Lopreiato JO, Yu CE,
Sectish TC, Landrigan CP; I-PASS Study Group. Changes in medical errors after
implementation of a handoff program. N Engl J Med. 2014 Nov 6;371(19):1803-12.
doi: 10.1056/NEJMsa1405556. PMID: 25372088.

Bigham MT, Logsdon TR, Manicone PE, Landrigan CP, Hayes LW, Randall KH,
Grover P, Collins SB, Ramirez DE, O'Guin CD, Williams CI, Warnick RJ, Sharek PJ.
Decreasing handoff-related care failures in children's hospitals. Pediatrics.
2014 Aug;134(2):e572-9. doi: 10.1542/peds.2013-1844. Epub 2014 Jul 7.
PMID: 25002665.

Starmer AJ, O'Toole JK, Rosenbluth G, Calaman S, Balmer D, West DC, Bale JF
Jr, Yu CE, Noble EL, Tse LL, Srivastava R, Landrigan CP, Sectish TC, Spector ND;
I-PASS Study Education Executive Committee. Development, implementation, and
dissemination of the I-PASS handoff curriculum: A multisite educational
intervention to improve patient handoffs. Acad Med. 2014 Jun;89(6):876-84. doi:
10.1097/ACM.0000000000000264. PMID: 24871238.

Kevat DA, Cameron PA, Davies AR, Landrigan CP, Rajaratnam SW. Safer hours for
doctors and improved safety for patients. Med J Aust. 2014 Apr 21;200(7):396-8.
PMID: 24794671.

Walsh KE, Bundy DG, Landrigan CP. Preventing health care-associated harm inchildren. JAMA. 2014 May 7;311(17):1731-2. doi: 10.1001/jama.2014.2038.
PMID: 24794361.

O'Toole JK, West DC, Starmer AJ, Yu CE, Calaman S, Rosenbluth G, Hepps JH,
Lopreiato JO, Landrigan CP, Sectish TC, Spector ND; I-PASS Study Education
Executive Committee. Placing faculty development front and center in a multisite
educational initiative: lessons from the I-PASS Handoff study. Acad Pediatr. 2014
May-Jun;14(3):221-4. doi: 10.1016/j.acap.2014.02.013. PMID: 24767774.

McCormick F, Kadzielski J, Evans BT, Landrigan CP, Herndon J, Rubash H.
Fatigue optimization scheduling in graduate medical education: reducing fatigue
and improving patient safety. J Grad Med Educ. 2013 Mar;5(1):107-11. doi:
10.4300/JGME-D-12-00021.1. PMID: 24404236; PMCID:
PMC3613293.

Simon TD, Starmer AJ, Conway PH, Landrigan CP, Shah SS, Shen MW, Sectish TC,
Spector ND, Tieder JS, Srivastava R, Willis LE, Wilson KM. Quality improvement
research in pediatric hospital medicine and the role of the Pediatric Research in
Inpatient Settings (PRIS) network. Acad Pediatr. 2013 Nov-Dec;13(6 Suppl):S54-60.
doi: 10.1016/j.acap.2013.04.006. Review. PMID: 24268086.

Starmer AJ, Sectish TC, Simon DW, Keohane C, McSweeney ME, Chung EY, Yoon CS,
Lipsitz SR, Wassner AJ, Harper MB, Landrigan CP. Rates of medical errors and
preventable adverse events among hospitalized children following implementation
of a resident handoff bundle. JAMA. 2013 Dec 4;310(21):2262-70. doi:
10.1001/jama.2013.281961. PMID: 24302089.

Landrigan CP. New questions on the road to safer health care. Pediatrics.
2013 May;131(5):e1621-2. doi: 10.1542/peds.2013-0647. Epub 2013 Apr 29.
PMID: 23629610.

O'Toole JK, Stevenson AT, Good BP, Guiot AB, Solan LG, Tse LL, Landrigan CP,
Sectish TC, Srivastava R, Starmer AJ, Spector ND; Initiative for Innovation in
Pediatric Education-Pediatric Research in Inpatient Settings Accelerating Safe
Signouts Study Group. Closing the gap: a needs assessment of medical students and
handoff training. J Pediatr. 2013 May;162(5):887-8.e1. doi:
10.1016/j.jpeds.2013.01.045. PMID: 23617969.

