Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Patrick M. Fuller, PhD
Instructor in Neurology, Harvard Medical School
Instructor, Department of Neurology, Beth Israel Deaconess Medical Center
Other Affiliation(s)
Harvard Institutes of Medicine
Inter-office Mail Address
BIDMC, HIM 819, Saper labEmail pfuller@bidmc.harvard.edu
Society Memberships
Society for NeuroscienceSleep Research Society
American Physiological Society
Sigma Xi
International Society for Gravitational Physiology
Research Unit(s)
Systems Neurobiology Group (Saper)
Research Interests
My research is focused on characterizing the neuronal substrates of ultradian (e.g., REM), circadian and homeostatic control systems, including the circuitry driving cortical arousal. I am interesting in elucidating the mechanisms of integration of homeostatic, circadian, emotional and cognitive inputs for behavioral state control, including sleep-wake regulation. Investigative approaches include chronic telemetry, ISH, RTqPCR, microarrays, IHC, behavioral recordings, modeling, neuronal tracers, neurotoxic lesions, genetically modified mice, and viral vectors (adenoassociated virus, AAV) for focal deletion/delivery of genes.
Mentor(s)
Research Funding
NINDS, Food Entrainable Circadian Oscillators, PI: PM Fuller
Cephalon, Inc., The ventrolateral preoptic nucleus: neuroanatomic substrate mediating armodafinil’s effects on wakefulness? PI: PM Fuller (Co-I: Saper, CB)
Cephalon, Inc., The ventrolateral preoptic nucleus: neuroanatomic substrate mediating armodafinil’s effects on wakefulness? PI: PM Fuller (Co-I: Saper, CB)
Selected Publications
Ingham ES, Günhan E, Fuller PM, Fuller CA. Immunotoxin-induced ablation of melanopsin retinal ganglion cells in a non-murine mammalian model.
J Comp Neurol. 2009 Sep 10;516(2):125-40. [PMID: 19575450]
Fuller PM, Lu J, Saper CB. Standards of evidence in chronobiology: A response.
J Circadian Rhythms. 2009 Jul 22;7:9. [PMID: 19624818]
Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia.
J Neurosci. 2009 Jul 22;29(29):9361-9. [PMID: 19625526]
Greco MA, Fuller PM, Jhou TC, Martin-Schild S, Zadina JE, Hu Z, Shiromani P, Lu J. Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus.
Brain Res. 2008 Dec 15;1245:96-107. Epub 2008 Sep 24. PubMed PMID: 18840417; [Central PMCID: PMC2753822]
Pedersen NP, Fuller PM, Lu J, Saper CB. In the flicker of an eye.
J Physiol. 2008 Jul 15;586(14):3305-6. [PMID: 18625803]
Fuller PM, Lu J, Saper CB. Differential rescue of light- and food-entrainable circadian rhythms.
Science. 2008 May 23;320(5879):1074-7. [PMID: 18497298]
Fuller PM, Fuller CA. Genetic evidence for a neurovestibular influence on the mammalian circadian pacemaker.
J Biol Rhythms. 2006 Jun;21(3):177-84. PubMed [PMID: 16731657]
Fuller PM, Baldwin KM, Fuller CA. Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity.
Am J Physiol Regul Integr Comp Physiol. 2006 Feb;290(2):R442-8. Epub 2005 Sep 22. [PMID: 16179485]
Fuller PM, Jones TA, Jones SM, Fuller CA. Evidence for macular gravity receptor modulation of hypothalamic, limbic and autonomic nuclei.
Neuroscience. 2004;129(2):461-71. [PMID: 15501603]
Fuller PM, Jones TA, Jones SM, Fuller CA. Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15723-8. Epub 2002 Nov 14. [PMID: 12434016]
Fuller PM, Warden CH, Barry SJ, Fuller CA. Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice.
J Appl Physiol. 2000 Oct;89(4):1491-8. [PMID: 11007587]
Reviews
Fuller PM, Saper CB, Lu J. The pontine REM switch: past and present.
J Physiol. 2007 Nov 1;584(Pt 3):735-41. Epub 2007 Sep 20. Review. [PMID: 17884926]
Saper CB, Fuller PM. Inducible clocks: living in an unpredictable world.
Cold Spring Harb Symp Quant Biol. 2007;72:543-50. Review. [PMID: 18419313]
Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback.
J Biol Rhythms. 2006 Dec;21(6):482-93. Review. [PMID: 17107938]
Books
Fuller, CA and Fuller, PM. Circadian Rhythms.
Encyclopedia of the Human Brain, ed. V.S. 2002
J Comp Neurol. 2009 Sep 10;516(2):125-40. [PMID: 19575450]
Fuller PM, Lu J, Saper CB. Standards of evidence in chronobiology: A response.
J Circadian Rhythms. 2009 Jul 22;7:9. [PMID: 19624818]
Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia.
J Neurosci. 2009 Jul 22;29(29):9361-9. [PMID: 19625526]
Greco MA, Fuller PM, Jhou TC, Martin-Schild S, Zadina JE, Hu Z, Shiromani P, Lu J. Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus.
Brain Res. 2008 Dec 15;1245:96-107. Epub 2008 Sep 24. PubMed PMID: 18840417; [Central PMCID: PMC2753822]
Pedersen NP, Fuller PM, Lu J, Saper CB. In the flicker of an eye.
J Physiol. 2008 Jul 15;586(14):3305-6. [PMID: 18625803]
Fuller PM, Lu J, Saper CB. Differential rescue of light- and food-entrainable circadian rhythms.
Science. 2008 May 23;320(5879):1074-7. [PMID: 18497298]
Fuller PM, Fuller CA. Genetic evidence for a neurovestibular influence on the mammalian circadian pacemaker.
J Biol Rhythms. 2006 Jun;21(3):177-84. PubMed [PMID: 16731657]
Fuller PM, Baldwin KM, Fuller CA. Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity.
Am J Physiol Regul Integr Comp Physiol. 2006 Feb;290(2):R442-8. Epub 2005 Sep 22. [PMID: 16179485]
Fuller PM, Jones TA, Jones SM, Fuller CA. Evidence for macular gravity receptor modulation of hypothalamic, limbic and autonomic nuclei.
Neuroscience. 2004;129(2):461-71. [PMID: 15501603]
Fuller PM, Jones TA, Jones SM, Fuller CA. Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15723-8. Epub 2002 Nov 14. [PMID: 12434016]
Fuller PM, Warden CH, Barry SJ, Fuller CA. Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice.
J Appl Physiol. 2000 Oct;89(4):1491-8. [PMID: 11007587]
Reviews
Fuller PM, Saper CB, Lu J. The pontine REM switch: past and present.
J Physiol. 2007 Nov 1;584(Pt 3):735-41. Epub 2007 Sep 20. Review. [PMID: 17884926]
Saper CB, Fuller PM. Inducible clocks: living in an unpredictable world.
Cold Spring Harb Symp Quant Biol. 2007;72:543-50. Review. [PMID: 18419313]
Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback.
J Biol Rhythms. 2006 Dec;21(6):482-93. Review. [PMID: 17107938]
Books
Fuller, CA and Fuller, PM. Circadian Rhythms.
Encyclopedia of the Human Brain, ed. V.S. 2002
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