Faculty Profile

Takao Hensch, PhD

Profile photo fpr Takao Hensch
Professor of Molecular and Cellular Biology, Professor of Neurology, Harvard University Faculty of Arts and Sciences

Other Affiliation(s)

Cellular Biology and Center for Brain Science

See publications

Inter-office Mail Address

FAS Northwest Labs RM 347.10

Phone 617-384-5882
Phone 617-919-4650

Email hensch@mcb.harvard.edu
Email giselle_grenier@harvard.edu

Society Memberships

Society for Neuroscience (US, Japan)

Research Unit(s)

Hensch Lab
Department of Molecular and Cellular Biology and Center for Brain Science
F.M. Kirby Neurobiology Center at Boston Children’s Hospital NIMH Silvio Conte Center for Mental Health Research
Harvard Center on the Developing Child
Division of Sleep Medicine (HMS)

Research Interests

Takao K. Hensch, PhD, is joint professor of Neurology, Harvard Medical School at Boston Children’s Hospital, and professor of Molecular and Cellular Biology at Harvard’s Center for Brain Science. After undergraduate studies at Harvard with J Allan Hobson, he trained at the University Tokyo (MPH) and as a Fulbright Fellow at the Max-Planck Institute for Brain Research with Wolf Singer, before receiving a PhD in neuroscience with Michael Stryker at the University of California, San Francisco in 1996. He then helped to launch the RIKEN Brain Science Institute as lab head for Neuronal Circuit Development and served as Group Director for Critical Period Mechanisms Research (and now special advisor) before returning to the United States in 2006. Professor Hensch has received several honors, including the Young Investigator Award from the Society for Neuroscience both in Japan (2001 Tsukahara Prize) and the United States (2005), as well as an NIH Director’s Pioneer Award (2007). He currently directs the NIMH Silvio O. Conte Center for Basic Mental Health Research at Harvard. He serves on the editorial board of various journals, including Neuron, Journal of Neuroscience, Journal of Neurodevelopmental Disorders, Neural Development, Neuroscience Research, and Frontiers in Neural Circuits. Professor Hensch’s research focuses on critical periods in brain development, which impacts not only the basic understanding of brain development, but also therapeutic approaches to devastating cognitive disorders later in life.


Brittany Petros 2015-
Chloe Li 2013-present
Nicholas Lee 2013-present
Ally Covello 2013-present
Yael Stovetzky 2014-present
Kimberly Schaefer 2014-present
Eric Lin 2010-2012
Yingna Liu, 2010-2012
Elizabeth Zhang 2008-2011
Mimmie Kwong 2008-2011
Susan DeWolf 2008-2011
Maya Ayoub 2010-2011 (internship)
Eunice Yang 2007 - 2010
Yutaro Komuro 2006 (internship)
Toral Surti 2005 (internship)

Rebecca Reh 2010-present
Luke Bogart 2010-present
Zhanlei Ye 2011-present
Ryoma Matsui 2011-present
Erin Diel 2013-present
Haneui Bae 2014-present
Kathleen Quast 2008-2013
Daniel Brady 2007-2012
Akiko Wagatsuma 2005-2009
Cecile Gurnot 2009-2013
Yoshiko Tsuchimoto 2000-2005

Sophie Knobloch 2014-present
Nathaniel Hodgson 2014-present
Hing-Cheong Lee 2010-present
Anne Takesian 2010-present
Yohei Kobayashi 2010-present
Yuichi Makino 2014-present
Maddalena Caiati 2013-present
Eun-Jun Yang 2013
Nadine Gogolla 2013
Tania Rinaldi Barkat 2013
Hirofumi Morishita 2011
Sayaka Sugiyama  2009
Judy Sng  2009
Anita Scheuber  2008
Yoko Yazaki-Sugiyama 2008
Nafiseh Atapour 2007
Hiroyuki Miyamoto 2007
Nobuko Mataga 1997-2007
Michela Fagiolini 2007
Hiroyuki Katagiri 2005
Youichi Iwai 2005
Istvan Katona 2004
Yoshitaka Matsuda 2004
Mariko Miyata 2001
Michael Silver 2000
John J Renger 2000

Research Funding

NIMH Silvio O Conte Center (PI): To develop methods for mapping critical period plasticity (Hensch), connectome (Lichtman) and imprintome (Dulac) of parvalbumin-cells across normal development and disorder models, using state-of-the-art super-resolution imaging (Zhuang) and bioinformatics techniques (Cuff). Public outreach and training of a new generation of mental health researchers is a major goal.