McSweeney ME, Landrigan CP, Jiang H, Starmer A, Lightdale JR. Answering
questions on call: pediatric resident physicians' use of handoffs and other
resources. J Hosp Med. 2013 Jun;8(6):328-33. doi: 10.1002/jhm.2038. Epub 2013 Apr
16. PMID: 23589463.

Cohen IG, Czeisler CA, Landrigan CP. Making residency work hour rules work. J
Law Med Ethics. 2013 Spring;41(1):310-4. doi: 10.1111/jlme.12021.
PMID: 23581673.

Hayes SM, Murray S, Castriotta RJ, Landrigan CP, Malhotra A. (Mis)
perceptions and interactions of sleep specialists and generalists: obstacles to
referrals to sleep specialists and the multidisciplinary team management of sleep
disorders. J Clin Sleep Med. 2012 Dec 15;8(6):633-42. doi: 10.5664/jcsm.2252.
PMID: 23243396; PMCID: PMC3501659.

Rosenbluth G, Landrigan CP. Sleep science, schedules, and safety in
hospitals: challenges and solutions for pediatric providers. Pediatr Clin North
Am. 2012 Dec;59(6):1317-28. doi: 10.1016/j.pcl.2012.09.001. Epub 2012 Oct 12.
PMID: 23116528.

Srivastava R, Landrigan CP. Development of the Pediatric Research in
Inpatient Settings (PRIS) Network: lessons learned. J Hosp Med. 2012
Oct;7(8):661-4. doi: 10.1002/jhm.1972. PMID: 23033225.

 Keren R, Luan X, Localio R, Hall M, McLeod L, Dai D, Srivastava R; Pediatric
Research in Inpatient Settings (PRIS) Network. Prioritization of comparative
effectiveness research topics in hospital pediatrics. Arch Pediatr Adolesc Med.
2012 Dec;166(12):1155-64. doi: 10.1001/archpediatrics.2012.1266.
PMID:23027409.

Landrigan CP, Srivastava R. Pediatric hospitalists: coming of age in 2012.
Arch Pediatr Adolesc Med. 2012 Aug;166(8):696-9. doi:
10.1001/archpediatrics.2012.484. PMID: 22869402.

McCormick F, Kadzielski J, Landrigan CP, Evans B, Herndon JH, Rubash HE.
Surgeon fatigue: a prospective analysis of the incidence, risk, and intervals of
predicted fatigue-related impairment in residents. Arch Surg. 2012
May;147(5):430-5. doi: 10.1001/archsurg.2012.84. PMID: 22785637.

Gordon MB, Sectish TC, Elliott MN, Klein D, Landrigan CP, Bogart LM, Amrock
S, Burke A, Chiang VW, Schuster MA. Pediatric residents' perspectives on reducing
work hours and lengthening residency: a national survey. Pediatrics. 2012
Jul;130(1):99-107. doi: 10.1542/peds.2011-3498. Epub 2012 Jun 4.
PMID: 22665414.

Auger KA, Landrigan CP, Gonzalez del Rey JA, Sieplinga KR, Sucharew HJ,
Simmons JM. Better rested, but more stressed? Evidence of the effects of resident
work hour restrictions. Acad Pediatr. 2012 Jul-Aug;12(4):335-43. doi:
10.1016/j.acap.2012.02.006. Epub 2012 May 22. PMID: 22626586.

Starmer AJ, Spector ND, Srivastava R, Allen AD, Landrigan CP, Sectish TC;
I-PASS Study Group. I-pass, a mnemonic to standardize verbal handoffs.
Pediatrics. 2012 Feb;129(2):201-4. doi: 10.1542/peds.2011-2966. Epub 2012 Jan 9.
PMID: 22232313.

Rajaratnam SM, Barger LK, Lockley SW, Shea SA, Wang W, Landrigan CP, O'Brien
CS, Qadri S, Sullivan JP, Cade BE, Epstein LJ, White DP, Czeisler CA; Harvard
Work Hours, Health and Safety Group. Sleep disorders, health, and safety in
police officers. JAMA. 2011 Dec 21;306(23):2567-78. doi: 10.1001/jama.2011.1851.
PMID: 22187276.

Landrigan CP. Healthcare provider working conditions and well-being: sharing
international lessons to improve patient safety. J Pediatr (Rio J). 2011
Nov-Dec;87(6):463-5. doi: doi:10.2223/JPED.2147. PMID: 22170042.

Chua KP, Gordon MB, Sectish T, Landrigan CP. Effects of a night-team system
on resident sleep and work hours. Pediatrics. 2011 Dec;128(6):1142-7. doi:
10.1542/peds.2011-1049. Epub 2011 Nov 28. PMID: 22123867.

