Faculty Profile

Patrick M. Fuller, PhD


Instructor in Neurology, Harvard Medical School
Instructor, Department of Neurology, Beth Israel Deaconess Medical Center

Other Affiliation(s)

Harvard Institutes of Medicine

See publications


Inter-office Mail Address

BIDMC, HIM 819, Saper lab

Email pfuller@bidmc.harvard.edu

Society Memberships

Society for Neuroscience
Sleep Research Society
American Physiological Society
Sigma Xi
International Society for Gravitational Physiology

Research Unit(s)

Systems Neurobiology Group (Saper)

Research Interests

My research is focused on characterizing the neuronal substrates of ultradian (e.g., REM), circadian and homeostatic control systems, including the circuitry driving cortical arousal.  I am interesting in elucidating the mechanisms of integration of homeostatic, circadian, emotional and cognitive inputs for behavioral state control, including sleep-wake regulation. Investigative approaches include chronic telemetry, ISH, RTqPCR, microarrays, IHC, behavioral recordings, modeling, neuronal tracers, neurotoxic lesions, genetically modified mice, and viral vectors (adenoassociated virus, AAV) for focal deletion/delivery of genes.

Mentor(s)

Clifford B. Saper, MD, PhD

Research Funding

NINDS, Food Entrainable Circadian Oscillators, PI: PM Fuller    

Cephalon, Inc., The ventrolateral preoptic nucleus: neuroanatomic substrate mediating armodafinil’s effects on wakefulness? PI: PM Fuller  (Co-I: Saper, CB)

Selected Publications

Saper CB and Fuller PM. Inducible Clocks: Living in an Unpredictable World
Cold Spring Harb Symp Quant Biol.  2007; Volume LXXII. 978-087969823-2

Fuller PM, Saper CB, Lu J.  The pontine REM switch: past and present.
J Physiol. 2007 Nov 1;584(Pt 3):735-41. Epub 2007 Sep 20. PMID: 17884926 

Fuller PM, Gooley JJ, Saper CB.  Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback.
J Biol Rhythms. 2006 Dec;21(6):482-93. Review. PMID: 17107938 

Fuller PM, Fuller CA.  Genetic evidence for a neurovestibular influence on the mammalian circadian pacemaker.
J Biol Rhythms. 2006 Jun;21(3):177-84. PMID: 16731657 

Fuller PM, Jones TA, Jones SM, Fuller CA. Evidence for macular gravity receptor modulation of hypothalamic, limbic and autonomic nuclei.
Neuroscience. 2004;129(2):461-71. PMID: 15501603 

Fuller PM, Jones TA, Jones SM, Fuller CA.  Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15723-8. Epub 2002 Nov 14. PMID: 12434016 

Fuller PM, Warden CH, Barry SJ, Fuller CA.  Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice.
J Appl Physiol. 2000 Oct;89(4):1491-8. PMID: 11007587 

Fuller, CA and Fuller, PM. Circadian Rhythms.
Encyclopedia of the Human Brain, ed. V.S. 2002

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