Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Orfeu M. Buxton, PhD
Instructor in Medicine, Harvard Medical School
Associate Neuroscientist, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Administrative Title(s)
Training Coordinator, Division of Sleep Medicine
Address
221 Longwood Ave, Suite BLI-438KBoston, MA 02115
USA
Inter-office Mail Address
BWH Division of Sleep Medicine, BLI-438KFax 617-507-9177
Email Orfeu@HMS.Harvard.edu
Society Memberships
Society for Research of Biological RhythmsSleep Research Society
American Physiological Society
Endocrine Society
National Postdoctoral Association
Research Unit(s)
Circadian Group, Division of Sleep Medicine, Brigham and Women's Hospital
Harvard Work Hours, Health, and Safety Group
Harvard Work Hours, Health, and Safety Group
Research Funding
NIH / NIA Program Project P01 AG009975 (Czeisler, PI)
“Sleep Aging and Circadian Rhythm Disorders”
Project 3 “Metabolic Aging: Endocrine And Cardiovascular Consequences Of Sleep Restriction
Role: Project Leader (Project 3)
NIH / NIA 1U01HD0591U01HD059753-01 (Berkman, PI)
“Family-Responsive Workplace Policies & Practice in Small Businesses with Low-Wage and Racially/Ethnically Diverse Workers”
The goal of our interdisciplinary Work, Family, and Health Network is to identify workplace practices and policies that impact the health of low-wage employees and their families and dependents so as to design effective work-based interventions to improve health outcomes.
Role: subcontract Principal Investigator (subcontract from Harvard School of Public Health)
Sepracor Inc., ESRC-0004 (Winkelman, PI)
“The effects of eszopiclone treatment (3mg for two months) to counteract the adverse metabolic consequences of primary insomnia”
This investigator-initiated project examines the reversibility of the effects of chronic primary insomnia on metabolic function.
Role: Co-PI and Project Leader
The Center for Health Design/C.H.E.R. (Solet, PI)
[Phase III] “Evidence Based Design Meets Evidence Based Medicine: Human Studies for Validating New Acoustic Guidelines for Healthcare Facilities Using a Collaborative and Trans-Disciplinary Approach for Improving Patient Outcomes”
The purpose of this project is to test the hypothesis that exposure to an acoustic environment adhering to evidence-based acoustical guidelines will evoke fewer physiologic arousal responses and be more conducive to improved sleep.
Role: subcontract Principal Investigator (subcontract from Cambridge Health Alliance)
Sepracor, Inc., ESRC-0977 (Buxton, PI)
“Effects of daytime eszopiclone administration in shift workers on overnight wakefulness during a subsequent simulated nightshift”
The goal of this project is to determine whether improving daytime sleep quality in shiftworkers improves subsequent nighttime wakefulness and neurobehavioral performance.
Role: PI
“Sleep Aging and Circadian Rhythm Disorders”
Project 3 “Metabolic Aging: Endocrine And Cardiovascular Consequences Of Sleep Restriction
Role: Project Leader (Project 3)
NIH / NIA 1U01HD0591U01HD059753-01 (Berkman, PI)
“Family-Responsive Workplace Policies & Practice in Small Businesses with Low-Wage and Racially/Ethnically Diverse Workers”
The goal of our interdisciplinary Work, Family, and Health Network is to identify workplace practices and policies that impact the health of low-wage employees and their families and dependents so as to design effective work-based interventions to improve health outcomes.
Role: subcontract Principal Investigator (subcontract from Harvard School of Public Health)
Sepracor Inc., ESRC-0004 (Winkelman, PI)
“The effects of eszopiclone treatment (3mg for two months) to counteract the adverse metabolic consequences of primary insomnia”
This investigator-initiated project examines the reversibility of the effects of chronic primary insomnia on metabolic function.
Role: Co-PI and Project Leader
The Center for Health Design/C.H.E.R. (Solet, PI)
[Phase III] “Evidence Based Design Meets Evidence Based Medicine: Human Studies for Validating New Acoustic Guidelines for Healthcare Facilities Using a Collaborative and Trans-Disciplinary Approach for Improving Patient Outcomes”
The purpose of this project is to test the hypothesis that exposure to an acoustic environment adhering to evidence-based acoustical guidelines will evoke fewer physiologic arousal responses and be more conducive to improved sleep.