Majekodunmi A, Landrigan CP. The effect of physician sleep deprivation on
patient safety in perinatal-neonatal medicine. Am J Perinatol. 2012
Jan;29(1):43-8. doi: 10.1055/s-0031-1286184. Epub 2011 Aug 30. Review.
PMID: 21879459.

Gordon MB, Melvin P, Graham D, Fifer E, Chiang VW, Sectish TC, Landrigan CP.
Unit-based care teams and the frequency and quality of physician-nurse
communications. Arch Pediatr Adolesc Med. 2011 May;165(5):424-8. doi:
10.1001/archpediatrics.2011.54. PMID: 21536957.

Blum AB, Shea S, Czeisler CA, Landrigan CP, Leape L. Implementing the 2009
Institute of Medicine recommendations on resident physician work hours,
supervision, and safety. Nat Sci Sleep. 2011 Jun 24;3:47-85. doi:
10.2147/NSS.S19649. Print 2011. PMID: 23616719; PMCID: PMC3630963.

Landrigan CP, Parry GJ, Bones CB, Hackbarth AD, Goldmann DA, Sharek PJ.
Temporal trends in rates of patient harm resulting from medical care. N Engl J
Med. 2010 Nov 25;363(22):2124-34. doi: 10.1056/NEJMsa1004404. Erratum in: N Engl
J Med. 2010 Dec 23;363(26):2573. PMID: 21105794.

Gordon JA, Alexander EK, Lockley SW, Flynn-Evans E, Venkatan SK, Landrigan
CP, Czeisler CA; Harvard Work Hours, Health, and Safety Group (Boston,
Massachusetts). Does simulator-based clinical performance correlate with actual
hospital behavior? The effect of extended work hours on patient care provided by
medical interns. Acad Med. 2010 Oct;85(10):1583-8. doi:
10.1097/ACM.0b013e3181f073f0. PMID: 20881679; PMCID: PMC3754850.

Sectish TC, Starmer AJ, Landrigan CP, Spector ND; I-PASS Study Group.
Establishing a multisite education and research project requires leadership,
expertise, collaboration, and an important aim. Pediatrics. 2010
Oct;126(4):619-22. doi: 10.1542/peds.2010-1793. Epub 2010 Sep 27.
PMID: 20876168.

Levine AC, Adusumilli J, Landrigan CP. Effects of reducing or eliminating
resident work shifts over 16 hours: a systematic review. Sleep. 2010
Aug;33(8):1043-53. Review. PMID: 20815185; PMCID: PMC2910534

Sharek PJ, Parry G, Goldmann D, Bones K, Hackbarth A, Resar R, Griffin FA,
Rhoda D, Murphy C, Landrigan CP. Performance characteristics of a methodology to
quantify adverse events over time in hospitalized patients. Health Serv Res. 2011
Apr;46(2):654-78. doi: 10.1111/j.1475-6773.2010.01156.x. Epub 2010 Aug 16.
PMID: 20722749; PMCID: PMC3064924.

Mittal VS, Sigrest T, Ottolini MC, Rauch D, Lin H, Kit B, Landrigan CP,
Flores G. Family-centered rounds on pediatric wards: a PRIS network survey of US
and Canadian hospitalists. Pediatrics. 2010 Jul;126(1):37-43. doi:
10.1542/peds.2009-2364. Epub 2010 Jun 29. PMID: 20587682.

Blum AB, Raiszadeh F, Shea S, Mermin D, Lurie P, Landrigan CP, Czeisler CA.
US public opinion regarding proposed limits on resident physician work hours. BMC
Med. 2010 Jun 1;8:33. doi: 10.1186/1741-7015-8-33. PMID: 20515479;
PMCID: PMC2901227.

Jha AK, Prasopa-Plaizier N, Larizgoitia I, Bates DW; Research Priority
Setting Working Group of the WHO World Alliance for Patient Safety. Patient
safety research: an overview of the global evidence. Qual Saf Health Care. 2010
Feb;19(1):42-7. doi: 10.1136/qshc.2008.029165. PMID: 20172882.

Landrigan CP. Resident sleep deprivation and critical care: the unintended
consequences of inaction. Crit Care Med. 2010 Mar;38(3):980-1. doi:
10.1097/CCM.0b013e3181d16bc6. PMID: 20168152.

