Faculty Profile

In memoriam: Edward Barry Bromfield, MD


Associate Professor of Neurology, Harvard Medical School
Associate Neurologist, Department of Neurology, Brigham and Women's Hospital

Administrative Title(s)

Chief, Division of EEG, Epilepsy, and Sleep Neurology, Brigham and Women's Hospital

Other Affiliation(s)

Faulkner Hospital

See publications


Society Memberships

American Epilepsy Society (Sleep Special Interest Group)
American Academy of Neurology

Research Unit(s)

Department of Neurology EEG Laboratory, Brigham and Women's Hospital

Trainees

Brendan Lucey, MD 2007-2009
Sebastian Espinosa, MD 2007-2009
Rohit Das, MD, 2007-2009
Ellen Bubrick, MD 2006-2007
Autumn Klein, MD, PhD 2005-2007
Jong Woo Lee, MD, PhD 2005-2006
Tracey Milligan, MD 2003-2005
David C. McCarthy, MD, PhD 2003-2005
K. Mortati, MD 2003-2005
Olga E. Golub, MD 2002-2004
Milena Pavlova, MD 2002-2003
F. Siddiqui, MD 2001-2003
M. Idrees Zahoor, MD 1999-2000

Selected Publications

Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
Epilepsy Behav. 2009 Sep 26. [Epub ahead of print] [PMID: 19786369]

Dworetzky BA, Bromfield EB, Townsend MK, Kang JH. A prospective study of smoking, caffeine, and alcohol as risk factors for seizures or epilepsy in young adult women: Data from the Nurses' Health Study II.
Epilepsia. 2009 Aug 19. [Epub ahead of print] [PMID: 19694796]

Sethi NK, Milligan TA, Hurwitz S, Bromfield EB. Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery.
Neurology. 2009 Jul 14;73(2):159; author reply 159. [PMID: 19597140]

Zhang YC, Bromfield EB, Hurwitz S, Nelson A, Sylvia K, Dworetzky BA. Comparison of outcomes of video/EEG monitoring between patients with epileptic seizures and those with psychogenic nonepileptic seizures.
Epilepsy Behav. 2009 Jul;15(3):303-7. Epub 2009 May 7. [PMID: 19362600]

Suarez RO, Golby A, Whalen S, Sato S, Theodore WH, Kufta CV, Devinsky O, Balish M, Bromfield EB. Contributions to singing ability by the posterior portion of the superior temporal gyrus of the non-language-dominant hemisphere: First evidence from subdural cortical stimulation, Wada testing, and fMRI.
Cortex. 2009 May 18. [Epub ahead of print] [PMID: 19570530]

Espinosa PS, Lee JW, Tedrow UB, Bromfield EB, Dworetzky BA. Sudden unexpected near death in epilepsy: malignant arrhythmia from a partial seizure.
Neurology. 2009 May 12;72(19):1702-3. [PMID: 19433745]

Herzog AG, Blum AS, Farina EL, Maestri XE, Newman J, Garcia E, Krishnamurthy KB, Hoch DB, Replansky S, Fowler KM, Smithson SD, Dworetzky BA, Bromfield EB. Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use.
Neurology. 2009 Mar 10;72(10):911-4. [PMID: 19273825]

Bianchi MT, Dworetzky BA, Bromfield EB. Auditory auras in patients with postencephalitic epilepsy: case series.
Epilepsy Behav. 2009 Jan;14(1):250-2. Epub 2008 Sep 16. [PMID: 18765301]

Bromfield EB, Dworetzky BA, Wyszynski DF, Smith CR, Baldwin EJ, Holmes LB. Valproate teratogenicity and epilepsy syndrome.
Epilepsia. 2008 Dec;49(12):2122-4. [PubMed PMID: 18557775]

Das RR, Lucey BP, Chou SH, Espinosa PS, Zamani AA, Dworetzky BA, Bromfield EB,Lee JW. The Utility of Conductive Plastic Electrodes in Prolonged ICU EEG Monitoring.
Neurocrit Care. 2008 Sep 20. [PubMed PMID:18807217]

Bubrick EJ, Dworetzky BA, Bromfield EB. Assessment of hairline EEG as a screening tool for nonconvulsive status epilepticus.
Epilepsia. 2007 Dec;48(12):2374-5. [PubMed PMID: 18088271]

Rossetti AO, Logroscino G, Bromfield EB. A clinical score for prognosis of status epilepticus in adults.
Neurology. 2006 Jun 13;66(11):1736-8. [PubMed PMID:16769951]

Rizzuto DS, Madsen JR, Bromfield EB, Schulze-Bonhage A, Kahana MJ. Human neocortical oscillations exhibit theta phase differences between encoding and retrieval.
Neuroimage. 2006 Jul 1;31(3):1352-8. [PubMed PMID:16542856]