Role: subcontract Principal Investigator (subcontract from Cambridge Health Alliance)
Sepracor, Inc., ESRC-0977 (Buxton, PI)
“Effects of daytime eszopiclone administration in shift workers on overnight wakefulness during a subsequent simulated nightshift”
The goal of this project is to determine whether improving daytime sleep quality in shiftworkers improves subsequent nighttime wakefulness and neurobehavioral performance.
Role: PI
Brief biography
Dr. Buxton joined the Division of Sleep Medicine in 2003 as an Associate Neuroscientist at Brigham & Women's Hospital with an appointment to the Harvard Medical School Faculty as an Instructor. To study the health consequences of sleep loss, and to extend recent findings associating insufficient or poor quality sleep with obesity, diabetes, and cardiovascular disease, he founded a Sleep and Metabolism Research Program within the Division of Sleep Medicine. Successful aging is a central focus of this work. Ongoing interdisciplinary human studies involve sleep loss, aging, and insomnia, as well as neurobehavioral performance, learning and memory consolidation, and health disparities. Dr. Buxton is a member of the Work, Family, and Health Network.
After earning a B.S. in Behavioral Neuroscience from the University of Pittsburgh and a stint as a small business owner, Dr. Buxton earned a doctoral degree in Neuroscience from Northwestern University, Evanston, Illinois, working with Professors Eve Van Cauter and Fred Turek. He obtained post-doctoral training in sleep and endocrinology with Dr. Van Cauter at the University of Chicago.
Dr. Buxton co-founded the National Postdoctoral Association, a member-driven organization that provides a unique, national voice for postdoctoral scholars. In the Harvard Division of Sleep Medicine, Dr. Buxton serves as Training Coordinator and Chair of the Education Committee.
Dr. Buxton joined the Division of Sleep Medicine in 2003 as an Associate Neuroscientist at Brigham & Women's Hospital with an appointment to the Harvard Medical School Faculty as an Instructor. To study the health consequences of sleep loss, and to extend recent findings associating insufficient or poor quality sleep with obesity, diabetes, and cardiovascular disease, he founded a Sleep and Metabolism Research Program within the Division of Sleep Medicine. Successful aging is a central focus of this work. Ongoing interdisciplinary human studies involve sleep loss, aging, and insomnia, as well as neurobehavioral performance, learning and memory consolidation, and health disparities. Dr. Buxton is a member of the Work, Family, and Health Network.
After earning a B.S. in Behavioral Neuroscience from the University of Pittsburgh and a stint as a small business owner, Dr. Buxton earned a doctoral degree in Neuroscience from Northwestern University, Evanston, Illinois, working with Professors Eve Van Cauter and Fred Turek. He obtained post-doctoral training in sleep and endocrinology with Dr. Van Cauter at the University of Chicago.
Dr. Buxton co-founded the National Postdoctoral Association, a member-driven organization that provides a unique, national voice for postdoctoral scholars. In the Harvard Division of Sleep Medicine, Dr. Buxton serves as Training Coordinator and Chair of the Education Committee.
Selected Publications
Buxton OM, Lee CW, L'Hermite-Baleriaux M, Turek FW, Van Cauter E. Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase.
Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R714-24. [PMID: 12571075]
Cunningham JM, Buxton OM, Weiss RE. Circadian variation in Cushing's disease and pseudo-Cushing states by analysis of F and ACTH pulsatility.
J Endocrinol Invest. 2002 Oct;25(9):791-9. [PMID: 12398238]
Buxton OM, Copinschi G, Van Onderbergen A, Karrison TG, Van Cauter E. A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag.
Sleep. 2000 Nov 1;23(7):915-27. [PMID: 11083601]
Valentinuzzi VS, Buxton OM, Chang AM, Scarbrough K, Ferrari EA, Takahashi JS, Turek FW. Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination.
Physiol Behav. 2000 May;69(3):269-75. [PMID: 10869592]
Horton TH, Buxton OM, Losee-Olson S, Turek FW. Twenty-four-hour profiles of serum leptin in siberian and golden hamsters: photoperiodic and diurnal variations.
Horm Behav. 2000 Jun;37(4):388-98. [PMID: 10860682]
Buxton OM, L'Hermite-Baleriaux M, Turek FW, van Cauter E. Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion.
Am J Physiol Regul Integr Comp Physiol. 2000 Feb;278(2):R373-82. [PMID: 10666138]
Naylor E, Buxton OM, Bergmann BM, Easton A, Zee PC, Turek FW. Effects of aging on sleep in the golden hamster.
