Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
James J. Quattrochi, MS, PhD
Assistant Professor of Neuroscience in the Department of Psychiatry, Harvard Medical School
Assistant Professor, Department of Psychiatry, Beth Israel Deaconess Medical Center
Administrative Title(s)
Director, Laboratory for Cellular and Molecular Neuroscience
Address
240 Longwood AvenueBoston, MA 02115
USA
Society Memberships
Society for NeuroscienceAmerican Association for the Advancement of Science
Sleep Research Society
American Academy of Sleep Medicine
Oligonucleotide Therapeutics Society
Society for Biomolecular Screening
International Association of Nanotechnology
Research Unit(s)
Laboratory for Cellular and Molecular Neuroscience, Beth Israel Deaconess Medical Center
Research Interests
The laboratory seeks answers to the question how activity-dependent changes in gene expression and signaling pathways regulate long-term changes in brain state, extending beyond sleep to long-term pathologies of addiction, depression, and chronic pain in which systems must react in a unified way to reset their activation levels and to how acute synaptic events trigger alterations in gene product long after the effects of drug have disappeared. Three central areas of investigation have emerged, translating advanced computational synthesis and behavioral analysis into new in vivo data: 1) Desktop to benchtop comparative models of PPT-III neurons; 2) Molecular switches responsible for long-term changes in sleep state; 3) Nanoscale targeted RNAi drug delivery system for in vivo retrograde gene silencing. These multidisciplinary studies hold promise in translating novel applicability for transcriptional control of new molecular targets.
Trainees
Takao Hensch, BA, 1989; Devin Binder, BA, 1992; Donna Siracuse, BA, 1994; John Koski, BA, 1996; Oscar Hsu, BA, 1996; Rern Lau, BA, 1997; Nancy Fu, BA, 2000; Laura Meeks, BA, 2000; Avram Heilman, BA, 2004; Arif Nathoo, MD MPA, 2005; Connie Taylor, BA, 2006; Arash Mostaghimi, MD MPP, 2006
Mentor(s)
Judy Lieberman; Robert Langer; Paula Hammond; Ronald Arky; James Beck; Robert Leffert
Research Funding
NIH/NHLBI, PI, Study of cellular and molecular controls of REM sleep
Teaching
ICON HMS, ICON FAS, ICON Pediatrics Clerkship, ICON Neurology Clerkship, ICON Patient Safety
Selected Publications
Nathoo A, Goldhoff P, Quattrochi J. Evaluation of an interactive case-based online network (ICON) in a problem based learning environment.
Adv Health Sci Edu. 2005;10:215-230.
Quattrochi J, Bazalakova M, Hobson JA. From synapse to gene product: prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum.
Brain Res Mol Brain Res. 2005;136:164-176.
Heilman A, Quattrochi J. Computational models of epileptiform activity in single neurons.
BioSystems. 2004;78:1-21.
Quattrochi J, Shapiro J, Verrier R, Hobson JA. Transient cardiorespiratory events during NREM sleep: a feline model for human microarousals.
J Sleep Res. 2000;9:185-192.
Quattrochi J, Hobson JA. Carbachol microinjection into the caudal peribrachial area induces long-term enhancement of PGO wave activity but not REM sleep.
J Sleep Res. 1999;8:281-290.
Quattrochi J, Datta S, Hobson JA. Cholinergic and noncholinergic afferents of the caudolateral parabrachial nucleus: a role in the long-term enhancement of REM sleep.
Neuroscience. 1998;83:1123-1136.
Hobson JA, Datta S, Calvo JM, Quattrochi J. Acetylcholine as a brain state modulator: triggering and long-term regulation of REM sleep.
Prog Brain Res. 1993;98:389-404.
Quattrochi J, Mamelak A, Binder D, Hobson JA. Dynamic suppression of REM sleep by parenteral administration of the serotonin-1 agonist eltoprazine.
Sleep. 1992;15:125-132.
Macklis JD, Quattrochi J. Restricted diffusion and stability of carbachol-fluorescent nanospheres in vivo.
NeuroReport. 1991;2:247-250.
Quattrochi J, Mamelak A, Madison R, Macklis J, Hobson JA. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres.
Science. 1989;245:984-986.
Adv Health Sci Edu. 2005;10:215-230.
Quattrochi J, Bazalakova M, Hobson JA. From synapse to gene product: prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum.
Brain Res Mol Brain Res. 2005;136:164-176.
Heilman A, Quattrochi J. Computational models of epileptiform activity in single neurons.
BioSystems. 2004;78:1-21.
Quattrochi J, Shapiro J, Verrier R, Hobson JA. Transient cardiorespiratory events during NREM sleep: a feline model for human microarousals.
J Sleep Res. 2000;9:185-192.
Quattrochi J, Hobson JA. Carbachol microinjection into the caudal peribrachial area induces long-term enhancement of PGO wave activity but not REM sleep.
J Sleep Res. 1999;8:281-290.
Quattrochi J, Datta S, Hobson JA. Cholinergic and noncholinergic afferents of the caudolateral parabrachial nucleus: a role in the long-term enhancement of REM sleep.
Neuroscience. 1998;83:1123-1136.
Hobson JA, Datta S, Calvo JM, Quattrochi J. Acetylcholine as a brain state modulator: triggering and long-term regulation of REM sleep.
Prog Brain Res. 1993;98:389-404.
Quattrochi J, Mamelak A, Binder D, Hobson JA. Dynamic suppression of REM sleep by parenteral administration of the serotonin-1 agonist eltoprazine.
Sleep. 1992;15:125-132.
Macklis JD, Quattrochi J. Restricted diffusion and stability of carbachol-fluorescent nanospheres in vivo.
NeuroReport. 1991;2:247-250.
Quattrochi J, Mamelak A, Madison R, Macklis J, Hobson JA. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres.
Science. 1989;245:984-986.
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