Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Sanjeev V. Kothare, MD
Associate Professor of Neurology, Harvard Medical School
Attending Pediatric Neurologist & Sleep Specialist, Department of Neurology, Children's Hospital Boston
Administrative Title(s)
Associate Director (Neurology), Center for Pediatric Sleep Disorders, Children’s Hospital Boston
Fellowship Director, Pediatric Sleep Medicine Training Program, Children’s Hospital Boston
Fellowship Director, Pediatric Sleep Medicine Training Program, Children’s Hospital Boston
Other Affiliation(s)
Attending Epileptologist, Division of Epilepsy & Clinical Neurophysiology
Address
Fegan 9, 300 Longwood AvenueChildren's Hospital
Boston, MA 02115
USA
Phone 617 355 5606 (epilepsy) / 781 216 2570 (sleep)
Email sanjeev.kothare@childrens.harvard.edu
Society Memberships
American Academy of Sleep MedicineAmerican Academy of Neurology
American Epilepsy Society
American Academy of Pediatrics
Child Neurology Society
Research Unit(s)
Sleep Center for Children, Children's Hospital
Research Interests
The interplay between diverse neurological disorders in children with sleep is my main area of clinical research. Specifically, the relationship between epilepsy and sleep in children in clinical practice has been my established area of clinical interest. In addition, recently I have developed interest in assessing sleep disorders in children with rare genetic syndromes (Angelman, Rett, Prader Willi, Williams, 15q duplication, 16p11 del) with a special emphasis on sudden death in sleep in this population. I am also interested in assessing imaging abnormalities of the brain of children with diverse sleep disorders like sleep apnea, sleep deprivation, obesity, delayed sleep phase syndrome, etc, and the effects of interventions in improving these abnormalities, assessed both on anatomical as well as functional MRI techniques. I have always been interested in developing and participating in multi-centric studies to evaluate use of medications in treating children with insomnia, and hypersomnia from diverse causes. I have also actively striven in developing collaboration with the biomedical engineering department so as to combine technological advances in computational analysis to evaluate multiple aspects of sleep physiology across ages. Finally, I am very interested in assessing effects of sleep education techniques in improving outcomes in diagnosis and interventions in children by primary care physicians, including residents in training.
Trainees
Jonathan Lipton, MD, PhD, July 2008-present
Umakanth Khatwa, MD, July 2008-present
CA Matadeen, MD, 2006
N Havaligi, MD, 2006
Mohammed Zihlif, MD, 2005
O Ajabe, MD, 2004
Umakanth Khatwa, MD, July 2008-present
CA Matadeen, MD, 2006
N Havaligi, MD, 2006
Mohammed Zihlif, MD, 2005
O Ajabe, MD, 2004
Research Funding
Commonwealth of Pennsylvania; 2005-2007, Department of Health, Grant for Human Impact, Project 1050425000, Fund 240417
Validation of a Sleep Questionnaire in a General Pediatric Population and Application to Detect Abnormalities of Sleep in Specialized Pediatric Patient Populations, Specifically, Children with Sickle Cell Disease
Role: Principal Investigator
Validation of a Sleep Questionnaire in a General Pediatric Population and Application to Detect Abnormalities of Sleep in Specialized Pediatric Patient Populations, Specifically, Children with Sickle Cell Disease
Role: Principal Investigator
Teaching
Fellowship Director, Pediatric Sleep Medicine, Drexel University College of Medicine, 2004-2007 (10hr/week)
Fellowship Director, Pediatric Sleep Medicine, Children’s Hospital, Boston, 2008 (10/hr/week)
2003, Grand Rounds, Department of Pediatrics, Drexel University College of Medicine and St. Christopher’s Hospital for Children, Philadelphia PA. Sleep disorders in childhood: an update
2004, CME Lecture, Workshop on Pediatric Epilepsy, Migraine and Sleep Disorders, Department of Pediatrics, Drexel University College of Medicine and St. Christopher’s Hospital for Children, Philadelphia PA. Evaluation of excessive daytime sleepiness in children and adolescents
