Faculty Profile

Geoffrey S. Gilmartin, MD


Instructor in Medicine, Harvard Medical School
Instructor, Department of Medicine, Beth Israel Deaconess Medical Center

Administrative Title(s)

Medical Director, Beth Israel Deaconess Medical Center Sleep Laboratory
Associate Director, Beth Israel Medical Center Sleep Medicine Fellowship Program
Clinical Director, Sleep Medicine, Pulmonary Division

See publications


Address

330 Brookline Avenue
GZ-402
Boston, MA 02215
USA

Inter-office Mail Address

Beth Israel Deaconess Medical Center
GZ-402

Phone 617-667-4120

Society Memberships

American Thoracic Society
American Academy of Sleep Medicine
Massachusetts Medical Society

Research Unit(s)

Laboratory to Study the Consequences of Sleep Disordered Breathing, Department of Medicine, Beth Israel Deaconess Medical Center

Research Interests

Dr. Gilmartin and his collaborators have designed and are implementing both animal and human studies to evaluate the vascular, metabolic and sympathetic nervous system responses to hypoxia in patients with OSA and normal volunteers.  The current protocols involve exposures to human subjects of 8 hours of hypoxia during a single exposure as well as two weeks of an 8-hour exposure to hypoxia overnight, every night.  Variables measured include MSNA (muscle sympathetic nerve activity), forearm blood flow (measured by venous occlusion plethysmography) and hypoxic ventilatory responses both before an after the exposures. In addition, ongoing clinical invetigations into the mechanisms of and response to treatment in central sleep apnea are a significant focus of his research. 

Trainees

Barbara Levarge, MD 2009-10
Patrick Troy, MD 2009-10
Adebola Owolewa, BS 2009
Trustin Ennacheril, MD 2008-09

Mentor(s)


Research Funding

Current

Vascular Function After Recent Exposure of Humans to Hypoxia (2006-10)
NIH/NHLBI (RO1-HL074972-01)
Co-Investigator
Investigation in human subjects of alterations in vascular function following exposure to intermittent hypoxia.  Role is primary responsibility for development and conduct of research protocols as well as data analysis and manuscript preparation.

Past

Time Domains of Sympathetic Activity Following Hypoxia (2003-07)
NIH/NHLBI (RO1-HL072648-01)
Co-Investigator
Project investigating the time course of sympathetic activity in humans following exposure to hypoxia of different durations.  Role was primary responsibility for development and conduct of research protocols as well as data analysis and manuscript preparation.
    
Vascular Control and Insulin Resistance in Obstructive Sleep Apnea (OSA) (2004-06)
National Sleep Foundation-Pickwick Society Award
Principal Investigator
National Sleep Foundation supported investigation of vascular and metabolic consequences of sleep apnea through physiologic studies in patients with Obstructive Sleep Apnea.

Teaching

Teaching of Students in Courses

2008-present    Subspecialty Clinician Rounds
                       Harvard Medical School
                       4th year Medical Students    4 hours/yr
2007-present    Respiratory Pathophysiology
                       Harvard Medical School
                       Medical Students    8 hours/year

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)

2009-present    Cardiovascular Consequences of Obstructive Sleep Apnea
                       Ambulatory Care Conference
                       Beth Israel Deaconess Medical Center-Internal Medicine Residency
                       Clinical Residents    4 hours/year
2008-present    Non-Invasive Ventilation in the Acute Care Setting
                       Beth Israel Deaconess Medical Center-Emergency Medicine Residency
                       Clinical Residents    4 hours/year
2007-present    Central Sleep Apnea
                       Brigham and Women’s Hospital/Beth Israel Deaconess Medical Center                        Fellowship Programs in Sleep Medicine
                       Clinical Fellows    4 hours/year
2006-present    Sleep Apnea-Mechanisms of Disease
                       Harvard Combined Program in Pulmonary and Critical Care Medicine
                       Clinical Fellows    8 hours/year
2006-present    Sleep and Fatigue-Impact on Medical Trainees
                       Beth Israel Deaconess Medical Center
                       Clinical Residents and Fellows    4 hours/year

