Division of Sleep Medicine @ Harvard Medical School
Trainee Profile
Anne-Marie Chang, PhD
Research Fellow in Medicine, Harvard Medical School
Research Fellow, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Address
221 Longwood Avenue, BLI 438Boston, MA 02115
USA
Inter-office Mail Address
BWH Division of Sleep Medicine, BLI 438Phone 617-525-6830
Fax 617-732-4013
Society Memberships
Sleep Research SocietySociety for Research of Biological Rhythms
Research Unit(s)
Division of Sleep Medicine, Brigham and Women's Hospital
Research Interests
Research efforts to date have focused on the identification and characterization of molecular mechanisms of the mammalian circadian clock and the genes that comprise them. Research goals include the careful characterization of circadian and sleep behavioral phenotypes by physiologic measures in order to identify the underlying genetic basis.
Mentor(s)
Selected Publications
Lee JH, Wang W, Silva EJ, Chang AM, Scheuermaier KD, Cain SW, Duffy JF. Neurobehavioral performance in young adults living on a 28-h day for 6 weeks.
Sleep. 2009 Jul 1;32(7):905-13. [PMID: 19639753]
Chang AM, Reid KJ, Gourineni R, Zee PC. Sleep timing and circadian phase in delayed sleep phase syndrome.
J Biol Rhythms. 2009 Aug;24(4):313-21. [PMID: 19625733]
Vitaterna MH, Ko CH, Chang AM, Buhr ED, Fruechte EM, Schook A, Antoch MP, Turek FW, Takahashi JS. The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9327-32. Epub 2006 Jun 5. [PMID: 16754844]
Reid KJ, Chang AM, Dubocovich ML, Turek FW, Takahashi JS, Zee PC. Familial advanced sleep phase syndrome.
Arch Neurol. 2001 Jul;58(7):1089-94. [PMID: 11448298]
Valentinuzzi VS, Buxton OM, Chang AM, Scarbrough K, Ferrari EA, Takahashi JS, Turek FW. Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination.
Physiol Behav. 2000 May;69(3):269-75. [PMID: 10869592]
King DP, Vitaterna MH, Chang AM, Dove WF, Pinto LH, Turek FW, Takahashi JS. The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.
Genetics. 1997 Jul;146(3):1049-60. [PMID: 9215907]
Antoch MP, Song EJ, Chang AM, Vitaterna MH, Zhao Y, Wilsbacher LD, Sangoram AM, King DP, Pinto LH, Takahashi JS. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.
Cell. 1997 May 16;89(4):655-67. [PMID: 9160756]
Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
Science. 1994 Apr 29;264(5159):719-25. [PMID: 8171325]
Sleep. 2009 Jul 1;32(7):905-13. [PMID: 19639753]
Chang AM, Reid KJ, Gourineni R, Zee PC. Sleep timing and circadian phase in delayed sleep phase syndrome.
J Biol Rhythms. 2009 Aug;24(4):313-21. [PMID: 19625733]
Vitaterna MH, Ko CH, Chang AM, Buhr ED, Fruechte EM, Schook A, Antoch MP, Turek FW, Takahashi JS. The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9327-32. Epub 2006 Jun 5. [PMID: 16754844]
Reid KJ, Chang AM, Dubocovich ML, Turek FW, Takahashi JS, Zee PC. Familial advanced sleep phase syndrome.
Arch Neurol. 2001 Jul;58(7):1089-94. [PMID: 11448298]
Valentinuzzi VS, Buxton OM, Chang AM, Scarbrough K, Ferrari EA, Takahashi JS, Turek FW. Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination.
Physiol Behav. 2000 May;69(3):269-75. [PMID: 10869592]
King DP, Vitaterna MH, Chang AM, Dove WF, Pinto LH, Turek FW, Takahashi JS. The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.
Genetics. 1997 Jul;146(3):1049-60. [PMID: 9215907]
Antoch MP, Song EJ, Chang AM, Vitaterna MH, Zhao Y, Wilsbacher LD, Sangoram AM, King DP, Pinto LH, Takahashi JS. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.
Cell. 1997 May 16;89(4):655-67. [PMID: 9160756]
Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
Science. 1994 Apr 29;264(5159):719-25. [PMID: 8171325]
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