2005, Grand Rounds, Cleveland Clinic, Cleveland OH, Evaluation of daytime sleepiness in children and adolescents
2005, Program Director and Lecturer, Satellite Symposium on Sleep Disorders, Annual Meeting of the Ibero-American Academy of Pediatric Neurology, Philadelphia PA. Evaluation of daytime sleepiness, Overview of sleep disorders, Parasomnias
2006, Grand Rounds, Sick Children’s Hospital, Toronto, Ontario, Canada. Evaluation of excessive daytime sleepiness in children
2006, Invited Lecture, Pediatric Sleep Disorders Symposium, 35th Annual Meeting of the Child Neurology Society, Pittsburgh PA, Laboratory evaluation of daytime sleepiness in children
2006, Invited Lecture, Annual Meeting of the Association of Child Neurology Nurses, Pittsburgh PA. Excessive daytime sleepiness in pediatric patients with neurological co-morbidities
2007, Grand Rounds, Children’s National Medical Center, Washington, DC. Co-morbidities
associated with sleep disorders
2008, Community Education Initiatives: to Massachusetts Nurses, Children’s Hospital Boston at Waltham. Getting enough quality sleep: Diagnosis and management of sleep problems in children. “The sleepy child: recognition, assessment & intervention”
2008, Annual course on sleep disorders in children, Child Neurology Society, Santiago, Chile. “Evaluation of a sleepy child”, “Neurological co-morbidities associated with sleep disorders”, “The newly recognized metabolic syndrome in children”
2008, Grand Rounds, Longwood Neurology Program, HMS, Sleep Co-morbidities associated with neurological disorders in children.
2008, Invited Lecture, Bresnan Course in Child Neurology, Boston, MA. The science of Sleep
2008, Invited Lecture, Bresnan Course in Child Neurology, Boston, MA. Approach to polysomnography
2009, Invited Lecture, The Clinical & Laboratory Assessment of the Sleepy Child
Orlando, Florida 42nd Annual Meeting of the American Clinical Neurophysiology Society, at the annual course on Sleep & Polysomnography
Fellowship Director, Pediatric Sleep Medicine, Children’s Hospital, Boston, 2008 (10/hr/week)
2003, Grand Rounds, Department of Pediatrics, Drexel University College of Medicine and St. Christopher’s Hospital for Children, Philadelphia PA. Sleep disorders in childhood: an update
2004, CME Lecture, Workshop on Pediatric Epilepsy, Migraine and Sleep Disorders, Department of Pediatrics, Drexel University College of Medicine and St. Christopher’s Hospital for Children, Philadelphia PA. Evaluation of excessive daytime sleepiness in children and adolescents
2005, Grand Rounds, Cleveland Clinic, Cleveland OH, Evaluation of daytime sleepiness in children and adolescents
2005, Program Director and Lecturer, Satellite Symposium on Sleep Disorders, Annual Meeting of the Ibero-American Academy of Pediatric Neurology, Philadelphia PA. Evaluation of daytime sleepiness, Overview of sleep disorders, Parasomnias
2006, Grand Rounds, Sick Children’s Hospital, Toronto, Ontario, Canada. Evaluation of excessive daytime sleepiness in children
2006, Invited Lecture, Pediatric Sleep Disorders Symposium, 35th Annual Meeting of the Child Neurology Society, Pittsburgh PA, Laboratory evaluation of daytime sleepiness in children
2006, Invited Lecture, Annual Meeting of the Association of Child Neurology Nurses, Pittsburgh PA. Excessive daytime sleepiness in pediatric patients with neurological co-morbidities
2007, Grand Rounds, Children’s National Medical Center, Washington, DC. Co-morbidities
associated with sleep disorders
2008, Community Education Initiatives: to Massachusetts Nurses, Children’s Hospital Boston at Waltham. Getting enough quality sleep: Diagnosis and management of sleep problems in children. “The sleepy child: recognition, assessment & intervention”
2008, Annual course on sleep disorders in children, Child Neurology Society, Santiago, Chile. “Evaluation of a sleepy child”, “Neurological co-morbidities associated with sleep disorders”, “The newly recognized metabolic syndrome in children”
2008, Grand Rounds, Longwood Neurology Program, HMS, Sleep Co-morbidities associated with neurological disorders in children.