NINDS (Hensch, Jensen, co-PI): To elucidate functional and cognitive consequences of early life seizures on progression of developmental critical periods in the auditory system. Evaluating the benefits and side-effects of neonatal seizure therapy will be a primary focus at Boston Children’s Hospital and Univ Pennsylvania.

NINDS (co-I; Arlotta, PI): To determine functional connectivity of specific GABAergic sub-circuits following genetic reprogramming of pyramidal cells.

NINDS (co-I; Rotenberg, PI): To establish the trajectory of oxidative damage and parvalbumin circuit impairment after traumatic brain injury using anatomical and physiological assays, as a potential critical period for therapeutic intervention.

NIMH (co-I; Berretta, PI): To determine in mouse and human the role of choroid plexus-derived OTX2 in maintaining parvalbumin circuit function and its consequences for mental illness.

Selected Publications

Kobayashi Y, Ye Z, Hensch TK. Clock genes control cortical critical period
timing. Neuron. 2015 Apr 8;86(1):264-75. doi: 10.1016/j.neuron.2015.02.036. Epub
2015 Mar 19. PMID: 25801703; PMCID: PMC4392344.

Morishita H, Cabungcal JH, Chen Y, Do KQ, Hensch TK. Prolonged Period of
Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons. Biol
Psychiatry. 2015 Jan 24. pii: S0006-3223(15)00043-8. doi: 10.1016/j.biopsych.2014.12.026. [Epub ahead of print] PMID: 25758057.

Werker JF, Hensch TK. Critical periods in speech perception: new directions.
Annu Rev Psychol. 2015 Jan 3;66:173-96. doi: 10.1146/annurev-psych-010814-015104.
Epub 2014 Sep 17. PMID: 25251488.

Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK. Sensory integration in
mouse insular cortex reflects GABA circuit maturation. Neuron. 2014 Aug
20;83(4):894-905. doi: 10.1016/j.neuron.2014.06.033. Epub 2014 Jul 31. PMID: 25088363; PMCID: PMC4177076.

Hensch TK. Bistable parvalbumin circuits pivotal for brain plasticity. Cell.
2014 Jan 16;156(1-2):17-9. doi: 10.1016/j.cell.2013.12.034. PMID:
24439367; PMCID: PMC4183967.

Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y,
Tamamaki N, Hensch TK, Itohara S, Yamakawa K. Nav1.1 haploinsufficiency in
excitatory neurons ameliorates seizure-associated sudden death in a mouse model
of Dravet syndrome. Hum Mol Genet. 2013 Dec 1;22(23):4784-804. doi:
10.1093/hmg/ddt331. Epub 2013 Aug 6. PMID: 23922229; PMCID: PMC3820136.

Kang E, Durand S, LeBlanc JJ, Hensch TK, Chen C, Fagiolini M. Visual acuity
development and plasticity in the absence of sensory experience. J Neurosci. 2013
Nov 6;33(45):17789-96. doi: 10.1523/JNEUROSCI.1500-13.2013. PMID: 24198369; PMCID: PMC3818552.

Toyoizumi T, Miyamoto H, Yazaki-Sugiyama Y, Atapour N, Hensch TK, Miller KD. A
theory of the transition to critical period plasticity: inhibition selectively
suppresses spontaneous activity. Neuron. 2013 Oct 2;80(1):51-63. doi:
10.1016/j.neuron.2013.07.022. Epub 2013 Oct 2. PMID: 24094102; PMCID: PMC3800182.

Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio
RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A,
Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller M. DNA methylation map
of mouse and human brain identifies target genes in Alzheimer's disease. Brain.
2013 Oct;136(Pt 10):3018-27. doi: 10.1093/brain/awt237. Epub 2013 Sep 11. PMID: 24030951; PMCID: PMC3784285.

Spatazza J, Lee HH, Di Nardo AA, Tibaldi L, Joliot A, Hensch TK, Prochiantz
A. Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. Cell Rep. 2013 Jun 27;3(6):1815-23. doi: 10.1016/j.celrep.2013.05.014. Epub 2013
Jun 13. PMID: 23770240; PMCID: PMC4119931.

Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do
KQ. Perineuronal nets protect fast-spiking interneurons against oxidative stress.
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9130-5. doi:
10.1073/pnas.1300454110. Epub 2013 May 13. PMID: 23671099; PMCID: PMC3670388.

Kobayashi Y, Hensch TK. Germline recombination by conditional gene targeting
with Parvalbumin-Cre lines. Front Neural Circuits. 2013 Oct 16;7:168. doi:
10.3389/fncir.2013.00168. eCollection 2013. PMID: 24137112; PMCID: PMC3797395.

