Division of Sleep Medicine @ Harvard Medical School
Trainee Profile
Heinrich S. Gompf, PhD
Research Fellow in Neurology, Harvard Medical School
Research Fellow, Division of Sleep Medicine, Department of Neurology, Beth Israel Deaconess Medical Center
Address
77 Avenue Louis PasteurHarvard Institutes of Medicine, 819
Boston, MA 02115
USA
Inter-office Mail Address
HIM-819Phone 617-667-0823
Fax 617-667-0810
Email hgompf@bidmc.harvard.edu
Society Memberships
Society for NeuroscienceResearch Unit(s)
Systems Neurobiology Group
Research Interests
Dr. Gompf’s primary research interests are the mechanisms by which external stimuli and the internal clock activate arousal systems. His approach has involved in vitro whole-cell patch-clamp and in vivo single unit neurophysiology, neuroanatomy and EEG monitoring of sleep and wakefulness in rats and mice.
Prior to joining the Division of Sleep Medicine, he described a role for hypothalamic orexin neurons in the regulation of locus coeruleus circadian activity and the effects of inhaled anesthetics. Currently, he is using novel social and environmental stimuli to study how arousal areas can override the circadian and homeostatic sleep drive.
Prior to joining the Division of Sleep Medicine, he described a role for hypothalamic orexin neurons in the regulation of locus coeruleus circadian activity and the effects of inhaled anesthetics. Currently, he is using novel social and environmental stimuli to study how arousal areas can override the circadian and homeostatic sleep drive.
Mentor(s)
Research Funding
National Institute on Aging
Selected Publications
Gompf HS, Aston-Jones G. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
Brain Res. 2008 Jun 3. [PMID: 18614159]
Gompf HS, Irwin RP, Allen CN. Retrograde suppression of GABAergic currents in a subset of SCN neurons.
Eur J Neurosci. 2006 Jun;23(12):3209-16. [PMID: 16820011]
Gompf HS, Moldavan MG, Irwin RP, Allen CN. Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic
signaling in the suprachiasmatic nucleus (SCN).
Neuroscience. 2005;132(4):955-65. [PMID: 15857701]
Gompf HS, Allen CN. GABAergic synapses of the suprachiasmatic nucleus exhibit a diurnal rhythm of
short-term synaptic plasticity.
Eur J Neurosci. 2004 May;19(10):2791-8. [PMID: 15147312]
Ikeda M, Sugiyama T, Wallace CS, Gompf HS, Yoshioka T, Miyawaki A, Allen CN. Circadian dynamics of cytosolic and nuclear Ca2+ in single suprachiasmatic
nucleus neurons.
Neuron. 2003 Apr 24;38(2):253-63. [PMID: 12718859]
Gompf H, Luft FC, Morano I. Nitric oxide synthase upregulation and the predelivery blood pressure decrease in
spontaneously hypertensive rats.
J Hypertens. 2002 Feb;20(2):255-61. [PMID: 11821710]
Nelson CS, Ikeda M, Gompf HS, Robinson ML, Fuchs NK, Yoshioka T, Neve KA, Allen CN. Regulation of melatonin 1a receptor signaling and trafficking by asparagine-124.
Mol Endocrinol. 2001 Aug;15(8):1306-17. [PMID: 11463855]
Brain Res. 2008 Jun 3. [PMID: 18614159]
Gompf HS, Irwin RP, Allen CN. Retrograde suppression of GABAergic currents in a subset of SCN neurons.
Eur J Neurosci. 2006 Jun;23(12):3209-16. [PMID: 16820011]
Gompf HS, Moldavan MG, Irwin RP, Allen CN. Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic
signaling in the suprachiasmatic nucleus (SCN).
Neuroscience. 2005;132(4):955-65. [PMID: 15857701]
Gompf HS, Allen CN. GABAergic synapses of the suprachiasmatic nucleus exhibit a diurnal rhythm of
short-term synaptic plasticity.
Eur J Neurosci. 2004 May;19(10):2791-8. [PMID: 15147312]
Ikeda M, Sugiyama T, Wallace CS, Gompf HS, Yoshioka T, Miyawaki A, Allen CN. Circadian dynamics of cytosolic and nuclear Ca2+ in single suprachiasmatic
nucleus neurons.
Neuron. 2003 Apr 24;38(2):253-63. [PMID: 12718859]
Gompf H, Luft FC, Morano I. Nitric oxide synthase upregulation and the predelivery blood pressure decrease in
spontaneously hypertensive rats.
J Hypertens. 2002 Feb;20(2):255-61. [PMID: 11821710]
Nelson CS, Ikeda M, Gompf HS, Robinson ML, Fuchs NK, Yoshioka T, Neve KA, Allen CN. Regulation of melatonin 1a receptor signaling and trafficking by asparagine-124.
Mol Endocrinol. 2001 Aug;15(8):1306-17. [PMID: 11463855]
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