Morrow EM, Lafayette JM, Bromfield EB, Fricchione G. Postictal psychosis: presymptomatic risk factors and the need for further investigation of genetics and pharmacotherapy.
Ann Gen Psychiatry. 2006 Jul 21;5:9. [PubMed PMID: 16859554]

Rossetti AO, Bromfield EB. Determinants of success in the use of oral levetiracetam in status epilepticus.
Epilepsy Behav. 2006 May;8(3):651-4. [PubMed PMID: 16495155]

Zhang YC, Bromfield EB, Hurwitz S, Nelson A, Sylvia K, Dworetzky BA. Comparison of outcomes of video/EEG monitoring between patients with epileptic seizures and those with psychogenic nonepileptic seizures.
Epilepsy Behav. 2009 Apr 23. [PubMed PMID: 19362600]

Herzog AG, Blum AS, Farina EL, Maestri XE, Newman J, Garcia E, Krishnamurthy KB, Hoch DB, Replansky S, Fowler KM, Smithson SD, Dworetzky BA, Bromfield EB. Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use.
Neurology. 2009 Mar 10;72(10):911-4. [PubMed PMID: 19273825]

Lee JW, Bromfield EB, Kesari S. Antiemetic properties of the antiepileptic drug levetiracetam.
N Engl J Med. 2008 Oct 23;359(17):1853. [PubMed PMID:18946077]

Rossetti AO, Logroscino G, Milligan TA, Michaelides C, Ruffieux C, Bromfield EB. Status Epilepticus Severity Score (STESS): a tool to orient early treatment strategy.
J Neurol. 2008 Oct;255(10):1561-6. [PubMed PMID:18769858]

Milligan TA, Hurwitz S, Bromfield EB. Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery.
Neurology. 2008 Aug 26;71(9):665-9. [PubMed PMID: 18725591]

Nogueira RG, Sheth KN, Duffy FH, Helmers SL, Bromfield EB. Bilateral tonic-clonic seizures with temporal onset and preservation of consciousness.
Neurology. 2008 May 27;70(22 Pt 2):2188-90. [PubMed PMID: 18505999]

15: Heinrichs SC, Bromfield EB. Behavioral measures in animal studies: relevance to patients with epilepsy.
Epilepsy Behav. 2008 May;12(4):612-21. [PubMed PMID: 18166501]

Sederberg PB, Schulze-Bonhage A, Madsen JR, Bromfield EB, Litt B, Brandt A,Kahana MJ. Gamma oscillations distinguish true from false memories.
Psychol Sci. 2007 Nov;18(11):927-32. [PubMed PMID: 17958703]

Seeley WW, Marty FM, Holmes TM, Upchurch K, Soiffer RJ, Antin JH, Baden LR, Bromfield EB. Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6.
Neurology. 2007 Jul 10;69(2):156-65. [PubMed PMID: 17620548]

Sederberg PB, Schulze-Bonhage A, Madsen JR, Bromfield EB, McCarthy DC, Brandt A, Tully MS, Kahana MJ. Hippocampal and neocortical gamma oscillations predict memory formation in humans.
Cereb Cortex. 2007 May;17(5):1190-6. [PubMed PMID: 16831858]

Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Dworetzky BA,Farina EL, Frye CA. Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy.
Epilepsia. 2006 Nov;47(11):1945-8. [PubMed PMID:17116037]

Dworetzky BA, Mortati KA, Rossetti AO, Vaccaro B, Nelson A, Bromfield EB.Clinical characteristics of psychogenic nonepileptic seizure status in the long-term monitoring unit.
Epilepsy Behav. 2006 Sep;9(2):335-8. [PubMed PMID: 16872909]

Bubrick E, Pavlova M, Bromfield E. Polysomnography with Full EEG Recording ? Who Benefits?
Epilepsia, in press. American Epilepsy Society 2007 Annual Meeting, P2.161.

Rossetti AO, Hurwitz S, Logroscino G, Bromfield EB.  Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation.
J Neurol Neurosurg Psychiatry. 2006 May;77(5):611-5. [PMID: 16614020]

Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hamalainen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA, Dale AM, Rosen BR, Stufflebeam SM.  The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients.
Epilepsy Res. 2006 Apr;69(1):80-6. Epub 2006 Mar 3. [PMID: 16516443]

Pal DK, Durner M, Klotz I, Dicker E, Shinnar S, Resor S, Cohen J, Harden C, Moshe SL, Ballaban-Gill K, Bromfield EB, Greenberg DA. Complex inheritance and parent-of-origin effect in juvenile myoclonic epilepsy.
Brain Dev. 2006 Mar;28(2):92-8. Epub 2006 Jan 18. [PMID: 16414227]

Rossetti AO, Logroscino G, Bromfield EB.  Refractory status epilepticus: effect of treatment aggressiveness on prognosis.
Arch Neurol. 2005 Nov;62(11):1698-702. [PMID: 16286542]

Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Dworetzky BA, Farina EL, Frye CA.  Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy.
Neurology. 2005 Oct 11;65(7):1016-20. [PMID: 16217052]