Sleep. 1998 Nov 1;21(7):687-93. [PMID: 11286344]
Scheen AJ, Buxton OM, Jison M, Van Reeth O, Leproult R, L'Hermite-Baleriaux M, Van Cauter E. Effects of exercise on neuroendocrine secretions and glucose regulation at different times of day.
Am J Physiol. 1998 Jun;274(6 Pt 1):E1040-9. [PMID: 9611154]
Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elevation of cortisol levels the next evening.
Sleep. 1997 Oct;20(10):865-70. [PMID: 9415946]
Buxton OM, Frank SA, L'Hermite-Baleriaux M, Leproult R, Turek FW, Van Cauter E. Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms.
Am J Physiol. 1997 Sep;273(3 Pt 1):E536-42. [PMID: 9316443]
Reviews, Book Chapters, and Editorials
“Single Slide Sets to Accompany the SRS Basics of Sleep Guide (version 1.1).” Charles J. Amlaner, Orfeu M. Buxton, editors. Sleep Research Society Educational Programs Committee. 2008.
“Slide Sets to Accompany the SRS Basics of Sleep Guide.” Charles J.
Amlaner, Orfeu M. Buxton, editors. Sleep Research Society Educational Programs Committee. 2007.
"Evidence-Based Design: The new AIA Guidelines on Noise and Privacy," Sykes, D.; Rockstroh, R.; Solet, J.; Buxton, O. Pg 47-49, Healthcare Design 09.06, Volume 6, Number 5, September 2006, www.hcdmagazine.com.
Czeisler, CA. OM Buxton, and SB Khalsa. The human circadian timing system and sleep-wake regulation. In, Principles and Practices of Sleep Medicine. M Kryger, T Roth, W Dement eds., 2005.
O'Connor PJ, SD Youngstedt, OM Buxton, and MD Breus. FIMS position statement on air travel and performance in sports. Fèdèration Internationale de Mèdecine du Sport (FIMS) Position Statement #16, 2004, pp-1-12. Available at URL: http://www.fims.org/files/311417173/PS16%20Air%20travel%20March%202004.pdf.
Shawn D. Youngstedt, Orfeu M. Buxton. Jet Lag and Athletic Performance.
Amer J Sports Med. 2003;5:219-226.
Orfeu M. Buxton and Stephen Gasior. You've got the data! Now advocate for change! Science NextWave. April 2002. http://nextwave.sciencemag.org/cgi/content/full/2002/04/16/2
Orfeu M. Buxton, Karine Spiegel, and Eve Van Cauter. Modulation of endocrine function and metabolism by sleep and sleep loss. In: T. Lee-Chiong, M. Carskadon, M. Sateia, vol. eds., Sleep Medicine 2002; 59-69.
Orfeu M. Buxton and Stephen Gasior. Surveying Postdocs: A tale from the trenches. Science NextWave. January 2002. http://nextwave.sciencemag.org/cgi/content/full/2002/01/03/5.
Eve Van Cauter and Orfeu M. Buxton. Circadian Modulation of Endocrine Secretion. In: J. Takahashi, F.W. Turek, R.Y. Moore, vol. eds., Handbook of Neurophysiology, 2001; 685-714.
Joaquin Recio, J.M. Míguez, Orfeu M. Buxton, Etienne Challet. Synchronizing circadian rhythms in early infancy.
Medical Hypotheses. 1997 Sep;49(3):229-34. [PMID: 9293467]
Orfeu M. Buxton, Mireille L'Hermite-Balériaux, Ulrich Hirschfeld, and Eve Van Cauter. Acute and delayed effects of exercise on human melatonin secretion.
J Biol Rhythms. 1997 Dec;12(6):568-74. [PMID: 9406031]
Am J Physiol Regul Integr Comp Physiol. 2003 Mar;284(3):R714-24. [PMID: 12571075]
Cunningham JM, Buxton OM, Weiss RE. Circadian variation in Cushing's disease and pseudo-Cushing states by analysis of F and ACTH pulsatility.
J Endocrinol Invest. 2002 Oct;25(9):791-9. [PMID: 12398238]
Buxton OM, Copinschi G, Van Onderbergen A, Karrison TG, Van Cauter E. A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag.
Sleep. 2000 Nov 1;23(7):915-27. [PMID: 11083601]
Valentinuzzi VS, Buxton OM, Chang AM, Scarbrough K, Ferrari EA, Takahashi JS, Turek FW. Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination.
