Division of Sleep Medicine @ Harvard Medical School
Trainee Profile
Mirjam Munch, PhD
Postdoctoral Research Fellow in Medicine, Harvard Medical School
Research Fellow, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Address
Division of Sleep Medicine, Department of Medicine, Brigham and Women’s Hospital221 Longwood Avenue, BLI438
Boston, MA 02115
USA
Email mmunch@partners.org
Society Memberships
Sleep Research SocietySociety for Research on Biological Rhythms
Swiss Society for Neuroscience
Swiss Society for Sleep Medicine and Chronobiology
Research Unit(s)
Circadian Group, Division of Sleep Medicine, Brigham and Women's Hospital
Research Interests
My research interest focuses on age-related circadian and homeostatic aspects of human sleep regulation and the influence of photic inputs on the circadian clock.
There is growing evidence that the interaction of circadian and homeostatic processes on sleep regulation change with age. How chronic sleep restriction impacts circadian and homeostatic sleep regulation, and their interaction, is not yet well understood. We are investigating the impact of chronic sleep restriction on sleep, daytime performance and metabolism in healthy young and older adults in order to see if the impact of sleep restriction is age-dependent. My research interest focuses on the impact on sleep and objective sleepiness during wake.
A second project focuses on the impact of evening exposure to blue enriched vs. bright light to improve subjective sleep quality, objective sleep variables and daytime performance in older volunteers with sleep disruption.
There is growing evidence that the interaction of circadian and homeostatic processes on sleep regulation change with age. How chronic sleep restriction impacts circadian and homeostatic sleep regulation, and their interaction, is not yet well understood. We are investigating the impact of chronic sleep restriction on sleep, daytime performance and metabolism in healthy young and older adults in order to see if the impact of sleep restriction is age-dependent. My research interest focuses on the impact on sleep and objective sleepiness during wake.
A second project focuses on the impact of evening exposure to blue enriched vs. bright light to improve subjective sleep quality, objective sleep variables and daytime performance in older volunteers with sleep disruption.
Mentor(s)
Research Funding
Current funding:
Jazz Pharmaceutical Fellowship Training Grant in Sleep Medicine
Completed funding:
Novartis Foundation (Switzerland), 2007-2008
L. & T. La-Roche Foundation (Switzerland), 2006-2007
Jazz Pharmaceutical Fellowship Training Grant in Sleep Medicine
Completed funding:
Novartis Foundation (Switzerland), 2007-2008
L. & T. La-Roche Foundation (Switzerland), 2006-2007
Selected Publications
Munch MY, Cain SW, Duffy JF. Biological Rhythms Workshop IC: sleep and rhythms.
Cold Spring Harbor Symposia on Quantitative Biology. 2007;72:35-46.
Munch M, Knoblauch V, Blatter K, Wirz-Justice A, Krauchi K, Cajochen C. Homeostatic sleep regulation under low sleep pressure: are there age effects?
Sleep 2007 June 1;30(6): 781-92.
Schmidt C, Peigneux P, Muto V, Schenkel M, Knoblauch V, Munch M, De Quervain D, Wirz-Justice A, Cajochen C. Encoding difficulty promotes postlearning changes in sleep spindle activity during napping.
J Neurosci. 2006 Aug 30;26(35):8976-82.
Cajochen C, Munch M, Knoblauch V, Blatter K, Wirz-Justice A. Age-related changes in the circadian and homeostatic regulation of human sleep.
Chronobiol Int. 2006;23(1-2):461-74. Review.
Munch M, Kobialka S, Steiner R, Oelhafen P, Wirz-Justice A, Cajochen C. Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men.
Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1421-8. Epub 2006 Jan 26.
Blatter K, Graw P, Munch M, Knoblauch V, Wirz-Justice A, Cajochen C. Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions.
Behav Brain Res. 2006 Apr 3;168(2):312-7. Epub 2006 Jan 18.
Cajochen C, Jud C, Munch M, Kobialka S, Wirz-Justice A, Albrecht U. Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans.
Eur J Neurosci. 2006 Feb;23(4):1082-6.
Blatter K, Opwis K, Munch M, Wirz-Justice A, Cajochen C. Sleep loss-related decrements in planning performance in healthy elderly depend on task difficulty.
