Sleep Research Society &
American Academy of Sleep Medicine
Undergraduate, Graduate and Postgraduate Training Opportunities
in Basic and Clinical Sleep Research and Sleep Medicine
2001 - V Edition
University of Pennsylvania School of Medicine
Unit for Experimental Psychiatry
Division of Sleep and Chronobiology
Department of Psychiatry
University of Pennsylvania School of Medicine
1013 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Phone: (215) 898-9665
FAX: (215) 573-6410
Faculty (Name, Email address)
Allan I. Pack, M.D., Ph.D. (Medicine)
Steven D. Douglas, MD (Microbiology)
Terri Weaver, Ph.D. (Nursing)
Jacqueline Kloss, Ph.D. (Psychology)
Margaret Rukstalis, M.D. (Psychiatry)
Types of Training Available
Undergraduate and graduate courses in sleep and circadian rhythms (e.g., BBB340 in Biological Basis of Behavior program in University of Pennsylvania College of Arts and Sciences and School of Medicine)
Undergraduate work-study and research assistantships
Pre-doctoral research fellowships on sleep and circadian regulation of neurobehavioral, psychophysiological and immunoendocrine functions
Preceptoring for early career awards to MDs and PhDs doing sleep/circadian research
Honors study and independent study students
Types of Funding Available:
Current Trainees (Names and Email address):
Brenda Ringell, M.D.
Anias de Bwnier
Independent study students:
Alejo Nawshin Ali
Anais de Brunier
Casey Jo Humbyrd
Phan Miriam Pogach
Trainees who have completed training [in the past five years] and current status (Name, Title, Institution, Email):
Melissa Mallis, Ph.D. Fatigue Countermeasures Program, NASA Ames Research Center
Deepak Chugh, M.D., MBChB Resident, Allegheny Medical School
Janet Mullington, Ph.D. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston
Tony Fernando, M.D. Physician, Auckland, New Zealand
Terri Weaver, Ph.D., RN Assoc. Professor University of Pennsylvania School of Nursing
Patricia Sollars, Ph.D. Asst. Professor, Colorado State University
Geoffrey Ott Graduate student, UCLA Neuroscience (Sleep Res. Training Program)
Marieke Dijkman Physician, Amsterdam, The Netherlands
Primary Research and/or Clinical Focus of Laboratory
We are conducting basic human neurobehavioral and neurobiological research,
involving both laboratory and field experiments. One important focus is the investigation of the homeostatic and circadian regulation of waking neurobehavioral functions, and the manner in which these processes interact to produce wakefulness. Specific areas of study include:
Technical Capabilities of Lab
Primary Training Focus
Fellowship and stipend support at all levels (undergraduate, medical student, graduate, post-doctorate, early career), as described above. Our laboratory is heavily invested in studying neurobehavioral (e.g., performance, cognitive, EEG, fMRI, metabolism, mood, somatic symptoms), neuroendocrine (e.g., cortisol, melatonin, thyroid axis, growth hormone, catecholamines), and in vitro and in vivo neuroimmune functions (e.g., cytokines, lymphocyte responses) in healthy humans as a function of sleep drive and circadian rhythmicity. Emphasis is placed on trainees taking responsibility for developing key aspects of research and bringing to publishable fruition as their product. Career development with achievable goals are priorities.
Other Training Opportunities
Graduate students in the Neuroscience Department and Psychology Department are eligible to work with Drs. Dinges, Van Dongen and Szuba who are members of the Institute of Neurological Sciences and the Training Faculty of the Center for Sleep and Respiratory Neurobiology at University of Pennsylvania.
Representative Publications For the Last Five Years
Dinges, DF. An overview of sleepiness and accidents. Journal of Sleep Research, 4(2):4-11, 1995.
Dinges, DF, Douglas, SD, Hamarman, S, Zaugg, L, Kapoor, S. Sleep deprivation and human immune function. Advances in Neuroimmunology, 5:97-110, 1995.
Leventhal, L, Freundlich, B, Lewis, J, Gillen, K, Henry, J, Dinges, DF: Controlled study of sleep parameters in patients with fibromyalgia. Journal of Clinical Rheumatology, 1(2):110-113, 1995.
Maislin, G, Pack, AI, Kribbs, NB, Smith, PL, Schwartz, AR, Kline, LR, Schwab, RJ, Dinges, DF. A survey screen for prediction of apnea. Sleep, 18(3):158-166, 1995.
Pack, AI, Pack, AM, Rodgman, E, Cucchiara, A, Dinges, DF, Schwab, CW. Characteristics of crashes attributed to the driver having fallen asleep. Accid. Anal. and Prev., 27(6):769-775, 1995.
Chugh, DK, Weaver, TE, Dinges, DF. Neurobehavioral consequences of arousals. Sleep, 19(10):S198-S201, 1996.
Gary, KA, Winokur, A, Douglas, SD, Kapoor, S, Zaugg, L, Dinges, DF. Total sleep deprivation & the thyroid axis: effects of sleep & waking activity. Aviation, Space, and Environmental Medicine, 67(6):513-519, 1996.
Dinges, DF, Chugh, DK. Physiologic correlates of sleep deprivation. In J.M. Kinney and HN Tucker (Ed.) Physiology, Stress and Malnutrition, New York: Lippincott-Raven, 1-27, 1997.
