Faculty Profile

Scott A. Sands, PhD

SSands 2017
Instructor in Medicine, Harvard Medical School
Associate Physiologist, Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital

See publications


Phone 617-278-0911
Fax 617-732-7337

Email sasands@bwh.harvard.edu

Society Memberships

American Thoracic Society

Research Unit(s)

Sleep Disordered Breathing Laboratory, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School

Research Interests

My work seeks to break new ground in personalized treatment of sleep apnea.

I aim to better understand the causes of sleep apnea, to develop new technology for
recognizing these causes clinically, and to find out what factors predict individual patient responses to treatments.

Trainees

Thilini Samarasinghe, PhD, 2009–2010
Simon Joosten, MBBS, PhD, 2010–2012
Shamim Nemati, PhD, 2010–2013
Kirk Kee, MBBS, 2011–2014
Philip Terrill, PhD, 2012–2014
Pamela DeYoung, 2013
Luigi Taranto Montemurro, MD, 2014–
Camila de Melo, 2015–2016
Melania Oliveira Marques, MD, 2015–
Ali Azarbarzin, PhD, 2015–
Ahmad Bamagoos, 2016–
Ludovico Messino, MD, 2017–

Mentor(s)

Andrew Wellman
David White
James Butler
Atul Malhotra
Matthew Naughton
Philip Berger

Research Funding

American Heart Association, PI: Scott Sands, Title: Sleep apnea phenotyping for personalized therapy using clinical polysomnography.

NIH/NHLBI, PI: Wellman, Title: Clinical Methods for Determining the Site and Severity of Pharyngeal Collapse

NIH/NHLBI, PI: Wellman,  Title: Validation of a phenotype model to predict response to alternative OSA treatments
    
NIH/NHLBI, PI: Pack, Title: Individual Differences in Obstructive Sleep Apnea

Selected Publications

Original Articles

Wilkinson MH, Skuza EM, Rennie GC, Sands SA, Yiallourou SR, Horne RSC, Berger PJ. Postnatal development of periodic breathing cycle duration in term and preterm infants. Pediatric Research, 2007; 62: 331-336. [PMID: 17622961]

Edwards BA, Sands SA, Skuza EM, Stockx EM, Brodecky V, Wilkinson MH, Berger PJ. Increased peripheral chemosensitivity via dopaminergic manipulation promotes respiratory instability in lambs. Respiration Physiology & Neurobiology, 2008; 164: 419-428.
[PMID: 18824144]

Sands SA, Camilleri P, Breuer RA, Cambrell GK, Alfredson RJ, Skuza EM, Berger PJ, Wilkinson MH. A novel method for the measurement of mechanical mobility. Journal of Sound & Vibration, 2009; 320: 559-575

Edwards BA, Sands SA, Feeney C, Skuza EM, Brodecky V, Wilkinson MH, Berger PJ. Continuous positive airway pressure reduces loop gain and resolves periodic central apneas in the lamb. Respiration Physiology & Neurobiology, 2009; 168: 239-249. [PMID: 19616133]

Edwards BA, Sands SA, Skuza EM, Brodecky V, Wilkinson MH, Berger PJ. Maturation of respiratory control and the propensity for breathing instability in a sheep model. Journal of Applied Physiology, 2009; 107: 1463-1471. [PMID: 19745191]

Sands SA, Edwards BA, Kelly VJ, Davidson MR, Wilkinson MH, Berger PJ. A model analysis of arterial oxygen desaturation during apnea in preterm infants. PLoS Computational Biology, 2009; 5: e1000588. [PMID: 19997495]

Sands SA, Kelly VJ, Edwards BA, Davidson MR, Wilkinson MH, Berger PJ. A dynamic model for assessing the impact of diffusing capacity on arterial oxygenation during apnea. Respiratory Physiology and Neurobiology, 2010; 171: 193-200. [PMID: 20385258]

