Faculty Profile

Tobias Loddenkemper, MD

Tobias Loddenkemper, MD
Associate Professor in Neurology, Harvard Medical School
Physician, Department of Neurobiology, Children's Hospital Boston

See publications

Society Memberships

American Academy of Neurology
American Clinical Neurophysiology Society
Child Neurology Society

Research Interests

What are we doing?

  • Comparative effectiveness and interventional clinical trials in pediatric status epilepticus and epileptic encephalopathies

How do we do it?

  • Inventing, evaluating and implementing clinically relevant biomarkers and treatment paradigms to assess and benchmark these based on clinical data, neurophysiology, imaging, pharmacogenomics and genetics, in collaboration with basic researcher locally, nationally, and internationally.
  • Developing and evaluating monitoring tools for clinical biomarkers to further clinical epilepsy outcome measures including seizure characterization, neuropsychological outcome assessment, and quality of life assessment by means of seizure sensors and electronic tools including ICISS, the RENCI seizure tracking and outcome prediction modeling software, and novel in- and outpatient monitoring devices and algorithms, and neurophysiological, biochemical and genetic periodicity markers and implement these techniques into clinical workflow.
  • Research networks and collaborations are essential for our work, like the pediatric status epilepticus research group (www.pserg.org), the Pediatric Epilepsy Research Consortium , the pediatric critical care epilepsy research group, the Critical Care EEG consortium, the pediatric neurocritical care research group and other consortia.

Selected Publications

See full list in PubMed

Harini C, Singh K, Takeoka M, Parulkar I, Bergin AM, Loddenkemper T, Kothare SV. Predictors of seizure occurrence in children undergoing pre-surgical monitoring.
Seizure. 2013 Oct;22(8):640-6. Epub 2013 May 29. [PMID: 23725741]

Berg AT, Baca CB, Loddenkemper T, Vickrey BG, Dlugos D. Priorities in pediatric epilepsy research: Improving children's futures today.
Neurology. 2013 Sep 24;81(13):1166-1175. Epub 2013 Aug 21. [PMID: 23966254]

Sánchez Fernández I, Peters JM, An S, Bergin AM, Takeoka M, Rotenberg A, Kothare SV, Riviello JJ Jr, Loddenkemper T. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep.
Pediatr Neurol. 2013 Sep;49(3):163-170.e4. [PMID: 23953953]

Olson HE, Lechpammer M, Prabhu SP, Ciarlini PD, Poduri A, Gooty VD, Anjum MW, Gorman MP, Loddenkemper T. Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis.
Epilepsia. 2013 Aug 23. [PMID: 23980696]

Khatwa U, Ramgopal S, Singh K, Loddenkemper T, Zarowski M, Kothare SV. The Diagnostic Yield of Pediatric Polysomnography Based on the Professional Background of Referring Physicians. Clin Pediatr (Phila). 2013 Aug 22. [PMID: 23969985]

Sánchez SM, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez Fernández I, Shults J, Williams K, Yang A, Abend NS. Electroencephalography monitoring in critically ill children: current practice and implications for future study design.
Epilepsia. 2013 Aug;54(8):1419-27. Epub 2013 Jul 12. [PMID: 23848569]

Gaspard N, Foreman B, Judd LM, Brenton JN, Nathan BR, McCoy BM, Al-Otaibi A, Kilbride R, Fernández IS, Mendoza L, Samuel S, Zakaria A, Kalamangalam GP, Legros B, Szaflarski JP, Loddenkemper T, Hahn CD, Goodkin HP, Claassen J, Hirsch LJ, Laroche SM. Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study.
Epilepsia. 2013 Aug;54(8):1498-503. Epub 2013 Jun 12. [PMID: 23758557]

Mane KK, Loddenkemper T, Fernández IS, Mikati MA, Tennison M, Schmitt C, Wilhelmsen K, Leviton A. Visual aids to medical data and computational diagnostics: new frontiers in pediatric neurology.
Epilepsy Behav. 2013 Aug;28(2):258-60. Epub 2013 Jun 4. [PMID: 23756296]

Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, McBain K, Nash KB, Payne E, Sánchez SM, Fernández IS, Shults J, Williams K, Yang A, Dlugos DJ. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.
Neurology. 2013 Jul 23;81(4):383-91. Epub 2013 Jun 21. [PMID: 23794680]