Dworetzky BA, Strahonja-Packard A, Shanahan CW, Paz J, Schauble B, Bromfield EB.  Characteristics of male veterans with psychogenic nonepileptic seizures.
Epilepsia. 2005 Sep;46(9):1418-22. [PMID: 16146437]

Rossetti AO, Bromfield EB.  Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes.
Eur Neurol. 2005;54(1):34-8. Epub 2005 Aug 10. [PMID: 16103676]

Rossetti AO, Bromfield EB. Efficacy of rapid IV administration of valproic acid for status epilepticus.
Neurology. 2005 Aug 9;65(3):500-1; author reply 500-1. No abstract available. [PMID: 16087935]

Rossetti AO, Dworetzky BA, Madsen JR, Golub O, Beckman JA, Bromfield EB. Ictal asystole with convulsive syncope mimicking secondary generalisation: a depth electrode study.
J Neurol Neurosurg Psychiatry. 2005 Jun;76(6):885-7. [PMID: 15897520]

Rossetti AO, Mortati KA, Black PM, Bromfield EB.  Simple partial seizures with hemisensory phenomena and dysgeusia: an insular pattern.
Epilepsia. 2005 Apr;46(4):590-1. [PMID: 15816958]

Greenberg DA, Cayanis E, Strug L, Marathe S, Durner M, Pal DK, Alvin GB, Klotz I, Dicker E, Shinnar S, Bromfield EB, Resor S, Cohen J, Moshe SL, Harden C, Kang H.  Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy.
Am J Hum Genet. 2005 Jan;76(1):139-46. Epub 2004 Nov 5. [PMID: 15532013]

Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Kelly KM, Farina EL, Frye CA.  Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs.
Epilepsia. 2004 Jul;45(7):764-8. [PMID: 15230699]

Silvestri R, Bromfield E. Recurrent nightmares and disorders of arousal in temporal lobe epilepsy.
Brain Res Bull. 2004 Jun 30;63(5):369-76. [PMID: 15245763]

Pavlova MK, Shea SA, Bromfield EB. Day/night patterns of focal seizures.
Epilepsy Behav. 2004 Feb;5(1):44-9. [PMID: 14751206]

Rizzuto DS, Madsen JR, Bromfield EB, Schulze-Bonhage A, Seelig D, Aschenbrenner-Scheibe R, Kahana MJ. Reset of human neocortical oscillations during a working memory task.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7931-6. Epub 2003 Jun 5. [PMID: 12792019]

Walker DG, Talos F, Bromfield EB, Black PM. Intraoperative magnetic resonance for the surgical treatment of lesions producing seizures.
J Clin Neurosci. 2002 Sep;9(5):515-20. [PMID: 12383406]

Cramer JA, Arrigo C, Van Hammee G, Bromfield EB. Comparison between the QOLIE-31 and derived QOLIE-10 in a clinical trial of levetiracetam.
Epilepsy Res. 2000 Aug;41(1):29-38. [PMID: 10924866]

Dworetzky BA, Hoch DB, Wagner AK, Salmanson E, Shanahan CW, Bromfield EB. The impact of a single seizure on health status and health care utilization.
Epilepsia. 2000 Feb;41(2):170-6. [PMID: 10691113]

Silvestri RC, Bromfield EB, Khoshbin S. Clozapine-induced seizures and EEG abnormalities in ambulatory psychiatric patients.
Ann Pharmacother. 1998 Nov;32(11):1147-51. [PMID: 9825078]

Reviews

Bromfield EB.  Epilepsy in patients with brain tumors and other cancers.
Rev Neurol Dis. 2004;1 Suppl 1:S27-33. Review. [PMID: 16400292]

Bromfield EB. Clinical use of anticonvulsants: a neurologist's perspective.
Harv Rev Psychiatry. 2003 Sep-Oct;11(5):257-68. Review. [PMID: 14555426]

Letters

Pavlova M, Bromfield E. Delayed sleep onset in patients with temporal vs. extratemporal epilepsy.
Epilepsia 2000;41(Suppl.7):172. 

Bromfield E, Richardson G, Nugent W, Robertson-Thompson A, Dworetzky B.  Sleep studies in adults undergoing epilepsy monitoring. 
EEG and Clin Neurophysiol; 1996;99:10P.

Posters

Dehghani N, Cash SS, Devinsky O, Doyle WK, Rossetti A, Bromfield EB, Madsen JR, Dale AM, Huang MX, Halgren E. Distribution and phase of sleep spindles across the human cortex: MEG and intracranial EEG.
Society for Neuroscience 2007 Annual Meeting, Poster 791.1/K1.

Cash SS, Deghani N, Ulbert I, Thesen T, Devinsky O, Doyle W, Wang C, Bromfield E, Rossetti A, Madsen JR, Halgren E; Neural generators of sleep spindles in humans inferred from microelectrode array recordings.
Society for Neuroscience 2007 Annual Meeting, Poster 791.7/K7.

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