Sleep Research Society &

American Academy of Sleep Medicine

Undergraduate, Graduate and Postgraduate Training Opportunities 

in Basic and Clinical Sleep Research and Sleep Medicine

2001 - V Edition


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Tokyo Medical and Dental University


Division of Biocybernetics, Department of System,

Institute of Biomedicals and Bioengineering,

Tokyo Medical and Dental University,

2-3-10 Kanda-surugadai, Chiyoda-ku Tokyo 101-0062



Phone: (81)-3-5280-8098 (Kazuki Honda, Ph.D.)

Fax:      (81)-3-5280-8005 (Kazuki Honda, Ph.D.)

Faculty (Name, Email address)

Shojiro Inoue, D.Sc.

Kazuki Honda, Ph.D.

Mayumi Kimura, Ph.D.

Yasuhisa Okano, M.Eng.

Types of Training Available

Graduate course: Sleep science
Special research course: Sleep science
Postdoctoral opportunity: Available if funded

Types of Funding Available       

Monbusho scholarship for graduate students

JSPS fellowship for postdoctoral fellows

Current Trainees (Names and Email address)

Graduate students:

Zili Luo

Moses Akanmu

Special Research students:

Tomio Kubota

Trainees who have completed training [in the past five years] and current status (Name, Title, Institution, Email)

Shi-Qing Zhang, M.D., Ph.D Postdoctoral Fellow Department of Obstetric and Gynecology, The University of Tokyo

Takeshi Hasegawa, M.D., Ph.D. Instructor Tokyo Medical and Dental University

Primary Research and/or Clinical Focus of Laboratory

Studies on the physiological roles of sleep substances in the regulation of sleep
Dynamic analysis of sleep-modulatory substances and neuronal activities in the brain
Time series analysis of sleep in relation to the circadian and reproductive rhythms
Correlation of endocrine activities with sleep and wakefulness
Spatio-temporal analysis of electrical activities in the sleeping brain

Technical Capabilities of Lab

Four isolated chambers with simultaneous recordings of EEG, EMG,
brain temperature, and continuous intracerebroventricular infusion
One isolated chamber for human sleep study
One isolated chamber for in vitro electrophysiological study
Automatic sleep data analysis system
Microdialysis system

Primary Training Focus

Human (Basic)

Other Training Opportunities              


Representative Publications For the Last Five Years

Ikeda M, Honda K, Inoue, S: Vitamin B12 amplifies light pulse-induced phase shifts of the circadian drinking rhythm in rats. Experientia 1996; 52: 691-694 .

Azuma S, Kodama T, Honda K, Inoue, S: State-dependent changes of extracellular glutamate in the medial preoptic area in freely behaving rats. Neuroscience Letters 1996; 214: 179-182.

Kimura M, Zhang S-Q, Inoue, S: Pregnancy-associated sleep changes in the rat. American Journal of Physiology 1996; 271: R1063-R1069.

Zhang S-Q, Kimura M, Inoue, S: Bromocriptine-induced blockade of pregnancy a ffects sleep patterns in rats. Neuroimmunomodulation 1996; 3: 219-226

Nishina H, Honda K, Okai T, Kozuma S, Inoue S, Taketani Y. Characteristic changes in sleep patterns during pregnancy in rats. Neurosci lett 1996; 203: 5-8.

Ikeda M, Inoue S. Circadian rhythms in vitamin B12 content of the rat brain. Nerosci Lett 1997; 228: 131-4.

Ikeda M, Azuma S, Inoue S. Vitamin B12 enhances GABA content but reduces glutamate content in the rat suprachiasmatic nucleus. Am J Physiol 1997; 273: R359-363.

Yu WH, Kimura M, McCann SM. Effect of somatostain on the release of gonadotropin in male rats. Proc Soc Exptl Biol Med 1997; 214: 83-86.

Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997;94: 1023-1028.

