Faculty Profile

Susan Redline, MD, MPH

Susan Redline, MD, MPH
Peter C. Farrell Professor of Sleep Medicine, Harvard Medical School
Senior Physician, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital
Physician, Division of Pulmonary Medicine, Department of Medicine, Beth Israel Deaconess Medical Center

See publications


Phone 617-983-7420

Email sredline@partners.org

Research Unit(s)

Division of Sleep Medicine
Program in Sleep and Cardiovascular Medicine

Research Interests

My research interests are primarily focused on: 1)  conducting epidemiological studies designed to elucidate the etiologies of sleep disorders, including the role of genetic and early life developmental factors, and 2) conducting epidemiological and clinical trials aimed at understanding the health outcomes, particularly the cardiovascular consequences, of sleep disorders and the role of sleep interventions in improving health.

I attempt to integrate physiology, clinical medicine, and genetics in epidemiological designs that include: 1) genetic epidemiological studies of sleep apnea and related traits; 2) development/participation in large multicenter observational studies of adult populations; 3) development of pediatric cohort studies to study subclinical markers of cardiovascular disease in relationship to sleep disorders; and 4) intervention trials. 


Trainees

Anna Mandalakas, MD, MPH, 1999-2006
Carol Rosen, MD, 1999-2005
Parvin Dorotskar, MD, 1999-2004
Amy Heneghan, MD, MPH, 2001-2005
Sanjay Patel, MD, MS, 2001-2003
Loreto Sulit, MD, 2002-2005
Michael Faulx, MD, 2002-2005
Sam Friedlander, MD, 2002-2003
John Grischkan, 2002-2003
Kenneth Monahan, MD, 2002-2006
Lisabeth Scalzi, MD, 2002-2007
Reena Mehra, MD, MS, 2002-2011
James Spilsbury, PhD, 2003-2010
Emma Larkin, PhD, 2003-2009
Krishna Anchala, MD, 2003-2004
Sinziana Seicean, 2003-2010
Andreea Seicean, 2004-2005
Robyn Strosacker, MD, 2005-2007
Sarah Lee Hirshfield, MD, 2005-2008
Lamia Ibrahim, MD, 2005-2007
Anna Maria Hibbs, MD, MS, 2006-2011
Kristen Ross, 2007-2011
Yamini Letvisky, MD, 2007-2009
Sogol Javaheri, 2007-2008
Basil Anderson, 2007-2008
Allison Weiss, 2008-2009
Judette Louis, MD, MPH, 2008-present
T. Weinstock, 2010-present
Brian Cade, 2010-present
N. Shah, 2010-present
Andre Boin, 2013

Research Funding

R01HL098433 (PI: Redline)    07/05/2010-04/30/2015
NIH       
Association of Sleep Disorders with Cardiovascular Health Across Ethnic Groups
This ancillary study to the Multiethnic Study of Atherosclerosis (MESA) is designed to add objective measurements of sleep apnea and sleep patterns (via in-home polysomnography and actigraphy) to 2500 MESA participants to address the role of sleep disturbances to the pathogenesis of cardiovascular disease across ethnic groups.

1-RO1 HL070839 (PI: Stone)    07/01/2003-04/30/2014
NIH/NHLBI
Outcomes of Sleep Disorders in Older Men (PSG Reading Center)
The objectives are to evaluate the association of sleep disturbances with mortality, cardiovascular disease, falls, metabolic dysfunction and fractures in 3000 older men recruited from the MrOS study, a multicenter study.  I provide leadership for protocol development and implementation, and over the processing, analysis, quality assurance and technical support for sleep data. These data will provide the source for analyses in the current proposal.

HHSN268200625233C/N01-HC-65233 Hispanic Community Health Study (UNC DCC PI: Chambless; BWH Reading Center PI: Redline)     10/01/2006-03/31/2013
NIH
This longitudinal multicenter study will recruit and comprehensively measure risk factors and health outcomes in 16000 Hispanic adults from 4 sites across the US. Il direct all aspects of the protocol related to measuring and interpreting sleep data.

1R01HL102830 (PI: Hanis, Reading Center PI: Redline)    07/07/2010-05/31/2014
NIH
GWAS for Sleep Apnea and Endothelial Function Among Mexican Americans
This study to will evaluate sleep apnea and indices of vascular disease in 1300 Mexican Americans to determine the contribution of genetic variation to obstructive sleep apnea, impaired endothelial function, central blood pressure, aortic stiffness and their profile and to determine whether type 2 diabetes and pre-diabetes mediate genomic associations with this axis of non-traditional risk factors. Dr Redline provides oversight for all measurements and interpretation of the new sleep apnea phenotypes.

HL94092 (PI: Redline) 09/01/1999-08/31/2004    Renewal:09/01/2004-08/31/2011
NIH/NHLBI Sleep Heart Health Study (SHHS)
This multi-center longitudinal study assesses the cardiovascular consequences of SDB in 6440 members of communities across the US (the Sleep Heart Health Study). Our Center pioneered approaches for collecting, processing, and analyzing complex polysomnography for such a study. I assist in the protocol development, provide centralized scoring, and quality control for sleep studies collected to better understand cardiovascular morbidity occurring with sleep apnea. Genotype data are available from three of the cohorts in SHHS.

