Faculty Profile

Joseph A. Majzoub, MD


Thomas Morgan Rotch Professor of Pediatrics; Professor of Medicine, Harvard Medical School
Senior Associate in Medicine, Division of Endocrinology, Department of Pediatrics, Children's Hospital Boston

Administrative Title(s)

Chief, Division of Endocrinology, Children's Hospital Boston

See publications


Society Memberships

Endocrine Society
American Society of Biological Chemists
American Federation for Clinical Research
Society for Pediatric Research
Lawson Wilkins Pediatric Endocrine Society
American Society for Clinical Investigation
Society for Neuroscience
American Pediatric Society

Research Interests

The ultimate goals of Joseph Majzoub's work are to understand how various stresses affect health.

The specific aims of the Majzoub laboratory's studies are to determine the impact of corticotropin releasing hormone (CRH) and vasopressin excess and deficiency on regulation of the neuroendocrine and behavioral responses to stress. The researchers seek to identify other neuropeptides related to CRH which may have similar functions. Because abnormal regulation of such neuropeptides likely contributes to disease, the molecules and their receptors are attractive targets for the development of new drugs.

Majzoub's work is also directed at determining how DNA variants in the gene for corticotropin releasing hormone affect stress and other behaviors, including appetite. He and his colleagues are currently working to define how transcriptional silencers interact with transciptional activators to regulate CRH gene expression.

Research Funding

2007-2012    NIH NIDDK T32DK07699
Research in Developmental Endocrinology and Metabolism
Role: PI

2007-2010    NIH 5R01HD034568 (PI: Gillman, Matthew)
Pre- and peri-natal predictors of childhood obesity
Role: Co-PI

Teaching Awards
A. Clifford Barger Award for Excellence in Mentoring, from Harvard Medical School

2002 Irving M. London Teaching Award, from Harvard Medical School-Massachusetts Institute of Technology Health Sciences Technology (HST) Program

Selected Publications

Sharara-Chami RI, Joachim M, Pacak K, Majzoub JA. Glucocorticoid treatment--effect on adrenal medullary catecholamine production.
Shock. 2010 Feb;33(2):213-7. [PMID: 19503019]

Fasting MH, Oken E, Mantzoros CS, Rich-Edwards JW, Majzoub JA, Kleinman K, Rifas-Shiman SL, Vik T, Gillman MW. Maternal levels of corticotropin-releasing hormone during pregnancy in relation to adiponectin and leptin in early childhood.
J Clin Endocrinol Metab. 2009 Apr;94(4):1409-15. Epub 2009 Feb 3. [PMID: 19190112]

Scribner KB, Pawlak DB, Aubin CM, Majzoub JA, Ludwig DS. Long-term effects of  dietary glycemic index on adiposity, energy metabolism, and physical activity in  mice.
Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1126-31. Epub 2008 Sep 9. [PMID: 18780772]

Linhart KB, Majzoub JA. Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin.
Endocrinology. 2008 Feb;149(2):681-6.  Epub 2007 Nov 8. [PMID: 17991729]

Gillman MW, Rich-Edwards JW, Huh S, Majzoub JA, Oken E, Taveras EM, Rifas-Shiman SL. Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity.
Obesity (Silver Spring). 2006 Sep;14(9):1647-53. [PMID: 17030976]

Strong EF, Kleinman KP, Gillman MW, Clark I, Emanuel RL, Majzoub JA, Rich-Edwards JW. Measuring corticotropin-releasing hormone in pregnant women - comparing blood collection protocols for epidemiological studies.
Paediatr Perinat Epidemiol. 2006 Jan;20(1):67-71. [PMID: 16420343]

Silverman ES, Breault DT, Vallone J Subramanian S, Yilmaz AD, Mathew S, Subramaniam V  Tantisira K, Pacák K, Weiss ST, Majzoub JA. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. 
J Allergy Clin Immunol 2004; 114: 747-54. [PMID: 15480311]

Jeong KH, Sakihara S, Widmaier EP, Majzoub JA. Impaired leptin expression and abnormal  response to fasting in corticotropin-releasing hormone-deficient mice. 
Endocrinology 2004; 145: 3174–3181. [PMID: 15033910]

Venihaki M, Sakihara S, Subramanian S, Dikkes P, Weninger SC, Liapakis G, Graf T, Majzoub JA. Urocortin III, a Brain Neuropeptide of the Corticotropin-Releasing Hormone Family:  Modulation by Stress and Attenuation of Some Anxiety-Like Behaviors.
J Neuroendocrinol 2004; 16: 411–22. [PMID: 15117334]

Seth K, Majzoub JA. REST/NRSF can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription.
Journal of Biology Chemistry 2001; 276: 13917-13923. [PMID: 11278361]

Karalis K, Goodwin G, Majzoub JA. Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of labor.
Nature Medicine 1996; 2: 556-560. [PMID: 8616715]

Muglia LJ, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need.
Nature 1995; 373: 427-432. [PMID: 10792002]

Reviews

Majzoub JA, Srivatsa A. Diabetes insipidus: clinical and basic aspects.
Pediatr Endocrinol Rev. 2006 Dec;4 Suppl 1:60-5. Review. [PMID: 17261971]


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