Faculty Profile

Milena Pavlova, MD


Assistant Professor of Neurology, Harvard Medical School
Associate Neurologist, Epilepsy, Department of Neurology, Brigham and Women's Hospital

Administrative Title(s)

Medical Director, Faulkner Sleep Center

See publications


Address

Brigham and Women's Faulkner Hospital
1153 Centre Street Suite 4970
Jamaica Plain, MA 02130
USA

Phone 617-983-7580

Society Memberships

Sleep Research Society
American Academy of Sleep Medicine

Research Unit(s)

Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Department of Neurology, Brigham and Woman’s – Faulkner Hospital

Research Interests

1)    Effects of sleep and circadian rhythms on epilepsy: Epilepsy is a chronic condition, but seizures occur at distinct times, which may not be random. Dr. Pavlova has lead three projects to determine how seizures, as well as EEG abnormalities seen in between seizures can be affected by sleep/wake state and by circadian rhythms.
2)    Effect of sleep and sleep loss on endocrine function: Dr. Pavlova is involved in 4 collaborative projects on the effects of sleep restriction on endocrine function, including:
3)    Parasomnia and EEG abnormalities.  Dr. Pavlova is involved in a project to determine frequency of EEG abnormalities among patients with parasomnia.

Dr. Pavlova is a trained clinician in neurology, neurophysiology and epilepsy, and in sleep medicine.  The Faulkner Sleep Center offers  Combined full montage video EEG/PSG monitoring laboratory upon request from the referring physicians.

Trainees


Jong Lee, MD 2006
Shilpa Rahangdale, MD 2006 - 2007
Ina E. Djolandic, MD 2006 - 2007
Ellen Bubrick, MD 2006 - Present
Autumn Klein, MD, PhD 2006 - Present
Sebastian Espinosa, MD MPH 2008 - 2009
Brendan Lucey, MD 2008 - 2009
Rohit Das, MD 2008 - 2009
Martina Vendrame 2009-2010
Kinberly Parkerson 2009-2010
Claus Reinsberger 2009-2010
Hae Won Shin 2010-2011
Shraddha Srinivasan 2010-2011

Mentor(s)

Mentor: Edward Barry Bromfield, MD
Research adviser: Steven A. Shea, PhD
Curriculum adviser: Tom Scammel, M.D.
Program directors: Charles A. Czeisler, Ph.D, MD, David P. White, M.D.

Research Funding

Completed: CATALYST 2010-2011- Breathing abnormalities associated with seizures

Teaching

Dr. Pavlova has taught in CME courses, such as the "Sleep Disorders in the Intensive Review of Neurology", and numerous Neurophysiology lectures.
Dr. Pavlova is also responsible for the sleep training of Neurophysiology fellows, and is involved in the training of neurology residents (mainly as attending on the neurology consult service).

Selected Publications

Pavlova M, Sheikh LS. Sleep in women.
Semin Neurol. 2011 Sep;31(4):397-403. [PMID: 22113512]

Buxton OM, Pavlova M, Reid EW, Wang W, Simonson DC, Adler GK. Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
Diabetes. 2010 Sep;59(9):2126-33. [PMID: 20585000]

Regestein Q, Natarajan V, Pavlova M, Kawasaki S, Gleason R, Koff E. Sleep debt and depression in female college students.
Psychiatry Res. 2010 Mar 30;176(1):34-9. [PMID: 20079935]

Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
Epilepsy Behav. 2009 Nov;16(3):461-7. [PMID: 19786369]

Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
Epilepsy Behav. 2009 16(3):461-467.  [PMID: 19786369]

Pavlova MK, Duffy JF, Shea SA. Polysomnographic respiratory abnormalities in asymptomatic individuals.
Sleep. 2008 Feb 1;31(2):241-8. [PMID: 18274272]

Pavlova MK, Shea SA, Bromfield EB. Day/night patterns of focal seizures.
Epilepsy Behav. 2004 Feb;5(1):44-9. [PMID: 14751206]

Pavlova M, Berg O, Gleason R, Walker F, Roberts S, Regestein Q. Self-reported hyperarousal traits among insomnia patients.
J Psychosom Res. 2001 Aug;51(2):435-41. [PMID: 11516766]

Regestein Q, Natarajan V, Pavlova M, Kawasaki S, Gleason R, Koff E. Sleep debt and depression in female college students.
Psychiatry Res. 2010 Mar 30;176(1):34-9. Epub 2010 Jan 15.[PMID: 20079935]

Pavlova MK, Sheikh L. Sleep in women.
Semin Neurol. 2011 Sep;31(4):397-403. Epub 2011 Nov 23. [PMID: 22113512]


Case Reports, Reviews and Chapters


Case Reports

Shin HW, Srinivasan S, Milligan TA, Pavlova M. Nocturnal Frontal Lobe Epilepsy.
Sleep Review. November, 2011.

Pavlova M.  Parasomnia with unusual electroencephalographic features. 
Sleep Review. January-February, 2010.

Pavlova M.  Breathing and Seizures. 
Sleep Review. June, 2010.


Reviews
Pavlova M.. Dissociation of obstructive sleep apnea from hypersomnolence and obesity in patients with stroke.
Journal Watch Neurology. August 10 2010.

Pavlova, M. Obstructive Sleep Apnea in Adults with Epilepsy.
Journal Watch Neurology. January 6, 2009.

Pavlova, M. Sleep Apnea and Seizures in Older Adults.
Journal Watch Neurology. March 25, 2008.

Pavlova M. Insomnia and Depression in Young Adults.
Journal Watch Neurology. October 28, 2008.

Pavlova, M. Chronic Fatigue, Unrefreshing Sleep, and Nocturnal Polysomnography.
Journal Watch Neurology. February 13, 2007.

Pavlova, M. Is daytime sleepiness an integral part of PD, or is it a result of the disease or of its treatment?
Journal Watch Neurology. April 6, 2006.

Pavlova, MD Association Between Daytime Sleepiness and Parkinson Disease.
Journal Watch Neurology. April 6, 2006.


Book Chapters
John Winkelman & Milena Pavlova.  Primary Disorders of Sleep. 
In: Anthony Schapira (ed). Neurology and Clinical Neuroscience, 2007.

Regestein QR, Pavlova M. Treatment of delayed sleep phase syndrome.
Gen Hosp Psychiatry. 1995 Sep;17(5):335-45. Review. [PMID: 8522148]

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