Faculty Profile

Daniel J. Gottlieb, MD, MPH

Associate Professor of Medicine, Harvard Medical School
Associate Physician, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital
Director, Sleep Disorders Center, VA Boston Healthcare System

See publications


Brigham and Women's Hospital
221 Longwood Ave. BLI 225E
Boston, MA 02115

Inter-office Mail Address


Society Memberships

American Academy of Sleep Medicine
Sleep Research Society
American Thoracic Society

Research Unit(s)

Program in Sleep and Cardiovascular Medicine, Program in Sleep Epidemiology

Research Interests

My research focuses on the epidemiology of the cardiovascular consequences of sleep disorders, with an emphasis on identification of susceptible populations based on genetic, demographic, behavioral and physiologic characteristics; and clinical trials of sleep apnea treatment to reduce cardiovascular risk and to reduce congestive heart failure morbidity and mortality, with an emphasis on alternatives to PAP therapy for those with asymptomatic or mildly symptomatic disease.  Secondary interests include the genetic epidemiology of common sleep phenotypes, including sleep apnea, insomnia, sleepiness and short sleep duration, and the cardiometabolic consequences of short sleep duration, insomnia, and other sleep disorders will also be pursued.

Research Funding

DVA/CSR&D I01 CX000578, PI: Gottlieb
Oxygen Versus PAP for Treatment of Sleep Apnea in Chronic Heart Failure.

DVA/RR&D I21 RX001351-01; PI: Gottlieb
Obstructive Sleep Apnea Treatment to Improve Cardiac Rehabilitation.

DVA/CSR&D: I01 CX008-12F PI: Goldstein
Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease.

DVA/HSR&D I01 HX000120, PI: Sparrow
An RCT of Telemedicine Interventions for OSA.


Associate Director, Sleep Medicine Fellowship Training Program, Boston University School of Medicine, co-supervising a weekly clinical case conference and giving five lectures annually.

Selected Publications

Gottlieb DJ, Punjabi NM, Mehra R, Patel SR, Quan SF, Babineau DC, Tracy RP, Rueschman M, Blumenthal RS, Lewis EF, Bhatt DL, Redline S.  CPAP versus Oxygen in Obstructive Sleep Apnea. 
N Engl J Med 2014;370.2276-85. [PMID: pending]

Chami HA, Fontes JD, Vasan RS, Keaney JF Jr, O’Connor GT, Larson MG, Benjamin EJ, Gottlieb DJ.  Vascular inflammation and sleep-disordered breathing in a community-based cohort. 
Sleep 2013;36:763-8.  [PMID: 23633759]

Chami HA, Resnick HE, Quan SF, Gottlieb DJ.  The association of incident cardiovascular disease with progression of sleep-disordered breathing. 
Circulation 2011; 123:1280-1286. [PMID:  21403097]

Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, Redline S, Resnick HE, Tong EK, Diener-West M, Shahar E.  A prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: The Sleep Heart Health Study. 
Circulation 2010; 122:352-360. [PMID: 20625114]

Chami HA, Keyes MJ, Vita JA, Mitchell GF, Larson MG, Fan S, Vasan RS, O’Connor GT, Benjamin EJ, Gottlieb DJ.  Brachial artery diameter, blood flow and flow-mediated dilatation in sleep-disordered breathing. 
Vascular Med 2009; 14:351-60.  [PMID: 19808720]

Chami HA, Devereux RB, Gottdiener JS, Mehra R, Roman MJ, Benjamin EJ, Gottlieb DJ.  Left ventricular morphology and systolic function in sleep-disordered breathing:  the Sleep Heart Health Study.
Circulation. 2008;117:2599-607. [PMID: 18458174]

Gottlieb DJ, O'Connor GT, Wilk JB: Genome-wide association of sleep and circadian phenotypes.
BMC Med Genet 2007; 8(Suppl 1):S9. doi:10.1186/1471-2350-8-S1-S9. [PMID: 17903308]

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