Clinical Supervisory and Training Responsibilities

2006-present    Sleep Clinic Preceptor    8 hours/week

Formal Teaching of Peers (e.g., CME and other continuing education courses)

2009                Sleep Apnea-Review and Update   
                       Winchester Hospital Grand Rounds    Winchester, MA
2008, 2009       Sleep Apnea-Mechanisms of Disease and Implications for Treatment   
                       Update in Internal Medicine (Harvard Medical School/Beth Israel Deaconess
                       Medical Center)    Boston, MA
2008                Cardiac Consequences of Sleep Apnea   
                       St. Luke’s Hospital Grand Rounds    New Bedford, MA

Selected Publications

Roberts DH, Gilmartin GS, Neeman N, Schulze JE, Cannistraro S, Ngo LH, Aronson MD, Weiss JW. Design and measurement of quality improvement indicators in ambulatory pulmonary care: creating a "culture of quality" in an academic pulmonary division.
Chest. 2009 Oct;136(4):1134-40. [PMID: 19809055]

Weiss MD, Tamisier R, Boucher J, Lynch M, Gilmartin G, Weiss JW, Thomas RJ. A pilot study of sleep, cognition, and respiration under 4 weeks of intermittent nocturnal hypoxia in adult humans.
Sleep Med. 2009 Aug;10(7):739-45. Epub 2009 Mar 17. [PMID: 19282237]

Tamisier R, Gilmartin GS, Launois SH, Pépin JL, Nespoulet H, Thomas R, Lévy P, Weiss JW. A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressure.
J Appl Physiol. 2009 Jul;107(1):17-24. Epub 2009 Feb 19. [PMID: 19228987]

Hunt BE, Tamisier R, Gilmartin GS, Curley M, Anand A, Weiss JW. Baroreflex responsiveness during ventilatory acclimatization in humans.
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1794-801. Epub 2008 Aug 29. [PMID: 18757487]

Gilmartin GS, Tamisier R, Curley M, Weiss JW. Ventilatory, hemodynamic, sympathetic nervous system, and vascular reactivity changes after recurrent nocturnal sustained hypoxia in humans.
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H778-85. Epub 2008 Jun 6. [PMID: 18539753]

Roberts DH, Gilmartin GS, Neeman N, Schulze JE, Cannistraro S, Ngo LH, Aronson MD, Weiss JW. Design and measurement of quality improvement indicators in ambulatory pulmonary care: creating a "culture of quality" in an academic pulmonary division.
Chest. 2009 Oct;136(4):1134-40. [PMID: 19809055]

Weiss MD, Tamisier R, Boucher J, Lynch M, Gilmartin G, Weiss JW, Thomas RJ. A  pilot study of sleep, cognition, and respiration under 4 weeks of intermittent nocturnal hypoxia in adult humans.
Sleep Med. 2009 Aug;10(7):739-45. Epub 2009 Mar 17. [PMID: 19282237]

Hunt BE, Tamisier R, Gilmartin GS, Curley M, Anand A, Weiss JW. Baroreflex responsiveness during ventilatory acclimatization in humans.
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1794-801. Epub 2008 Aug 29. [PMID: 18757487]

Gilmartin GS, Tamisier R, Curley M, Weiss JW. Ventilatory, hemodynamic, sympathetic nervous system, and vascular reactivity changes after recurrent nocturnal sustained hypoxia in humans.
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H778-85. Epub 2008 Jun 6. [PMID: 18539753]

Thomas RJ, Mietus JE, Peng CK, Gilmartin G, Daly RW, Goldberger AL, Gottlieb DJ. Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based method.
Sleep. 2007 Dec 1;30(12):1756-69. [PMID: 18246985]