Sands SA, Edwards BA, Kelly VJ, Davidson MR, Wilkinson MH, Berger PJ. A model investigation of the impact of ventilation-perfusion mismatch on oxygenation during apnea in preterm infants. Journal of Theoretical Biology, 2010; 264: 657-662. [PMID: 20362590]

Yiallourou SR*, Sands SA*, Walker AW, Horne RSC. Postnatal development of baroreflex sensitivity in infancy. Journal of Physiology, 2010; 588: 2193-2203. *Equal contribution. [PMID: 20421281]

Sands SA, Edwards BA, Kelly VJ, Skuza EM, Davidson MR, Wilkinson MH, Berger PJ. Mechanism underlying accelerated arterial oxygen desaturation during recurrent apnea. American Journal of Respiratory and Critical Care Medicine, 2010; 182: 961-969.
[PMID: 20522790]

Yiallourou SR, Sands SA, Walker AW, Horne RSC. Baroreflex Sensitivity during Sleep in Infants: Impact of Sleeping Position and Sleep State. SLEEP, 2011; 34: 725-732. [PMID: 21629360]

Nemati S, Edwards BA, Sands SA, Berger PJ, Wellman A, Verghese GC, Malhotra A, Butler JP. Model-based characterization of ventilatory stability using spontaneous breathing. Journal of Applied Physiology, 2011; 111: 55-67. [PMID: 21474696]

Sands SA, Edwards BA, Kee K, Turton A, Skuza EM, Roebuck T, O'Driscoll DM, Hamilton GS, Naughton MT, Berger PJ. Loop gain as a means to predict a positive airway pressure suppression of Cheyne-Stokes respiration in heart failure patients. American Journal of Respiratory and Critical Care Medicine, 2011; 184: 1067-75. [PMID: 21816941]

Witcombe NB, Yiallourou SR, Sands SA, Walker AM, Horne RS. Preterm birth alters the maturation of baroreflex sensitivity in sleeping infants. Pediatrics, 2012; 129: 89-96. [PMID: 22157139]
Joosten SA, Turton A, Sands SA, Hamza K, Berger PJ, Hamilton GS. Phenotypes of patients with mild to moderate obstructive sleep apnoea as confirmed by cluster analysis. Respirology, 2012; 17: 99-107. [PMID: 21848707]

Yiallourou SR, Sands SA, Walker AM, Horne RS. Maturation of heart rate and blood pressure variability during sleep in term-born infants. SLEEP 2012; 35: 177-186. [PMID: 22294807]

Edwards BA, Sands SA, Eckert DJ, White DP, Butler JP, Owens RL, Malhotra A, Wellman A. Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea. Journal of Physiology, 2012; 590: 1199-211. [PMID: 22219335]

Stuart-Andrews C, Kelly VJ, Sands SA, Lewis AJ, Ellis MJ, Thompson B. Automated detection of the phase III slope during inert gas washout testing. Journal of Applied Physiology, 2012; 112: 1073-81. [PMID: 22174406]

Kelly VJ, Brown NJ, Sands SA, Borg BM, King GG, Thompson BR. The effect of airway smooth muscle tone on airway distensibility measured by the Forced Oscillation Technique in adults with asthma. Journal of Applied Physiology 2012; 112: 1494-503. [PMID: 22362406]

Owens RL, Edwards BA, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume. Journal of Applied Physiology, 2012; 113:691-9. [PMID: 22628372]

Edwards BA, Connolly JG, Campana LM, Sands SA, Trinder JA, White DP, Wellman A, Malhotra A. Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea. SLEEP, 2013; 36: 281-5. [PMID: 23372276]

Yiallourou SR, Witcombe NB, Sands SA, Walker AM, Horne RS. The development of autonomic cardiovascular control is altered by preterm birth. Early Human Development, 2013; 89: 145-52. [PMID: 23058299]

Wellman A, Edwards BA, Sands SA, Owens RL, Nemati S, Butler J, Passaglia CL, Jackson AC, Malhotra A, White DP. A simplified method for determining phenotypic traits in patients with obstructive sleep apnea. Journal of Applied Physiology, 2013; 114: 911-22. [PMID: 23349453]