Hisatsune C, Miyamoto H, Hirono M, Yamaguchi N, Sugawara T, Ogawa N, Ebisui
E, Ohshima T, Yamada M, Hensch TK, Hattori M, Mikoshiba K. IP3R1 deficiency in
the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering
tonic Purkinje cell firings in mice. Front Neural Circuits. 2013 Oct 4;7:156.
doi: 10.3389/fncir.2013.00156. eCollection 2013. PMID: 24109434; PMCID: PMC3790101.

Gervain J, Vines BW, Chen LM, Seo RJ, Hensch TK, Werker JF, Young AH.
Valproate reopens critical-period learning of absolute pitch. Front Syst
Neurosci. 2013 Dec 3;7:102. doi: 10.3389/fnsys.2013.00102. eCollection 2013. PMID: 24348349; PMCID: PMC3848041.

Ito S, Ogiwara I, Yamada K, Miyamoto H, Hensch TK, Osawa M, Yamakawa K. Mouse
with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment. Neurobiol Dis. 2013 Jan;49:29-40. doi: 10.1016/j.nbd.2012.08.003. Epub 2012 Aug 16. PMID: 22986304.

Takesian AE, Hensch TK. Balancing plasticity/stability across brain
development. Prog Brain Res. 2013;207:3-34. doi: 10.1016/B978-0-444-63327-9.00001-1. Review. PMID: 24309249.

Durand S, Patrizi A, Quast KB, Hachigian L, Pavlyuk R, Saxena A, Carninci P,
Hensch TK, Fagiolini M. NMDA receptor regulation prevents regression of visual
cortical function in the absence of Mecp2. Neuron. 2012 Dec 20;76(6):1078-90.
doi: 10.1016/j.neuron.2012.12.004. PMID: 23259945; PMCID: PMC3733788.

Bilimoria PM, Hensch TK, Bavelier D. A mouse model for too much TV? Trends
Cogn Sci. 2012 Nov;16(11):529-31. doi: 10.1016/j.tics.2012.09.001. Epub 2012 Sep
19. PMID: 22999015; PMCID: PMC3482269.

Miyamoto H, Nakamaru-Ogiso E, Hamada K, Hensch TK. Serotonergic integration
of circadian clock and ultradian sleep-wake cycles. J Neurosci. 2012 Oct
17;32(42):14794-803. doi: 10.1523/JNEUROSCI.0793-12.2012. PMID: 23077063.

Yang EJ, Lin EW, Hensch TK. Critical period for acoustic preference in mice.
Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17213-20. doi:
10.1073/pnas.1200705109. Epub 2012 Oct 8. PMID: 23045690; PMCID: PMC3477391.

Weikum WM, Oberlander TF, Hensch TK, Werker JF. Prenatal exposure to
antidepressants and depressed maternal mood alter trajectory of infant speech
perception. Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17221-7. doi:
10.1073/pnas.1121263109. Epub 2012 Oct 8. PMID: 23045665; PMCID: PMC3477387.

Beurdeley M, Spatazza J, Lee HH, Sugiyama S, Bernard C, Di Nardo AA, Hensch TK, Prochiantz A. Otx2 binding to perineuronal nets persistently regulates
plasticity in the mature visual cortex. J Neurosci. 2012 Jul 4;32(27):9429-37.
doi: 10.1523/JNEUROSCI.0394-12.2012. PMID: 22764251; PMCID: PMC3419577.

Hensch TK, Bilimoria PM. Re-opening Windows: Manipulating Critical Periods
for Brain Development. Cerebrum. 2012 Jul;2012:11. Epub 2012 Aug 29. PMID: 23447797;  PMCID: PMC3574806.

Saxena A, Wagatsuma A, Noro Y, Kuji T, Asaka-Oba A, Watahiki A, Gurnot C,
Fagiolini M, Hensch TK, Carninci P. Trehalose-enhanced isolation of neuronal
sub-types from adult mouse brain. Biotechniques. 2012 Jun;52(6):381-5. doi:
10.2144/0000113878. PMID: 22668417; PMCID: PMC3696583.

Maurer D, Hensch TK. Amblyopia: background to the special issue on stroke
recovery. Dev Psychobiol. 2012 Apr;54(3):224-38. doi: 10.1002/dev.21022. Review.
PMID: 22415912.

Barkat TR, Polley DB, Hensch TK. A critical period for auditory
thalamocortical connectivity. Nat Neurosci. 2011 Jul 31;14(9):1189-94. doi:
10.1038/nn.2882. PMID: 21804538; PMCID: PMC3419581.

Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK,
Arlotta P. Excitatory projection neuron subtypes control the distribution of
local inhibitory interneurons in the cerebral cortex. Neuron. 2011 Feb
24;69(4):763-79. doi: 10.1016/j.neuron.2011.01.015. PMID: 21338885; PMCID: PMC3061282.

Hackett TA, Barkat TR, O'Brien BM, Hensch TK, Polley DB. Linking topography
to tonotopy in the mouse auditory thalamocortical circuit. J Neurosci. 2011 Feb
23;31(8):2983-95. doi: 10.1523/JNEUROSCI.5333-10.2011. PMID: 21414920;
PMCID: PMC3073837.

Morishita H, Miwa JM, Heintz N, Hensch TK. Lynx1, a cholinergic brake, limits
plasticity in adult visual cortex. Science. 2010 Nov 26;330(6008):1238-40. doi:
10.1126/science.1195320. Epub 2010 Nov 11. PMID: 21071629; PMCID: PMC3387538.

Bavelier D, Levi DM, Li RW, Dan Y, Hensch TK. Removing brakes on adult brain
plasticity: from molecular to behavioral interventions. J Neurosci. 2010 Nov
10;30(45):14964-71. doi: 10.1523/JNEUROSCI.4812-10.2010. Review. PMID:
21068299; PMCID: PMC2992973.

Yazaki-Sugiyama Y, Kang S, Câteau H, Fukai T, Hensch TK. Bidirectional
plasticity in fast-spiking GABA circuits by visual experience. Nature. 2009 Nov
12;462(7270):218-21. doi: 10.1038/nature08485. PMID: 19907494.

Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK. Common
circuit defect of excitatory-inhibitory balance in mouse models of autism. J
Neurodev Disord. 2009 Jun;1(2):172-81. doi: 10.1007/s11689-009-9023-x. Epub 2009
Jul 11. PMID: 20664807; PMCID: PMC2906812.

Hensch TK, Brand AH. Development. Editorial overview. Curr Opin Neurobiol.
2009 Apr;19(2):109-11. doi: 10.1016/j.conb.2009.06.009. Epub 2009 Jul 13. PMID: 19604684.

Sugiyama S, Prochiantz A, Hensch TK. From brain formation to plasticity:
insights on Otx2 homeoprotein. Dev Growth Differ. 2009 Apr;51(3):369-77. doi:
10.1111/j.1440-169X.2009.01093.x. Epub 2009 Feb 27. Review. PMID: 19298552.

Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y,
Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV,
Yamakawa K. Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Hum Mol Genet. 2009 Mar 15;18(6):1099-109. doi:
10.1093/hmg/ddp006. Epub 2009 Jan 15. PMID: 19147686.

Plessy C, Fagiolini M, Wagatsuma A, Harasawa N, Kuji T, Asaka-Oba A, Kanzaki
Y, Fujishima S, Waki K, Nakahara H, Hensch TK, Carninci P. A resource for
transcriptomic analysis in the mouse brain. PLoS One. 2008 Aug 20;3(8):e3012.
doi: 10.1371/journal.pone.0003012. PMID: 18714383; PMCID:

Sugiyama S, Di Nardo AA, Aizawa S, Matsuo I, Volovitch M, Prochiantz A,
Hensch TK. Experience-dependent transfer of Otx2 homeoprotein into the visual
cortex activates postnatal plasticity. Cell. 2008 Aug 8;134(3):508-20. doi:
10.1016/j.cell.2008.05.054. PMID: 18692473.

Morishita H, Hensch TK. Critical period revisited: impact on vision. Curr
Opin Neurobiol. 2008 Feb;18(1):101-7. doi: 10.1016/j.conb.2008.05.009. Epub 2008
Jun 3. Review. PMID: 18534841.

Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T,
Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K. Nav1.1
localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit
basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci.
2007 May 30;27(22):5903-14. PMID: 17537961.

Katagiri H, Fagiolini M, Hensch TK. Optimization of somatic inhibition at
critical period onset in mouse visual cortex. Neuron. 2007 Mar 15;53(6):805-12.
PMID: 17359916.

Illes J, Blakemore C, Hansson MG, Hensch TK, Leshner A, Maestre G,
Magistretti P, Quirion R, Strata P. International perspectives on engaging the
public in neuroethics. Nat Rev Neurosci. 2005 Dec;6(12):977-82. Review. Erratum
in: Nat Rev Neurosci. 2006 Jun;7(6):500. PMID: 16340957; PMCID: PMC1794674.

Hensch TK. Critical period plasticity in local cortical circuits. Nat Rev
Neurosci. 2005 Nov;6(11):877-88. Review. PMID: 16261181.

Hensch TK. Recovery in the blink of an eye. Neuron. 2005 Oct 20;48(2):166-8.
PMID: 16242396.

Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R,
Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE,Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A,Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, diBernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET,  Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo  S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y; FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group). The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. Erratum in: Science. 2006 Mar 24;311(5768):1713. PMID: 16141072.

Hensch TK. Critical period mechanisms in developing visual cortex. Curr Top
Dev Biol. 2005;69:215-37. Review. PMID: 16243601.

Hensch TK, Fagiolini M. Excitatory-inhibitory balance and critical period
plasticity in developing visual cortex. Prog Brain Res. 2005;147:115-24. Review.
PMID: 15581701.

Mataga N, Mizuguchi Y, Hensch TK. Experience-dependent pruning of dendritic
spines in visual cortex by tissue plasminogen activator. Neuron. 2004 Dec 16;44(6):1031-41. PMID: 15603745.

Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK. Specific
GABAA circuits for visual cortical plasticity. Science. 2004 Mar
12;303(5664):1681-3. PMID: 15017002.

Hensch TK, Stryker MP. Columnar architecture sculpted by GABA circuits in developing cat visual cortex. Science. 2004 Mar 12;303(5664):1678-81. PMID: 15017001; PMCID: PMC2562723.

Hensch TK. Critical period regulation. Annu Rev Neurosci. 2004;27:549-79.
Review. PMID: 15217343.

Miyamoto H, Hensch TK. Reciprocal interaction of sleep and synaptic
plasticity. Mol Interv. 2003 Oct;3(7):404-17. Review. PMID: 14993461.

Hirozane-Kishikawa T, Shiraki T, Waki K, Nakamura M, Arakawa T, Kawai J,
Fagiolini M, Hensch TK, Hayashizaki Y, Carninci P. Subtraction of cap-trapped
full-length cDNA libraries to select rare transcripts. Biotechniques. 2003
Sep;35(3):510-6, 518. PMID: 14513556.

Hensch TK. Controlling the critical period. Neurosci Res. 2003
Sep;47(1):17-22. Review. PMID: 12941442.

Iwai Y, Fagiolini M, Obata K, Hensch TK. Rapid critical period induction bytonic inhibition in visual cortex. J Neurosci. 2003 Jul 30;23(17):6695-702.
PMID: 12890762.

Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res. 2003 Jun;13(6B):1273-89. PMID: 12819125; PMCID: PMC403712.

Miyamoto H, Katagiri H, Hensch T. Experience-dependent slow-wave sleep
development. Nat Neurosci. 2003 Jun;6(6):553-4. PMID: 12754515.

Fagiolini M, Katagiri H, Miyamoto H, Mori H, Grant SG, Mishina M, Hensch TK.  Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate
receptor 2A signaling. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2854-9. Epub 2003 Feb 18. PMID: 12591944; PMCID: PMC151430.

Mataga N, Nagai N, Hensch TK. Permissive proteolytic activity for visual
cortical plasticity. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7717-21. PMID: 12032349; PMCID: PMC124331.

Renger JJ, Hartman KN, Tsuchimoto Y, Yokoi M, Nakanishi S, Hensch TK.
Experience-dependent plasticity without long-term depression by type 2
metabotropic glutamate receptors in developing visual cortex. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1041-6. PMID: 11805343; PMCID: PMC117426.

Mataga N, Fujishima S, Condie BG, Hensch TK. Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J Neurosci. 2001 Dec 15;21(24):9724-32. PMID: 11739581.

Fagiolini M, Hensch TK. Inhibitory threshold for critical-period activation in primary visual cortex. Nature. 2000 Mar 9;404(6774):183-6. PMID:

Hensch TK. Whisking away space in the brain. Neuron. 1999 Nov;24(3):492-3.
Review. PMID: 10595498.

Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF. Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science. 1998 Nov 20;282(5393):1504-8. PMID: 9822384; PMCID: PMC2851625.

Hensch TK, Gordon JA, Brandon EP, McKnight GS, Idzerda RL, Stryker MP.
Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice. J Neurosci. 1998 Mar
15;18(6):2108-17. Review. PMID: 9482797; PMCID: PMC2553093.

Hensch TK, Stryker MP. Ocular dominance plasticity under metabotropic
glutamate receptor blockade. Science. 1996 Apr 26;272(5261):554-7. PMID: 8614806.

Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature. 1996 Feb 29;379(6568):837-40. PMID: 8587609.

Ajima A, Hensch T, Kado RT, Ito M. Differential blocking action of Joro
spider toxin analog on parallel fiber and climbing fiber synapses in cerebellar Purkinje cells. Neurosci Res. 1991 Oct;12(1):281-6. PMID: 1684239.

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