Tamisier R, Hunt BE, Gilmartin GS, Curley M, Anand A, Weiss JW. Hemodynamics and muscle sympathetic nerve activity after 8 h of sustained hypoxia in healthy humans.
Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3027-35. Epub 2007 Sep  14. [PMID: 17873026]

Thomas RJ, Tamisier R, Boucher J, Kotlar Y, Vigneault K, Weiss JW, Gilmartin G. Nocturnal hypoxia exposure with simulated altitude for 14 days does not significantly alter working memory or vigilance in humans. Sleep. 2007 Sep 1;30(9):1195-203. [PMID: 17910391]

Gilmartin G, Tamisier R, Anand A, Cunnington D, Weiss JW. Evidence of impaired hypoxic vasodilation after intermediate-duration hypoxic exposure in humans.
Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2173-80. Epub 2006 Apr 28. [PMID: 16648184]

Gilmartin G, Ernst A. Metastatic Ovarian Carcinoma to the Airway.
Journal of Bronchology. 2002;9(1):25-26.

Reviews/Chapters/Editorials

Gilmartin GS, Daly R, Thomas RJ. Recognition and management of complex sleep-disordered breathing. 
Current Opinion in Pulmonary Medicine. 2005;11(6):485-93.

Gilmartin GS, Thomas RJ. Mechanisms of Arousal from Sleep and Their Consequences.
In: Current Opinion in Pulmonary Medicine. Lippincott Williams and Wilkins; 2004. p. 468-74.

Gilmartin G, Koziel H.  Pneumocystis Carinii Pneumonia in Adult Non-HIV Disorders.
In: Journal of Intensive Care Medicine. Thousand Oaks (CA): Sage Publications; 2002. p. 283-301.

Abstracts

Lynch ME, Gilmartin GS, Curley MJ, Tamisier R, Prabakar C, Weiss JW. Changes in Flow-Mediated Vasodilation after 2 weeks of Continuous vs. Cyclic Nocturnal Hypoxia in Humans.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A196.

Gilmartin GS, Prabakar C, Curley M, Tamisier R, Weiss JW. Changes in Insulin Sensitivity in Human Subjects Exposed to 14 Nights of Hypoxia.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A195.

Curley MJ, Gilmartin GS, Prabakar C, Lynch ME, Tamisier R, Weiss JW. Changes in Sympathetic Nervous System Activity and Hemodynamics after 4 weeks of Cyclic, Nocturnal Hypoxia in Normal Volunteers.
Proceddings of the American Thoracic Society. 2006;3(Abstracts):A195.

R Tamisier, GS Gilmartin, M Curley, AN Anand, JW Weiss.  8-Hour Poikilocapnic Hypoxia Causes Decreases in Muscle Sympathetic Nerve Activity (MSNA) and Blunted Vagal Baroreflex in Normal Human Volunteers.
American Journal of Critical Care Medicine. 2005;2(Abstract Issue): A878.

R Tamisier, GS Gilmartin, AN Anand, MJ Curley, JW Weiss.  Fourteen Days of Nocturnal Sustained Hypoxia Induces Increases in Muscle Sympathetic Nerve Activity (MSNA) and Arterial Blood Pressure in Normal Human Volunteers. 
American Journal of Respiratory and Critical Care Medicine. 2005;2(Abstract Issue): A877.

Ingenito EP, Tsai L, Gilmartin G.  Bronchoscopic Volume Reduction (BVR) Using Biopolymers Which Target Fibroblast, Machrophage, and Epithelial Cell Responses.
American Journal of Respiratory and Critical Care Medicine. 2001:163(5).

GS Gilmartin, R Tamisier, AN Anand, D Cunnington, JW Weiss.  Evidence of Impaired Hypoxic Vasodilation after Intermediate Duration Hypoxic Exposure.
American Journal of Respiratory and Critical Care Medicine. 2005;2(Abstract Issue): A235.

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