Leviton A, Loddenkemper T, Pomeroy SL. Clinical practice guidelines and practice parameters for the child neurologist.
J Child Neurol. 2013 Jul;28(7):917-25. Epub 2013 Apr 10. [PMID: 23576411]

Taimouri V, Akhondi-Asl A, Tomas-Fernandez X, Peters JM, Prabhu SP, Poduri A, Takeoka M, Loddenkemper T, Bergin AM, Harini C, Madsen JR, Warfield SK. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy.
Int J Comput Assist Radiol Surg. 2013 Jun 23. [PMID: 23793723]

Glauser TA, Loddenkemper T. Management of childhood epilepsy.
Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):656-81. Erratum in: Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):568. Dosage error in article text. [PMID: 23739103]

Singh K, Katz ES, Zarowski M, Loddenkemper T, Llewellyn N, Manganaro S, Gregas M, Pavlova M, Kothare SV. Cardiopulmonary complications during pediatric seizures: a prelude to understanding SUDEP.
Epilepsia. 2013 Jun;54(6):1083-91. Epub 2013 Apr 5. [PMID: 23731396]

Allred E, An S, Leviton A, Loddenkemper T, McCrave J, Nichol SM. Should readmission within 30 days after discharge of children hospitalized for a neurologic disorder be considered a quality assurance failure?
J Child Neurol. 2013 Jun;28(6):758-61. Epub 2013 Mar 25. [PMID: 23529907]

Fernández IS, Loddenkemper T, Datta A, Kothare S, Riviello JJ Jr, Rotenberg A. Electroencephalography in the Pediatric Emergency Department: When Is It Most Useful?
J Child Neurol. 2013 Apr 16. [PMID: 23594820]

Ramgopal S, Thome-Souza S, Loddenkemper T. Chronopharmacology of anti-convulsive therapy.
Curr Neurol Neurosci Rep. 2013 Apr;13(4):339.Review. [PMID: 23456771]

Fernández IS, Chapman KE, Peters JM, Kothare SV, Nordli DR Jr, Jensen FE, Berg AT, Loddenkemper T. The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2013 Apr;54(4):741-50. Epub 2012 Nov 16. [PMID: 23163318]

Sanchez SM, Carpenter J, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Kessler SK, Loddenkemper T, Riviello JJ Jr, Abend NS; Pediatric Critical Care EEG Group. Pediatric ICU EEG monitoring: current resources and practice in the United States and Canada.
J Clin Neurophysiol. 2013 Apr;30(2):156-60. Review. [PMID: 23545766]

Abend NS, Chapman KE, Gallentine WB, Goldstein J, Hyslop AE, Loddenkemper T, Nash KB, Riviello JJ Jr, Hahn CD; Pediatric Critical Care EEG Group (PCCEG) and the Critical Care EEG Monitoring Research Consortium (CCEMRC). Electroencephalographic monitoring in the pediatric intensive care unit.
Curr Neurol Neurosci Rep. 2013 Mar;13(3):330. Review. [PMID: 23335026]

Chavakula V, Sánchez Fernández I, Peters JM, Popli G, Bosl W, Rakhade S, Rotenberg A, Loddenkemper T. Automated quantification of spikes.
Epilepsy Behav. 2013 Feb;26(2):143-52. Epub 2013 Jan 3. [PMID: 23291250]

Sánchez Fernández I, Ramgopal S, Powell C, Gregas M, Zarowski M, Shah A, Vendrame M, Alexopoulos AV, Kothare SV, Loddenkemper T. Clinical evolution of seizures: distribution across time of day and sleep/wakefulness cycle.
J Neurol. 2013 Feb;260(2):549-57. Epub 2012 Oct 2. [PMID: 23052595]

Fogarasi A, Loddenkemper T, Mellado C, Tuxhorn I, Evers G, Sarco D, Burgess RC, Halász P, Barsis P, Gyorsok Z, Gyimesi C, Kóbor J, Siegler Z, Janszky J, Jakus R, Rásonyi G, Ebner A, Woermann FG, Sahin M. Sturge-Weber syndrome: clinical and radiological correlates in 86 patients.
Ideggyogy Sz. 2013 Jan 30;66(1-2):53-7. [PMID: 23607230]

Sánchez Fernández I, Chapman KE, Peters JM, Harini C, Rotenberg A, Loddenkemper T. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management.
Epilepsy Res Treat. 2013;2013:583531. Epub 2013 Aug 6. [PMID: 23991336]