1RC2HL101417-01 (PI: Redline)    09/30/09-08/31/2011
NIH
Phase II Trial of Sleep Apnea Treatment to Reduce Cardiovascular Morbidity
This comparative effectiveness study compares changes in intermediate markers of CVD after 3 months of sleep apnea treatment in patients recruited from cardiology practices randomized to nocturnal oxygen supplementation vs CPAP.

1R01 HL083075 NIH/NHLBI (PI: Redline)    09/25/2006-07/31/2011       
A Randomized Controlled Study of Adenotonsillectomy for Childhood Sleep Apnea
This multicenter study addresses the hypothesis that adenotonsillectomy for treatment of obstructive sleep apnea in children aged 5 to 9 years will result in improvements in health outcomes determined 6 months following adenotonsillectomy.  460 children with sleep apnea will be recruited from 4 sites and randomized to early surgery vs watchful waiting, with determination of neurocognitive, behavioral and physiological outcomes. I provide overall leadership for this multi-center study.

Awards and Honors
1984 Northern Ohio Lung Association’s Charles Popelka Research Award    
1996 Award of Tenure, Case Western Reserve University
1998-2001 Million Dollar Professor, Case Western Reserve University
1999 US Delegate, NIH-Italian Joint Conference on Pulmonary Disorders
2007 Spotlight on Women Scholarship Award, Case Western Reserve University
2008 Annenberg Award (Sleep In Infancy and Childhood Award)
2008 Elected to Association of American Physicians (AAP)
2008 Cleveland CTSC Appreciation Award

Selected Publications

Yeboah J, Redline S, Johnson C, Tracy R, Ouyang P, Blumenthal RS, Burke GL, Herrington DM. Association between sleep apnea, snoring, incident cardiovascular events and all-cause mortality in an adult population: MESA.
Atherosclerosis. 2011 Dec;219(2):963-8. Epub 2011 Aug 22. [PMID: 22078131]

Billings ME, Auckley D, Benca R, Foldvary-Schaefer N, Iber C, Redline S, Rosen CL, Zee P, Kapur VK. Race and Residential Socioeconomics as Predictors of CPAP Adherence.
Sleep. 2011 Dec 1;34(12):1653-8. [PMID: 22131602]

Ross KR, Storfer-Isser A, Hart MA, Kibler AM, Rueschman M, Rosen CL, Kercsmar
CM, Redline S. Sleep-Disordered Breathing is Associated with Asthma Severity in Children.
J Pediatr. 2011 Nov 30. [Epub ahead of print] [PMID: 22133422]

Redline S, Foody J. Sleep disturbances: time to join the top 10 potentially modifiable cardiovascular risk factors?
Circulation. 2011 Nov 8;124(19):2049-51. [PMID: 22064955]

Monahan K, Redline S. Role of obstructive sleep apnea in cardiovascular disease.
Curr Opin Cardiol. 2011 Nov;26(6):541-7. [PMID: 21993356]

N'diaye A, Chen GK, Palmer CD, Ge B, Tayo B, Mathias RA, Ding J, Nalls MA, Adeyemo A, Adoue V, Ambrosone CB, Atwood L, Bandera EV, Becker LC, Berndt SI, Bernstein L, Blot WJ, Boerwinkle E, Britton A, Casey G, Chanock SJ, Demerath E, Deming SL, Diver WR, Fox C, Harris TB, Hernandez DG, Hu JJ, Ingles SA, John EM, Johnson C, Keating B, Kittles RA, Kolonel LN, Kritchevsky SB, Le Marchand L, Lohman K, Liu J, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, North KE, Nyante S, Ogunniyi A, Ostrander EA, Papanicolaou G, Patel S, Pettaway CA, Press MF, Redline S, Rodriguez-Gil JL, Rotimi C, Rybicki BA, Salako B, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Stram AH, Stram DO, Strom SS, Suktitipat B, Thun MJ, Witte JS, Yanek LR, Ziegler RG, Zheng W, Zhu X, Zmuda JM, Zonderman AB, Evans MK, Liu Y, Becker DM, Cooper RS, Pastinen T, Henderson BE, Hirschhorn JN, Lettre G, Haiman CA. Correction: identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
PLoS Genet. 2011 Nov;7(11). [PMID: 22140371]

Redline S, Amin R, Beebe D, Chervin RD, Garetz SL, Giordani B, Marcus CL, Moore RH, Rosen CL, Arens R, Gozal D, Katz ES, Mitchell RB, Muzumdar H, Taylor HG, Thomas N, Ellenberg S. The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population.
Sleep. 2011 Nov 1;34(11):1509-17. [PMID: 22043122; [Central PMCID: PMC3198206]

Beaudreau SA, Spira AP, Stewart A, Kezirian EJ, Lui LY, Ensrud K, Redline S, Ancoli-Israel S, Stone KL; for the Study of Osteoporotic Fractures. Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women.
Sleep Med. 2011 Oct 25. [Epub ahead of print] [PMID: 22033120]

Koo BB, Drummond C, Surovec S, Johnson N, Marvin SA, Redline S. Validation of a polyvinylidene fluoride impedance sensor for respiratory event classification during polysomnography.
J Clin Sleep Med. 2011 Oct 15;7(5):479-85. [PMID: 22003343]