2008, Invited Lecture, Bresnan Course in Child Neurology, Boston, MA. The science of Sleep
2008, Invited Lecture, Bresnan Course in Child Neurology, Boston, MA. Approach to polysomnography
2009, Invited Lecture, The Clinical & Laboratory Assessment of the Sleepy Child
Orlando, Florida 42nd Annual Meeting of the American Clinical Neurophysiology Society, at the annual course on Sleep & Polysomnography
Committees
Childhood Sleep Disorders & Development Steering Committee, American Academy of Sleep Medicine, Westchester, IL. 2007 to present, Vice Chair, 2008 to present
Childhood Sleep Disorders & Development Steering Committee, American Academy of Sleep Medicine, Westchester, IL. 2007 to present, Vice Chair, 2008 to present
Selected Publications
Cruz MJ, Valencia I, Legido A, Kothare SV, Khurana DS, Yum S, Hardison HH, Melvin JJ, Marks HG. Efficacy and tolerability of topiramate in pediatric migraine.
Pediatr Neurol. 2009 Sep;41(3):167-70. [PMID: 19664530]
Lipton J, Megerian JT, Kothare SV, Cho YJ, Shanahan T, Chart H, Ferber R, Adler-Golden L, Cohen LE, Czeisler CA, Pomeroy SL. Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma.
Neurology. 2009 Jul 28;73(4):323-5. [PMID: 19636054]
Valencia I, Piñol-Ripoll G, Khurana DS, Hardison HH, Kothare SV, Melvin JJ, Marks HG, Legido A. Efficacy and safety of lamotrigine monotherapy in children and adolescents with epilepsy.
Eur J Paediatr Neurol. 2009 Mar;13(2):141-5. Epub 2008 Jun 27. [PMID: 18585941]
Tilmanne J, Urbain J, Kothare MV, Wouwer AV, Kothare SV. Algorithms for sleep-wake identification using actigraphy: a comparative study and new results.
J Sleep Res. 2009 Mar;18(1):85-98. [PMID: 19250177]
Goraya JS, Cruz M, Valencia I, Kaleyias J, Khurana DS, Hardison HH, Marks H, Legido A, Kothare SV. Sleep study abnormalities in children with attention deficit hyperactivity disorder.
Pediatr Neurol. 2009 Jan;40(1):42-6. [PMID: 19068253]
Lipton J, Becker RE, Kothare SV. Insomnia of childhood.
Curr Opin Pediatr. 2008 Dec;20(6):641-9. [PMID: 19005332]
Kothare SV, Pomeroy SL. Pediatric sleep medicine in 2008: state-of-the-art.
Curr Opin Pediatr. 2008 Dec;20(6):639-40. [PMID: 19023916]
Bokala S, Napalinga K, Carvalho K, Pinninti N, Valencia I, Legido A, Kothare SV. Correlates of periodic limb movements of sleep in pediatric population.
Pediatric Neurology 2008; 39: 33-39. [PMID: 18555170]
KaleyiasJ, Cruz M, Goraya GS, Valencia I, Khurana DS, Legido A, Kothare SV. Spectrum of polysomnographic abnormalities in children with epilepsy.
Pediatr Neurol 2008; 39:170-176. [PMID: 18725061]
Kaleyias J, Grant M, Coleman C, Luck L, Dampier C, Kothare SV. Occurrence of obstructive sleep apnea in children with sickle cell disease suspicious of sleep disordered breathing.