Walter LM, Yiallourou SR, Vlahandonis A, Sands SA, Johnson CA, Nixon GM, Davey MJ, Trinder J, Walker AM, Horne RSC. Impaired blood pressure control in children with obstructive sleep apnea. Sleep Medicine, 2013; 14: 858-66. [PMID: 23768837]

Kelly VJ, Sands SA, Harris RS, Venegas JG, Brown NJ, King GG, Thompson BR. Respiratory system reactance is an independent determinant of asthma control. Journal of Applied Physiology, 2013; 115: 1360-9. [PMID: 23990243]

DeYoung PN, Bakker JP, Sands SA, Batool-Anwar S, Connolly JG, Butler JP, Malhotra A. Acoustic pharyngometry measurement of minimal cross-sectional airway area is a significant independent predictor of moderate-to-severe obstructive sleep apnea. Journal of Clinical Sleep Medicine, 2013; 15: 1161-4. [PMID: 24235897]

Vlahandonis A, Yiallourou SR, Sands SA, Nixon GM, Davey MJ, Walter LM, Horne RSC. Long-term changes in heart rate variability in elementary school-aged children with sleep disordered breathing. Sleep Medicine, 2014; 15: 76-82. [PMID: 24274998]

Vlahandonis A, Yiallourou SR, Sands SA, Nixon GM, Walter LM, Horne RSC. Response to ‘‘The unnormalized spectral indices of heart rate variability should be presented in conjunction with normalized versions of the same variables.’’ Sleep Medicine. 2014; 15: 843-4.
[PMID: 24933085]

Javaheri S, Sands SA, Edwards BA. Acetazolamide attenuates sleep apnea yet paradoxically augments the hypercapnic ventilatory response in patients with heart failure and Hunter-Cheyne-Stokes breathing. Annals of the American Thoracic Society, 2014; 11:80-6. [PMID: 24251826]

Vlahandonis A, Yiallourou SR, Sands SA, Nixon GM, Davey MJ, Walter LM, Horne RSC. Long-term changes in blood pressure control in elementary school-aged children with sleep disordered breathing. Sleep Medicine, 2014; 15: 83-90. [PMID: 24239497]

Owens RL, Edwards BA, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. The classical Starling Resistor model often does not predict inspiratory airflow patterns in the human upper airway. Journal of Applied Physiology, 2014; 15: 1105-12. [PMID: 24458746]

Edwards BA, Wellman A, Sands SA, Owens RL, Eckert DJ, White DP, Malhotra A. Obstructive sleep apnea in older adults is a distinctly different physiological phenotype. SLEEP, 2014; 37: 1227-36. [PMID: 25061251]

Genta PR, Owens RL, Edwards BA, Sands SA, Eckert DJ, Butler JP, Loring SH, Malhotra A, Jackson AC, White DP, Wellman A. Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway. Respiratory Physiology and Neurobiology, 2014; 15: 55-9. [PMID: 25020212]

Sands SA, Eckert DJ, Jordan AS, Edwards BA, Owens RL, Butler JP, Schwab RJ, Loring SH, Malhotra A, White DP, Wellman A. Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea. American Journal of Respiratory and Critical Care Medicine. 2014; 190:930-7. [PMID: 25191791]

Edwards BA, Sands SA, Owens RL, White DP, Genta PR, Butler JP, Malhotra A, Wellman A. Effects of hyperoxia and hypoxia on the physiological traits responsible for obstructive sleep apnoea. Journal of Physiology. 2014; 592:4523-35. [PMID: 25085887]

Edwards BA, Eckert DJ, McSharry DG, Sands SA, Desai A, Kehlmann G, Bakker JP, Genta PR, Owens RL, White DP, Wellman A, Malhotra A. Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine. 2014; 190:1293-300. [PMID: 25191791]

Wellman A, Genta PR, Owens RL, Edwards BA, Sands SA, Loring SH, White DP, Jackson AC, Pedersen OF, Butler JP. Test of the Starling resistor model in the human upper airway during sleep. Journal of Applied Physiology, 2014; 116: 1105-12. [PMID: 24458746]