Fernández IS, Peters J, Takeoka M, Rotenberg A, Prabhu S, Gregas M, Riviello JJ Jr, Kothare S, Loddenkemper T. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity.
J Child Neurol. 2013 Jan;28(1):83-9. Epub 2012 Apr 24. [PMID: 22532549]

Sánchez Fernández I, Loddenkemper T, Peters JM, Kothare SV. Electrical status epilepticus in sleep: clinical presentation and pathophysiology.
Pediatr Neurol. 2012 Dec;47(6):390-410. Review. [PMID: 23127259]

Blumberg J, Fernández IS, Vendrame M, Oehl B, Tatum WO, Schuele S, Alexopoulos AV, Poduri A, Kellinghaus C, Schulze-Bonhage A, Loddenkemper T. Dacrystic seizures: demographic, semiologic, and etiologic insights from a multicenter study in long-term video-EEG monitoring units.
Epilepsia. 2012 Oct;53(10):1810-9. Epub 2012 Jul 10. [PMID: 22780551]

Sánchez Fernández I, Loddenkemper T. Pediatric focal epilepsy syndromes.
J Clin Neurophysiol. 2012 Oct;29(5):425-40. Review. [PMID: 23027100]

Ramgopal S, Vendrame M, Shah A, Gregas M, Zarowski M, Rotenberg A, Alexopoulos AV, Wyllie E, Kothare SV, Loddenkemper T. Circadian patterns of generalized tonic-clonic evolutions in pediatric epilepsy patients.
Seizure. 2012 Sep;21(7):535-9. Epub 2012 Jun 19. [PMID: 22717517]

Fernández IS, Peters JM, Hadjiloizou S, Prabhu SP, Zarowski M, Stannard KM, Takeoka M, Rotenberg A, Kothare SV, Loddenkemper T. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep.
Epilepsia. 2012 Jul;53(7):1185-95. Epub 2012 May 11. [PMID: 22578248]

Ramgopal S, Shah A, Zarowski M, Vendrame M, Gregas M, Alexopoulos AV, Loddenkemper T, Kothare SV. Diurnal and sleep/wake patterns of epileptic spasms in different age groups.
Epilepsia. 2012 Jul;53(7):1170-7. Epub 2012 May 11. [PMID: 22578060.

Bateman LM, Begley CE, Ben-Menachem E, Berg AT, Berkovic SF, Cascino GD, Drazkowski J, Edwards JC, Engel J Jr, French JA, Gilliam FD, Hoerth MT, Jehi LE, Kanner AM, Krauss GL, Labiner DM, Loddenkemper T, Luders HO, McKhann GM 2nd, McLachlan R, Modi A, Pennell PB, Shafer PO, Sirven JI, Stern JM, Szaflarski JP, Theodore WH. Overcoming barriers to successful epilepsy management.
Epilepsy Curr. 2012 Jul;12(4):158-60. [PMID: 22936891]
Loddenkemper T. Chrono-epileptology: time to reconsider seizure timing.
Seizure. 2012 Jul;21(6):411. [PMID: 22698973]

Poh MZ, Loddenkemper T, Reinsberger C, Swenson NC, Goyal S, Madsen JR, Picard RW. Autonomic changes with seizures correlate with postictal EEG suppression.
Neurology. 2012 Jun 5;78(23):1868-76. Epub 2012 Apr 25. [PMID: 22539579]

Segal E, Vendrame M, Gregas M, Loddenkemper T, Kothare SV. Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy.
Pediatr Neurol. 2012 Jun;46(6):359-62. [PMID: 22633630]

Sánchez Fernández I, Takeoka M, Tas E, Peters JM, Prabhu SP, Stannard KM, Gregas M, Eksioglu Y, Rotenberg A, Riviello JJ Jr, Kothare SV, Loddenkemper T. Early thalamic lesions in patients with sleep-potentiated epileptiform activity.
Neurology. 2012 May 29;78(22):1721-7. Epub 2012 Apr 25. [PMID: 22539569]
Poh MZ, Loddenkemper T, Reinsberger C, Swenson NC, Goyal S, Sabtala MC, Madsen JR, Picard RW. Convulsive seizure detection using a wrist-worn electrodermal activity and accelerometry biosensor.
Epilepsia. 2012 May;53(5):e93-7. Epub 2012 Mar 20. [PMID: 22432935]