Inoue S, Kimura M, kovalzon VM, MikhalevaⅡ, Prudchenko IA. Structure-function interrelationships in the hypnogenic effects of the delta sleep-inducing peptide(DSIP) and its analogs. Neurochemistry 1997; 14(2): 168-174.

Honda K, Riehl J, Inoue S, Mignot E, Nishino S. Central administration of vitamin B12 aggravates cataplexy in canine narcolepsy. NeuroReport 1997; 8: 3861-3865.

McLay RN, Kimura M, Banks WA, Kastin AJ. Granulocyte-macrophage colony stimulating factor crosses the blood-brain barrier and blood-spinal cord barrier. Brain 1997; 120: 2083-2091.

McCann SM, Kimura M, Karanth S, Yu WH, Rettori V. Nitric Oxide controls the hypothalamic-pituitary response to cytokines. Neuroimmunomodulation 1997; 4: 98-106.

Kimura M, Yu WH, Rettori V, McCann SM. Granulocyte-macrophage colony stimulaing factor suppresses LHRH release by inhibition of nitric oxide synthase and stimulation of gamma-aminobutyric acid release. Neuroimmunomodulation 1997; 4: 237-43.

Ikeda M, Inoue S. Simultaneous recording of circadian rhythms of brain and intraperitoneal temperatures and locomotor and drinking activities in the rat. Biol Rhythm Res 1998; 29(2): 142-50.

Kimura M, Zhang SQ, Inoue S. An animal model for pregnancy-associated sleep disorder. Psychiatr Clin Neurosci 1998; 52(2): 209-211.

Kimura M, Kapas L, JM Krueger. Oxidized glutathione promotes sleep in rabbits. Brain Res Bull 1998; 45(6): 545-548.

Ikeda M, Asai M, Moriya T, Sagara M, Inoue S, Shibata S. Methylcobalamin amplifies melatonin-induced circadian phase shifts by facilitation of melatonin synthesis in the rat pineal gland. Brain Res 1998; 795: 98-104.

Nishino S, Honda K, Riehl J, okura M, Mignot E. Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans. NeuroReport 1998; 9: 3653-3661.

Okano Y, Inoue S. Differential effects of soft and hard pillow on nap. Rep Inst Med Dent Eng 1998; 32: 45-48.

Inoue S, Honda K. VitaminB12 promotes sleep and modulates the circadian rhythm of sleep and brain temperature in rats. Sleep Hypnosis 1999; 1(2): 98-104.

Kimura M, Kodama T, Zhang SQ, Honda Y, Inoue S. Colony-stimulating factors(CSFs) in REM sleep and nonREM sleep regulation. Psychiatr Clin Neurosci 1999; 53(2): 105-7.

Zhang SQ, Kimura M, Inoue S. Roles of prolactin in sleep regulation in cyclic rats. Psychiatr clin Neurosci 1999; 53(2): 101-103.

Honda K, Reihl J, Mignot E, Nishino S. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep. NeuroReport 1999; 10: 3717-3724.

Honda K, Lee SP, Inoue S. Syringin enhances slow wave sleep in unrestrained rats. Rep Inst Biomatr Bioeng 1999; 33: 75-79.

Inoue S, Honda K. Vitamin B12 promotes sleep and modulates the circadian rhythm of sleep and brain temperature in rats. Sleep and Hypnosis 1999; 1: 98-104.

Kimura M, Kodama T, Agulia C, Zhang SQ, Inoue S. Granulocyre-macropharge colony-stimulating factor modulates rapid eye movement (REM) sleep and non-REM sleep in rats. J. Neurosci 2000; 20(14): 5544-5551.

Riehl J, Honda K, Hong J, Kwan M, Mignot E, Nishino S. Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy. Neuropsycopharmacology 2000; 23: 34-45.

Honda K, Sagara M, Ikeda M, Inoue S. Reduced glutathione regulates sleep in unrestrained rats by ploducing oxidized glutathione. Sleep Hypnosis 2000; 2(1): 26-30.

www link for the Lab

Faculty Research Interests