Faculty Profile

Andrew J. K. Phillips, PhD

Andrew Phillips profile photo 2015
Assistant Professor of Medicine, Harvard Medical School
Associate Biophysicist, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

See publications


Inter-office Mail Address

Division of Sleep Medicine, Brigham & Women’s Hospital, 221 Longwood Ave. Suite 438, Boston MA 02115

Phone 617-278-0057

Email ajphillips@partners.org

Society Memberships

Sleep Research Society
Society for Research on Biological Rhythms
Australasian Sleep Association





Research Unit(s)

Analytic and Modeling Unit, Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School; Circadian Group, Division of Sleep Medicine, Brigham and Women's Hospital

Research Interests

I use mathematical models of physiology to gain insights into sleep and circadian rhythms in humans and other species. Current research interests include:
1) Understanding how the sleep-regulatory circuits in the mammalian brain give rise to observed sleep behaviors, including differences in sleep duration and timing between individuals and between species.
2) Understanding how interactions with our environment and social interactions affect sleep and circadian timing.
3) Understanding the effects of chronically insufficient sleep on sleep physiology and cognitive performance.
4) Modeling the effects of stimuli and pharmaceuticals on sleep and circadian rhythms.
5) Predicting how individuals will perform under different schedules and optimizing individuals’ performances.

Trainees

Peyton Greenside, 2010-2011 (Harvard U. Honors thesis – Magna; Herchel Smith Harvard Postgraduate Scholarship)
Emily Breslow, 2011- (Harvard U. Honors thesis – Summa; John E. Dowling Award for Best Thesis in Neurobiology)
William Clerx (Harvard U. Honors thesis – Summa), 2013-2015
Krithika Swaminathan 2014-2015
Anne Kelley 2014-2015


Mentor(s)


Research Funding

Current
NIH/NHLBI R00 HL119618, Phillips (PI), 2015-2018, “Integration of sleep/wake network models across multiple temporal and spatial scales.”

NIH/NIGMS R01 GM105018, Czeisler/Klerman (PI), 2013-2018, “Multi-scale modeling of sleep behaviors in social networks.”

Completed
NSBRI Postdoctoral Fellowship, Phillips (PI), 2009-2012, “Physiologically-based modeling of sleep-wake scheduling and the effects of pharmaceuticals.”

NIH/NHLBI K99 HL119618, Phillips (PI), 2013-2015, “Integration of sleep/wake network models across multiple temporal and spatial scales.”


Teaching

Harvard U. MCB186, “Circadian Biology: From cellular oscillators to sleep regulation”, TA (2009-2012), Invited lecturer (2009-2015)
U. of Michigan, Calculus I (2013)

Honors
2014 Chair’s Research Award, Brigham and Women’s Hospital
2010 Richard E. Kronauer Award in Recognition of Excellence in Biomathematical modeling, Society for Research on Biological Rhythms
2010 School of Physics Postgraduate Alumni Prize for most outstanding PhD thesis, University of Sydney

Selected Publications

Fulcher BD, Phillips AJK, Postnova S, Robinson PA. A physiologically based model of orexinergic stabilization of sleep and wake. PLoS One 2014 Mar 20;9(3):e91982. [PMID: 24651580]

Phillips AJK, Robinson PA, Klerman EB. Arousal state feedback as a potential physiological generator of the ultradian REM/NREM sleep cycle. J Theor Biol 2013 Feb;319:75-97. [PMID: 23220346]

Phillips AJK, Chen PY, Robinson PA. Probing the mechanisms of chronotype using quantitative modeling. J Biol Rhythms 2010 Jun;25(3):217-27. [PMID: 20484693]

Phillips AJK, Robinson PA, Kedziora DJ, Abeysuriya RG. Mammalian sleep dynamics: How diverse features arise from a common physiological framework. PLoS Comput Biol 2010 Jun;6(6):e1000826. [PMID:20585613]

Phillips AJ, Robinson PA. Potential formulation of sleep dynamics.
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Feb;79(2 Pt 1):021913. Epub 2009 Feb 24.[PMID: 19391784]

Fulcher BD, Phillips AJ, Robinson PA. Modeling the impact of impulsive stimuli on sleep-wake dynamics. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Nov;78(5 Pt 1):051920. Epub 2008 Nov 20. [PMID: 19113168]

Phillips AJ, Robinson PA. Sleep deprivation in a quantitative physiologically based model of the ascending arousal system. J Theor Biol. 2008 Dec 21;255(4):413-23. Epub 2008 Aug 29. [PMID: 18805427]

Phillips AJ, Robinson PA. A quantitative model of sleep-wake dynamics based on
the physiology of the brainstem ascending arousal system.
J Biol Rhythms. 2007 Apr;22(2):167-79. [PMID: 17440218]

Henderson JA, Phillips AJ, Robinson PA. Multielectrode electroencephalogram power spectra: theory and application to approximate correction of volume conduction effects.
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 May;73(5 Pt 1):051918. Epub 2006 May 31. [PMID: 16802978]


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