Fung MM, Peters K, Redline S, Ziegler MG, Ancoli-Israel S, Barrett-Connor E, Stone KL; Osteoporotic Fractures in Men Research Group. Decreased slow wave sleep increases risk of developing hypertension in elderly men.
Hypertension. 2011 Oct;58(4):596-603. Epub 2011 Aug 29. [PMID: 21876072]

N'Diaye A, Chen GK, Palmer CD, Ge B, Tayo B, Mathias RA, Ding J, Nalls MA, Adeyemo A, Adoue V, Ambrosone CB, Atwood L, Bandera EV, Becker LC, Berndt SI, Bernstein L, Blot WJ, Boerwinkle E, Britton A, Casey G, Chanock SJ, Demerath E, Deming SL, Diver WR, Fox C, Harris TB, Hernandez DG, Hu JJ, Ingles SA, John EM, Johnson C, Keating B, Kittles RA, Kolonel LN, Kritchevsky SB, Le Marchand L, Lohman K, Liu J, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, North KE, Nyante S, Ogunniyi A, Ostrander EA, Papanicolaou G, Patel S, Pettaway CA, Press MF, Redline S, Rodriguez-Gil JL, Rotimi C, Rybicki BA, Salako B, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Stram AH, Stram DO, Strom SS, Suktitipat B, Thun MJ, Witte JS, Yanek LR, Ziegler RG, Zheng W, Zhu X, Zmuda JM, Zonderman AB, Evans MK, Liu Y, Becker DM, Cooper RS, Pastinen T, Henderson BE, Hirschhorn JN, Lettre G, Haiman CA. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
PLoS Genet. 2011 Oct;7(10):e1002298. Epub 2011 Oct 6. [PMID: 21998595]

Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Ensrud KE, Stefanick ML, Laffan A, Stone KL; Osteoporotic Fractures in Men (MrOS) Study Group. Association of sleep characteristics and cognition in older community-dwelling men: the MrOS  sleep study.
Sleep. 2011 Oct 1;34(10):1347-56. [PMID: 21966066]

Spira AP, Beaudreau SA, Stone KL, Kezirian EJ, Lui LY, Redline S, Ancoli-Israel S, Ensrud K, Stewart A; for the Osteoporotic Fractures in Men Study. Reliability and Validity of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in Older Men.
J Gerontol A Biol Sci Med Sci. 2011 Sep 20. [Epub ahead of print] [PMID: 21934125]

Koo BB, Blackwell T, Ancoli-Israel S, Stone KL, Stefanick ML, Redline S; Osteoporotic Fractures in Men (MrOS) Study Group. Association of incident cardiovascular disease with periodic limb movements during sleep in older men: outcomes of sleep disorders in older men (MrOS) study.
Circulation. 2011 Sep 13;124(11):1223-31. Epub 2011 Aug 22. [PMID: 21859975]

Tran VA, Johnson N, Redline S, Zhang GQ. OnWARD: Ontology-driven web-based framework for multi-center clinical studies.
J Biomed Inform. 2011 Sep 8. [Epub ahead of print] [PMID: 21924379]

Ross C, Ancoli-Israel S, Redline S, Stone K, Fredman L. Association between insomnia symptoms and weight change in older women: caregiver-study of osteoporotic fractures study.
J Am Geriatr Soc. 2011 Sep;59(9):1697-704. doi: 10.1111/j.1532-5415.2011.03569.x. Epub 2011 Aug 30. [PMID: 21883114]

Blackwell T, Ancoli-Israel S, Redline S, Stone KL; Osteoporotic Fractures in Men (MrOS) Study Group. Factors that may influence the classification of sleep-wake by wrist actigraphy: the MrOS Sleep Study.
J Clin Sleep Med. 2011 Aug 15;7(4):357-67. [PMID: 21897772]

Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, Ancoli-Israel S, Stone KL. Sleep-disordered breathing, hypoxia, and risk of mild  cognitive impairment and dementia in older women.
JAMA. 2011 Aug 10;306(6):613-9. [PMID: 21828324]

Seicean S, Neuhauser D, Strohl K, Redline S. An exploration of differences in sleep characteristics between Mexico-born US immigrants and other Americans to address the Hispanic Paradox.
Sleep. 2011 Aug 1;34(8):1021-31. [PMID: 21804664]

Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Boerwinkle E, Cai Q, Caporaso N, Casey G, Cupples LA, Deming SL, Diver WR, Divers J, Fornage M, Gillanders EM, Glessner J, Harris CC, Hu JJ, Ingles SA, Isaacs W, John EM, Kao WH, Keating B, Kittles RA, Kolonel LN, Larkin E, Le Marchand L, McNeill LH, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, Nyante S, Papanicolaou GJ, Press MF, Psaty BM, Reiner AP, Rich SS, Rodriguez-Gil JL, Rotter JI, Rybicki BA, Schwartz AG, Signorello LB, Spitz M, Strom SS, Thun MJ, Tucker MA, Wang Z, Wiencke JK, Witte JS, Wrensch M, Wu X,
Yamamura Y, Zanetti KA, Zheng W, Ziegler RG, Zhu X, Redline S, Hirschhorn JN, Henderson BE, Taylor HA Jr, Price AL, Hakonarson H, Chanock SJ, Haiman CA, Wilson JG, Reich D, Myers SR. The landscape of recombination in African Americans.
Nature. 2011 Jul 20;476(7359):170-5. doi: 10.1038/nature10336. [PMID: 21775986]