Sánchez Fernández I, Hadjiloizou S, Eksioglu Y, Peters JM, Takeoka M, Tas E, Abdelmoumen I, Rotenberg A, Kothare SV, Riviello JJ Jr, Loddenkemper T. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep.
Pediatr Neurol. 2012 May;46(5):312-8. [PMID: 22520353]

Vendrame M, Guilhoto LM, Loddenkemper T, Gregas M, Bourgeois BF, Kothare SV. Outcomes of epileptic spasms in patients aged less than 3 years: single-center United States experience.
Pediatr Neurol. 2012 May;46(5):276-80. [PMID: 22520347]

Peters JM, Tomas-Fernandez M, van Putten MJ, Loddenkemper T. Behavioral measures and EEG monitoring using the Brain Symmetry Index during the Wada test in children.
Epilepsy Behav. 2012 Mar;23(3):247-53. Epub 2012 Feb 16. [PMID: 22341967]

Vendrame M, Loddenkemper T, Zarowski M, Gregas M, Shuhaiber H, Sarco DP, Morales A, Nespeca M, Sharpe C, Haas K, Barnes G, Glaze D, Kothare SV. Analysis of EEG patterns and genotypes in patients with Angelman syndrome.
Epilepsy Behav. 2012 Mar;23(3):261-5. Epub 2012 Feb 16. [PMID: 22341959]

Leviton A, Nichol SM, Allred EN, Loddenkemper T. What is quality improvement and why should child neurologists care?
J Child Neurol. 2012 Feb;27(2):251-7. Epub 2011 Oct 12. Review. [PMID: 21997846]

Stamoulis C, Fernández IS, Chang BS, Loddenkemper T. Signal subspace integration for improved seizure localization.
Conf Proc IEEE Eng Med Biol Soc. 2012;2012:1016-9. [PMID: 23366067]

McLaughlin BL, Mariano LJ, Prakash SR, Kindle AL, Czarnecki A, Modarres MH, Rotenberg A, Loddenkemper T, Shoeb A, Schachter SC. An electroencephalographic recording platform for real-time seizure detection.
Conf Proc IEEE Eng Med Biol Soc. 2012;2012:875-8. [PMID: 23366032]

Loddenkemper T, Wyllie E, Hirsch E. Epileptic syndromes with focal seizures of childhood and adolescence.
Handb Clin Neurol. 2012;107:195-208. Review. [PMID: 22938972]

Loddenkemper T, Syed TU, Ramgopal S, Gulati D, Thanaviratananich S, Kothare SV, Alshekhlee A, Koubeissi MZ. Risk factors associated with death in in-hospital pediatric convulsive status epilepticus.
PLoS One. 2012;7(10):e47474. Epub 2012 Oct 26. [PMID: 23110074]

Loddenkemper T, Vendrame M, Zarowski M, Gregas M, Alexopoulos AV, Wyllie E, Kothare SV. Circadian patterns of pediatric seizures.
Neurology. 2011 Jan 11;76(2):145-53. [PMID: 21220719]

Guilhoto LM, Loddenkemper T, Vendrame M, Bergin A, Bourgeois BF, Kothare SV. Higher evening antiepileptic drug dose for nocturnal and early-morning seizures.
Epilepsy Behav. 2011 Feb;20(2):334-7. Epub 2010 Dec 30. [PMID: 21195032]

Poh MZ, Loddenkemper T, Swenson NC, Goyal S, Madsen JR, Picard RW. Continuous
monitoring of electrodermal activity during epileptic seizures using a wearable sensor.
Conf Proc IEEE Eng Med Biol Soc. 2010;2010:4415-8. [PMID: 21095760]

Zarowski M, Loddenkemper T, Vendrame M, Alexopoulos AV, Wyllie E, Kothare SV. Circadian distribution and sleep/wake patterns of generalized seizures in children.
Epilepsia. 2011 Mar 22. [Epub ahead of print] [PMID: 21426332]

Loddenkemper T, Lockley SW, Kaleyias J, Kothare SV. Chronobiology of epilepsy: diagnostic and therapeutic implications of chrono-epileptology.
J Clin Neurophysiol. 2011 Apr;28(2):146-53. [PMID: 21399517]

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