Terrill PI, Edwards BA, Nemati S, White DP, Butler JP, Owens RL, Malhotra A, Wellman A, Sands SA. Quantifying the Ventilatory Control Contribution to Sleep Apnoea Using Polysomnography. European Respiratory Journal, 2015; 45: 408-18. [PMID: 25323235]

Owens RL, Eckert DJ, Jordan AS, Edwards BA, Sands SA, Malhotra A, White DP, Wellman A. An integrative model of physiological traits can be used to predict obstructive sleep apnea and response to non positive airway pressure therapy. SLEEP. 2015; 38:961-70.
[PMID: 25515107]

Joosten SA, Sands SA, Skuza EM, Ong C, Lau K, Berger PJ, Hamilton GS. Evaluation of the role of lung volume and airway size and shape in supine-predominant obstructive sleep apnoea patients. Respirology. 2015; 20:819-27. [PMID: 25939705]

Samarasinghe TD, Sands SA, Skuza EM, Joshi MS, Nold-Petry CA, Berger PJ. The effect of prenatal maternal infection on respiratory function in mouse offspring: evidence for enhanced chemosensitivity. J Appl Physiol. 2015; 119:299-307. [PMID: 26023231]

Stanchina M, Robinson K, Corrao W, Donat W, Sands SA, Malhotra A. Clinical use of loop gain measures to determine continuous positive airway pressure efficacy in patients with complex sleep apnea. A pilot study. Ann Am Thorac Soc. 2015;12:1351-7. [PMID: 26214564]

Genta PR, Edwards BA, Sands SA, Owens RL, Butler JP, Loring SH, White DP, Wellman A. Tube law of the pharyngeal airway in sleeping patients with obstructive sleep apnea. Sleep. 2016 (Feb); 39:337-43. [PMID: 26446124]

Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Medicine, 2016 (Sep); 42:1427-36. [PMID: 27342819]

Taranto-Montemurro L, Edwards BA, Sands SA, Marques M, Eckert DJ, White DP, Wellman A. Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility During Non-REM Sleep in Healthy Subjects. American Journal of Respiratory and Critical Care Medicine. 2016 (Oct) 194:878-885. [PMID: 26967681]

Taranto-Montemurro L, Sands SA, Edwards BA, Eckert DJ, White DP, Wellman A. Response to the Letter: Is the Muscle the Only Potential Target of Desipramine in Sleep Apnea Syndrome? Am J Resp Crit Care Med. [PMID: 28186830]

Li Y, Owens RL, Sands SA, Orr J, Moraes W, DeYoung P, Smales E, Jen R, Malhotra A. The Effect of Donepezil on Arousal Threshold and Apnea Hypopnea Index: A Randomized, Double-blind Cross-over Study. Annals of the American Thoracic Society. 2016 (Nov); 13:2012-2018. [PMID: 27442715]

Sands SA, Edwards BA, Kee K, Stuart-Andrews C, Skuza EM, Roebuck T, Turton A, Hamilton GS, Naughton MT, Berger PJ. Control theory prediction of resolved Cheyne-Stokes respiration in heart failure. European Respiratory Journal. 2016 (Nov); 48:1351-1359. [PMID: 27587554]

Edwards BA, Sands SA, Owens RL, Eckert DJ, Landry S, White DP, Malhotra A, Wellman A. The combination of supplemental oxygen and a hypnotic markedly improves obstructive sleep apnea. SLEEP. 2016 (Nov); 39:1973-1983. [PMID: 27634790]

Edwards BA, Andara C, Landry S, Sands SA, Joosten SA, Owens RL, White DP, Hamilton GS, Wellman A. Upper-airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Obstructive Sleep Apnea Patients. American Journal of Respiratory and Critical Care Medicine. 2016 (Dec); 194:1413-1422. [PMID: 27181367]

