Faculty Profile

Janet Mullington, PhD


Professor of Neurology, Harvard Medical School
Professor, Department of Neurology, Beth Israel Deaconess Medical Center

See publications


Address

330 Brookline Ave, Human Sleep and Chronobiology Research Unit
DA-779
Boston, MA 02115
USA

Phone 617-667-0434
Fax 617-667-5210

Email jmulling@bidmc.harvard.edu

Society Memberships

Sleep Research Society
Canadian Sleep Research Society
Society for Neuroscience
World Federation of Sleep Societies
German Society for Sleep Research and Sleep Medicine
International Society for Neuroimmuno Modulation
New York Academy of Sciences
American Physiological Association
Association of Professional Sleep Societies

Research Unit(s)

Human Sleep & Chronobiology Research Unit
Systems Neurobiology Group
Division of Sleep Medicine

Trainees

Past Trainees
Brian J. Murray, MD, 2000-2001
Sarah B. Ewing, 2000-2002
Hans Meier-Ewert, MD, 2000-2002
Diwakar D. Balachadran, MD, 2001-2002
Elsa Sanchez, 2001-2004
Guibenson Hyppolite, 2002-2004
Christine Ann McDevitt, PA-C, 2002-2004
Josiane Broussard, 2002-2005
Monica Hsiung Wojcik, 2004-2005
Samantha Powell, 2004
Melynda D. Casement, 2005-2006
Jessica Yang, 2005-2008
Jaime J. Barea, 2005
Theodore Nyame, 2005
Ahmad Reza Hossani-Madani, MS, 2005-2006
Peilian Guan, 2005-2006
Samira Rahman, 2006
Jude E. Telfort, 2006
Maria Toth, MD, PhD, 2006-2008
Alejandro Sanchez, BS, 2007-2009
Martina Grosse Sundrup, 2007-2008
Jeanette Wat, 2008
Faith Nwaoha, 2008
Frank Berkman, 2008
Shakeilla Howell, 2008
Norah Simpson, PhD, 2009-2011
Andrew Rivera, 2011
Dezmond-Taylor Douglas, 2011

Current Trainees
Jennifer Scott-Sutherland, MS, 2007-present
Monica Haack, PhD, 2002-present
Gabriel Santangelo,m 2008-present
Michael McKenery, 2009-present

Research Funding

Current
R01 HL106782 (Mullington, Janet M.)   3/1/2011-2/28/2015
NIH/NHLBI, Type R01
Repeated Challenge of Insufficient Sleep: Effects on Endothelial Function
This project involves testing the effects of repeated cycles of sleep loss with partial recovery intervening, on endothelial function, inflammatory and coagulatory mediators and indicators of autonomic function.
Role: Principal Investigator

R01 HL105544 (Haack, M.)     6/15/2011-6/14/2015
NIH/NHLBI, Type R01
Repeating patterns of sleep restriction and recovery – do we get used to it?
The goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems. Aims are to test whether the hypothalamic-pituitary, sympatho-adrenal, and inflammatory stress responses sensitize across repeated cycles of sleep restriction.
Role: Co-Investigator

UL1 RR025758-01 (L. Nadler)      5/19/2008-09/23/2011     
NIH/NCRR - Harvard Clinical and Translational Science Center
The HCTSC is a clinical and translational research program which provides support to investigators with sponsored research funding support to facilitate patient-oriented research. Investigations carried out in the HCTSC include studies of normal and abnormal human physiology and studies of the cause, prevention, progression, control and cure of diseases that afflict individuals of all ages and ethnic backgrounds.  The HCTSC also provides a unique environment for mentored training of health professionals in issues related to patient-oriented research.
Role: Associate Program Director, Harvard-Thorndike Clinical Research Center at Beth Israel Deaconess Medical Center.