J Sleep Res. 2005 Dec;14(4):409-17.
Knoblauch V, Munch M, Blatter K, Martens WL, Schroder C, Schnitzler C, Wirz-Justice A, Cajochen C. Age-related changes in the circadian modulation of sleep spindle frequency during nap sleep.
Sleep 2005 Sep 1;28(9):1093-101.
Munch M, Knoblauch V, Blatter C, Schroder C, Schnitzler C, Krauchi K, Wirz-Justice A, Cajochen C. Age-related attenuation of the evening circadian arousal signal in humans.
Neurobiol Aging 2005 Oct;26(9):1307-19. Epub 2005 Apr 18.
Cajochen C, Munch M, Kobialka S, Steiner R, Oelhafen P, Orgul S, Wirz-Justice A. High sensitivity of human melatonin, alertness, thermoregulation and heart rate to short wavelength light.
J Clin Endocrinol Metab 2005 Mar;90(3):1311-6. Epub 2004 Dec 7.
Munch M, Knoblauch V, Blatter K, Schroder C, Krauchi K, Wirz-Justice A, Cajochen C. The frontal predominance in human EEG delta activity after sleep loss decreases with age.
Eur J Neurosci. 2004 Sep; 20(5): 1402-10.
Cold Spring Harbor Symposia on Quantitative Biology. 2007;72:35-46.
Munch M, Knoblauch V, Blatter K, Wirz-Justice A, Krauchi K, Cajochen C. Homeostatic sleep regulation under low sleep pressure: are there age effects?
Sleep 2007 June 1;30(6): 781-92.
Schmidt C, Peigneux P, Muto V, Schenkel M, Knoblauch V, Munch M, De Quervain D, Wirz-Justice A, Cajochen C. Encoding difficulty promotes postlearning changes in sleep spindle activity during napping.
J Neurosci. 2006 Aug 30;26(35):8976-82.
Cajochen C, Munch M, Knoblauch V, Blatter K, Wirz-Justice A. Age-related changes in the circadian and homeostatic regulation of human sleep.
Chronobiol Int. 2006;23(1-2):461-74. Review.
Munch M, Kobialka S, Steiner R, Oelhafen P, Wirz-Justice A, Cajochen C. Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men.
Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1421-8. Epub 2006 Jan 26.
Blatter K, Graw P, Munch M, Knoblauch V, Wirz-Justice A, Cajochen C. Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions.
Behav Brain Res. 2006 Apr 3;168(2):312-7. Epub 2006 Jan 18.
Cajochen C, Jud C, Munch M, Kobialka S, Wirz-Justice A, Albrecht U. Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans.
Eur J Neurosci. 2006 Feb;23(4):1082-6.
Blatter K, Opwis K, Munch M, Wirz-Justice A, Cajochen C. Sleep loss-related decrements in planning performance in healthy elderly depend on task difficulty.
J Sleep Res. 2005 Dec;14(4):409-17.
Knoblauch V, Munch M, Blatter K, Martens WL, Schroder C, Schnitzler C, Wirz-Justice A, Cajochen C. Age-related changes in the circadian modulation of sleep spindle frequency during nap sleep.
Sleep 2005 Sep 1;28(9):1093-101.
Munch M, Knoblauch V, Blatter C, Schroder C, Schnitzler C, Krauchi K, Wirz-Justice A, Cajochen C. Age-related attenuation of the evening circadian arousal signal in humans.
Neurobiol Aging 2005 Oct;26(9):1307-19. Epub 2005 Apr 18.
Cajochen C, Munch M, Kobialka S, Steiner R, Oelhafen P, Orgul S, Wirz-Justice A. High sensitivity of human melatonin, alertness, thermoregulation and heart rate to short wavelength light.
J Clin Endocrinol Metab 2005 Mar;90(3):1311-6. Epub 2004 Dec 7.
Munch M, Knoblauch V, Blatter K, Schroder C, Krauchi K, Wirz-Justice A, Cajochen C. The frontal predominance in human EEG delta activity after sleep loss decreases with age.
Eur J Neurosci. 2004 Sep; 20(5): 1402-10.
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