Physiol Behav. 2000 May;69(3):269-75. [PMID: 10869592]
Horton TH, Buxton OM, Losee-Olson S, Turek FW. Twenty-four-hour profiles of serum leptin in siberian and golden hamsters: photoperiodic and diurnal variations.
Horm Behav. 2000 Jun;37(4):388-98. [PMID: 10860682]
Buxton OM, L'Hermite-Baleriaux M, Turek FW, van Cauter E. Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion.
Am J Physiol Regul Integr Comp Physiol. 2000 Feb;278(2):R373-82. [PMID: 10666138]
Naylor E, Buxton OM, Bergmann BM, Easton A, Zee PC, Turek FW. Effects of aging on sleep in the golden hamster.
Sleep. 1998 Nov 1;21(7):687-93. [PMID: 11286344]
Scheen AJ, Buxton OM, Jison M, Van Reeth O, Leproult R, L'Hermite-Baleriaux M, Van Cauter E. Effects of exercise on neuroendocrine secretions and glucose regulation at different times of day.
Am J Physiol. 1998 Jun;274(6 Pt 1):E1040-9. [PMID: 9611154]
Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elevation of cortisol levels the next evening.
Sleep. 1997 Oct;20(10):865-70. [PMID: 9415946]
Buxton OM, Frank SA, L'Hermite-Baleriaux M, Leproult R, Turek FW, Van Cauter E. Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms.
Am J Physiol. 1997 Sep;273(3 Pt 1):E536-42. [PMID: 9316443]
Reviews, Book Chapters, and Editorials
“Single Slide Sets to Accompany the SRS Basics of Sleep Guide (version 1.1).” Charles J. Amlaner, Orfeu M. Buxton, editors. Sleep Research Society Educational Programs Committee. 2008.
“Slide Sets to Accompany the SRS Basics of Sleep Guide.” Charles J.
Amlaner, Orfeu M. Buxton, editors. Sleep Research Society Educational Programs Committee. 2007.
"Evidence-Based Design: The new AIA Guidelines on Noise and Privacy," Sykes, D.; Rockstroh, R.; Solet, J.; Buxton, O. Pg 47-49, Healthcare Design 09.06, Volume 6, Number 5, September 2006, www.hcdmagazine.com.
Czeisler, CA. OM Buxton, and SB Khalsa. The human circadian timing system and sleep-wake regulation. In, Principles and Practices of Sleep Medicine. M Kryger, T Roth, W Dement eds., 2005.
O'Connor PJ, SD Youngstedt, OM Buxton, and MD Breus. FIMS position statement on air travel and performance in sports. Fèdèration Internationale de Mèdecine du Sport (FIMS) Position Statement #16, 2004, pp-1-12. Available at URL: http://www.fims.org/files/311417173/PS16%20Air%20travel%20March%202004.pdf.
Shawn D. Youngstedt, Orfeu M. Buxton. Jet Lag and Athletic Performance.
Amer J Sports Med. 2003;5:219-226.
Orfeu M. Buxton and Stephen Gasior. You've got the data! Now advocate for change! Science NextWave. April 2002. http://nextwave.sciencemag.org/cgi/content/full/2002/04/16/2
Orfeu M. Buxton, Karine Spiegel, and Eve Van Cauter. Modulation of endocrine function and metabolism by sleep and sleep loss. In: T. Lee-Chiong, M. Carskadon, M. Sateia, vol. eds., Sleep Medicine 2002; 59-69.
Orfeu M. Buxton and Stephen Gasior. Surveying Postdocs: A tale from the trenches. Science NextWave. January 2002. http://nextwave.sciencemag.org/cgi/content/full/2002/01/03/5.
Eve Van Cauter and Orfeu M. Buxton. Circadian Modulation of Endocrine Secretion. In: J. Takahashi, F.W. Turek, R.Y. Moore, vol. eds., Handbook of Neurophysiology, 2001; 685-714.
Joaquin Recio, J.M. Míguez, Orfeu M. Buxton, Etienne Challet. Synchronizing circadian rhythms in early infancy.
Medical Hypotheses. 1997 Sep;49(3):229-34. [PMID: 9293467]
Orfeu M. Buxton, Mireille L'Hermite-Balériaux, Ulrich Hirschfeld, and Eve Van Cauter. Acute and delayed effects of exercise on human melatonin secretion.
J Biol Rhythms. 1997 Dec;12(6):568-74. [PMID: 9406031]
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