Faculty Profile

Quentin R. Regestein, MD

Quentin R. Regestein, MD
Associate Professor of Psychiatry, Harvard Medical School
Associate Psychiatrist, Department of Psychiatry, Brigham and Women's Hospital

See publications

Inter-office Mail Address

BWH Psychiatry
221 Longwood Avenue
Rm M-56

Phone 617-525-1244

Email qregestein@partners.org

Society Memberships

Sleep Research Society
Narcolepsy Network

Research Interests

Dr. Regestein is psychiatrist clinically focused on patients with sleep, attention and fatigue disorders. He has done studies relevant to psychosomatic issues, e.g., on the hypothalamic regulation of emotion, hippocampal regulation of avoidance conditioning and cortisol level, effects of prenatal progesterone exposure on sexual behavior, CNS mechanisms of cardiac arrhythmias and EEG correlates of arousal. Clinical studies have pertained to ventricular arrhythmia, Cushing's disease, insomnia, sleep apnea, narcolepsy, chronic fatigue and attention deficit disorders. He has been involved in industry-sponsored trials of hypnotic drugs and exogenous ovarian steroids. He has studied mood, sleep and cognitive problems prevalent in midlife women. Most recently, he is attempting to use cognitive performance test data to find objective markers for psychiatric diagnoses, and is collaborating with an MIT group to model general properties of behavior. As a member of the DSM-III-R and DSM-IV task forces, Dr. Regestein helped define sleep disorders. He is on the medical advisory board of Narcolepsy Network and the editorial board of Menopause.


R Shapskyianova, MD 1993-1994
Milena K. Pavlova, MD 1994-1999
M Hammod, MD 1999-2001
Friebely, EdD, 2001-2005

Research Funding

Pfizer, PI: Q Regestein, A crossover, double-blind comparison of tolterodine vs. placebo on nocturia in postmenopausal women.


Course Director, Psychiatry Forum

Dr. Regestein has given over 250 Continuing Medical Education lectures across the United States and in Europe on topics related to psychiatric and sleep disorders.

Selected Publications

Regestein Q,  Natarajan V, Pavlova M,  Kawasaki S.  Gleason R, Koff E. Sleep debt and depression in female college students  
J Psychiat Res 2010 (in press)

Edell-Gustafsson U, Carstensen J, Regestein Q, Swahn E, Svanborg E. Hyperarousal, depression and quality of life--validity and reliability of the Swedish version of the Hyperarousal Scale.
Scand J Caring Sci. 2006 Mar;20(1):58-67. [PMID: 16489961]

Regestein QR, Friebely J, Shifren JL, Scharf MB, Wiita B, Carver J, Schiff I. Self-reported sleep in postmenopausal women.
Menopause.2004 Mar-Apr;11(2):198-207. [PMID: 15021450] 

Regestein QR, Friebely J, Shifren J, Schiff I. Neuropsychological effects of methyltestosterone in women using menopausal hormone replacement.
J Womens Health Gend Based Med. 2001 Sep;10(7):671-6. [PMID: 11571096] 

Pavlova M, Berg O, Gleason R, Walker F, Roberts S, Regestein Q. Self-reported hyperarousal traits among insomnia patients.
J Psychosom Res. 2001 Aug;51(2):435-41. [PMID: 11516766] 

Friebely JS, Shifren JL, Schiff I, Regestein QR. Preliminary observations on differing psychological effects of conjugated and Esterified estrogen treatments.
J Womens Health Gend Based Med. 2001 Mar;10(2):181-7. [PMID: 11268301] 

Hammad MA, Barsky AJ, Regestein QR. Correlation between somatic sensation inventory scores and hyperarousal scale scores.
Psychosomatics. 2001 Jan-Feb;42(1):29-34. [PMID: 11161118]

Regestein QR, Monk TH. Delayed sleep phase syndrome: a review of its clinical aspects.
Am J Psychiatry. 1995 Apr; 152(4):602-8. [PMID: 7694911] 

Regestein QR, Dambrosia J, Hallett M, Murawski B, Paine M. Daytime alertness in patients with primary insomnia.
Am J Psychiatry. 1993 Oct; 150(10):1529-34. [PMID: 8379559]

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