Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Monika Haack, PhD
Instructor in Neurology, Harvard Medical School
Instructor, Department of Neurology, Beth Israel Deaconess Medical Center
Address
330 Brookline AvenueDana 779
Boston, MA 02215
USA
Inter-office Mail Address
Beth Israel Deaconess Medical Center East Campus, Dana 779Phone 617-667-5234
Fax 617-667-5210
Email mhaack@bidmc.harvard.edu
Society Memberships
Sleep Research Society (SRS)Psychoneuroimmunology Research Society (PNIRS)
German Sleep Society (DGSM)
Research Unit(s)
Human Sleep and Chronobiology Research Unit, Beth Israel Deaconess Medical Center
Research Interests
My research interest focuses on the impact of sleep quantity and quality on emotional and physical well-being, in particular pain experiences, and whether inflammatory processes link the association between sleep and pain. We study the sleep-pain relationship in experimental models of prolonged partial sleep deprivation and total sleep deprivation, and will shortly begin testing pain thresholds in patients suffering from primary insomnia. In addition to the impact of insufficient sleep on the analgesic and inflammatory system, I am interested in whether improvement of sleep quantity and quality has a beneficial influence on different systems. Currently, we are testing whether sleep extension lowers blood pressure and inflammatory markers.
Mentor(s)
Research Funding
American Heart Association (AHA), PI Monika Haack
Restoring Sleep Homeostasis to Lower BP: A Behavioral Prevention and Treatment Approach
Sepracor, PI Janet Mullington
Pain perception and skill learning in normal sleepers and insomniacs.
NIH/NHLBI, PI Janet Mullington
Adiposity, BP & the Inflammatory Response to Sleep Loss
NIH/NIA, PI Janet Mullington
Aging & the Inflammatory, Metabolic and Autonomic Response to Sleep Loss
Restoring Sleep Homeostasis to Lower BP: A Behavioral Prevention and Treatment Approach
Sepracor, PI Janet Mullington
Pain perception and skill learning in normal sleepers and insomniacs.
NIH/NHLBI, PI Janet Mullington
Adiposity, BP & the Inflammatory Response to Sleep Loss
NIH/NIA, PI Janet Mullington
Aging & the Inflammatory, Metabolic and Autonomic Response to Sleep Loss
Selected Publications
Haack M, Lee E, Cohen DA, Mullington JM. Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain.
Pain. 2009 Sep;145(1-2):136-41. Epub 2009 Jun 27. [PMID: 19560866]
Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers.
Sleep. 2007 Sep 1;30(9):1145-52. [PMID: 17910386]
Schuld A, Birkmann S, Beitinger P, Haack M, Kraus T, Dalal MA,Holsboer F, Pollmächer T. Low doses of dexamethasone affect immune parameters in the absence of immunological stimulation.
Exp Clin Endocrinol Diabetes. 2006 Jun;114(6):322-8. [PMID: 16868892].
Haack M, Mullington JM. Sustained sleep restriction reduces emotional and physical well-being.
Pain. 2005 Dec 15;119(1-3):56-64. Epub 2005 Nov 16. [PMID: 16297554]
Himmerich H, Schuld A, Haack M, Kaufmann C, Pollmächer T. Early prediction of changes in weight during six weeks of treatment with antidepressants.
J Psychiatr Res. 2004 Sep-Oct;38(5):485-9. [PMID: 15380398]
Haack M, Pollmächer T, Mullington JM. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers.
Brain Behav Immun. 2004 Jul;18(4):361-7. [PMID: 15157953]
Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone.
J Psychiatr Res. 2003 Nov-Dec;37(6):463-70. [PMID: 14563377]
Kraus T, Haack M, Schuld A, Hinze-Selch D, Koethe D, Pollmächer T. Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine.
Pharmacopsychiatry. 2002 Nov;35(6):220-5. [PMID: 12518269]
Straub RH, Schuld A, Mullington J, Haack M, Scholmerich J, Pollmächer T. The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects.
J Endocrinol. 2002 Nov;175(2):467-74. [PMID: 12429044]
Reichenberg A, Kraus T, Haack M, Schuld A, Pollmächer T, Yirmiya R. Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion.
