Faculty Profile

Anna Kalinchuk, PhD

Instructor of Psychiatry, Harvard Medical School
Instructor of Psychiatry, Department of Psychiatry, Harvard Medical School

See publications

Society Memberships

European SRS

Research Unit(s)

Research Interests

Neurochemical regulation of sleep homeostasis; roles of adenosine, nitric oxide and inducible nitric oxide synthase in the regulation of recovery sleep response after sleep deprivation.

Research Funding


Nitric oxide-mediated mechanisms of sleep regulation: spatial and temporal aspects
Principal Investigator: Anna V. Kalinchuk, PhD.
Sleep Research Society Foundation
Period: September 1, 2008 – September 1, 2009.

Role of Adenosine and NF-kB in Prolonged Wakefulness: A Molecular Study
Principal Investigator: Radhika Basheer, Ph.D.
Medical Research Service Merit Award, Department of Veterans Affairs
Period: April 1, 2006 – March 31, 2010
The molecular mechanisms underlying the long term effects of sleep deprivation (SD).


Synaptic Basis of Sleep Cycle Control (MERIT Award, fourth 5 year approval)
Principal Investigator: Robert W. McCarley, M.D.
NIMH R37 MH39683
Period: September 1, 1987 - April 30, 2002
Period: May 1, 2002 - April 30, 2007
Cholinergic and adenosinergic mechanisms of sleep (completed).   

Nitric oxide and the regulation of behavioral state
Principal Investigator: Paul A. Rosenberg, M.D. (Program Director: Tarja Porkka-Heiskanen, M.D., PhD.).
P50 HL 60292/13
Period: September 1, 2003 – August, 31, 2008
NO-mediated mechanisms of homeostatic sleep control (completed).

Selected Publications

Gass N, Porkka-Heiskanen T, Kalinchuk AV. The role of the basal forebrain adenosine receptors in sleep homeostasis.
Neuroreport. 2009 Jul 15;20(11):1013-8. [PMID: 19491711]

Rytkönen KM, Wigren HK, Kostin A, Porkka-Heiskanen T, Kalinchuk AV. Nitric oxide mediated recovery sleep is attenuated with aging.
Neurobiol Aging. 2008 Dec 4. [Epub ahead of print] [PMID: 19058880]

Kalinchuk AV, McCarley RW, Stenberg D, Porkka-Heiskanen T, Basheer R. The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions.
Neuroscience. 2008 Nov 11;157(1):238-53. Epub 2008 Aug 27. [PMID: 18805464]

Kostin A, Stenberg D, Kalinchuk AV, Porkka-Heiskanen T. Nitric oxide modulates the discharge rate of basal forebrain neurons.
Psychopharmacology (Berl). 2008 Nov;201(1):147-60. Epub 2008 Jul 26. [PMID: 18661122]

Kalinchuk AV, Porkka-Heiskanen T, McCarley RW. Basal forebrain and saporin cholinergic lesions: the devil dwells in delivery details.
Sleep. 2006 Nov 1;29(11):1385-7; discussion 1387-9. [PMID: 17162984]

Kalinchuk AV, Lu Y, Stenberg D, Rosenberg PA, Porkka-Heiskanen T. Nitric oxide production in the basal forebrain is required for recovery sleep.
J Neurochem. 2006 Oct;99(2):483-98. [PMID: 17029601]

Kalinchuk AV, Stenberg D, Rosenberg PA, Porkka-Heiskanen T. Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction.
Eur J Neurosci. 2006 Sep;24(5):1443-56. [PMID: 16987226]

Porkka-Heiskanen T, Kalinchuk A, Alanko L, Huhtaniemi I, Stenberg D. Orexin A and B levels in the hypothalamus of female rats: the effects of the estrous cycle and age.
Eur J Endocrinol. 2004 May;150(5):737-42. [PMID: 15132733]

Kalinchuk AV, Urrila AS, Alanko L, Heiskanen S, Wigren HK, Suomela M, Stenberg D, Porkka-Heiskanen T. Local energy depletion in the basal forebrain increases sleep.
Eur J Neurosci. 2003 Feb;17(4):863-9. [PMID: 12603276]


Porkka-Heiskanen T, Kalinchuk A, Alanko L, Urrila A, Stenberg D. Adenosine, energy metabolism, and sleep.
ScientificWorldJournal. 2003 Aug 20;3:790-8. Review. [PMID: 12941976]

Porkka-Heiskanen T, Alanko L, Kalinchuk A, Stenberg D. Adenosine and sleep.
Sleep Med Rev. 2002 Aug;6(4):321-32. Review. [PMID: 12531135]

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