Completed
R01 AG28324 (Mullington, Janet M.)    08/01/2006 - 07/31/2010 (in no-cost extension)
NIH/NIA, Type R01
Aging & the Inflammatory, Metabolic and Autonomic Response to Sleep Loss
This project involves a testing of wake maintenance systems using a 64 hour vigil to challenge the inflammatory (measured in blood), metabolic (hormonal and glucose tolerance testing) and autonomic systems (catecholamine and blood pressure). We hypothesize that the inflammatory response to sleep loss will increase with aging, particularly in the healthy elderly who are mildly to moderately overweight.
Role: Principal Investigator

Sepracor, Inc. (Mullington, Janet M.)     06/01/2008-05/31/2010
Investigator Initiated Research Grant
Pain perception and skill learning in insomniacs and normal sleepers
This pilot study tests the hypothesis that patients with insomnia have increased pain perception compared to healthy controls.
Role: Principal Investigator

R01 HL075501 (Mullington, Janet M.)     09/30/2003 - 05/31/2008
NIH/HLBI, Type R01 Adiposity, BP & the Inflammatory Response to Sleep Loss
The major goals of this project are to investigate individual differences in the inflammatory response to sleep deprivation, and to test the hypothesis that blood pressure mediates the effects of sleep deprivation on inflammation.
Role: Principal Investigator

Teaching

Current
R01 HL106782 (Mullington, Janet M.)   3/1/2011-2/28/2015
NIH/NHLBI, Type R01
Repeated Challenge of Insufficient Sleep: Effects on Endothelial Function
This project involves testing the effects of repeated cycles of sleep loss with partial recovery intervening, on endothelial function, inflammatory and coagulatory mediators and indicators of autonomic function.
Role: Principal Investigator

R01 HL105544 (Haack, M.)     6/15/2011-6/14/2015
NIH/NHLBI, Type R01
Repeating patterns of sleep restriction and recovery – do we get used to it?
The goal of this study is to test the hypothesis that repeated exposure to cycles of insufficient sleep increases susceptibility to a variety of disease states by progressively compromising the integrity of stress response systems. Aims are to test whether the hypothalamic-pituitary, sympatho-adrenal, and inflammatory stress responses sensitize across repeated cycles of sleep restriction.
Role: Co-Investigator

UL1 RR025758-01 (L. Nadler)      5/19/2008-09/23/2011     
NIH/NCRR - Harvard Clinical and Translational Science Center
The HCTSC is a clinical and translational research program which provides support to investigators with sponsored research funding support to facilitate patient-oriented research. Investigations carried out in the HCTSC include studies of normal and abnormal human physiology and studies of the cause, prevention, progression, control and cure of diseases that afflict individuals of all ages and ethnic backgrounds.  The HCTSC also provides a unique environment for mentored training of health professionals in issues related to patient-oriented research.
Role: Associate Program Director, Harvard-Thorndike Clinical Research Center at Beth Israel Deaconess Medical Center.

Completed
R01 AG28324 (Mullington, Janet M.)    08/01/2006 - 07/31/2010 (in no-cost extension)
NIH/NIA, Type R01
Aging & the Inflammatory, Metabolic and Autonomic Response to Sleep Loss
This project involves a testing of wake maintenance systems using a 64 hour vigil to challenge the inflammatory (measured in blood), metabolic (hormonal and glucose tolerance testing) and autonomic systems (catecholamine and blood pressure). We hypothesize that the inflammatory response to sleep loss will increase with aging, particularly in the healthy elderly who are mildly to moderately overweight.
Role: Principal Investigator

Sepracor, Inc. (Mullington, Janet M.)     06/01/2008-05/31/2010
Investigator Initiated Research Grant
Pain perception and skill learning in insomniacs and normal sleepers
This pilot study tests the hypothesis that patients with insomnia have increased pain perception compared to healthy controls.
Role: Principal Investigator

R01 HL075501 (Mullington, Janet M.)     09/30/2003 - 05/31/2008
NIH/HLBI, Type R01 Adiposity, BP & the Inflammatory Response to Sleep Loss
The major goals of this project are to investigate individual differences in the inflammatory response to sleep deprivation, and to test the hypothesis that blood pressure mediates the effects of sleep deprivation on inflammation.
Role: Principal Investigator

