Faculty Profile

I am interested in the epidemiology of sleep disorders, particularly sleep disordered breathing. Current projects are the following: Sleep Heart Health Study (Observational cohort study to determine the cardiovascular consequences of sleep-disordered breathing; Role: Steering Committee Chair and PI of the University of Arizona site), Tucson Children’s Assessment of Sleep Apnea (TuCASA, Observational cohort study to determine the impact of sleep disordered breathing in children; Role: PI), and the Applied Positive Pressure Long-term Efficacy Study (APPLES, Randomized clinical trial to determine the neurocognitive consequences of sleep disordered breathing; Role: PI University of Arizona site).

Dana Epstein, RN, PhD 1994-96
Derek Loewy, PhD 1996-98
Maria Martinez, MD 1999-2000
Abdul Hourani, MD 2000-01
Arnel Bobadilla, MD 2001-02
James L. Goodwin, PhD 2000-02
Carol M. Baldwin, RN, PhD 2002-04
Graciela Silva, PhD 2005-06

Tucson Children's Assessment of Sleep Apnea Study
Sponsor: NHLBI

Sleep Heart Health Study, Tucson Field Center
Sponsor: NHLBI

Applied Positive Pressure Long-term Efficacy Study-Tucson Field Center
Sponsor: NHLBI via subcontract from Stanford University

Budhiraja R, Quan SF, Punjabi NM, Drake CL, Dickman R, Fass R. Power Spectral Analysis of the Sleep Electroencephalogram in Heartburn Patients With or Without Gastroesophageal Reflux Disease (GERD): A Feasibility Study.
J Clin Gastroenterol. 2009 Aug 5. [Epub ahead of print] [PMID: 19661813]

Silva GE, An MW, Goodwin JL, Shahar E, Redline S, Resnick H, Baldwin CM, Quan SF. Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS).
Sleep. 2009 Aug 1;32(8):1049-57. [PMID: 19725256]

Rice A, Costy-Bennett S, Goodwin JL, Quan SF, Fregosi RF. Control of breathing in children with mild sleep apnoea: a six-year follow up study.
Eur Respir J. 2009 Jul 2. [Epub ahead of print] [PMID: 19574325]

O'Connor GT, Caffo B, Newman AB, Quan SF, Rapoport DM, Redline S, Resnick HE,
Samet J, Shahar E. Prospective study of sleep-disordered breathing and
hypertension: the Sleep Heart Health Study. Am J Respir Crit Care Med. 2009 Jun
15;179(12):1159-64. Epub 2009 Mar 5. [PMID: 19264976]

Quan SF. Work hours during residency training--the IOM speaketh.
J Clin Sleep Med. 2009 Feb 15;5(1):9-10. [PMID: 19317372]

Quan SF. Everywhere a conflict.
J Clin Sleep Med. 2008 Dec 15;4(6):531. [PMID: 19110879]

Ambrogio C, Koebnick J, Quan SF, Ranieri M, Parthasarathy S. Assessment of sleep in ventilator-supported critically III patients.
Sleep. 2008 Nov 1;31(11):1559-68. [PMID: 19014076]

Quan SF, Berry RB, Buysse D, Collop NA, Grigg-Damberger M, Harding SM, Iber C, McCall WV, Sateia MJ, Sheldon SH, Silber MH, Sorscher A, Ward SL, Veasey S, Woodson BT, Hess B, Kangilaski R. Development and results of the first ABMS subspecialty Certification Examination in Sleep Medicine.
J Clin Sleep Med. 2008 Oct 15;4(5):505-8. [PMID: 18853709]

Vasquez MM, Goodwin JL, Drescher AA, Smith TW, Quan SF. Associations of dietary intake and physical activity with sleep disordered breathing in the Apnea Positive Pressure Long-Term Efficacy Study (APPLES).
J Clin Sleep Med. 2008 Oct 15;4(5):411-8. [PMID: 18853696]

Guerra S, Sherrill DL, Kurzius-Spencer M, Venker C, Halonen M, Quan SF, Martinez FD. The course of persistent airflow limitation in subjects with and without asthma.
Respir Med. 2008 Oct;102(10):1473-82. Epub 2008 Aug 6. [PMID: 18684603]

Sharief I, Silva GE, Goodwin JL, Quan SF. Effect of sleep disordered breathing on the sleep of bed partners in the Sleep Heart Health Study.
Sleep. 2008 Oct 1;31(10):1449-56. [PMID: 18853943]

Quan SF, Budhiraja R, Parthasarathy S. Is there a bidirectional relationship between obesity and sleep-disordered breathing?
J Clin Sleep Med. 2008 Jun 15;4(3):210-1. [PMID: 18595432]

