Faculty Profile

Luigi Taranto Montemurro, MD


Instructor in Medicine, Harvard Medical School
Associate Scientist, Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital

See publications


Address

221 Longwood Avenue
Boston, MA 02115
USA

Inter-office Mail Address

Suite BLI038A

Phone 617 732 6541

Email ltarantomontemurro@bwh.harvard.edu

Society Memberships

American Thoracic Society

Research Unit(s)

Division of Sleep Medicine, Sleep Disordered Breathing Laboratory (Wellman)

Research Interests

My research activity is based on a new pharmacological approach for treating obstructive sleep apnea (OSA) targeting specific traits causing the disorder.

The data I am collecting are providing further evidence for the role of pharyngeal muscle activity and arousal threshold in OSA pathogenesis and will possibly demonstrate the feasibility of treating OSA with medications.

This research is expected to produce a strategy for pharmacological treatment of OSA in a significant subgroup of patients who cannot tolerate the current treatment options. 

Trainees

Dan Vena, PhD 2018-
L. Messineo, MD 2013-2017
E. Perger, MD 2014-2017
Camila de Melo 2015-2016


Mentor(s)

Andrew Wellman, MD, PhD
David White, MD
Douglas Bradley, MD, FRCPC
Stefania Redolfi, MD, PhD
Prof. Claudio Tantucci

Selected Publications

Taranto-Montemurro L, Sands SA, Grace KP, Azarbarzin A, Messineo L, Salant R,
White DP, Wellman DA. Neural memory of the genioglossus muscle during sleep is
stage-dependent in healthy subjects and obstructive sleep apnoea patients. J
Physiol. 2018 Jul 18. doi: 10.1113/JP276618. [Epub ahead of print] [PMID:
30022493]

de Melo CM, Taranto-Montemurro L, Butler JP, White DP, Loring SH, Azarbarzin
A, Marques M, Berger PJ, Wellman A, Sands SA. Stable Breathing in Patients With
Obstructive Sleep Apnea Is Associated With Increased Effort but Not Lowered
Metabolic Rate. Sleep. 2017 Oct 1;40(10). doi: 10.1093/sleep/zsx128. [PMID:28977669]

Taranto-Montemurro L, Sands SA, Azarbarzin A, Marques M, de Melo CM, Edwards
BA, Eckert DJ, Messineo L, White DP, Wellman A. Effect of 4-Aminopyridine on
Genioglossus Muscle Activity during Sleep in Healthy Adults. Ann Am Thorac Soc.
2017 Jul;14(7):1177-1183. doi: 10.1513/AnnalsATS.201701-006OC. [PMID: 28387543]

Taranto-Montemurro L, Sands SA, Edwards BA, Azarbarzin A, Marques M, de Melo
C, Eckert DJ, White DP, Wellman A. Effects of Tiagabine on Slow Wave Sleep and
Arousal Threshold in Patients With Obstructive Sleep Apnea. Sleep. 2017 Feb
1;40(2). doi: 10.1093/sleep/zsw047. [PMID: 28364504]

Taranto-Montemurro L, Messineo L, Perger E, Salameh M, Pini L, Corda L,
Ferliga M, Tantucci C. Cardiac Sympathetic Hyperactivity in Patients with Chronic
Obstructive Pulmonary Disease and Obstructive Sleep Apnea. COPD. 2016
Dec;13(6):706-711. Epub 2016 Jul 6. [PMID: 27383268]

Taranto-Montemurro L, Sands SA, Edwards BA, Azarbarzin A, Marques M, de Melo
C, Eckert DJ, White DP, Wellman A. Desipramine improves upper airway
collapsibility and reduces OSA severity in patients with minimal muscle
compensation. Eur Respir J. 2016 Nov;48(5):1340-1350. doi:
10.1183/13993003.00823-2016. Epub 2016 Oct 6. [PMID: 27799387]

Taranto-Montemurro L, Edwards BA, Sands SA, Marques M, Eckert DJ, White DP,
Wellman A. Desipramine Increases Genioglossus Activity and Reduces Upper Airway
Collapsibility during Non-REM Sleep in Healthy Subjects. Am J Respir Crit Care
Med. 2016 Oct 1;194(7):878-885. [PMID: 26967681]

Taranto Montemurro L, Floras JS, Millar PJ, Kasai T, Gabriel JM, Spaak J,
Coelho FMS, Bradley TD. Inverse relationship of subjective daytime sleepiness to
sympathetic activity in patients with heart failure and obstructive sleep apnea.
Chest. 2012 Nov;142(5):1222-1228. doi: 10.1378/chest.11-2963. [PMID:
23303285]

Bottini P, Taranto-Montemurro L, Novali M, Bettinzoli M, Roca E, Andreoli C,
Bentivoglio M, Corda L, Tantucci C. Effects of CPAP on systemic hypertension inOSAH: a monocentric, observational, cohort study. Respir Med. 2012
Sep;106(9):1329-34. doi: 10.1016/j.rmed.2012.05.007. Epub 2012 Jun 28.
[PMID: 22748748]

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