Faculty Profile

Satvinder Kaur, PhD


Instructor in Neurology, Harvard Medical School
Instructor in Neurology, Department of Neurology, Beth Israel Deaconess Medical Center

See publications


Society Memberships

Society for Neuroscience
SRS

Research Unit(s)

System Neurobiology group (Saper), Beth Israel Deaconess Medical Center

Research Interests

My research interests are to understand the underlying mechanisms for the control of arousal and generation of ultradian rhythms like REM sleep. Investigative approaches to understand such mechaisms are: targeted lesions of selective neurons in different brain areas by conjugated immunotoxins or by the use of conditional transgenic mouse models. 

Teaching

Conducted Lab techniques class for Anatomy graduate students (year 2005 & 2006) in Department of Anatomy and Neurobiology, Dalhousie University.

Selected Publications

Kaur S, Thankachan S, Begum S, Liu M, Blanco-Centurion C, Shiromani PJ. Hypocretin-2 saporin lesions of the ventrolateral periaquaductal gray (vlPAG) increase REM sleep in hypocretin knockout mice.
PLoS One. 2009 Jul 22;4(7):e6346. [PMID: 19623260]

Thankachan S, Kaur S, Shiromani PJ. Activity of pontine neurons during sleep and cataplexy in hypocretin knock-out mice.
J Neurosci. 2009 Feb 4;29(5):1580-5. [PMID: 19193905]

Liu M, Thankachan S, Kaur S, Begum S, Blanco-Centurion C, Sakurai T, Yanagisawa M, Neve R, Shiromani PJ. Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice.
Eur J Neurosci. 2008 Oct;28(7):1382-93. [PMID: 18973565]

Kaur S, Junek A, Black MA, Semba K. Effects of ibotenate and 192IgG-saporin lesions of the nucleus basalis magnocellularis/substantia innominata on spontaneous sleep and wake states and on recovery sleep after sleep deprivation in rats.
J Neurosci. 2008 Jan 9;28(2):491-504. [PMID: 18184792]

Kaur S, Thankachan S, Begum S, Blanco-Centurion C, Sakurai T, Yanagisawa M, Shiromani PJ. Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice.
Brain Res. 2008 Apr 18;1205:47-54. Epub 2008 Feb 21. [PMID: 18343358]

Zhang S, Lin L, Kaur S, Thankachan S, Blanco-Centurion C, Yanagisawa M, Mignot E, Shiromani PJ. The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats.
Neuroscience. 2007 Aug 10;148(1):34-43. Epub 2007 Jul 6. [PMID: 17618058]

Kaur S, Rusak B. Optic enucleation eliminates circadian rhythm shifts induced by stimulating the intergeniculate leaflet in Syrian hamsters.
Neurosci Lett. 2007 Nov 5;427(2):107-11. Epub 2007 Sep 19. [PMID: 17931778]

Book Articles

Mallick, B.N., Kaur, S, Thankachan, S. and Pal, D. (2004) Role of wakefulness area in the brainstem reticular formation in regulating rapid eye movement sleep. In: Lader, M, Daniel P. Cardinali and Pandi-Perumal, S.R. (eds.) Sleep and Sleep Disorders: A Neuropsycholpharmacological Approach (Vol. 1& 2), Landes Bioscience. Texas, USA; 1-8.

Mallick, B. N, Thankachan S, Kaur S, Jha S.K. (2001) Application of biophysical correlates to study neural regulation of some physiological phenomena. In: Saradhi, P.P. (eds.) Biophysical Processes in Living Systems, Science Publishers Inc. Enfield, NH, USA; 327-341.

Mallick B N, Kaur S, Jha S K and Siegel J M (1999) Possible role of GABA in the regulation of REM sleep with special reference to REM-OFF neurons. In Mallick, B. N. and Inoue, S. (eds.), The rapid eye movement sleep, Marcel and Dekker, New York, pp. 153-166.

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