Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Atul Malhotra, MD
Associate Professor of Medicine, Harvard Medical School
Associate Physician, Division of Sleep Medicine and Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital
Administrative Title(s)
Medical Director, Brigham and Women's Hospital Sleep Disorders Program
Clinical Chief, Division of Sleep Medicine, Brigham and Women's Hospital
Clinical Chief, Division of Sleep Medicine, Brigham and Women's Hospital
Other Affiliation(s)
Beth Israel Deaconess Medical Center
Massachusetts General Hospital
Massachusetts General Hospital
Inter-office Mail Address
BWH Sleep Disorders Program221 Longwood Avenue, BLI 042
Fax 617-732-7337
Society Memberships
American Academy of Sleep MedicineSleep Research Society
American Thoracic Society
American College of Chest Physicians
Society of Critical Care Medicine
Research Unit(s)
Sleep Disorders Research Program, Medical Chronobiology Group, Division of Sleep Medicine, Brigham and Women's Hospital
Research Interests
My two major research foci are the pathogenesis of sleep apnea and the metabolic/cardiovascular complications of sleep disorders. The pathogenesis studies include anatomical ones using imaging, upper airway physiology, and control of breathing. These studies are ultimately designed to define the various contributors to apnea in different individuals. We have developed multivariate statistical models, computational finite element computational models, and an intact rat model to assess the various factors that are important in apnea pathogenesis. The ultimate goal is to define specific therapeutic targets for OSA patients of varying phenotypes. The rat studies are exploring the neurochemistry of the various components of upper airway reflexes with an eventual goal of defining potential pharmacological targets for OSA therapy. The metabolic/cardiovascular studies seek to separate obesity effects from OSA influences by assessing a host of autonomic, microcirculatory, inflammatory, hemostatic, metabolic, and hemodynamic variables. These studies include a cross sectional study comparing OSA patients with weight matched controls, an interventional study to assess the changes in the various biomarkers with OSA therapy, and the impact of weight loss on these biomarkers following gastric bypass surgery. The ultimate goal of these studies is to improve our understanding of apnea complications and to lay the groundwork for a multicenter clinical trial to determine the impact of treatment on OSA outcome. We also participate in industry-related science focused on the development of new diagnostic and therapeutic strategies in OSA.
Trainees
S. Crowley, 1999
S. Lazic, 2001
E. Ruffing, 2001
M. Stanchina, 2002-2004
A. Jordan, PhD, 2003-2005
K. Steiner, MD, 2005-2006
A. Nguyen, 2005-2006
M. Eikermann, 2005-2007
E. Bajwa, 2005-2006
S. Yim Yeh, MD, 2005-2008
S. Xi, 2006-2007
S. Rahangdale, MD, 2006-2008
P. Merchia, 2006-2007
Y. Lo, 2006-2007
D. Eckert, PhD, 2006-Present
S. Bertisch, 2006-2008
L. Campana, 2007-Present
J. Saboisky, PhD, 2007-Present
A. Schomer, 2007-2008
M. Litinski, 2007-2008
R. Owens, 2008-Present
L. Ye, 2008-Present
S. Nemati, 2008-Present
B. Edwards, 2009-Present
S. Kavuk, 2009-Present
G. Kehlmann, 2009-2010
M. Gandhi, 2009-2010
S. Sands, 2010
S. Lazic, 2001
E. Ruffing, 2001
M. Stanchina, 2002-2004
A. Jordan, PhD, 2003-2005
K. Steiner, MD, 2005-2006
A. Nguyen, 2005-2006
M. Eikermann, 2005-2007
E. Bajwa, 2005-2006
S. Yim Yeh, MD, 2005-2008
S. Xi, 2006-2007
S. Rahangdale, MD, 2006-2008