Honors and Awards
University of Ottawa Research Award, 1988-1990
Medical Research Council of Canada Research Scholarship, 1989-1991
Canadian Sleep Research Award, Toronto, Canada, 1990
German Academic Exchange Award, 1992-1993

Selected Publications


Haack M, Serrador J, Cohen D, Simpson N, Meier-Ewert H, Mullington JM. Increasing sleep duration to lower beat-to-beat blood pressure: a pilot study.
J  Sleep Res. 2012 Nov 22. [PMID: 23171375]

Solarz DE, Mullington JM, Meier-Ewert HK. Sleep, inflammation and cardiovascular disease.
Front Biosci (Elite Ed). 2012 Jun 1;4:2490-501. [PMID: 22652655]

Dushay J, Gao C, Gopalakrishnan GS, Crawley M, Mitten EK, Wilker E, Mullington J, Maratos-Flier E. Short-Term Exenatide Treatment Leads to Significant Weight Loss in a Subset of Obese Women Without Diabetes.
Diabetes Care. 2011 Oct 31. [PMID: 22040840]

Mullington JM, Czeisler CA, Goel N, Krueger JM, Balkin TJ, Johns M, Shaw PJ. Panel discussion: current status of measuring sleepiness.
J Clin Sleep Med. 2011 Oct 15;7(5 Suppl):S22-5. [PMID: 22003325]

Haack M, Scott-Sutherland J, Santangelo G, Simpson NS, Sethna N, Mullington JM. Pain sensitivity and modulation in primary insomnia.
Eur J Pain. 2011 Aug 23. [PMID: 21868271]

Mullington JM, Simpson NS, Meier-Ewert HK, Haack M. Sleep loss and inflammation.
Best Pract Res Clin Endocrinol Metab. 2010 Oct;24(5):775-84. Review. [PMID: 21112025]

Haack M, Lee E, Cohen DA, Mullington JM. Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain.
Pain. 2009 Sep;145(1-2):136-41. Epub 2009 Jun 27. [PMID: 19560866]

Mullington JM. Let her sleep...but how much?
Sleep. 2009 Jul 1;32(7):841-2. [PMID: 19639744]

Mullington JM, Haack M, Toth M, Serrador JM, Meier-Ewert HK. Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation.
Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):294-302. Review. [PMID: 19110131]

Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers.
Sleep. 2007 Sep 1;30(9):1145-52. [PMID: 17910386]

Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.
J Exp Med. 2006 Jun 12;203(6):1447-58. Epub 2006 May 15. [PMID: 16702604]

Casement MD, Broussard JL, Mullington JM, Press DZ. The contribution of sleep to improvements in working memory scanning speed: a study of prolonged sleep restriction.
Biol Psychol. 2006 May;72(2):208-12. Epub 2005 Dec 27. [PMID: 16384630]

Haack M, Mullington JM. Sustained sleep restriction reduces emotional and physical well-being.
Pain. 2005 Dec 15;119(1-3):56-64. Epub 2005 Nov 16. [PMID: 16297554]

Schuld A, Haack M, Hinze-Selch D, Mullington J, Pollmacher T. Experimental studies on the interaction between sleep and the immune system in humans.
Psychother Psychosom Med Psychol. 2005 Jan;55(1):29-35. Review. German. [PMID: 15647993]

Haack M, Pollmacher T, Mullington JM. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers.
Brain Behav Immun. 2004 Jul;18(4):361-7. [PMID: 15157953]

Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.
J Am Coll Cardiol. 2004 Feb 18;43(4):678-83. [PMID: 14975482]

Mullington JM, Chan JL, Van Dongen HP, Szuba MP, Samaras J, Price NJ, Meier-Ewert HK, Dinges DF, Mantzoros CS. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men.
J Neuroendocrinol. 2003 Sep;15(9):851-4. [PMID: 12899679]