Rothschild JM, Keohane CA, Rogers S, Gardner R, Lipsitz SR, Salzberg CA, Yu
T, Yoon CS, Williams DH, Wien MF, Czeisler CA, Bates DW, Landrigan CP. Risks ofcomplications by attending physicians after performing nighttime procedures.
JAMA. 2009 Oct 14;302(14):1565-72. doi: 10.1001/jama.2009.1423.
PMID: 19826026.

Gaies MG, Morris SA, Hafler JP, Graham DA, Capraro AJ, Zhou J, Landrigan CP,
Sandora TJ. Reforming procedural skills training for pediatric residents: a
randomized, interventional trial. Pediatrics. 2009 Aug;124(2):610-9. doi:
10.1542/peds.2008-2658. Epub 2009 Jul 27. PMID: 19651582.

Cappuccio FP, Lockley SW, Landrigan CP. Cappuccio response to correspondence.
QJM. 2009 May;102(5):363-4. doi: 10.1093/qjmed/hcp032. Epub 2009 Mar 24.
PMID: 19318371.

Barger LK, Lockley SW, Rajaratnam SM, Landrigan CP. Neurobehavioral, health,
and safety consequences associated with shift work in safety-sensitive
professions. Curr Neurol Neurosci Rep. 2009 Mar;9(2):155-64. Review.
PMID: 19268039.

Cappuccio FP, Bakewell A, Taggart FM, Ward G, Ji C, Sullivan JP, Edmunds M,
Pounder R, Landrigan CP, Lockley SW, Peile E; Warwick EWTD Working Group.
Implementing a 48 h EWTD-compliant rota for junior doctors in the UK does not
compromise patients' safety: assessor-blind pilot comparison. QJM. 2009
Apr;102(4):271-82. doi: 10.1093/qjmed/hcp004. Epub 2009 Jan 27.
PMID: 19174502; PMCID: PMC2659599.

Landrigan CP. Driving drowsy. J Clin Sleep Med. 2008 Dec 15;4(6):536-7.
PMID: 19110881; PMCID: PMC2603529.

Volpp KG, Landrigan CP. Building physician work hour regulations from firs tprinciples and best evidence. JAMA. 2008 Sep 10;300(10):1197-9. doi:10.1001/jama.300.10.1197.
PMID: 18780848.

Landrigan CP, Conway PH, Stucky ER, Chiang VW, Ottolini MC. Variation in
pediatric hospitalists' use of proven and unproven therapies: a study from the
Pediatric Research in Inpatient Settings (PRIS) network. J Hosp Med. 2008
Jul;3(4):292-8. doi: 10.1002/jhm.347. PMID: 18698602.

Landrigan CP, Fahrenkopf AM, Lewin D, Sharek PJ, Barger LK, Eisner M, Edwards
S, Chiang VW, Wiedermann BL, Sectish TC. Effects of the accreditation council for
graduate medical education duty hour limits on sleep, work hours, and safety.
Pediatrics. 2008 Aug;122(2):250-8. doi: 10.1542/peds.2007-2306.
PMID: 18676540.

Janney M, Landrigan C. Improving nurse working conditions: towards safer
models of hospital care. J Hosp Med. 2008 May;3(3):181-3. doi: 10.1002/jhm.339.
PMID: 18571805.

Owens JA, Avidan A, Baldwin D, Landrigan C. Improving sleep hygiene. Arch
Intern Med. 2008 Jun 9;168(11):1229-30; author reply 1230. doi:
10.1001/archinte.168.11.1229-b. PMID: 18541835.

Walsh KE, Landrigan CP, Adams WG, Vinci RJ, Chessare JB, Cooper MR, Hebert
PM, Schainker EG, McLaughlin TJ, Bauchner H. Effect of computer order entry on
prevention of serious medication errors in hospitalized children. Pediatrics.
2008 Mar;121(3):e421-7. doi: 10.1542/peds.2007-0220. PMID: 18310162.

Fahrenkopf AM, Sectish TC, Barger LK, Sharek PJ, Lewin D, Chiang VW, Edwards
S, Wiedermann BL, Landrigan CP. Rates of medication errors among depressed andburnt out residents: prospective cohort study. BMJ. 2008 Mar 1;336(7642):488-91.
doi: 10.1136/bmj.39469.763218.BE. Epub 2008 Feb 7.
PMID: 18258931; PMCID: PMC2258399.

