Faculty Profile

Matt T. Bianchi, MD, PhD

Assistant Professor of Neurology, Harvard Medical School
Assistant in Neurology, Sleep Division, Department of Neurology, Massachusetts General Hospital
Director, Sleep Division

See publications

Society Memberships


Research Interests

My major research interest is in understanding sleep architecture features that contribute to symptoms related to non-refreshing sleep, from both “trait” (inter-individual differences) and “state” (night-to-night variation in those with fluctuating symptoms) perspectives.  The approach involves quantitative analysis and modeling of sleep stage transition dynamics, using standard scoring rules as well as novel “state” designations (for example, based on cardiopulmonary metrics).  Because we and others have shown that the routine 1-night clinical sleep study contains insufficient data for robust architecture/transition analysis, I am focusing on long-term unobtrusive sleep monitoring in the home setting. 

The major clinical focus is currently on insomnia, with particular emphasis on sleep state misperception.  However, the exciting aspect to these home monitoring systems is their easy translation to neurological and psychiatric populations in which sleep disturbance is hypothesized to be related to the disease pathogenesis or response to treatment. 

Active collaborations continue with Dr Robert Thomas (BIDMC) on cardiopulmonary coupling methods, Dr Elizabeth Klerman (BWH) on computational modeling of sleep architecture, and Dr Syd Cash (MGH) on invasive electrophysiology of human sleep in epilepsy patients undergoing surgical evaluation. 

Finally, I have interests in decision theory applied to Neurological populations, including those with sleep disorders (Bayesian approaches, Markov decision trees, and quantifying the impact of uncertainty of input parameters used in these strategies).


Jesse Chu-Shore, PhD, 2009-2010
Ravi Kudesia, BA, 2010
Nathaniel Eiseman, BS, 2011-2012
Mihaela Bazalakova, MD, 2012-2013


Research Funding

2009-2011    Fellow, Clinical Investigator Training Program (Harvard, MIT, Merck, Pfizer), "Computational fingerprinting of sleep architecture in health and disease"

1/1/2011 - 12/30/2013  Center for Integration of Medicine and Innovative Technology Young Clinician Award
“Novel home monitoring approaches to insomnia diagnosis and treatment”

10/1/2011 - 9/30/2013  KL2 Medical Research Investigator Training Fellowship Harvard Catalyst, “Quantitative phenotyping of insomnia”

Selected Publications

Eiseman NA, Westover MB, Ellenbogen JM, Bianchi MT.  The Impact of Body Posture and Sleep Stages on Sleep Apnea Severity in Adults.
J Clin Sleep Med. 2012; 15;8(6):655-66. [PMID: 23243399]

Proctor A, Bianchi MT. Clinical pharmacology in sleep medicine.
ISRN Pharmacol. 2012; 914168. [PMID: 23213564] 

Bianchi MT, Thomas RJ. Technical advances in the characterization of the complexity of sleep and sleep disorders.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Nov 19. [PMID: 23174482] 

Kelly JM, Strecker RE, Bianchi MT. Recent developments in home sleep-monitoring devices.
ISRN Neurol. 2012; 768-794. [PMID: 23097718]

Bianchi MT, Wang W, Klerman EB.  Sleep misperception in healthy adults.
J Clin Sleep Med. 2012; 8(5):547-54. [PMID: 23066367]

Bianchi MT, Thomas RJ, Ellenbogen JM.  Hypnotics and Mortality Risk.
J Clin Sleep Med. 2012 15;8(4):351-2. [PMID: 22893762]

Kelly JM, Schwamm LH, Bianchi MT. Sleep telemedicine: a survey study of patient preferences.
ISRN Neurol. 2012,135329. [PMID: 22844614]

Kelly JM, Bianchi MT. Mammalian Sleep Genetics.
Neurogenetics. 2012 Nov;13(4):287-326. [PMID: 22976546]

Kudesia RS, Bianchi MT. Decreased nocturnal awakenings in young adults performing bikram yoga: a low-constraint home sleep monitoring study.
ISRN Neurology. 2012:153745. [PMID: 22577578]

Citi L, Bianchi MT, Klerman EB, Barbieri R. Instantaneous monitoring of sleep fragmentation by point process heart rate variability and respiratory dynamics. 
Conf Proc IEEE Eng Med Biol Soc. 2011;7735-8. [PMID: 22256131]

Bianchi MT, Eiseman NA, Cash SS, Mietus J, Peng CK, Thomas RJ. Probabilistic sleep architecture models in patients with and without sleep apnea.
J Sleep Res. 2011; 21(3):330-41. [PMID: 21955148]

Eiseman NA, Westover MB, Mietus JE, Thomas RJ, Bianchi MT. Classification algorithms for predicting sleepiness and sleep apnea severity.
J Sleep Res. 2011; 21(1): 101-112. [PMID: 21752133]

Chu-Shore J, Westover MB, Bianchi MT. Power Law versus Exponential State Transition  Dynamics: Application to Sleep-Wake Architecture.
PLoS One. 2010 Dec 2;5(12):e14204.[PMID: 21151998]

Bianchi MT, Cash SS, Mietus J, Peng CK, Thomas R. Obstructive sleep apnea alters sleep stage  transition dynamics.
PLoS One. 2010 Jun 28;5(6):e11356. [PMID: 20596541]

Bianchi, MT.  Screening for Obstructive Sleep Apnea: Bayes Weighs In.
The Open Sleep Journal. 2009; 2:56-59.

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