Faculty Profile

Rui Wang, PhD

Rui Wang
Assistant Professor of Medicine, Harvard Medical School
Associate Biostatistician, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

See publications


Phone 857-307-0355

Email rwang8@partners.org

Society Memberships

American Statistical Association

Research Unit(s)

Program in Sleep and Cardiovascular Medicine

Research Interests

My research interests include the development and application of statistical methodologies in the area of sleep medicine epidemiology. Sleep disorders impact large fractions of the populations. I am interested in developing methods to elucidate the complex inter-relationship between cardiovascular diseases and sleep disorders, and to identify novel targets for cardiovascular disease reduction that related to common, treatable sleep disorders, using data from clinical trials and epidemiological studies. In the analysis of clinical trials, it is often important to investigate whether treatment effects vary among group of patients defined by patient characteristics.

Currently I am working on developing statistical methodologies to recommend treatment that optimizes the outcome for each individual. In addition, I am also interested in the design and analysis of cluster randomized trials, where a group of subjects, as opposed to individuals, are randomized to each of the treatment arms in the trial. The particular questions I am addressing include how the complex correlation structure within clusters affects the sample size and power of the trial, and how to analyze data from such trials efficiently, taking into account the correlation structure and the issue of missing data.

Mentor(s)

Stephen W. Lagakos, PhD
Susan Redline, MD, MPH

Selected Publications

Wang R, Goyal R, Lei Q, Essex M, De Gruttola V. Sample size considerations in the design of cluster randomized trials of combination HIV prevention.
Clin Trials. 2014 Mar 20;11(3):309-318. [PMID: 24651566]

Weinstock TG, Rosen CL, Marcus CL, Garetz S, Mitchell RB, Amin R, Paruthi S, Katz E, Arens R, Weng J, Ross K, Chervin RD, Ellenberg S, Wang R, Redline S. Predictors of obstructive sleep apnea severity in adenotonsillectomy candidates.
Sleep. 2014 Feb 1;37(2):261-9. [PMID: 24497655]

Wang R, Ware JH. Detecting moderator effects using subgroup analyses.
Prev Sci. 2013 Apr;14(2):111-20. [PMID: 21562742]

Billings ME, Rosen CL, Wang R, Auckley D, Benca R, Foldvary-Schaefer N, Iber C, Zee P, Redline S, Kapur VK. Is the relationship between race and continuous positive airway pressure adherence mediated by sleep duration?
Sleep. 2013 Feb 1;36(2):221-7. [PMID: 23372269]

Claggett B, Lagakos SW, Wang R. Augmented cross-sectional studies with abbreviated follow-up for estimating HIV incidence.
Biometrics. 2012 Mar;68(1):62-74. [PMID: 21668904]

Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for rapid molecular analysis of human tumor samples.
Sci Transl Med. 2011 Feb 23;3(71):71ra16. [PMID: 21346169]

Wang R, Tian L, Cai T, Wei LJ. Nonparametric inference procedure for percentiles of the random effects distribution in meta analysis.
The Annals of Applied Statistics. 2010 4(1):520-532.

Wang R, Lagakos SW, Gray RJ. Testing and interval estimation for two-sample survival comparisons with small sample sizes and unequal censoring.
Biostatistics. 2010 Oct;11(4):676-92. [PMID: 20439258]

Wang R, Lagakos SW. Augmented cross-sectional prevalence testing for estimating HIV incidence.
Biometrics. 2010 Sep;66(3):864-74. [PMID: 19912174]

Finkelstein DM, Wang R, Ficociello LH, Schoenfeld DA. A score test for association of a longitudinal marker and an event with missing data.
Biometrics.  2010 Sep;66(3):726-32. [PMID: 19754923]

Wang R, Lagakos SW. On the use of adjusted cross-sectional estimators of HIV incidence.
J Acquir Immune Defic Syndr. 2009 Dec;52(5):538-47. [PMID: 19881357]

Wang R, Lagakos SW. Inference after variable selection using restricted permutation methods.
Can J Stat. 2009 Dec 1;37(4):625-644. [PMID: 20368768]

Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. Statistics in medicine--reporting of subgroup analyses in clinical trials.
N Engl J Med. 2007 Nov 22;357(21):2189-94. [PMID: 18032770]

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