Landrigan CP, Czeisler CA, Barger LK, Ayas NT, Rothschild JM, Lockley SW;
Harvard Work Hours, Health and Safety Group. Effective implementation of
work-hour limits and systemic improvements. Jt Comm J Qual Patient Saf. 2007
Nov;33(11 Suppl):19-29. PMID: 18173163.

Lockley SW, Barger LK, Ayas NT, Rothschild JM, Czeisler CA, Landrigan CP;
Harvard Work Hours, Health and Safety Group. Effects of health care provider work
hours and sleep deprivation on safety and performance. Jt Comm J Qual Patient
Saf. 2007 Nov;33(11 Suppl):7-18. PMID: 18173162.

Gaies MG, Landrigan CP, Hafler JP, Sandora TJ. Assessing procedural skills
training in pediatric residency programs. Pediatrics. 2007 Oct;120(4):715-22.
PMID: 17908757.

Srivastava R, Landrigan CP, Ross-Degnan D, Soumerai SB, Homer CJ, Goldmann
DA, Muret-Wagstaff S. Impact of a hospitalist system on length of stay and cost
for children with common conditions. Pediatrics. 2007 Aug;120(2):267-74.
PMID: 17671051.

Walsh KE, Adams WG, Bauchner H, Vinci RJ, Chessare JB, Cooper MR, Hebert PM,
Schainker EG, Landrigan CP. Medication errors related to computerized order entry
for children. Pediatrics. 2006 Nov;118(5):1872-9. PMID: 17079557.

Landrigan CP, Barger LK, Cade BE, Ayas NT, Czeisler CA. Interns' compliancewith accreditation council for graduate medical education work-hour limits. JAMA.
2006 Sep 6;296(9):1063-70. PMID: 16954485.

Conway PH, Edwards S, Stucky ER, Chiang VW, Ottolini MC, Landrigan CP.
Variations in management of common inpatient pediatric illnesses: hospitalists
and community pediatricians. Pediatrics. 2006 Aug;118(2):441-7. PMID: 16882793.

Lockley SW, Landrigan CP, Barger LK, Czeisler CA; Harvard Work Hours Health
and Safety Group. When policy meets physiology: the challenge of reducing
resident work hours. Clin Orthop Relat Res. 2006 Aug;449:116-27. Review.
PMID: 16770285.

Landrigan CP, Conway PH, Edwards S, Srivastava R. Pediatric hospitalists: a
systematic review of the literature. Pediatrics. 2006 May;117(5):1736-44.
PMID: 16651332.

Lye PS, Rauch DA, Ottolini MC, Landrigan CP, Chiang VW, Srivastava R,
Muret-Wagstaff S, Ludwig S. Pediatric hospitalists: report of a leadership
conference. Pediatrics. 2006 Apr;117(4):1122-30. PMID: 16585306.

Rothschild JM, Hurley AC, Landrigan CP, Cronin JW, Martell-Waldrop K, Foskett
C, Burdick E, Czeisler CA, Bates DW. Recovery from medical errors: the critical
care nursing safety net. Jt Comm J Qual Patient Saf. 2006 Feb;32(2):63-72.
PMID: 16568919.

Lilly CM, Landrigan CP. A shift for the better. Chest. 2005
Dec;128(6):3787-8. PMID: 16354844.

Landrigan CP. Sliding down the Bell curve: effects of 24-hour work shifts on physicians' cognition and performance. Sleep. 2005 Nov;28(11):1351-3.
PMID: 16335321.

Landrigan CP, Lockley SW, Czeisler CA. Effect of intern's consecutive work
hours on safety, medical education and professionalism. Crit Care. 2005 Oct
5;9(5):528-30; author reply 528-30. Epub 2005 May 24. PMID: 16277743;
PMCID: PMC1297601.

McBride SC, Chiang VW, Goldmann DA, Landrigan CP. Preventable adverse events
in infants hospitalized with bronchiolitis. Pediatrics. 2005 Sep;116(3):603-8.
PMID: 16140699.

Rothschild JM, Landrigan CP, Cronin JW, Kaushal R, Lockley SW, Burdick E,
Stone PH, Lilly CM, Katz JT, Czeisler CA, Bates DW. The Critical Care Safety
Study: The incidence and nature of adverse events and serious medical errors in
intensive care. Crit Care Med. 2005 Aug;33(8):1694-700. PMID: 16096443.