Psychoneuroendocrinology. 2002 Nov;27(8):945-56. [PMID: 12383455]
Haack M, Kraus T, Schuld A, Dalal M, Koethe D, Pollmächer T. Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures.
Psychoneuroendocrinology. 2002 Nov;27(8):921-31. [PMID: 12383453]
Haack M, Schuld A, Kraus T, Pollmächer T. Effects of sleep on endotoxin-induced host responses in healthy men.
Psychosom Med. 2001 Jul-Aug;63(4):568-78. [PMID: 11485110]
Dalal MA, Schuld A, Haack M, Uhr M, Geisler P, Eisensehr I, Noachtar S, Pollmächer T. Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients.
Neurology. 2001 Jun 26;56(12):1749-51. Erratum in: Neurology 2002 Jan 22;58(2):334. [PMID: 11425946]
Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmächer T. Cytokine-associated emotional and cognitive disturbances in humans.
Arch Gen Psychiatry. 2001 May;58(5):445-52. [PMID: 11343523]
Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmächer T. Low leptin levels but normal body mass indices in patients with depression or schizophrenia.
Neuroendocrinology. 2001 Apr;73(4):243-7. [PMID: 11340338]
Kraus T, Zimmermann U, Schuld A, Haack M, Hinze-Selch D, Pollmächer T. The physiopathology of weight regulation during treatment with psychotropic drugs.
Fortschr Neurol Psychiatr. 2001 Mar;69(3):116-37. German. [PMID: 11305122]
Schuld A, Blum WF, Uhr M, Haack M, Kraus T, Holsboer F, Pollmächer T. Reduced leptin levels in human narcolepsy.
Neuroendocrinology. 2000 Oct;72(4):195-8. [PMID: 11070422]
Schuld A, Kraus T, Haack M, Hinze-Selch D, Zobel AW, Holsboer F, Pollmächer T. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients.
Psychoneuroendocrinology. 2001 Jan;26(1):65-76. [PMID: 11070335]
Schuld A, Kraus T, Haack M, Hinze-Selch D, Kuhn M, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors during treatment with olanzapine.
Schizophr Res. 2000 Jun 16;43(2-3):164-6. [PMID: 11001592]
Schuld A, Kraus T, Hinze-Selch D, Haack M, Pollmächer T. Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia.
Acta Psychiatr Scand. 2000 Aug;102(2):153-5. [PMID: 10937789]
Hinze-Selch D, Schuld A, Kraus T, Kuhn M, Uhr M, Haack M, Pollmächer T. Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: A longitudinal study in patients treated with amitriptyline or paroxetine.
Neuropsychopharmacology. 2000 Jul;23(1):13-9. [PMID: 10869882]
Schuld A, Kuhn M, Haack M, Kraus T, Hinze-Selch D, Lechner C, Pollmächer T. A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia.
Pharmacopsychiatry. 2000 May;33(3):109-11. [PMID: 10855462]
Haack M, Reichenberg A, Kraus T, Schuld A, Yirmiya R, Pollmächer T. Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men.
Cytokine. 2000 Jun;12(6):694-8. [PMID: 10843747]
Schuld A, Kraus T, Haack M, Hinze-Selch D, Pollmächer T. Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder.
J Sleep Res. 1999 Dec;8(4):321-2. [PMID: 10646174]
Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kuhn M, Schuld A, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis.
J Psychiatr Res. 1999 Sep-Oct;33(5):407-18. [PMID: 10504009]
Pollmächer T, Kraus T, Haack M, Uhr M, Mullington J. Salmonella abortus equi endotoxin does not affect leptin plasma levels in healthy humans.
J Infect Dis. 1999 Apr;179(4):1047-8. [PMID: 10068609]
Kraus T, Haack M, Schuld A, Hinze-Selch D, Kuhn M, Uhr M, Pollmächer T. Body weight and leptin plasma levels during treatment with antipsychotic drugs.
Am J Psychiatry. 1999 Feb;156(2):312-4. [PMID: 9989571]
Books, Chapters, Reviews
Mullington JM, Haack M, Toth M, Serrador JM, Meier-Ewert HK. Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation.
Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):294-302. Review. [PMID: 19110131]
Schuld A, Haack M, Hinze-Selch D, Mullington J, Pollmächer T. Experimental studies on the interaction between sleep and the immune system in humans
Psychother Psychosom Med Psychol. 2005 Jan;55(1):29-35. Review. German. [PMID: 15647993]
Pollmächer T, Haack M, Schuld A, Reichenberg A, Yirmiya R. Low levels of circulating inflammatory cytokines--do they affect human brain functions?
Brain Behav Immun. 2002 Oct;16(5):525-32. Review. [PMID: 12401466]
Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D. On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors.
Fortschr Neurol Psychiatr. 2001 Sep;69 Suppl 2:S65-74. Review. German. [PMID: 11533853]
Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullington J. Experimental immunomodulation, sleep, and sleepiness in humans.
Ann N Y Acad Sci. 2000;917:488-99. Review. [PMID: 11268376]
Pollmächer T, Haack M, Schuld A, Kraus T, Hinze-Selch D. Effects of antipsychotic drugs on cytokine networks.
J Psychiatr Res. 2000 Nov-Dec;34(6):369-82. Review. [PMID: 11165304]
Pain. 2009 Sep;145(1-2):136-41. Epub 2009 Jun 27. [PMID: 19560866]
Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers.
Sleep. 2007 Sep 1;30(9):1145-52. [PMID: 17910386]
Schuld A, Birkmann S, Beitinger P, Haack M, Kraus T, Dalal MA,Holsboer F, Pollmächer T. Low doses of dexamethasone affect immune parameters in the absence of immunological stimulation.
Exp Clin Endocrinol Diabetes. 2006 Jun;114(6):322-8. [PMID: 16868892].
Haack M, Mullington JM. Sustained sleep restriction reduces emotional and physical well-being.
Pain. 2005 Dec 15;119(1-3):56-64. Epub 2005 Nov 16. [PMID: 16297554]
Himmerich H, Schuld A, Haack M, Kaufmann C, Pollmächer T. Early prediction of changes in weight during six weeks of treatment with antidepressants.
J Psychiatr Res. 2004 Sep-Oct;38(5):485-9. [PMID: 15380398]
Haack M, Pollmächer T, Mullington JM. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers.
Brain Behav Immun. 2004 Jul;18(4):361-7. [PMID: 15157953]
Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone.
J Psychiatr Res. 2003 Nov-Dec;37(6):463-70. [PMID: 14563377]
Kraus T, Haack M, Schuld A, Hinze-Selch D, Koethe D, Pollmächer T. Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine.
Pharmacopsychiatry. 2002 Nov;35(6):220-5. [PMID: 12518269]
Straub RH, Schuld A, Mullington J, Haack M, Scholmerich J, Pollmächer T. The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects.
J Endocrinol. 2002 Nov;175(2):467-74. [PMID: 12429044]
Reichenberg A, Kraus T, Haack M, Schuld A, Pollmächer T, Yirmiya R. Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion.
Psychoneuroendocrinology. 2002 Nov;27(8):945-56. [PMID: 12383455]
Haack M, Kraus T, Schuld A, Dalal M, Koethe D, Pollmächer T. Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures.
Psychoneuroendocrinology. 2002 Nov;27(8):921-31. [PMID: 12383453]
Haack M, Schuld A, Kraus T, Pollmächer T. Effects of sleep on endotoxin-induced host responses in healthy men.
Psychosom Med. 2001 Jul-Aug;63(4):568-78. [PMID: 11485110]
Dalal MA, Schuld A, Haack M, Uhr M, Geisler P, Eisensehr I, Noachtar S, Pollmächer T. Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients.
Neurology. 2001 Jun 26;56(12):1749-51. Erratum in: Neurology 2002 Jan 22;58(2):334. [PMID: 11425946]
Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmächer T. Cytokine-associated emotional and cognitive disturbances in humans.
