Sleep Research Society &

American Academy of Sleep Medicine

Undergraduate, Graduate and Postgraduate Training Opportunities 

in Basic and Clinical Sleep Research and Sleep Medicine

2001 - V Edition

 

Home Page

Laboratories

 

 

 

 

Institution

University of Pennsylvania School of Medicine

Address

Unit for Experimental Psychiatry

Division of Sleep and Chronobiology

Department of Psychiatry

University of Pennsylvania School of Medicine

1013 Blockley Hall

423 Guardian Drive

Philadelphia, PA 19104-6021

USA

 

Phone: (215) 898-9665

FAX: (215) 573-6410

Faculty (Name, Email address)

David F. Dinges, Ph.D. (Director) dinges@mail.med.upenn.edu

Naomi L. Rogers, Ph.D. nrogers@mail.med.upenn.edu 

Marty P. Szuba, M.D. mszuba@mail.med.upenn.edu 

Hans P. A. Van Dongen, Ph.D. vdongen@mail.med.upenn.edu  

 

COLLABORATIVE FACULTY

Allan I. Pack, M.D., Ph.D. (Medicine)

Steven D. Douglas, MD (Microbiology)

Terri Weaver, Ph.D. (Nursing)

Jacqueline Kloss, Ph.D. (Psychology)

Margaret Rukstalis, M.D. (Psychiatry)

Types of Training Available

Undergraduate and Graduate:

Undergraduate and graduate courses in sleep and circadian rhythms (e.g., BBB340 in Biological Basis of Behavior program in University of Pennsylvania College of Arts and Sciences and School of Medicine)

Undergraduate work-study and research assistantships

Pre-doctoral research fellowships on sleep and circadian regulation of neurobehavioral, psychophysiological and immunoendocrine functions

Preceptoring for early career awards to MDs and PhDs doing sleep/circadian research

Honors study and independent study students

Post-doctoral:

post-doctoral research fellowships on sleep and circadian regulation of neurobehavioral, psychophysiological and immunoendocrine functions

Types of Funding Available:

Work-study stipends for undergraduates 

Research assistantships (part-time and fulltime) for undergraduates, pre-med

students, and pre-graduate school students 

Graduate student support 

Pre-doctoral fellowships 

Post-doctoral fellowships 

Current Trainees (Names and Email address):

 

Post-doctoral Fellows:

Brenda Ringell, M.D.

 

Pre-doctoral Fellows:

Nicholas Price

Maurice Baynard

 

Graduate students:

 

Research Trainees:

Kimberly McConnell

 

Honors students:

Mariel Focseneanu

Anias de Bwnier

 

Independent study students:

Kay O'Meara

Paul Tung

 

Undergraduate trainees:

Alejo Nawshin Ali

Eileen Chang

Anais de Brunier

Mariel Focseneanu

Lauren Hittner

Casey Jo Humbyrd

Polina Mamontov

Yaniz Padilla

Lawrence Park

Phan Miriam Pogach

Christine Ryan

Melissa Torres

Lsiang-tso

Paul Tung

Shweta Antani

Clifford Bersamira

Boram Kim

Luz-Adriana Samper

Neha Shah

Trainees who have completed training [in the past five years] and current status (Name, Title, Institution, Email):

Melissa Mallis, Ph.D. Fatigue Countermeasures Program, NASA Ames Research Center

Deepak Chugh, M.D., MBChB Resident, Allegheny Medical School

Janet Mullington, Ph.D. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston

Tony Fernando, M.D. Physician, Auckland, New Zealand

Terri Weaver, Ph.D., RN Assoc. Professor University of Pennsylvania School of Nursing

Patricia Sollars, Ph.D. Asst. Professor, Colorado State University

Geoffrey Ott Graduate student, UCLA Neuroscience (Sleep Res. Training Program)

Marieke Dijkman Physician, Amsterdam, The Netherlands

 

Primary Research and/or Clinical Focus of Laboratory

We are conducting basic human neurobehavioral and neurobiological research,

involving both laboratory and field experiments. One important focus is the investigation of the homeostatic and circadian regulation of waking neurobehavioral functions, and the manner in which these processes interact to produce wakefulness. Specific areas of study include:

the effects of sleep deprivation on behavioral and physiological functioning
the cumulative development of sleepiness and brain dysfunction from acute total and sustained partial sleep loss
neurobehavioral deficits due to sleepiness and hypoxemia from obstructive sleep apnea syndrome
neuroimaging during sleep and sleep loss
neuroendocrine and neuroimmune functions in relation to sleep, sleep loss, and circadian rhythms
sleep disturbance in psychopathology
causes of insomnia and excessive sleepiness in the elderly
effects of irregular, prolonged, and shifted work schedules on human health and safety
development of behavioral, biological, and technological countermeasures to inadequate sleep and to daytime sleepiness
effects of caffeine, posture and stimulation of brain functions during sleep deprivation
individual differences in regulation of sleep and waking neurobehavioral performance