Quan SF. Guests and ghosts begone-guest authorship and ghostwriting and the Journal of Clinical Sleep Medicine.
J Clin Sleep Med. 2008 Jun 15;4(3):203. [PMID: 18595430]

Kushida CA, Chediak A, Berry RB, Brown LK, Gozal D, Iber C, Parthasarathy S, Quan SF, Rowley JA; Positive Airway Pressure Titration Task Force; American Academy of Sleep Medicine. Clinical guidelines for the manual titration of positive airway pressure in patients with obstructive sleep apnea.
J Clin Sleep Med. 2008 Apr 15;4(2):157-71. [PMID: 18468315]

Quan SF, Redline S. Hypopnea scoring in the Sleep Heart Health Study.
Chest. 2008 Apr;133(4):1054-5; discussion 1055. [PMID: 18398136]

Zhao Q, Sherrill DL, Goodwin JL, Quan SF. Association Between Sleep Disordered Breathing and Behavior in School-Aged Children: The Tucson Children's Assessment of Sleep Apnea Study.
Open Epidemiol J. 2008;1:1-9. [PMID: 18568089]

Schey R, Dickman R, Parthasarathy S, Quan SF, Wendel C, Merchant J, Powers J, Han B, van Handel D, Fass R. Sleep deprivation is hyperalgesic in patients with gastroesophageal  reflux disease.
Gastroenterology. 2007 Dec;133(6):1787-95. [PMID: 18054551]

Venker CC, Goodwin JL, Roe DJ, Kaemingk KL, Mulvaney S, Quan SF. Normative psychomotor vigilance task performance in children ages 6 to 11--the Tucson Children's Assessment of Sleep Apnea (TuCASA).
Sleep Breath. 2007 Dec;11(4):217-24. [PMID: 17333098]

Silva GE, Goodwin JL, Sherrill DL, Arnold JL, Bootzin RR, Smith T, Walsleben JA, Baldwin CM, Quan SF. Relationship between reported and measured sleep times:  the sleep heart health study (SHHS). 
J Clin Sleep Med. 2007 Oct 15;3(6):622-30. [PMID: 17993045]

Quan SF, O'connor GT, Quan JS, Redline S, Resnick HE, Shahar E, Siscovick D,Sherrill DL. Association of physical activity with sleep-disordered breathing.
Sleep Breath. 2007 Jan 13; [Epub ahead of print][PMID: 17221274]

Quan SF, Wright R, Baldwin CM, Kaemingk KL, Goodwin JL, Kuo TF, Kaszniak A, Boland LL, Caccappolo E, Bootzin RR. Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study.
Sleep Med. 2006 Sep;7(6):498-507. Epub 2006 Jul 3. [PMID: 16815753]

Kushida CA, Nichols DA, Quan SF, Goodwin JL, White DP, Gottlieb DJ, Walsh JK, Schweitzer PK, Guilleminault C, Simon RD, Leary EB, Hyde PR, Holmes TH, Bloch DA, Green S, McEvoy LK, Gevins A, Dement WC.  The Apnea Positive Pressure Long-term Efficacy Study (APPLES): rationale, design, methods, and procedures.
J Clin Sleep Med. 2006 Jul 15;2(3):288-300. [PMID: 17561541]

Goodwin JL, Kaemingk KL, Mulvaney SA, Morgan WJ, Quan SF. Clinical screening of school children for polysomnography to detect sleep-disordered breathing--the Tucson Children's Assessment of Sleep Apnea study (TuCASA).
J Clin Sleep Med. 2005 Jul 15;1(3):247-54. [PMID: 16429591]

Parthasarathy S, Haynes PL, Budhiraja R, Habib MP, Quan SF. A national survey of the effect of sleep medicine specialists and American Academy of Sleep Medicine Accreditation on management of obstructive sleep apnea.
J Clin Sleep Med. 2006 Apr 15;2(2):133-42. [PMID: 17557485]

Quan SF, Katz R, Olson J, Bonekat W, Enright PL, Young T, Newman A. Factors associated with incidence and persistence of symptoms of disturbed sleep in an elderly cohort: the Cardiovascular Health Study.
Am J Med Sci. 2005 Apr;329(4):163-72. [PMID: 15832098]

Parthasarathy S, Habib M, Quan SF. How are automatic positive airway pressure and related devices prescribed by sleep physicians? A web-based survey.
J Clin Sleep Med. 2005 Jan 15;1(1):27-34. [PMID: 17561612]

Quan SF, Gersh BJ; National Center on Sleep Disorders Research; National Heart, Lung, and Blood Institute. Cardiovascular consequences of sleep-disordered breathing: past, present and future: report of a workshop from the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute.
Circulation. 2004 Mar 2;109(8):951-7. No abstract available. [PMID: 14993147]

