Division of Sleep Medicine @ Harvard Medical School
Trainee Profile
Danny J. Eckert, PhD
Research Fellow in Medicine, Harvard Medical School
Research Fellow, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Address
Brigham and Women’s Hospital, Division of Sleep Medicine, Sleep Disorders Program221 Longwood Ave.
Boston, MA 02115
USA
Inter-office Mail Address
BLI-038Phone 617-732-5619
Fax 617-732-7337
Email deckert@rics.bwh.harvard.edu
Society Memberships
Associated Professional Sleep SocietiesAmerican Thoracic Society
Australasian Sleep Association
Thoracic Society of Australia and New Zealand
Australian Society for Medical Research
Research Unit(s)
Sleep Disorders Program
Research Interests
I am currently working on several projects investigating the pathogenesis of obstructive sleep apnea. The aim of one such study is to investigate the role of arousal from sleep (brief awakenings) as a pathogenic mechanism in sleep apnea and exploring strategies to manipulate the arousal threshold as a novel sleep apnea treatment for certain patients.
A separate study utilizing several techniques is aimed at determining the influences of both short and long-term exposure to apneahypopnea on a variety of neuromuscular traits that are likely to be important in obstructive sleep apnea pathogenesis. These include; upper airway dilator muscle responses to negative pressure stimulation, dilator muscle force and fatigability, sensory processing of respiratory stimuli and the potential for event-related peripheral neuropathy. In the same study we are exploring the potential for CPAP therapy to alter these important responses.
A separate study utilizing several techniques is aimed at determining the influences of both short and long-term exposure to apneahypopnea on a variety of neuromuscular traits that are likely to be important in obstructive sleep apnea pathogenesis. These include; upper airway dilator muscle responses to negative pressure stimulation, dilator muscle force and fatigability, sensory processing of respiratory stimuli and the potential for event-related peripheral neuropathy. In the same study we are exploring the potential for CPAP therapy to alter these important responses.
Mentor(s)
Selected Publications
Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep.
Chest. 2009 Apr;135(4):957-64. Epub 2008 Dec 31. [PMID: 19118266]
Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea.
Sleep. 2009 Mar 1;32(3):361-8. [PMID: 19294956]
Eckert DJ, McEvoy RD, George KE, Thomson KJ, Catcheside PG. Effects of hypoxia on genioglossus and scalene reflex responses to brief pulses of negative upper-airway pressure during wakefulness and sleep in healthy men.
J Appl Physiol. 2008 May;104(5):1426-35. [PMID: 18292297]
Eckert DJ, Malhotra A. Pathophysiology of adult obstructive sleep apnea.
Proc Am Thorac Soc. 2008 Feb 15;5(2):144-53. [PMID: 18250206]
Eckert DJ, Saboisky JP, Jordan AS, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea.
J Clin Sleep Med. 2007 Oct 15;3(6):570-3. [PMID: 17993036]
Hlavac MC, Catcheside PG, Adams A, Eckert DJ, McEvoy RD. The effects of hypoxia on load compensation during sustained incremental resistive loading in patients with obstructive sleep apnea.
J Appl Physiol. 2007 Jul;103(1):234-9. [PMID: 17412784]
Eckert DJ, McEvoy RD, George KE, Thomson KJ, Catcheside PG. Genioglossus reflex inhibition to upper-airway negative-pressure stimuli during wakefulness and sleep in healthy males.
J Physiol. 2007 Jun 15;581(Pt 3):1193-205. [PMID: 17395627]
Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment.
Chest. 2007 Feb;131(2):595-607. [PMID: 17296668]
Nalivaiko E, Catcheside PG, Adams A, Jordan AS, Eckert DJ, McEvoy RD. Cardiac changes during arousals from non-REM sleep in healthy volunteers.
Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1320-7. [PMID: 17110530]
Hlavac MC, Catcheside PG, McDonald R, Eckert DJ, Windler S, McEvoy RD. Hypoxia impairs the arousal response to external resistive loading and airway occlusion during sleep.
Sleep. 2006 May 1;29(5):624-31. [PMID: 16774152]
Eckert DJ, Catcheside PG, Stadler DL, McDonald R, Hlavac MC, McEvoy RD. Acute sustained hypoxia suppresses the cough reflex in healthy subjects.
Am J Respir Crit Care Med. 2006 Mar 1;173(5):506-11. [PMID: 16322644]
Eckert DJ, Catcheside PG, McDonald R, Adams AM, Webster KE, Hlavac MC, McEvoy
RD. Sustained hypoxia depresses sensory processing of respiratory resistive loads.
Am J Respir Crit Care Med. 2005 Oct 15;172(8):1047-54. [PMID: 15976376]
Eckert DJ, Catcheside PG, McEvoy RD. Blunted sensation of dyspnoea and near fatal asthma.
Eur Respir J. 2004 Aug;24(2):197-9. [PMID: 15332384]
O'Donoghue FJ, Catcheside PG, Eckert DJ, McEvoy RD. Changes in respiration in NREM sleep in hypercapnic chronic obstructive pulmonary disease.