 

Technical Capabilities of Lab

facilities for multi-day (around the clock) experiments on human sleep deprivation
temporal isolation facilities for prolonged circadian rhythm experiments
state-of-the-art digital, ambulatory, portable EEG / EOG / EMG recorders
EEG signal processing hardware/software
time-locked integration of facial video, EEG, and performance
core body temperature assessment
actigraphy and actillume hardware/software
computer-based, portable performance/neurobehavioral assessment systems
blood/saliva/urine processing facilities for neuroendocrine and neuroimmune measures
fully integrated desktop computer and network environment.

 

Primary Training Focus

Human (Basic)
Human (Clinical Research)

Fellowship and stipend support at all levels (undergraduate, medical student, graduate, post-doctorate, early career), as described above. Our laboratory is heavily invested in studying neurobehavioral (e.g., performance, cognitive, EEG, fMRI, metabolism, mood, somatic symptoms), neuroendocrine (e.g., cortisol, melatonin, thyroid axis, growth hormone, catecholamines), and in vitro and in vivo neuroimmune functions (e.g., cytokines, lymphocyte responses) in healthy humans as a function of sleep drive and circadian rhythmicity. Emphasis is placed on trainees taking responsibility for developing key aspects of research and bringing to publishable fruition as their product. Career development with achievable goals are priorities.

Other Training Opportunities

Graduate students in the Neuroscience Department and Psychology Department are eligible to work with Drs. Dinges, Van Dongen and Szuba who are members of the Institute of Neurological Sciences and the Training Faculty of the Center for Sleep and Respiratory Neurobiology at University of Pennsylvania.

Representative Publications For the Last Five Years

 

Dinges, DF. An overview of sleepiness and accidents. Journal of Sleep Research, 4(2):4-11, 1995.

Dinges, DF, Douglas, SD, Hamarman, S, Zaugg, L, Kapoor, S. Sleep deprivation and human immune function. Advances in Neuroimmunology, 5:97-110, 1995.

Leventhal, L, Freundlich, B, Lewis, J, Gillen, K, Henry, J, Dinges, DF: Controlled study of sleep parameters in patients with fibromyalgia. Journal of Clinical Rheumatology, 1(2):110-113, 1995.

Maislin, G, Pack, AI, Kribbs, NB, Smith, PL, Schwartz, AR, Kline, LR, Schwab, RJ, Dinges, DF. A survey screen for prediction of apnea. Sleep, 18(3):158-166, 1995.

Pack, AI, Pack, AM, Rodgman, E, Cucchiara, A, Dinges, DF, Schwab, CW. Characteristics of crashes attributed to the driver having fallen asleep. Accid. Anal. and Prev., 27(6):769-775, 1995.

Chugh, DK, Weaver, TE, Dinges, DF. Neurobehavioral consequences of arousals. Sleep, 19(10):S198-S201, 1996.

Gary, KA, Winokur, A, Douglas, SD, Kapoor, S, Zaugg, L, Dinges, DF. Total sleep deprivation & the thyroid axis: effects of sleep & waking activity. Aviation, Space, and Environmental Medicine, 67(6):513-519, 1996.

Dinges, DF, Chugh, DK. Physiologic correlates of sleep deprivation. In J.M. Kinney and HN Tucker (Ed.) Physiology, Stress and Malnutrition, New York: Lippincott-Raven, 1-27, 1997.

Dinges, DF, Pack, F, Williams, K., Gillen, KA, Powell, JW, Ott, GE, Aptowicz, C, Pack, AI. Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep, 20(4):267-277, 1997.

Rogers N.L., van den Heuvel C.J., Dawson D. Effect of melatonin and cortisol on in vitro cellular immune function. Journal of Pineal Research 1997, 22: 75-80.

Rogers N.L., Roberts T., Dawson D. Understanding shiftwork. Journal of Occupational, Health and Safety – Australia New Zealand 1997, 13: 429-437.

Van Dongen, HPA, Kerkhof, GA, Klöppel, H-B. Seasonal covariation of the circadian phases of rectal temperature and slow wave sleep onset. Journal of Sleep Research, 6(1), 19-25, 1997.