Van Dongen HP, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.
Sleep. 2003 Mar 15;26(2):117-26. Erratum in: Sleep. 2004 Jun 15;27(4):600. [PMID: 12683469]

Straub RH, Schuld A, Mullington J, Haack M, Scholmerich J, Pollmacher T. The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects.
J Endocrinol. 2002 Nov;175(2):467-74. [PMID: 12429044]

Van Dongen HP, Price NJ, Mullington JM, Szuba MP, Kapoor SC, Dinges DF. Caffeine eliminates psychomotor vigilance deficits from sleep inertia.
Sleep. 2001 Nov 1;24(7):813-9. [PMID: 11683484]

Mullington JM, Hinze-Selch D, Pollmacher T. Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.
Ann N Y Acad Sci. 2001 Mar;933:201-10. Review. [PMID: 12000021]

Meier-Ewert HK, Ridker PM, Rifai N, Price N, Dinges DF, Mullington JM. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects.
Clin Chem. 2001 Mar;47(3):426-30. [PMID: 11238292]

Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight.
J Allergy Clin Immunol. 2001 Jan;107(1):165-70. [PMID: 11150007]

Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, Pollmacher T. Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers.
J Clin Endocrinol Metab. 2000 Dec;85(12):4624-9. [PMID: 11134118]

Mullington J, Korth C, Hermann DM, Orth A, Galanos C, Holsboer F, Pollmacher T. Dose-dependent effects of endotoxin on human sleep.
Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R947-55. [PMID: 10749783]

Pollmacher T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullington J. Experimental immunomodulation, sleep, and sleepiness in humans.
Ann N Y Acad Sci. 2000;917:488-99. Review. [PMID: 11268376]

Schuld A, Mullington J, Hermann D, Hinze-Selch D, Fenzel T, Holsboer F, Pollmacher T. Effects of granulocyte colony-stimulating factor on night sleep in humans.
Am J Physiol. 1999 Apr;276(4 Pt 2):R1149-55. [PMID: 10198397]

Pollmacher T, Kraus T, Haack M, Uhr M, Mullington J. Salmonella abortus equi endotoxin does not affect leptin plasma levels in healthy humans.
J Infect Dis. 1999 Apr;179(4):1047-8. No abstract available. [PMID: 10068609]

Hinze-Selch D, Becker EW, Stein GM, Berg PA, Mullington J, Holsboer F, Pollmacher T. Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients.
Neuropsychopharmacology. 1998 Aug;19(2):114-22. [PMID: 9629565]

Hermann DM, Mullington J, Hinze-Selch D, Schreiber W, Galanos C, Pollmacher T. Endotoxin-induced changes in sleep and sleepiness during the day.
Psychoneuroendocrinology. 1998 Jul;23(5):427-37. [PMID: 9802118]

Hinze-Selch D, Wetter TC, Zhang Y, Lu HC, Albert ED, Mullington J, Wekerle H, Holsboer F, Pollmacher T. In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls.
Neurology. 1998 Apr;50(4):1149-52. [PMID: 9566413]

Broughton R, Krupa S, Boucher B, Rivers M, Mullington J. Impaired circadian waking arousal in narcolepsy-cataplexy.
Sleep Res Online. 1998;1(4):159-65. [PMID: 11382873]

Pollmacher T, Hinze-Selch D, Fenzel T, Kraus T, Schuld A, Mullington J. Plasma levels of cytokines and soluble cytokine receptors during treatment with haloperidol.
Am J Psychiatry. 1997 Dec;154(12):1763-5. [PMID: 9396961]
 
Pollmacher T, Mullington J, Lauer CJ. REM sleep disinhibition at sleep onset: a comparison between narcolepsy and depression.
Biol Psychiatry. 1997 Oct 15;42(8):713-20. [PMID: 9325565]

Hinze-Selch D, Mullington J, Orth A, Lauer CJ, Pollmacher T. Effects of clozapine on sleep: a longitudinal study.
Biol Psychiatry. 1997 Aug 15;42(4):260-6. [PMID: 9270902]