J Physiol. 2004 Sep 1;559(Pt 2):663-73. [PMID: 15235077]
Eckert DJ, Catcheside PG, Smith JH, Frith PA, McEvoy RD. Hypoxia suppresses symptom perception in asthma.
Am J Respir Crit Care Med. 2004 Jun 1;169(11):1224-30. [PMID: 15020291]
Jordan AS, Eckert DJ, Catcheside PG, McEvoy RD. Ventilatory response to brief arousal from non-rapid eye movement sleep is greater in men than in women.
Am J Respir Crit Care Med. 2003 Dec 15;168(12):1512-9. [PMID: 14525799]
Reviews
Eckert DJ, Malhotra A, Jordan AS. Mechanisms of apnea.
Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):313-23. Review. [PMID: 19110133]
Owens RL, Eckert DJ, Yeh SY, Malhotra A. Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature.
Curr Opin Pulm Med. 2008 Nov;14(6):519-24. Review. [PMID: 18812828]
Chest. 2009 Apr;135(4):957-64. Epub 2008 Dec 31. [PMID: 19118266]
Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea.
Sleep. 2009 Mar 1;32(3):361-8. [PMID: 19294956]
Eckert DJ, McEvoy RD, George KE, Thomson KJ, Catcheside PG. Effects of hypoxia on genioglossus and scalene reflex responses to brief pulses of negative upper-airway pressure during wakefulness and sleep in healthy men.
J Appl Physiol. 2008 May;104(5):1426-35. [PMID: 18292297]
Eckert DJ, Malhotra A. Pathophysiology of adult obstructive sleep apnea.
Proc Am Thorac Soc. 2008 Feb 15;5(2):144-53. [PMID: 18250206]
Eckert DJ, Saboisky JP, Jordan AS, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea.
J Clin Sleep Med. 2007 Oct 15;3(6):570-3. [PMID: 17993036]
Hlavac MC, Catcheside PG, Adams A, Eckert DJ, McEvoy RD. The effects of hypoxia on load compensation during sustained incremental resistive loading in patients with obstructive sleep apnea.
J Appl Physiol. 2007 Jul;103(1):234-9. [PMID: 17412784]
Eckert DJ, McEvoy RD, George KE, Thomson KJ, Catcheside PG. Genioglossus reflex inhibition to upper-airway negative-pressure stimuli during wakefulness and sleep in healthy males.
J Physiol. 2007 Jun 15;581(Pt 3):1193-205. [PMID: 17395627]
Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment.
Chest. 2007 Feb;131(2):595-607. [PMID: 17296668]
Nalivaiko E, Catcheside PG, Adams A, Jordan AS, Eckert DJ, McEvoy RD. Cardiac changes during arousals from non-REM sleep in healthy volunteers.
Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1320-7. [PMID: 17110530]
Hlavac MC, Catcheside PG, McDonald R, Eckert DJ, Windler S, McEvoy RD. Hypoxia impairs the arousal response to external resistive loading and airway occlusion during sleep.
Sleep. 2006 May 1;29(5):624-31. [PMID: 16774152]
Eckert DJ, Catcheside PG, Stadler DL, McDonald R, Hlavac MC, McEvoy RD. Acute sustained hypoxia suppresses the cough reflex in healthy subjects.
Am J Respir Crit Care Med. 2006 Mar 1;173(5):506-11. [PMID: 16322644]
Eckert DJ, Catcheside PG, McDonald R, Adams AM, Webster KE, Hlavac MC, McEvoy
RD. Sustained hypoxia depresses sensory processing of respiratory resistive loads.
Am J Respir Crit Care Med. 2005 Oct 15;172(8):1047-54. [PMID: 15976376]
Eckert DJ, Catcheside PG, McEvoy RD. Blunted sensation of dyspnoea and near fatal asthma.
Eur Respir J. 2004 Aug;24(2):197-9. [PMID: 15332384]
O'Donoghue FJ, Catcheside PG, Eckert DJ, McEvoy RD. Changes in respiration in NREM sleep in hypercapnic chronic obstructive pulmonary disease.
J Physiol. 2004 Sep 1;559(Pt 2):663-73. [PMID: 15235077]
Eckert DJ, Catcheside PG, Smith JH, Frith PA, McEvoy RD. Hypoxia suppresses symptom perception in asthma.
Am J Respir Crit Care Med. 2004 Jun 1;169(11):1224-30. [PMID: 15020291]
Jordan AS, Eckert DJ, Catcheside PG, McEvoy RD. Ventilatory response to brief arousal from non-rapid eye movement sleep is greater in men than in women.
Am J Respir Crit Care Med. 2003 Dec 15;168(12):1512-9. [PMID: 14525799]
Reviews
Eckert DJ, Malhotra A, Jordan AS. Mechanisms of apnea.
Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):313-23. Review. [PMID: 19110133]
Owens RL, Eckert DJ, Yeh SY, Malhotra A. Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature.
Curr Opin Pulm Med. 2008 Nov;14(6):519-24. Review. [PMID: 18812828]
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