Estes NA 3rd, Sacco RL, Al-Khatib SM, Ellinor PT, Bezanson J, Alonso A, Antzelevitch C, Brockman RG, Chen PS, Chugh SS, Curtis AB, DiMarco JP, Ellenbogen KA, Epstein AE, Ezekowitz MD, Fayad P, Gage BF, Go AS, Hlatky MA, Hylek EM, Jerosch-Herold M, Konstam MA, Lee R, Packer DL, Po SS, Prystowsky EN, Redline S,  Rosenberg Y, Van Wagoner DR, Wood KA, Yue L, Benjamin EJ. American Heart Association atrial fibrillation research summit: a conference report from the American Heart Association.
Circulation. 2011 Jul 19;124(3):363-72. Epub 2011 Jun 27. [PMID: 21709057]

Zhu X, Young JH, Fox E, Keating BJ, Franceschini N, Kang S, Tayo B, Adeyemo A, Sun YV, Li Y, Morrison A, Newton-Cheh C, Liu K, Ganesh SK, Kutlar A, Vasan RS, Dreisbach A, Wyatt S, Polak J, Palmas W, Musani S, Taylor H, Fabsitz R, Townsend  RR, Dries D, Glessner J, Chiang CW, Mosley T, Kardia S, Curb D, Hirschhorn JN, Rotimi C, Reiner A, Eaton C, Rotter JI, Cooper RS, Redline S, Chakravarti A, Levy D. Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.
Hum Mol Genet. 2011 Jun 1;20(11):2285-95. Epub 2011 Mar 21. [PMID: 21422096]

Hamidovic A, Kasberger JL, Young TR, Goodloe RJ, Redline S, Buxbaum SG, Benowitz NL, Bergen AW, Butler KR, Franceschini N, Gharib SA, Hitsman B, Levy D,  Meng Y, Papanicolaou GJ, Preis SR, Spring B, Styn MA, Tong EK, White WB, Wiggins  KL, Jorgenson E. Genetic variability of smoking persistence in African Americans.
Cancer Prev Res (Phila). 2011 May;4(5):729-34. Epub 2011 Mar 24. [PMID: 21436384]

Paudel ML, Taylor BC, Ancoli-Israel S, Stone KL, Tranah G, Redline S, Barrett-Connor E, Stefanick ML, Ensrud KE. Rest/activity rhythms and cardiovascular disease in older men.
Chronobiol Int. 2011 Apr;28(3):258-66. [PMID: 21452921]

Javaheri S, Storfer-Isser A, Rosen CL, Redline S. Association of short and long sleep durations with insulin sensitivity in adolescents.
J Pediatr. 2011 Apr;158(4):617-23. Epub 2010 Dec 10. [PMID: 21146189]

Field JJ, Stocks J, Kirkham FJ, Rosen CL, Dietzen DJ, Semon T, Kirkby J, Bates P, Seicean S, DeBaun MR, Redline S, Strunk RC. Airway hyperresponsiveness in children with sickle cell anemia.
Chest. 2011 Mar;139(3):563-8. Epub 2010 Aug  19. [PMID: 20724735]

Moore M, Kirchner HL, Drotar D, Johnson N, Rosen C, Redline S. Correlates of  adolescent sleep time and variability in sleep time: the role of individual and health related characteristics.
Sleep Med. 2011 Mar;12(3):239-45. [PMID: 21316300]

Thompson CL, Larkin EK, Patel S, Berger NA, Redline S, Li L. Short duration of sleep increases risk of colorectal adenoma.
Cancer. 2011 Feb 15;117(4):841-7.  doi: 10.1002/cncr.25507. Epub 2010 Oct 8. [PMID: 20936662]

Brown DL, Anderson CS, Chervin RD, Kushida CA, Lewin DS, Malow BA, Redline S, Goldman EB. Ethical issues in the conduct of clinical trials in obstructive sleep apnea.
J Clin Sleep Med. 2011 Feb 15;7(1):103-8. Review. [PMID: 21344041]

Smith JG, Magnani JW, Palmer C, Meng YA, Soliman EZ, Musani SK, Kerr KF, Schnabel RB, Lubitz SA, Sotoodehnia N, Redline S, Pfeufer A, Müller M, Evans DS,
Nalls MA, Liu Y, Newman AB, Zonderman AB, Evans MK, Deo R, Ellinor PT, Paltoo DN, Newton-Cheh C, Benjamin EJ, Mehra R, Alonso A, Heckbert SR, Fox ER; Candidate-gene Association Resource (CARe) Consortium. Genome-wide association studies of the PR interval in African Americans.
PLoS Genet. 2011 Feb 10;7(2):e1001304. [PMID: 21347284]

Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, Haiman CA, Hartiala J, Harris TB, Hazen SL, Heckbert SR, Henderson BE,  Hirschhorn JN, Keating BJ, Kritchevsky SB, Larkin E, Li M, Rudock ME, McKenzie CA, Meigs JB, Meng YA, Mosley TH, Newman AB, Newton-Cheh CH, Paltoo DN, Papanicolaou GJ, Patterson N, Post WS, Psaty BM, Qasim AN, Qu L, Rader DJ, Redline S, Reilly MP, Reiner AP, Rich SS, Rotter JI, Liu Y, Shrader P, Siscovick  DS, Tang WH, Taylor HA, Tracy RP, Vasan RS, Waters KM, Wilks R, Wilson JG,
Fabsitz RR, Gabriel SB, Kathiresan S, Boerwinkle E. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
PLoS Genet. 2011 Feb 10;7(2):e1001300. [PMID: 21347282]

Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert  J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ,  Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou  C, Boer A, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong  CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M,
Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ; Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT; Meena Kumari on behalf of the Whitehall II Study and the
WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.
Am J Hum Genet. 2011 Jan 7;88(1):6-18. Epub 2010 Dec 30. [PMID: 21194676]

Wassel CL, Lange LA, Keating BJ, Taylor KC, Johnson AD, Palmer C, Ho LA, Smith NL, Lange EM, Li Y, Yang Q, Delaney JA, Tang W, Tofler G, Redline S, Taylor HA Jr, Wilson JG, Tracy RP, Jacobs DR Jr, Folsom AR, Green D, O'Donnell CJ, Reiner AP. Association of genomic loci from a cardiovascular gene SNP array with  fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).
Blood. 2011 Jan 6;117(1):268-75. Epub 2010 Oct 26. [PMID: 20978265]

Liu Y, Patel S, Nibbe R, Maxwell S, Chowdhury SA, Koyuturk M, Zhu X, Larkin EK, Buxbaum SG, Punjabi NM, Gharib SA, Redline S, Chance MR. Systems biology analyses of gene expression and genome wide association study data in obstructive sleep apnea.
Pac Symp Biocomput. 2011:14-25. [PMID: 21121029]

Canales MT, Paudel ML, Taylor BC, Ishani A, Mehra R, Steffes M, Stone KL, Redline S, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Group. Sleep-disordered breathing and urinary albumin excretion in older men.
Sleep Breath. 2011 Jan;15(1):137-44. Epub 2010 Feb 26. [PMID: 20186573]

Larkin EK, Patel SR, Zhu X, Tracy RP, Jenny NS, Reiner AP, Walston J, Redline S. Study of the relationship between the interleukin-6 gene and obstructive sleep apnea.
Clin Transl Sci. 2010 Dec;3(6):337-9. [PMID: 21207764]

Larkin EK, Patel SR, Goodloe RJ, Li Y, Zhu X, Gray-McGuire C, Adams MD, Redline S. A candidate gene study of obstructive sleep apnea in European Americans and African Americans.
Am J Respir Crit Care Med. 2010 Oct 1;182(7):947-53. Epub 2010 Jun 10. [PMID: 20538960]

Zanobetti A, Redline S, Schwartz J, Rosen D, Patel S, O'Connor GT, Lebowitz M, Coull BA, Gold DR. Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas. Am
J Respir Crit Care Med. 2010  Sep 15;182(6):819-25. Epub 2010 May 27. [PMID: 20508218]

Mehra R, Xu F, Babineau DC, Tracy RP, Jenny NS, Patel SR, Redline S. Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results  of the Cleveland Family Study.
Am J Respir Crit Care Med. 2010 Sep 15;182(6):826-33. Epub 2010 May 27. [PMID:  20508215]

Weiss A, Xu F, Storfer-Isser A, Thomas A, Ievers-Landis CE, Redline S. The association of sleep duration with adolescents' fat and carbohydrate consumption.
Sleep. 2010 Sep;33(9):1201-9. [PMID: 20857867]

Weiss AR, Johnson NL, Berger NA, Redline S. Validity of activity-based devices to estimate sleep.
J Clin Sleep Med. 2010 Aug 15;6(4):336-42. PubMed PMID: 20726281]

Gottlieb DJ, Yenokyan G, Newman AB, O'Connor GT, Punjabi NM, Quan SF, Redline S, Resnick HE, Tong EK, Diener-West M, Shahar E. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study.
Circulation. 2010 Jul 27;122(4):352-60. Epub 2010 Jul 12. [PMID: 20625114]

Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O'Connor GT, Resnick HE, Diener-West M, Sanders MH, Wolf PA, Geraghty EM, Ali T, Lebowitz M, Punjabi NM. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study.
Am J Respir Crit Care Med. 2010 Jul 15;182(2):269-77. Epub 2010 Mar 25. [PMID: 20339144]

Johnson MC, Kirkham FJ, Redline S, Rosen CL, Yan Y, Roberts I, Gruenwald J, Marek J, DeBaun MR. Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation.
Blood. 2010 Jul 8;116(1):16-21. Epub 2010 Apr 8. [PMID: 20378754]

Mullin JE, Cooper B, Seicean S, Strunk R, Rosen C, Redline S, Kemp J, DeBaun MR. Variability of pulse oximetry measurement over 1 year in children with sickle cell disease depends on initial oxygen saturation measurement.
Pediatr Blood Cancer. 2010 Jul 1;54(7):1017-9. [PMID: 20135701]

Musunuru K, Lettre G, Young T, Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q, Chen MH, Lapchyk N, Crenshaw A, Ziaugra L, Rachupka A, Benjamin EJ, Cupples LA, Fornage M, Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C, Nizzari MM, Paltoo DN, Papanicolaou GJ, Patel SR, Psaty BM, Rader DJ, Redline S, Rich SS, Rotter JI, Taylor HA Jr, Tracy RP, Vasan RS, Wilson JG, Kathiresan S, Fabsitz RR, Boerwinkle E, Gabriel SB; NHLBI Candidate Gene Association Resource. Candidate gene association resource (CARe): design, methods, and proof of concept.
Circ Cardiovasc Genet. 2010 Jun;3(3):267-75. Epub 2010 Apr 17. [PMID: 20400780]