Dinges, DF, Pack, F, Williams, K., Gillen, KA, Powell, JW, Ott, GE, Aptowicz, C, Pack, AI. Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. Sleep, 20(4):267-277, 1997.
Rogers N.L., van den Heuvel C.J., Dawson D. Effect of melatonin and cortisol on in vitro cellular immune function. Journal of Pineal Research 1997, 22: 75-80.
Rogers N.L., Roberts T., Dawson D. Understanding shiftwork. Journal of Occupational, Health and Safety – Australia New Zealand 1997, 13: 429-437.
Van Dongen, HPA, Kerkhof, GA, Klöppel, H-B. Seasonal covariation of the circadian phases of rectal temperature and slow wave sleep onset. Journal of Sleep Research, 6(1), 19-25, 1997.
Weaver, TE, Kribbs, NB, Pack, AI, Klein, LR, Chugh, DK, Maislin, G, Smith, PL, Schwartz, AR, Shuburt, MN, Gillen, KA, Dinges, DF. Night-to-night variability in CPAP use over first 3 months of treatment. Sleep, 20(4):278-283, 1997.
Weaver, TE, Laizner, A, Evans, LK, Maislin, G, Chugh, DK, Lyons, K, Smith, PL, Schwartz, AR, Redline, S, Pack, AI,Dinges, DF. An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep, 20(10): 835-843, 1997.
Dawson D., Rogers N.L., van den Heuvel C.J., Kennaway D.J., Lushington K. Effects of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs. Journal of Biological Rhythms 1998, 13: 531-537.
Lushington K., Lack L., Kennaway D.J., Rogers N.L., van den Heuvel C.J., Dawson D. 6-sulphatoxymelatonin excretion and self-reported sleep in good sleeping controls and insomniacs aged 55-80 years. Journal of Sleep Research 1998, 7:75-78.
Rogers N.L., Phan O., Kennaway D.J., Dawson D. Effect of daytime administration of oral melatonin administration on neurobehavioural performance in humans. Journal of Pineal Research 1998, 25: 47-53.
Van Dongen, HPA. Inter- and intra-individual differences in circadian phase. Ph.D. thesis, Leiden University, ISBN 90-803851-2-3, 1998.
Van Dongen, HPA, Kerkhof, GA, Souverijn, JHM. Absence of seasonal variation in the phase of the endogenous circadian rhythm in humans. Chronobiology International, 15(6), 623-632, 1998.
Van Dongen, HPA, Mullington, J, Dinges, DF. Circadian phase delay during 88-hour sleep deprivation in dim light: Differences among body temperature, plasma melatonin and plasma cortisol. Sleep-wake Research in The Netherlands, 9, 33-36, 1998.
Ross, RJR, Ball, WA, Sanford, LD, Morrison, AR, Dinges, DF, Silver, SM, Kribbs, NB, Mulvaney, FD, Gehrman, PR, McGinnis, DE. Rapid eye movement sleep changes during the adaptation night in combat veterans with posttraumatic stress disorder. Society of Biological Psychiatry, 1999; 45: 938-941.
Birketvedt, GS, Florholmen, J, Sundsfjord, J, Osterud, B, Dinges, DF, Bilker, W, Stunkard, A. Behavioral and neuroendocrine characteristics of the night-eating syndrome. JAMA, 282(7): 657-663, 1999.
Dinges, DFD, Achermann, P. Future considerations for models of human neurobehavioral function. Journal of Biological Rhythms, 14: 598-601,1999.
Findley, LJ, Suratt, PM, Dinges, DF. Time-on-task decrements in "Steer Clear" performance of patients with Sleep Apnea and narcolepsy. Sleep, 22(6): 804-809, 1999.
Jewett, ME, Dijk, D-J, Kronauer, RE, Dinges, DF. Dose response relationship between sleep duration and human psycho-motor vigilance and subjective alertness. Sleep, 22(2): 171-179, 1999.
Powell, NB, Riley, RW, Schechtman, KB, Blumen, MB, Dinges, DF; Guilleminault, C. A comparative model: Reaction time performance in sleep-disordered breathing versus alcohol-impaired controls. Laryngoscope, 109; 1648– 1654, 1999.
Van Dongen, HPA, Olofsen, E, Van Hartevelt, JH, Kruyt, EW. A procedure of multiple period searching in unequally spaced time-series with the Lomb-Scargle method. Biological Rhythm Research, 30(2), 149-177, 1999.
Van Dongen, HPA, Olofsen, E, VanHartevelt, JH, Kruyt, EW. Searching for biologicalrhythms: Peak detection in the periodogram of unequally spaced data. Journal of Biological Rhythms, 14(6), 617-620, 1999.
Murphy, PJ, Rogers, NL, Cambell, SS. Age differences in the spontaneous termination of sleep. Journal of Sleep Research, 2000, 9: 27-34.
Van Dongen, HPA, Dinges, DF. Circadian rhythms in fatigue, alertness and performance. In MH Kryger, T Roth & WC Dement (eds.) Principles and practice of sleep medicine (3 rd ed.). WB Saunders, Philadelphia, 2000, P:391-399.
www link for the Lab
Faculty Research Interests