Arch Gen Psychiatry. 2001 May;58(5):445-52. [PMID: 11343523]
Neuroendocrinology. 2001 Apr;73(4):243-7. [PMID: 11340338]
Kraus T, Zimmermann U, Schuld A, Haack M, Hinze-Selch D, Pollmächer T. The physiopathology of weight regulation during treatment with psychotropic drugs.
Fortschr Neurol Psychiatr. 2001 Mar;69(3):116-37. German. [PMID: 11305122]
Schuld A, Blum WF, Uhr M, Haack M, Kraus T, Holsboer F, Pollmächer T. Reduced leptin levels in human narcolepsy.
Neuroendocrinology. 2000 Oct;72(4):195-8. [PMID: 11070422]
Schuld A, Kraus T, Haack M, Hinze-Selch D, Zobel AW, Holsboer F, Pollmächer T. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients.
Psychoneuroendocrinology. 2001 Jan;26(1):65-76. [PMID: 11070335]
Schuld A, Kraus T, Haack M, Hinze-Selch D, Kuhn M, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors during treatment with olanzapine.
Schizophr Res. 2000 Jun 16;43(2-3):164-6. [PMID: 11001592]
Schuld A, Kraus T, Hinze-Selch D, Haack M, Pollmächer T. Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia.
Acta Psychiatr Scand. 2000 Aug;102(2):153-5. [PMID: 10937789]
Hinze-Selch D, Schuld A, Kraus T, Kuhn M, Uhr M, Haack M, Pollmächer T. Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: A longitudinal study in patients treated with amitriptyline or paroxetine.
Neuropsychopharmacology. 2000 Jul;23(1):13-9. [PMID: 10869882]
Schuld A, Kuhn M, Haack M, Kraus T, Hinze-Selch D, Lechner C, Pollmächer T. A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia.
Pharmacopsychiatry. 2000 May;33(3):109-11. [PMID: 10855462]
Haack M, Reichenberg A, Kraus T, Schuld A, Yirmiya R, Pollmächer T. Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men.
Cytokine. 2000 Jun;12(6):694-8. [PMID: 10843747]
Schuld A, Kraus T, Haack M, Hinze-Selch D, Pollmächer T. Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder.
J Sleep Res. 1999 Dec;8(4):321-2. [PMID: 10646174]
Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kuhn M, Schuld A, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis.
J Psychiatr Res. 1999 Sep-Oct;33(5):407-18. [PMID: 10504009]
Pollmächer T, Kraus T, Haack M, Uhr M, Mullington J. Salmonella abortus equi endotoxin does not affect leptin plasma levels in healthy humans.
J Infect Dis. 1999 Apr;179(4):1047-8. [PMID: 10068609]
Kraus T, Haack M, Schuld A, Hinze-Selch D, Kuhn M, Uhr M, Pollmächer T. Body weight and leptin plasma levels during treatment with antipsychotic drugs.
Am J Psychiatry. 1999 Feb;156(2):312-4. [PMID: 9989571]
Books, Chapters, Reviews
Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):294-302. Review. [PMID: 19110131]
Schuld A, Haack M, Hinze-Selch D, Mullington J, Pollmächer T. Experimental studies on the interaction between sleep and the immune system in humans
Psychother Psychosom Med Psychol. 2005 Jan;55(1):29-35. Review. German. [PMID: 15647993]
Pollmächer T, Haack M, Schuld A, Reichenberg A, Yirmiya R. Low levels of circulating inflammatory cytokines--do they affect human brain functions?
Brain Behav Immun. 2002 Oct;16(5):525-32. Review. [PMID: 12401466]
Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D. On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors.
Fortschr Neurol Psychiatr. 2001 Sep;69 Suppl 2:S65-74. Review. German. [PMID: 11533853]
Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullington J. Experimental immunomodulation, sleep, and sleepiness in humans.
Ann N Y Acad Sci. 2000;917:488-99. Review. [PMID: 11268376]
Pollmächer T, Haack M, Schuld A, Kraus T, Hinze-Selch D. Effects of antipsychotic drugs on cytokine networks.
J Psychiatr Res. 2000 Nov-Dec;34(6):369-82. Review. [PMID: 11165304]
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