Tranah GJ, Parimi N, Blackwell T, Ancoli-Israel S, Ensrud KE, Cauley JA, Redline S, Lane N, Paudel ML, Hillier TA, Yaffe K, Cummings SR, Stone KL. Postmenopausal hormones and sleep quality in the elderly: a population based study.
BMC Womens Health. 2010 May 4;10:15. [PMID: 20441593]

Rohan J, Drotar D, McNally K, Schluchter M, Riekert K, Vavrek P, Schmidt A, Redline S, Kercsmar C. Adherence to pediatric asthma treatment in economically disadvantaged African-American children and adolescents: an application of growth curve analysis.
J Pediatr Psychol. 2010 May;35(4):394-404. Epub 2009 Aug 26. [PMID: 19710251]

Ibrahim LH, Jacono FJ, Patel SR, Thomas RJ, Larkin EK, Mietus JE, Peng CK, Goldberger AL, Redline S. Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique.
Sleep. 2010 May;33(5):643-6. [PMID: 20469806]

Redline S, Lewis EF. Gravitational influences and shifting propensity for sleep apnea: another source of heterogeneity or a new intervention target?
Circulation. 2010 Apr 13;121(14):1583-5. Epub 2010 Mar 29. [PMID: 20351240]

Reynolds CF 3rd, Redline S; DSM-V Sleep-Wake Disorders Workgroup and Advisors. The DSM-v sleep-wake disorders nosology: an update and an invitation to the sleep community.
J Clin Sleep Med. 2010 Feb 15;6(1):9-10. [PMID: 20191931]

Tranah GJ, Blackwell T, Ancoli-Israel S, Paudel ML, Ensrud KE, Cauley JA, Redline S, Hillier TA, Cummings SR, Stone KL; Study of Osteoporotic Fractures Research Group. Circadian activity rhythms and mortality: the study of osteoporotic fractures.
J Am Geriatr Soc. 2010 Feb;58(2):282-91. Epub 2010 Jan 26. [PMID: 20374404]

Paudel ML, Taylor BC, Ancoli-Israel S, Blackwell T, Stone KL, Tranah G, Redline S, Cummings SR, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study. Rest/activity rhythms and mortality rates in older men: MrOS Sleep Study.
Chronobiol Int. 2010 Jan;27(2):363-77. [PMID: 20370475]

Reynolds CF 3rd, Redline S; DSM-V Sleep-Wake Disorders Workgroup and Advisors. The DSM-V sleep-wake disorders nosology: an update and an invitation to the sleep community.
Sleep. 2010 Jan;33(1):10-1. [PMID: 20120613]

Monahan K, Storfer-Isser A, Mehra R, Shahar E, Mittleman M, Rottman J, Punjabi N, Sanders M, Quan SF, Resnick H, Redline S. Triggering of nocturnal arrhythmias by sleep-disordered breathing events.
J Am Coll Cardiol. 2009 Nov 3;54(19):1797-804. [PMID: 19874994].

Ensrud KE, Blackwell TL, Redline S, Ancoli-Israel S, Paudel ML, Cawthon PM, Dam TT, Barrett-Connor E, Leung PC, Stone KL; Osteoporotic Fractures in Men Study Group. Sleep disturbances and frailty status in older community-dwelling men.
J Am Geriatr Soc. 2009 Nov;57(11):2085-93. Epub 2009 Sep 28. [PMID: 19793160]

McNally KA, Rohan J, Schluchter M, Riekert KA, Vavrek P, Schmidt A, Redline S, Kercsmar C, Drotar D. Adherence to combined montelukast and fluticasone treatment in economically disadvantaged african american youth with asthma.
J Asthma. 2009 Nov;46(9):921-7. [PMID: 19905919]

Moore M, Kirchner HL, Drotar D, Johnson N, Rosen C, Ancoli-Israel S, Redline S. Relationships among sleepiness, sleep time, and psychological functioning in adolescents.
J Pediatr Psychol. 2009 Nov-Dec;34(10):1175-83. Epub 2009 Jun 3. [PMID: 19494088]

Redline S. Does sleep disordered breathing increase hypertension risk? A practical perspective on interpreting the evidence.
J Clin Sleep Med. 2009 Oct 15;5(5):406-8. [PMID: 19961022]

Ross KR, Hart MA, Storfer-Isser A, Kibler AM, Johnson NL, Rosen CL, Kercsmar CM, Redline S. Obesity and obesity related co-morbidities in a referral population of children with asthma.
Pediatr Pulmonol. 2009 Sep;44(9):877-84. [PMID: 19639627]

Silva GE, An MW, Goodwin JL, Shahar E, Redline S, Resnick H, Baldwin CM, Quan SF. Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS).
Sleep. 2009 Aug;32(8):1049-57. [PMID: 19725256]

Winkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ. Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study.
Sleep. 2009 Jun;32(6):772-8. PubMed PMID: 19544754]

Stone KL, Ewing SK, Ancoli-Israel S, Ensrud KE, Redline S, Bauer DC, Cauley JA, Hillier TA, Cummings SR. Self-reported sleep and nap habits and risk of mortality in a large cohort of older women.
J Am Geriatr Soc. 2009 Apr;57(4):604-11. Epub 2009 Feb 10. [PMID: 19220560]