Pollmacher T, Fenzel T, Mullington J, Hinze-Selch D. The influence of clozapine treatment on plasma granulocyte colony-stimulating (G-CSF) levels.
Pharmacopsychiatry. 1997 Jul;30(4):118-21. [PMID: 9271776]

Pollmacher T, Hinze-Selch D, Mullington J, Fenzel T, Holsboer F. Smoking affects plasma-soluble interleukin-2 receptor levels in patients with schizophrenia.
Arch Gen Psychiatry. 1997 Jan;54(1):89-90. No abstract available. [PMID: 9006405]

Pollmacher T, Mullington J, Korth C, Schreiber W, Hermann D, Orth A, Galanos C, Holsboer F. Diurnal variations in the human host response to endotoxin.
J Infect Dis. 1996 Nov;174(5):1040-5. [PMID: 8896506]

Pollmacher T, Korth C, Schreiber W, Hermann D, Mullington J. Effects of repeated administration of granulocyte colony-stimulating factor (G-CSF) on neutrophil counts, plasma cytokine, and cytokine receptor levels.
Cytokine. 1996 Oct;8(10):799-803. [PMID: 8980882]

Pollmacher T, Hinze-Selch D, Mullington J. Effects of clozapine on plasma cytokine and soluble cytokine receptor levels.
J Clin Psychopharmacol. 1996 Oct;16(5):403-9. [PMID: 8889915]

Mullington J, Hermann D, Holsboer F, Pollmacher T. Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation.
Neuroendocrinology. 1996 Sep;64(3):233-41. [PMID: 8875441]

Korth C, Mullington J, Schreiber W, Pollmacher T. Influence of endotoxin on daytime sleep in humans.
Infect Immun. 1996 Apr;64(4):1110-15. [PMID: 8606066]

Pollmacher T, Korth C, Mullington J, Schreiber W, Sauer J, Vedder H, Galanos C, Holsboer F. Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men.
Blood. 1996 Feb 1;87(3):900-5. [PMID: 8562960]

Hinze-Selch D, Mullington J, Pollmacher T. Clozapine, cytokines, fever and sleep.
Wien Med Wochenschr. 1996;146(13-14):311-3. German. [PMID: 9012164]

Hinze-Selch D, Mullington J, Pollmacher T. Sleep during clozapine-induced fever in a schizophrenic patient.
Biol Psychiatry. 1995 Nov 15;38(10):690-3. No abstract available. [PMID: 8555381]

Pollmacher T, Hinze-Selch D, Mullington J, Holsboer F. Clozapine-induced increase in plasma levels of soluble interleukin-2 receptors.
Arch Gen Psychiatry. 1995 Oct;52(10):877-8. No abstract available. [PMID: 7575109]

Pollmacher T, Mullington J, Korth C, Hinze-Selch D. Influence of host defense activation on sleep in humans.
Adv Neuroimmunol. 1995;5(2):155-69. Review. [PMID: 7496610]

Broughton R, Mullington J. Chronobiological aspects of narcolepsy.
Sleep. 1994 Dec;17(8 Suppl):S35-44. Review. [PMID: 7701198]

Mullington J, Broughton R. Daytime sleep inertia in narcolepsy-cataplexy.
Sleep. 1994 Feb;17(1):69-76. [PMID: 8191205]

Mullington J, Broughton R. Scheduled naps in the management of daytime sleepiness in narcolepsy-cataplexy.
Sleep. 1993 Aug;16(5):444-56. [PMID: 8378686]

Broughton R, Mullington J. Circasemidian sleep propensity and the phase-amplitude maintenance model of human sleep/wake regulation.
J Sleep Res. 1992 Jun;1(2):93-98. [PMID: 10607032]

Purcell S, Mullington J, Moffitt A, Hoffmann R, Pigeau R. Dream self-reflectiveness as a learned cognitive skill.
Sleep. 1986;9(3):423-37. [PMID: 3764289]

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