Weaver, TE, Kribbs, NB, Pack, AI, Klein, LR, Chugh, DK, Maislin, G, Smith, PL, Schwartz, AR, Shuburt, MN, Gillen, KA, Dinges, DF. Night-to-night variability in CPAP use over first 3 months of treatment. Sleep, 20(4):278-283, 1997.

Weaver, TE, Laizner, A, Evans, LK, Maislin, G, Chugh, DK, Lyons, K, Smith, PL, Schwartz, AR, Redline, S, Pack, AI,Dinges, DF. An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep, 20(10): 835-843, 1997.

Dawson D., Rogers N.L., van den Heuvel C.J., Kennaway D.J., Lushington K. Effects of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs. Journal of Biological Rhythms 1998, 13: 531-537.

Lushington K., Lack L., Kennaway D.J., Rogers N.L., van den Heuvel C.J., Dawson D. 6-sulphatoxymelatonin excretion and self-reported sleep in good sleeping controls and insomniacs aged 55-80 years. Journal of Sleep Research 1998, 7:75-78.

Rogers N.L., Phan O., Kennaway D.J., Dawson D. Effect of daytime administration of oral melatonin administration on neurobehavioural performance in humans. Journal of Pineal Research 1998, 25: 47-53.

Van Dongen, HPA. Inter- and intra-individual differences in circadian phase. Ph.D. thesis, Leiden University, ISBN 90-803851-2-3, 1998.

Van Dongen, HPA, Kerkhof, GA, Souverijn, JHM. Absence of seasonal variation in the phase of the endogenous circadian rhythm in humans. Chronobiology International, 15(6), 623-632, 1998.

Van Dongen, HPA, Mullington, J, Dinges, DF. Circadian phase delay during 88-hour sleep deprivation in dim light: Differences among body temperature, plasma melatonin and plasma cortisol. Sleep-wake Research in The Netherlands, 9, 33-36, 1998.

Ross, RJR, Ball, WA, Sanford, LD, Morrison, AR, Dinges, DF, Silver, SM, Kribbs, NB, Mulvaney, FD, Gehrman, PR, McGinnis, DE. Rapid eye movement sleep changes during the adaptation night in combat veterans with posttraumatic stress disorder. Society of Biological Psychiatry, 1999; 45: 938-941.

Birketvedt, GS, Florholmen, J, Sundsfjord, J, Osterud, B, Dinges, DF, Bilker, W, Stunkard, A. Behavioral and neuroendocrine characteristics of the night-eating syndrome. JAMA, 282(7): 657-663, 1999.

Dinges, DFD, Achermann, P. Future considerations for models of human neurobehavioral function. Journal of Biological Rhythms, 14: 598-601,1999.

Findley, LJ, Suratt, PM, Dinges, DF. Time-on-task decrements in "Steer Clear" performance of patients with Sleep Apnea and narcolepsy. Sleep, 22(6): 804-809, 1999.

Jewett, ME, Dijk, D-J, Kronauer, RE, Dinges, DF. Dose response relationship between sleep duration and human psycho-motor vigilance and subjective alertness. Sleep, 22(2): 171-179, 1999.

Powell, NB, Riley, RW, Schechtman, KB, Blumen, MB, Dinges, DF; Guilleminault, C. A comparative model: Reaction time performance in sleep-disordered breathing versus alcohol-impaired controls. Laryngoscope, 109; 1648– 1654, 1999.

Van Dongen, HPA, Olofsen, E, Van Hartevelt, JH, Kruyt, EW. A procedure of multiple period searching in unequally spaced time-series with the Lomb-Scargle method. Biological Rhythm Research, 30(2), 149-177, 1999.

Van Dongen, HPA, Olofsen, E, VanHartevelt, JH, Kruyt, EW. Searching for biologicalrhythms: Peak detection in the periodogram of unequally spaced data. Journal of Biological Rhythms, 14(6), 617-620, 1999.

Murphy, PJ, Rogers, NL, Cambell, SS. Age differences in the spontaneous termination of sleep. Journal of Sleep Research, 2000, 9: 27-34.

Van Dongen, HPA, Dinges, DF. Circadian rhythms in fatigue, alertness and performance. In MH Kryger, T Roth & WC Dement (eds.) Principles and practice of sleep medicine (3 rd ed.). WB Saunders, Philadelphia, 2000, P:391-399.

www link for the Lab

 

Faculty Research Interests