Anderson B, Storfer-Isser A, Taylor HG, Rosen CL, Redline S. Associations of executive function with sleepiness and sleep duration in adolescents.
Pediatrics. 2009 Apr;123(4):e701-7. [PMID: 19336360]

Rao MN, Blackwell T, Redline S, Stefanick ML, Ancoli-Israel S, Stone KL; Osteoporotic Fractures in Men (MrOS) Study Group. Association between sleep architecture and measures of body composition.
Sleep. 2009 Apr;32(4):483-90. [PMID: 19413142]

Sammalisto S, Hiekkalinna T, Schwander K, Kardia S, Weder AB, Rodriguez BL, Doria A, Kelly JA, Bruner GR, Harley JB, Redline S, Larkin EK, Patel SR, Ewan AJ, Weber JL, Perola M, Peltonen L. Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects.
Eur J Hum Genet. 2009 Feb;17(2):258-66. Epub 2008 Sep 10. [PMID: 18781184]

Kezirian EJ, Harrison SL, Ancoli-Israel S, Redline S, Ensrud K, Goldberg AN, Claman DM, Spira AP, Stone KL; Study of Osteoporotic in Men Research Group. Behavioral correlates of sleep-disordered breathing in older men.
Sleep. 2009 Feb;32(2):253-61. [PMID: 19238813]

Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O'Connor GT, Rapoport DM, Redline S, Resnick HE, Robbins JA, Shahar E, Unruh ML, Samet JM. Sleep-disordered breathing and mortality: a prospective cohort study.
PLoS Med. 2009 Aug;6(8):e1000132. Epub 2009 Aug 18. [PMID: 1968804]

Monahan K, Storfer-Isser A, Mehra R, Shahar E, Mittleman M, Rottman J, Punjabi , Sanders M, Quan SF, Resnick H, Redline S. Triggering of nocturnal arrhythmias  by sleep-disordered breathing events.
J Am Coll Cardiol. 2009 Nov;54(19):1797-804. [PMID: 19874994]

Mehra R, Stone KL, Varosy P, Hoffman A, Marcus G,  Blackwell T, Ibrahim O, Salem R, Redline S. Nocturnal Arrhythmias across a Spectrum of Obstructive and Central Sleep Disordered Breathing in Older Men: The MrOS Sleep Study.
Arch Intern Med. 2009;169(12):1147-55. [PMID: 19546416]

Patel SR, Zhu X, Storfer-Isser A, Mehra R, Jenny NS, Tracy R, Redline S. Sleep duration and biomarkers of inflammation.
Sleep. 2009 Feb 1;32(2):200-4. [PMID: 19238807]

O'Connor GT, Caffo B, Newman AB, Quan SF, Rapoport DM, Redline S, Resnick HE,  Samet J, Shahar E. Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study.
Am J Respir Crit Care Med. 2009 Jun 15;179(12):1159-64. Epub 2009 Mar 5. [PMID: 19264976]

Nock N, Li L, Larkin EK, Patel SR, Redline S. Evidence for ‘Syndrome Z’: A Hierarchical Five-Factor Model of the Metabolic Syndrome with Sleep Disturbance Measures.
Sleep. 2009.  32(5):615-22. [PMID: 9480228]

Larkin EK, Patel SR, Elston RC, Gray-McGuire C, Zhu X, Redline S. Assessment of Genetic Effects in Sleep Apnea and Body Mass Index by Linkage Analysis.
Ann Genet Epidem. 2008 72(Pt 6):762-73. [PMCID: PMCI2677984]

Javaheri S, Storfer-Isser A, Rosen CL, Redline S.  Sleep Quality and Elevated Blood Pressure In Adolescents. Circulation 2008. 118(10):1034-40. [PMID: 18711015]

Patel SR, Larkin EK, Redline S. Shared genetic basis for obstructive sleep apnea and adiposity measures. 
Int J Obes (Lond). 2008 May;32(5):795-800. Epub 2008 Jan 22. [PMID: 18209735]

Redline S; Budhiraja R, Kapur V,  Marcus CL,  Mateika J, Mehra R, Parthasarthy S, Romanuik J, Strohl KP,  Sulit LG, Wise MS,  Quan SF. Reliability and validity of respiratory event measurement and scoring.
J Clin Sleep Med. 2007:3(2);169-200. [PMID: 17557426]

Mehra R, Stone KL, Blackwell T,Ancoli Israel A Dam T, Stefanick M, Redline S. Prevalence and Correlates of  Sleep-Disordered Breathing in Older Men: the MrOS Sleep Study.
J Am Gerontol Soc. 2007; 55(9):1356-64. [PMID: 17767677]

Redline S, Storfer-Isser A, Rosen CL, Johnson NL, Kirchner HL, Emancipator J,  Kibler AM. Association between metabolic syndrome and sleep-disordered breathing  in adolescents.
Am J Respir Crit Care Med. 2007 Aug 15;176(4):401-8. Epub 2007 May 31. [PMID: 17541017]

Patel SR, Larking EK, Mignot E, Lin L, Redline S. The Association of Angiotensin Converting Enzyme (ACE) Polymorphisms with Sleep Apnea and Hypertension.
Sleep 2007 30(4):531-3. [PMID: 17520798]