Fregosi RF, Quan SF, Kaemingk KL, Morgan WJ, Goodwin JL, Cabrera R, Gmitro A.  Sleep-disordered breathing, pharyngeal size and soft tissue anatomy in children.
J Appl Physiol. 2003 Nov;95(5):2030-8. Epub 2003 Aug 1. [PMID: 12897029]

Kaemingk KL, Pasvogel AE, Goodwin JL, Mulvaney SA, Martinez F, Enright PL, Rosen GM, Morgan WJ, Fregosi RF, Quan SF.  Learning in children and sleep disordered breathing: findings of the Tucson Children's Assessment of Sleep Apnea (tuCASA) prospective cohort study.
J Int Neuropsychol Soc. 2003 Nov;9(7):1016-26. [PMID: 14738283]

Enright PL, Goodwin JL, Sherrill DL, Quan JR, Quan SF; Tucson Children's Assessment of Sleep Apnea study.  Blood pressure elevation associated with sleep-related breathing disorder in a community sample of white and Hispanic children: the Tucson Children's Assessment of Sleep Apnea study.
Arch Pediatr Adolesc Med. 2003 Sep;157(9):901-4. [PMID: 12963596]

Goodwin JL, Kaemingk KL, Fregosi RF, Rosen GM, Morgan WJ, Sherrill DL, Quan SF.  Clinical outcomes associated with sleep-disordered breathing in Caucasian and Hispanic children--the Tucson Children's Assessment of Sleep Apnea study (TuCASA).
Sleep. 2003 Aug 1;26(5):587-91. [PMID: 12938812]

Quan SF, Goodwin JL, Babar SI, Kaemingk KL, Enright PL, Rosen GM, Fregosi RF, Morgan WJ. Sleep architecture in normal Caucasian and Hispanic children aged 6-11 years recorded during unattended home polysomnography: experience from the Tucson Children's Assessment of Sleep Apnea Study (TuCASA).
Sleep Med. 2003 Jan;4(1):13-9. [PMID: 14592355]

Quan SF, Griswold ME, Iber C, Nieto FJ, Rapoport DM, Redline S, Sanders M, Young T; Sleep Heart Health Study (SHHS) Research Group.  Short-term variablility of respiration and sleep during unattended nonlaboratory polysomnogaphy--the Sleep Heart Health Study.
Sleep. 2002 Dec;25(8):843-9. [PMID: 12489889]

Goodwin JL, Enright PL, Kaemingk KL, Rosen GM, Morgan WJ, Fregosi RF, Quan SF.  Feasibility of using unattended polysomnography in children for research--report of the Tucson Children's Assessment of Sleep Apnea study (TuCASA).
Sleep. 2001 Dec 15;24(8):937-44. [PMID: 11766164]

Holberg CJ, Natrajan S, Cline MG, Quan SF. Familial Aggregation and Segregation Analysis of Snoring and Symptoms of Obstructive Sleep Apnea.
Sleep Breath. 2000;4(1):21-30. [PMID: 11894196]

Sherrill DL, Kotchou K, Quan SF. Association of physical activity and human sleep disorders.
Arch Intern Med. 1998 Sep 28;158(17):1894-8. [PMID: 9759685]

Quan SF, Howard BV, Iber C, Kiley JP, Nieto FJ, O'Connor GT, Rapoport DM, Redline S, Robbins J, Samet JM, Wahl PW.  The Sleep Heart Health Study: design, rationale, and methods.
Sleep. 1997 Dec;20(12):1077-85. [PMID: 9493915]

Dodge R, Cline MG, Quan SF. The natural history of insomnia and its relationship to respiratory symptoms.
Arch Intern Med. 1995 Sep 11;155(16):1797-800. [PMID: 7654114]

Klink ME, Dodge R, Quan SF. The relation of sleep complaints to respiratory symptoms in a general population.
Chest. 1994 Jan;105(1):151-4. [PMID: 8275723]

Reviews

Budhiraja R, Parthasarathy S, Quan SF. Endothelial dysfunction in obstructive sleep apnea.
J Clin Sleep Med. 2007 Jun 15;3(4):409-15. Review. [PMID: 17694731]

Redline S, Budhiraja R, Kapur V, Marcus CL, Mateika JH, Mehra R, Parthasarthy S, Somers VK, Strohl KP, Sulit LG, Gozal D, Wise MS, Quan SF. The scoring of respiratory events in sleep: reliability and validity.
J Clin Sleep Med. 2007 Mar 15;3(2):169-200. Review. [PMID: 17557426]