Faculty Profile

Jessie P. Bakker, BS, MS, PhD


Instructor in Medicine, Harvard Medical School
Associate Epidemiologist, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

See publications


Address

Division of Sleep and Circadian Disorders
221 Longwood Avenue, Suite BL230
Boston, MA 02115
USA

Phone 617-732-5987

Email jpbakker@partners.org

Society Memberships

American Academy of Sleep Medicine
American Thoracic Society
American Heart Association

Research Interests

I began performing clinical trials in the sleep apnea population in 2007 when I commenced my PhD at the University of Otago, having completed a Master of Science degree researching diagnostic techniques of sleep-disordered breathing in the pediatric population.  During my time in New Zealand, I led three clinical trials investigating technological modifications of CPAP, with outcomes including treatment adherence, daytime sleepiness, and various surrogate markers of cardiovascular health.  My other major focus during this time was a quantitative and qualitative investigation of ethnic disparities in CPAP adherence, and strategies to improve adherence with an emphasis on patient-centered outcomes.

I commenced my postdoctoral studies in February 2011 at the Division of Sleep Medicine, Brigham & Women’s Hospital.  My initial focus was an investigation of the effects of CPAP and bariatric surgery on cardiovascular outcomes in patients with obstructive sleep apnea.  Since receiving funding as a co-investigator on a 5-year NIH R01 in 2012, I have been leading a study investigating the cardiovascular link between type 2 diabetes and obstructive sleep apnea.  There is evidence that the majority of obese patients with type 2 diabetes suffer from undiagnosed obstructive sleep apnea, which may be responsible for the elevated cardiovascular risk seen in these patients despite optimal medical control of blood pressure, glucose and lipids.  In addition to this ongoing project, I am currently working on developing a sleep patient advisory panel at Brigham & Women’s Hospital.  Concurrently, I am designing a clinical trial of an intervention designed to maximize adherence to CPAP focusing on patient-centered functional outcomes, which I hope to commence in 2014.

Alongside this research, I have pursued several avenues of ongoing education including Harvard-based courses in Applied Biostatistics and Fundamentals in Clinical Trials.

Mentor(s)

Atul Malhotra, MD
Sanjay Patel, MD, MS

Research Funding

NIH/NHLBI, co-PI: Sanjay Patel MD and Aristidis Veves MD. 
"Obstructive sleep apnea increases cardiovascular risk in type 2 diabetes.”

Selected Publications


Bakker, J.P., Edwards, B.A., Gautam, S.P., Montesi, S.B., Durán-Cantolla, J., Aizpuru Barandiarán, F., Barbé, F., Sánchez-de-la-Torre, M., Malhotra, A.  Blood pressure improvement with continuous positive airway pressure is independent of obstructive sleep apnea severity.  Journal of Clinical Sleep Medicine (in-press)

Bakker, J.P., O’Keefe, K.M., Neill, A.M., Campbell, A.J.  Continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea: Māori, Pacific and European experiences.  Journal of Primary Health Care (in-press)

Neilan, T.G., Farhad, H., Dodson, J., Shah, R.V., Abbasi, S., Bakker, J.P, Michaud, G., van der Geest, R., Blankstein, R., Steigner, M., John, R., Jerosch-Herold, M., Malhotra, A., Kwong, R.  The effect of sleep apnea and continuous positive airway pressure on cardiac structure and recurrence of atrial fibrillation. 
J Am Heart Assoc. 2013 Nov 25;2(6):e000421. [PMID: 24275628]

Montesi, S.B., Bakker, J.P., Macdonald, M., Hueser, L., Pittman, S., White, D.P., Malhotra, A.  Air leak during CPAP titration as a risk factor for central apnea. 
Journal of Clinical Sleep Medicine. 2013;  9(11): 1187-1191. [PMID: 24235901]

DeYoung, P.N., Bakker, J.P., Sands, S.A., Batool-Anwar, S., Connolly, J.G., Butler, J.P., Malhotra, A.  Acoustic pharyngometry measurement of minimal cross-sectional airway area is a significant independent predictor of moderate-to-severe obstructive sleep apnea. 
Journal of Clinical Sleep Medicine. 2013;9(11):1161-1164. [PMID: 24235897]

Kaczmarek, E., Bakker, J.P., Clarke, D.N., Csizmadia, E., Kocher, O., Veves, A., Tecilazich, F., O’Donnell, C.P., Ferran, C., Malhotra, A.  Molecular biomarkers of vascular dysfunction in obstructive sleep apnea. 
PLOS One. 2013;8(7):e70559. [PMID: 23923005]