Ensrud KE, Blackwell TL, Ancoli-Israel S, Redline S, Yaffe K, Diem S, Claman D, Stone KL. Use of Selective Serotonin Reuptake Inhibitors and Sleep Disturbances in Community Dwelling Older Women.
J Am Geriatr Soc. 2006 54(10):1508-15. [PMID: 17038067]

Mehra R Storfer-Isser M.S. A, Kirchner HK, Johnson N, Jenny N, Tracy RP, Redline S.  Interleukin-6 Soluble Receptor: A Novel Marker of Moderate to Severe Sleep-Disordered Breathing.
Arch Intern Med. 2006; 166(16):1725-31.  [PMID: 16983050]

Spilsbury J, Storfer Isser A, Kirchner HL,  Nelson L, Rosen CL,  Drotar D, Redline S.  Neighborhood  Disadvantage as a Risk Factor for Pediatric Obstructive Sleep Apnea.
J Pediatrs. 2006; 149(3):342-7.  [PMID: 16939744]

Larkin EK, Patel SR, Redline S, Mignot E, Elston RC, Hallmayer J. Apolipoprotein E and Obstructive Sleep Apnea” Evaluating Whether a Candidate Gene Explains Linkage.
Genet Epidem 2005 Dec 22. [PMID: 16374834]

Mehra R, Benjamin E, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, Sahadevan J, Redline S. Association of Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: Sleep Heart Health Study.
Am J Respir Crit Care Med. 2006; 173(8):910-6. [PMCID: PMCI2662909]

Emancipator J,  Storfer-Isser A, Taylor HG,  Rosen CL, Kirchner HL, Johnson NL, Zambito AM, Redline S. Variation of Cognition and Achievement with Sleep Disordered Breathing in Full and Pre-term Children.
Archives Pediatr Adolesc Med. 2006; 160: 203-210. [PMID: 16461879]

Larkin EK,  Rosen CL, Kirchner HL, Storfer-Isser A,  Emancipator JL, Johnson NL,  Zambito AM, Tracy RP, Jenny NJ, Redline S. Variation of C-Reactive Protein Levels In Adolescents:  Association with Sleep Disordered Breathing and Sleep Duration.
Circulation. 2005; 19;111(15):1978-84. [PMID: 15837952]

Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE.  Sleep disordered breathing, glucose intolerance, and insulin resistance: The Sleep Heart Health Study.
Am J Epidemiol 2004; 15;160(6):521-30.  [PMID: 15353412]

Patel RS, Palmer LJ, Larkin EK, Jenny N, White DP, Redline S. Relationship between obstructive sleep apnea and diurnal leptin rhythms.
Sleep 2004;27(2):235-239. [PMID: 15124716]

Palmer LJ, Buxbaum SG, Larkin E, Patel SR, Elston RC, Tishler PV, Redline S.  A whole genome scan for obstructive sleep apnea and obesity in African-American families.
Am J  Respir Crit Care Med 2004:169(12):1314-1321. [PMID: 15070816]

Redline S, Kirchner HL, Quan SF, Gottlieb DJ, Kapur V, Newman A. The effects of age, sex, ethnicity and sleep disordered breathing on sleep architecture. The Sleep Hearth Health Study.
Archives Int Med. 2004;164:406-418. [PMID: 14980992]

Redline S, Schluchter MD, Larkin E, Tishler PV.  Predictors of longitudinal change in sleep-disordered breathing in a non-clinic population. 
Sleep. 2003; 26(6):703-9.  [PMID: 14572123]

Rosen CR, Larkin EL, Kirchner LK, Emancipator J, Bivins S, Surovec  S, Martin R, Redline S. Prevalence and risk factors for sleep-disordered breathing in 8 to 11 year-old children: association with race and prematurity.
J Pediatric 2003; 142(4):383-389. [PMID: 12712055]

Tishler PV, Larkin EK, Schluchter MD, Redline S.  The incidence of sleep disordered breathing in an urban adult population.
JAMA 2003; 289:2230-2237. [PMID: 12734134]

Palmer LJ, Buxbaum SG, Larkin E, Patel SR, Elston RC, Tishler PV, Redline S. A whole-genome scan for obstructive sleep apnea and obesity.
Am J Hum Genet. 2003 Feb;72(2):340-50. Epub 2002 Dec 23. [PMID: 12506338]

Buxbaum SG, Elston RC, Tishler PV, Redline S.  Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation Analysis.  Genet Epidemiol. 2002; 22(3): 243-53.  [PMID: 11921084]

Nieto FJ, Young T, Lind B, Shahar E, Samet J, Redline S, D’Agostino R, Newman A, Lebowitz  MD, Pickering  TG.  Sleep-disordered breathing, sleep apnea, and hypertension: The Sleep Heart Health Study.
JAMA. 2000. 283:1829-1836. [PMID: 10770144]

Redline S, Tishler PV, Schluchter M, Aylor J, Clark K, Graham, G. Risk factors for sleep-disordered breathing in children: Associations with obesity, race, and respiratory problems.
Am J Respir Crit Care Med. 159:1527-1532; 1999. [PMID: 10228121]

Redline S, Adams N, Strauss M, Winters M, Roebuck T, Rosenberg C.  Improved outcomes after CPAP treatment in mild sleep disordered breathing.
Am J Respir Crit Care Med. 1998; 157:858-865. [PMID: 9517603]


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