J Ped Hematol Oncol 2008; 30(9): 659-665. [PMID: 18776757]
Kothare SV, Kaleyias J. The clinical & laboratory assessment of the sleepy child.
Seminars in Pediatric Neurology 2008; 15: 61-69. [PMID: 18555192]
Vendrame M, Kaleyias J, Valencia I, Legido A, Kothare SV. Polysomnographic findings in children with headaches.
Pediatric Neurology 2008 39: 6-11. [PMID: 18555166]
Vendrame M, Havaligi N, Matadeen-Ali C, Adams R, Kothare SV. Narcolepsy in Children: A single center clinical experience.
Pediatr Neurol 2008; 38:314-320. [PMID: 18410846]
Flint J, Kothare SV, Zihlif M, Suarez E, Adams R, Legido A, DeLuca F. Association between inadequate sleep and insulin resistance in obese children.
J Pediatr 2007;150(4):364-369. [PMID: 17382111]
Kothare SV, Adams R, Valencia I, Faerber EC, Grant M. Improved sleep and neurocognitive functions in a child with thalamic lesions on sodium oxybate.
Neurology 2007;68(14):1157-1158. [PMID: 17404202]
Khurana DS, Reumann M, Hobdell EF, Neff S, Valencia I, Legido A, Kothare SV. Vagus nerve stimulation in children with refractory epilepsy: unusual complications and relationship to sleep disordered breathing.
Child Nerv Syst 2007;23(11):1309-1312. [PMID: 17619887]
Havaligi N, Matadeen-Ali C, Khurana DS, Marks H, Kothare SV. The treatment of drop attacks in Coffin Lowry syndrome with the use of sodium oxybate.
Pediatr Neurol 2007; 37:373-4. [PMID: 17950427]
Herrera M, Valencia I, Grant M, Metroka, D, Chialastri A, Kothare SV. Bruxism in children: effect on sleep architecture and daytime cognitive performance.
Sleep 2006;29(9):1143-1148. [PMID: 17040002]
Kaleyias J, Grant, M, Darbari F, Ajagbe O, Cepelowicz-Rajter J, Kothare SV. Detection of cortical arousals in children using frontal (Fz) EEG leads in addition to conventional central (C3/C4) leads.
J Clin Sleep Med 2006; 2(3): 305-308. [PMID: 17561542]
Reviews
Kothare SV, Kaleyias J. Narcolepsy and other hypersomnias in children.
Curr Opin Pediatr. 2008 Dec;20(6):666-75. Review. [PMID: 19023917]
Letter to The Editor
Maski KP, Kothare SV. Searching for marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy.
Sleep. 2009 Feb 1;32(2):137. [PMID: 19238799]
Pediatr Neurol. 2009 Sep;41(3):167-70. [PMID: 19664530]
Lipton J, Megerian JT, Kothare SV, Cho YJ, Shanahan T, Chart H, Ferber R, Adler-Golden L, Cohen LE, Czeisler CA, Pomeroy SL. Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma.
Neurology. 2009 Jul 28;73(4):323-5. [PMID: 19636054]
Valencia I, Piñol-Ripoll G, Khurana DS, Hardison HH, Kothare SV, Melvin JJ, Marks HG, Legido A. Efficacy and safety of lamotrigine monotherapy in children and adolescents with epilepsy.
Eur J Paediatr Neurol. 2009 Mar;13(2):141-5. Epub 2008 Jun 27. [PMID: 18585941]
Tilmanne J, Urbain J, Kothare MV, Wouwer AV, Kothare SV. Algorithms for sleep-wake identification using actigraphy: a comparative study and new results.
J Sleep Res. 2009 Mar;18(1):85-98. [PMID: 19250177]
Goraya JS, Cruz M, Valencia I, Kaleyias J, Khurana DS, Hardison HH, Marks H, Legido A, Kothare SV. Sleep study abnormalities in children with attention deficit hyperactivity disorder.