Bakker, J.P., Balachandran, J., Tecilazich, F., DeYoung, P., Smales, E., Veves, A., Malhotra, A.  A pilot study of the effects of bariatric surgery and CPAP treatment on vascular function in obese subjects with obstructive sleep apnea. 
Internal Medicine Journal. 2013;43(9):993-998. [PMID: 23800096]

Bakker, J.P., Montesi, S.B., Malhotra, A.  Obstructive sleep apnoea: New associations and approaches. 
The Lancet Respiratory Medicine. 2013;1(1):e15-16.  [PMID: 24321811]

Sharma, B., Neilan, T.G., Kwong, R.Y., Mandry, D., Owens, R.L., McSharry, D.G., Bakker, J.P., Malhotra, A.  Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea. 
COPD: Journal of Chronic Obstructive Pulmonary Disease. 2012;10(1):4-10. [PMID: 23272670]

Montesi, S.B., Edwards, B.A., Malhotra, A., Bakker, J.P.  The effect of continuous positive airway pressure treatment on blood pressure: A systematic review and meta-analysis of randomized controlled trials. 
Journal of Clinical Sleep Medicine. 2012;8(5):587-596. [PMID: 23066375]

Sharma, B.K., Bakker, J.P., McSharry, D.G., Desai, A.S., Javaheri, S., Malhotra, A.  Adaptive servo-ventilation for treatment of sleep-disordered breathing in heart failure: A systematic review and meta-analysis. 
Chest. 2012; 142(5):1211-1221. [PMID: 22722232]

Bakker, J.P., Campbell, A.J., Neill, A.M.  Increased mortality risk in congestive heart failure with co-morbid sleep apnoea: ten year follow-up. 
Internal Medicine Journal. 2011; 42(11):1264-1268.  [PMID: 23157523]

Bradley, J., Galland, B., Bakker, J.P., Tan, E., Gray, A., Taylor, B., Dawes, P.  Pulse transit time and the assessment of childhood sleep-disordered breathing. 
Archives of Otolaryngology Head & Neck Surgery. 2012; 138(4):398-403, [PMID: 22508264]

Balachandran, J.S., Bakker, J.P., Rahangdale, S., Yim-Yeh, S., Mietus, J.E., Goldberger, A.L., Malhotra, A.  Effect of mild, asymptomatic obstructive sleep apnea on daytime heart rate variability and impedance cardiography measurements. 
American Journal of Cardiology. 2012;109(1):140-145. [PMID: 21945139]

Bakker J.P., Malhotra A., Patel S.R. Obstructive Sleep Apnea: Epidemiology of Sleep Apnea [book chapter].
In: Essentials of Sleep Medicine pp 91-114.  Badr, M.S. (editor), Totowa, NJ: Humana Press (2012).

Bakker, J.P., Neill, A.M., Campbell, A.J.  Nasal versus oronasal continuous positive airway pressure masks for obstructive sleep apnea: a pilot investigation of pressure requirement, residual disease and leak. 
Sleep & Breathing. 2012; 16(3):709-716. [PMID: 21800222]

Bakker, J.P., O’Keeffe, K.M., Neill, A.M., Campbell, A.J.  Ethnic disparities in CPAP adherence in New Zealand: effects of socioeconomic status, health literacy and self-efficacy. 
Sleep. 2011; 34(11):1595. [PMID: 22043130]

Bakker, J.P., Campbell, A.J., Neill, A.M.  Pulse wave analysis in a pilot randomized controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnea. 
Sleep & Breathing. 2011; 15(3):325. [PMID: 20628825]

Campbell, A.J., Signal, T.L., O’Keeffe, K.M., Bakker, J.P.  Narcolepsy in New Zealand: Pathway to diagnosis and effect on quality of life. 
New Zealand Medical Journal. 2011; 124(1336):51.  [PMID: 21946744]

Bakker, J.P., Marshall, N.S.  Flexible pressure delivery modification of continuous positive airway pressure for obstructive sleep apnea does not improve compliance with therapy: Systematic review and meta-analysis. 
Chest. 2011; 139(6):1322, [PMID: 21193533]

Bakker, J., Campbell, A., Neill, A. Randomised controlled trial of auto-adjusting positive airway pressure in morbidly obese patients requiring high therapeutic pressure delivery. 
Journal of Sleep Research. 2011; 20:233. [PMID: 20607425]

Bakker, J., Campbell, A., Neill, A. Randomized controlled trial comparing flexible and continuous positive airway pressure delivery: effects on compliance, objective and subjective sleepiness and vigilance. 
Sleep. 2010; 33(4):523.  [PMID: 20394322]


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