Division of Sleep Medicine @ Harvard Medical School
Trainee Profile
Julian Peter Saboisky, PhD
Research Fellow in Medicine, Harvard Medical School
Research Fellow, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Address
Brigham and Women's Hospital221 Longwood Avenue, 036 BLI
Boston, MA 02115
USA
Phone 617-732-6541
Fax 617-732-7337
Email JSABOISKY@partners.org
Society Memberships
SRSAustralian Neuroscience Society (ANS)
Australian Physiological Society (AuPS)
Research Unit(s)
Sleep Disorders Program
Research Interests
I am interested in understanding the parameters of human respiratory control. The focus of my work has centered on the detailed and technically demanding single motor unit physiological measurements and the information they bestow. In humans, single motor unit measurements are the most detailed obtainable information in understanding the influences on motoneurones.
In recent studies (as part of my PhD) I examined at the discharge characteristics of five human inspiratory “pump muscles”, including the diaphragm, scalene, 2nd parasternal intercostal, and 3rd and 5th space dorsal external intercostal muscles. I followed this project by looking at similar characteristics in the human genioglossus muscle in normal subjects. In these series of studies we found the genioglossus muscle activity to be a complex interaction of six types of single motor unit activity: Inspiratory Phasic, Inspiratory Tonic, Expiratory Phasic, Expiratory Tonic, Tonic Other and Tonic. We also examined the genioglossus activity in obstructive sleep apnea and found evidence for neurogenic changes in these patients.
Most recently, I have joined the Sleep Disorders Research Program at Brigham and Women’s Hospital, where we actively research sleep apnea pathogenesis and my primary focus is examining single motor units in the upper airway musculature.
In recent studies (as part of my PhD) I examined at the discharge characteristics of five human inspiratory “pump muscles”, including the diaphragm, scalene, 2nd parasternal intercostal, and 3rd and 5th space dorsal external intercostal muscles. I followed this project by looking at similar characteristics in the human genioglossus muscle in normal subjects. In these series of studies we found the genioglossus muscle activity to be a complex interaction of six types of single motor unit activity: Inspiratory Phasic, Inspiratory Tonic, Expiratory Phasic, Expiratory Tonic, Tonic Other and Tonic. We also examined the genioglossus activity in obstructive sleep apnea and found evidence for neurogenic changes in these patients.
Most recently, I have joined the Sleep Disorders Research Program at Brigham and Women’s Hospital, where we actively research sleep apnea pathogenesis and my primary focus is examining single motor units in the upper airway musculature.
Mentor(s)
Selected Publications
Hoang P, Saboisky JP, Gandevia SC, Herbert RD. Passive mechanical properties of gastrocnemius in people with multiple sclerosis.
Clin Biomech (Bristol, Avon). 2009 Mar;24(3):291-8. Epub 2009 Jan 30. [PMID: 19185961]
Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during sleep onset.
Sleep. 2008 Apr 1;31(4):525-33. [PMID: 18457240]
Saboisky JP, Butler JE, McKenzie DK, Gorman RB, Trinder JA, White DP, Gandevia SC. Neural drive to human genioglossus in obstructive sleep apnoea.
J Physiol. 2007 Nov 15;585(Pt 1):135-46. [PMID: 17916615]
Saboisky JP, Butler JE, Walsh LD, Gandevia SC. New display of the timing and firing frequency of single motor units.
J Neurosci Methods. 2007 May 15;162(1-2):287-92. [PMID: 17336391]
Lim J, Gorman RB, Saboisky JP, Gandevia SC, Butler JE. Optimal electrode placement for noninvasive electrical stimulation of human abdominal muscles.
J Appl Physiol. 2007 Apr;102(4):1612-7. [PMID: 17185493]
Saboisky JP, Gorman RB, De Troyer A, Gandevia SC, Butler JE. Differential activation among five human inspiratory motoneuron pools during tidal breathing.
J Appl Physiol. 2007 Feb;102(2):772-80. [PMID: 17053105]
Saboisky JP, Butler JE, Fogel RB, Taylor JL, Trinder JA, White DP, Gandevia SC. Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing.
J Neurophysiol. 2006 Apr;95(4):2213-21. [PMID: 16306175]
Saboisky J, Marino FE, Kay D, Cannon J. Exercise heat stress does not reduce central activation to non-exercised human skeletal muscle.
Exp Physiol. 2003 Nov;88(6):783-90. [PMID: 14603378]
Reviews
Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in obstructive sleep apnoea.
Expert Opin Ther Targets. 2009 Jul;13(7):795-809. Review. [PMID: 19530985]
Eckert DJ, Saboisky JP, Jordan AS, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea.
J Clin Sleep Med. 2007 Oct 15;3(6):570-3. Review. [PMID: 17993036]
Clin Biomech (Bristol, Avon). 2009 Mar;24(3):291-8. Epub 2009 Jan 30. [PMID: 19185961]
Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during sleep onset.
Sleep. 2008 Apr 1;31(4):525-33. [PMID: 18457240]
Saboisky JP, Butler JE, McKenzie DK, Gorman RB, Trinder JA, White DP, Gandevia SC. Neural drive to human genioglossus in obstructive sleep apnoea.
J Physiol. 2007 Nov 15;585(Pt 1):135-46. [PMID: 17916615]
Saboisky JP, Butler JE, Walsh LD, Gandevia SC. New display of the timing and firing frequency of single motor units.
J Neurosci Methods. 2007 May 15;162(1-2):287-92. [PMID: 17336391]
Lim J, Gorman RB, Saboisky JP, Gandevia SC, Butler JE. Optimal electrode placement for noninvasive electrical stimulation of human abdominal muscles.
J Appl Physiol. 2007 Apr;102(4):1612-7. [PMID: 17185493]
Saboisky JP, Gorman RB, De Troyer A, Gandevia SC, Butler JE. Differential activation among five human inspiratory motoneuron pools during tidal breathing.
J Appl Physiol. 2007 Feb;102(2):772-80. [PMID: 17053105]
Saboisky JP, Butler JE, Fogel RB, Taylor JL, Trinder JA, White DP, Gandevia SC. Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing.
J Neurophysiol. 2006 Apr;95(4):2213-21. [PMID: 16306175]
Saboisky J, Marino FE, Kay D, Cannon J. Exercise heat stress does not reduce central activation to non-exercised human skeletal muscle.
Exp Physiol. 2003 Nov;88(6):783-90. [PMID: 14603378]
Reviews
Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in obstructive sleep apnoea.
Expert Opin Ther Targets. 2009 Jul;13(7):795-809. Review. [PMID: 19530985]
Eckert DJ, Saboisky JP, Jordan AS, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea.
J Clin Sleep Med. 2007 Oct 15;3(6):570-3. Review. [PMID: 17993036]
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