Sands SA, Mebrate Y, Edwards BA, Nemati S, Manisty CH, Desai AS, Wellman A, Willson K, Francis DP, Butler JP, Malhotra A. Resonance as the Mechanism of Daytime Periodic Breathing in Patients with Heart Failure. American Journal of Respiratory and Critical Care Medicine. 2017 (Jan); 15:237-246. [PMID: 27559818]

Azarbarzin A, Sands SA, Taranto-Montemurro L, Oliveira Marques MD, Genta PR, Edwards BA, Butler J, White DP, Wellman A. Estimation of pharyngeal collapsibility during sleep by peak inspiratory airflow. SLEEP. 2017 (Jan); 40: zsw005. [PMID: 27634788]

Taranto-Montemurro L, Sands SA, Edwards BA, Azarbarzin A, Marques M, de Melo C, Eckert DJ, White DP, Wellman A. Effects of Tiagabine on Slow Wave Sleep and Arousal Threshold in Patients with Obstructive Sleep Apnea. SLEEP. 2017 (Feb); 40: zsw047. [PMID: 27923429]

Marques M, Genta PR, Sands SA, Azarbarzin A, de Melo CM, Taranto-Montemurro L, White DP, Wellman A. Effect of sleeping position on upper airway patency in obstructive sleep apnea is determined by the pharyngeal structure causing collapse. SLEEP. 2017 (Mar); 1: 40(3): zsx005.

Taranto-Montemurro L**, Sands SA, Edwards BA, Azarbarzin A, Oliveira Marques MD, de Melo CM, Eckert DJ, White DP, Wellman A. Desipramine improves upper airway collapsibility and reduces obstructive sleep apnoea severity in patients with minimal muscle compensation. European Respiratory Journal. In Press. [PMID: 27799387]

Lee RWW, Sutherland K, Sands SA, Edwards BA, Chan TO, Ng S, Hui DS, Cistulli P. Differences in Respiratory Arousal Threshold in Caucasians and Chinese Patients with Obstructive Sleep Apnoea. Respirology. In Press. [PMID: 28303676]

Landry S, Joosten SA, Eckert DJ, Jordan AS, Sands SA, White DP, Malhotra A, Wellman A, Hamilton GS, Edwards BA. Therapeutic CPAP requirement predicts the response to the combination of oxygen and a hypnotic for the treatment of obstructive sleep apnoea (OSA). Respirology. In Press. [PMID: 28409851]

Taranto-Montemurro L, Sands SA, Azarbarzin A, Marques M, de Melo C, Edwards BA, Eckert DJ, Messineo L, White DP, Wellman A. Effect of 4-aminopyridine on genioglossus muscle activity during sleep in healthy adults. Annals of the American Thoracic Society. In Press. [PMID: 28387543]

Landry S, Joosten SA, Eckert DJ, Jordan AS, Sands SA, White DP, Malhotra A, Wellman A, Hamilton GS, Edwards BA. Therapeutic CPAP level predicts upper airway collapsibility in patients with obstructive sleep apnea. SLEEP. In Press. [PMID: 28419320]

Joosten SA, Leong P, Landry SA, Sands SA, Terrill PI, Mann D, Turton A, Rangaswamy J, Andara C, Burgess G, Mansfield D, Hamilton GS, Edwards BA. Loop gain predicts the response to upper airway surgery in patients with obstructive sleep apnoea: Ventilatory control abnormalities predict surgical responsiveness. SLEEP. In Press. [PMID: 28531336]

Genta PR, Sands SA, Butler JP, Loring SH, Katz ES, Demko BG, Kezirian EJ, White DP, Wellman A. Airflow shape is associated with the pharyngeal structure causing obstructive sleep apnea. Chest. In Press.

Joosten SA. Landry SA, Sands SA, Terrill PI, Mann D, Andara C, Skuza EM, Turton A, Berger, PJ, Hamilton GS, Edwards BA. Dynamic loop gain increases upon adopting the supine body position during sleep in patients with obstructive sleep apnoea. Respirology. In Press.

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