Pediatr Neurol. 2009 Jan;40(1):42-6. [PMID: 19068253]
Lipton J, Becker RE, Kothare SV. Insomnia of childhood.
Curr Opin Pediatr. 2008 Dec;20(6):641-9. [PMID: 19005332]
Kothare SV, Pomeroy SL. Pediatric sleep medicine in 2008: state-of-the-art.
Curr Opin Pediatr. 2008 Dec;20(6):639-40. [PMID: 19023916]
Bokala S, Napalinga K, Carvalho K, Pinninti N, Valencia I, Legido A, Kothare SV. Correlates of periodic limb movements of sleep in pediatric population.
Pediatric Neurology 2008; 39: 33-39. [PMID: 18555170]
KaleyiasJ, Cruz M, Goraya GS, Valencia I, Khurana DS, Legido A, Kothare SV. Spectrum of polysomnographic abnormalities in children with epilepsy.
Pediatr Neurol 2008; 39:170-176. [PMID: 18725061]
Kaleyias J, Grant M, Coleman C, Luck L, Dampier C, Kothare SV. Occurrence of obstructive sleep apnea in children with sickle cell disease suspicious of sleep disordered breathing.
J Ped Hematol Oncol 2008; 30(9): 659-665. [PMID: 18776757]
Kothare SV, Kaleyias J. The clinical & laboratory assessment of the sleepy child.
Seminars in Pediatric Neurology 2008; 15: 61-69. [PMID: 18555192]
Vendrame M, Kaleyias J, Valencia I, Legido A, Kothare SV. Polysomnographic findings in children with headaches.
Pediatric Neurology 2008 39: 6-11. [PMID: 18555166]
Vendrame M, Havaligi N, Matadeen-Ali C, Adams R, Kothare SV. Narcolepsy in Children: A single center clinical experience.
Pediatr Neurol 2008; 38:314-320. [PMID: 18410846]
Flint J, Kothare SV, Zihlif M, Suarez E, Adams R, Legido A, DeLuca F. Association between inadequate sleep and insulin resistance in obese children.
J Pediatr 2007;150(4):364-369. [PMID: 17382111]
Kothare SV, Adams R, Valencia I, Faerber EC, Grant M. Improved sleep and neurocognitive functions in a child with thalamic lesions on sodium oxybate.
Neurology 2007;68(14):1157-1158. [PMID: 17404202]
Khurana DS, Reumann M, Hobdell EF, Neff S, Valencia I, Legido A, Kothare SV. Vagus nerve stimulation in children with refractory epilepsy: unusual complications and relationship to sleep disordered breathing.
Child Nerv Syst 2007;23(11):1309-1312. [PMID: 17619887]
Havaligi N, Matadeen-Ali C, Khurana DS, Marks H, Kothare SV. The treatment of drop attacks in Coffin Lowry syndrome with the use of sodium oxybate.
Pediatr Neurol 2007; 37:373-4. [PMID: 17950427]
Herrera M, Valencia I, Grant M, Metroka, D, Chialastri A, Kothare SV. Bruxism in children: effect on sleep architecture and daytime cognitive performance.
Sleep 2006;29(9):1143-1148. [PMID: 17040002]
Kaleyias J, Grant, M, Darbari F, Ajagbe O, Cepelowicz-Rajter J, Kothare SV. Detection of cortical arousals in children using frontal (Fz) EEG leads in addition to conventional central (C3/C4) leads.
J Clin Sleep Med 2006; 2(3): 305-308. [PMID: 17561542]
Reviews
Kothare SV, Kaleyias J. Narcolepsy and other hypersomnias in children.
Curr Opin Pediatr. 2008 Dec;20(6):666-75. Review. [PMID: 19023917]
Letter to The Editor
Maski KP, Kothare SV. Searching for marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy.
Sleep. 2009 Feb 1;32(2):137. [PMID: 19238799]
Site Map | Contact Us | © 2006 by the President and Fellows of Harvard College