Landrigan CP. The safety of inpatient pediatrics: preventing medical errors
and injuries among hospitalized children. Pediatr Clin North Am. 2005
Aug;52(4):979-93, vii. Review. PMID: 16009253.

Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly
CM, Stone PH, Lockley SW, Bates DW, Czeisler CA. Effect of reducing interns' work
hours on serious medical errors in intensive care units. N Engl J Med. 2004 Oct
28;351(18):1838-48. PMID: 15509817.

Lockley SW, Cronin JW, Evans EE, Cade BE, Lee CJ, Landrigan CP, Rothschild
JM, Katz JT, Lilly CM, Stone PH, Aeschbach D, Czeisler CA; Harvard Work Hours,
Health and Safety Group. Effect of reducing interns' weekly work hours on sleep
and attentional failures. N Engl J Med. 2004 Oct 28;351(18):1829-37. PMID:
15509816.

Willson DF, Landrigan CP, Horn SD, Smout RJ. Complications in infants
hospitalized for bronchiolitis or respiratory syncytial virus pneumonia. J
Pediatr. 2003 Nov;143(5 Suppl):S142-9. PMID: 14615713.

Fortescue EB, Kaushal R, Landrigan CP, McKenna KJ, Clapp MD, Federico F,
Goldmann DA, Bates DW. Prioritizing strategies for preventing medication errors
and adverse drug events in pediatric inpatients. Pediatrics. 2003 Apr;111(4 Pt
1):722-9. PMID: 12671103.

Olsen SJ, Bleasdale SC, Magnano AR, Landrigan C, Holland BH, Tauxe RV, Mintz
ED, Luby S. Outbreaks of typhoid fever in the United States, 1960-99. Epidemiol
Infect. 2003 Feb;130(1):13-21. PMID: 12613741; PMCID: PMC2869934.

Landrigan CP, Muret-Wagstaff S, Chiang VW, Nigrin DJ, Goldmann DA,
Finkelstein JA. Senior resident autonomy in a pediatric hospitalist system. Arch
Pediatr Adolesc Med. 2003 Feb;157(2):206-7. PMID: 12580695.

Bunyavanich S, Landrigan CP, McMichael AJ, Epstein PR. The impact of climate
change on child health. Ambul Pediatr. 2003 Jan-Feb;3(1):44-52. Review.
PMID: 12540254.

Landrigan CP, Srivastava R, Muret-Wagstaff S, Soumerai SB, Ross-Degnan D,
Graef JW, Homer CJ, Goldmann DA. Impact of a health maintenance organization
hospitalist system in academic pediatrics. Pediatrics. 2002 Oct;110(4):720-8.
PMID: 12359785.

Landrigan CP, Muret-Wagstaff S, Chiang VW, Nigrin DJ, Goldmann DA,
Finkelstein JA. Effect of a pediatric hospitalist system on housestaff education
and experience. Arch Pediatr Adolesc Med. 2002 Sep;156(9):877-83.  PMID:12197794.

Landrigan C, Srivastava R, Muret-Wagstaff S, Dyck IJ, Homer CJ, Goldmann DA.
Pediatric hospitalists: what do we know, and where do we go from here? Ambul
Pediatr. 2001 Nov-Dec;1(6):340-5. PubMed PMID: 11888426.

Srivastava R, Landrigan C, Gidwani P, Harary OH, Muret-Wagstaff S, Homer CJ.
Pediatric hospitalists in Canada and the United States: a survey of pediatric
academic department chairs. Ambul Pediatr. 2001 Nov-Dec;1(6):338-9. PMID:  1888425.

Nigrovic LE, Lumeng C, Landrigan C, Chiang VW. Rotavirus cerebellitis? Clin
Infect Dis. 2002 Jan 1;34(1):130. PMID: 11731961.

Landrigan C. Preventable deaths and injuries during magnetic resonance
imaging. N Engl J Med. 2001 Sep 27;345(13):1000-1. PMID: 11575283.

Kaushal R, Bates DW, Landrigan C, McKenna KJ, Clapp MD, Federico F, Goldmann
DA. Medication errors and adverse drug events in pediatric inpatients. JAMA. 2001
Apr 25;285(16):2114-20. PMID: 11311101.

Kim R, Landrigan C, Mossmann P, Sparrow D, Hu H. Age and secular trends in
bone lead levels in middle-aged and elderly men: three-year longitudinal
follow-up in the Normative Aging Study. Am J Epidemiol. 1997 Oct 1;146(7):586-91.
PMID: 9326437.

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