Faculty Profile

Natalie Shaw, MD, MMSc


Instructor
Clinical and Research Fellow, Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital

See publications


Inter-office Mail Address

Mass General Hospital, REU, BHX5, 55 Fruit St, Boston, MA 02114

Fax 617-726-5357

Email nshaw@partners.org

Research Interests

As a Pediatric Endocrinologist, I am particularly interested in the control of puberty, and specifically in the augmentation of luteinizing hormone (LH) secretion at the time of puberty that initially occurs only during sleep. My preliminary studies suggest that deep sleep may play a role in LH pulse initiation. I am also interested in the related question of how increased levels of sex steroids secreted during puberty may feed back to alter sleep architecture during adolescence.

Mentor(s)

Janet Hall, MD

Research Funding

NIH-NICHD1F32HD062315-01A1 (Shaw PI) 7/1/10-6/30/12
The effect of sleep apnea on nocturnal GnRH/LH secretion in children during early puberty.

Boston Area Diabetes Endocrinology Research Center Pilot Grant (Shaw PI) 7/1/12-6/30/14 The effect of slow-wave sleep disruption on insulin sensitivity in pubertal children.

Pediatric Endocrine Society Clinical Scholars Award (Shaw PI) 7/1/12-6/30/14
The interaction between sleep and reproductive hormone secretion during puberty.

NIH-NICHD 1F32HD062315-01A1  (PI: Shaw)  7/1/10-6/30/12
The effect of sleep apnea on nocturnal GnRH/LH secretion in children in early puberty.

Charles King Trust (PI Shaw) 7/1/10-6/30/12
The effect of sleep apnea on nocturnal GnRH/LH secretion in children in early puberty.

Boston Area Diabetes Endocrinology Research Center Pilot and Feasibility Grant (PI Shaw) 7/1/12-6/30/14
The effect of slow-wave sleep deprivation on insulin sensitivity in pubertal children.

Pediatric Endocrine Society Clinical Scholar Award (Shaw PI) 7/1/12-6/30/14
The interaction between sleep and reproductive hormone secretion during puberty.

Selected Publications

Shaw ND*, Klingman KM*, Srouji SS, Histed SN, Hall JE. Gonadotropin responses to estrogen-positive and -negative feedback are identical in African-American and Caucasian women.
J Clin Endocrinol Metab. 2012 Jan;97(1):E106-9. [PMID: 22049179]

Marsh EE*, Shaw ND*, Klingman KM, Tiamfook-Morgan TO, Yialamas MA, Sluss PM, Hall JE. Estrogen levels are higher across the menstrual cycle in African-American women compared with Caucasian women.
J Clin Endocrinol Metab. 2011 Oct;96(10):3199-206. Epub 2011 Aug 17. [PMID: 21849524]

Shaw ND, Srouji SS, Histed SN, Hall JE. Differential effects of aging on estrogen negative and positive feedback.
Am J Physiol Endocrinol Metab. 2011 Aug;301(2):E351-5. Epub 2011 May 10. [PMID: 21558550]

Shaw ND*, Gill S*, Lavoie HB, Marsh EE, Hall JE. Persistence of sleep-associated decrease in GnRH pulse frequency in the absence of gonadal steroids.
J Clin Endocrinol Metab. 2011 Aug;96(8):2590-5. Epub 2011 Jun 6. [PMID: 21646369]

Shaw ND, Seminara SB, Welt CK, Au MG, Plummer L, Hughes VA, Dwyer AA, Martin KA, Quinton R, Mericq V, Merino PM, Gusella JF, Crowley WF Jr, Pitteloud N, Hall JE. Expanding the phenotype and genotype of female GnRH deficiency.
J Clin Endocrinol Metab. 2011 Mar;96(3):E566-76. Epub 2011 Jan 5. [PMID: 21209029]

Shaw ND, Histed SN, Srouji SS, Yang J, Lee H, Hall JE. Estrogen negative feedback on gonadotropin secretion: evidence for a direct pituitary effect in women.
J Clin Endocrinol Metab. 2010 Apr;95(4):1955-61. Epub 2010 Feb 4. [PMID: 20133465]

Shaw ND, Srouji SS, Histed SN, McCurnin KE, Hall JE. Aging attenuates the pituitary response to gonadotropin-releasing hormone.
J Clin Endocrinol Metab. 2009 Sep;94(9):3259-64. Epub 2009 Jun 23. [PMID: 19549740]

Quattrin T, Liu E, Shaw N, Shine B, Chiang E. Obese children who are referred to the pediatric endocrinologist: characteristics and outcome.
Pediatrics. 2005 Feb;115(2):348-51. [PMID: 15687443]

Brosh RM Jr, Karow JK, White EJ, Shaw ND, Hickson ID, Bohr VA. Potentinhibition of werner and bloom helicases by DNA minor groove binding drugs.
Nucleic Acids Res. 2000 Jun 15;28(12):2420-30. [PMID: 10871376]

*Contributed equally as first authors

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