P. Merchia, 2006-2007
Y. Lo, 2006-2007
D. Eckert, PhD, 2006-Present
S. Bertisch, 2006-2008
L. Campana, 2007-Present
J. Saboisky, PhD, 2007-Present
A. Schomer, 2007-2008
M. Litinski, 2007-2008
R. Owens, 2008-Present
L. Ye, 2008-Present
S. Nemati, 2008-Present
B. Edwards, 2009-Present
S. Kavuk, 2009-Present
G. Kehlmann, 2009-2010
M. Gandhi, 2009-2010
S. Sands, 2010
Research Funding
RO1 HL73146 (2003-2009)
"Sleep Apnea and Obesity: Cardiovascular Risk Assessment"
Role: PI
American Heart Association (0840159N) (2008-2013)
"Established Investigator Award"
Role: PI
R01 HL085188-01A2 (2008-2012)
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea Pathogenesis
Role: PI
R01 HL090897-01A2 (2009-2013)
"Mechanisms Underlying the Aging Predisposition to Obstructive Sleep Apnea"
Role: PI
K24 HL 093218 - 01 A1 (2009-2014)
"Assessment of Upper Airway Mechanics Using Newer EMG Techniques"
Role: PI
"Sleep Apnea and Obesity: Cardiovascular Risk Assessment"
Role: PI
American Heart Association (0840159N) (2008-2013)
"Established Investigator Award"
Role: PI
R01 HL085188-01A2 (2008-2012)
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea Pathogenesis
Role: PI
R01 HL090897-01A2 (2009-2013)
"Mechanisms Underlying the Aging Predisposition to Obstructive Sleep Apnea"
Role: PI
K24 HL 093218 - 01 A1 (2009-2014)
"Assessment of Upper Airway Mechanics Using Newer EMG Techniques"
Role: PI
Teaching
Co-director of HST 100 (Respiratory Physiology and Pathophysiology)
Weekly teaching conference for Pulmonary and Critical Care fellowship in the Harvard-wide program
Frequent lectures to house staff at all Harvard hospitals and to participants at Harvard CME courses
Chairman of the Education Committee for the American Thoracic Society (2006-Present)
Program Chair for the Respiratory Neurobiology and Sleep Assembly at the American Thoracic Society
Director of the National Sleep Medicine Course for the AASM (2005-Present)
Weekly teaching conference for Pulmonary and Critical Care fellowship in the Harvard-wide program
Frequent lectures to house staff at all Harvard hospitals and to participants at Harvard CME courses
Chairman of the Education Committee for the American Thoracic Society (2006-Present)
Program Chair for the Respiratory Neurobiology and Sleep Assembly at the American Thoracic Society
Director of the National Sleep Medicine Course for the AASM (2005-Present)
Selected Publications
Original Submissions:
Kezirian EJ, White DP, Malhotra A, Ma W, McCulloch CE, Goldberg AN. Inter-rater reliability of drug-induced sleep endoscopy.
Arch Otol Head Neck Surg in press.
Owens R, Wellman A, Malhotra A. The chicken-or-egg debate in OSA pathogenesis.
Sleep. 2009 Oct 1;32(10):1255-6. [PMID: 19848354]
Fassbender P, Geldner G, Blobner M, Hofmockel R, Rex C, Gautam S, Malhotra A, Eikermann M. Clinical predictors of duration of action of cisatracurium and rocuronium administered long-term.
Am J Crit Care. 2009 Sep;18(5):439-45.[PMID: 19723864]
Buckley JD, Addrizzo-Harris DJ, Clay AS, Curtis JR, Kotloff RM, Lorin SM, Murin S, Sessler CN, Rogers PL, Rosen MJ, Spevetz A, King TE Jr, Malhotra A, Parsons PE. Multisociety task force recommendations of competencies in Pulmonary and Critical Care Medicine.
Am J Respir Crit Care Med. 2009 Aug 15;180(4):290-5. [PMID: 19661252]
Wiznitzer A, Mayer A, Novack V, Sheiner E, Gilutz H, Malhotra A, Novack L. Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.
Am J Obstet Gynecol. 2009 Jul 23. [PMID: 1963192]
Griesdale, D, de Souza, R, van Dam, R, Heyland, DK, Cook, D, Malhotra, A, Dhaliwal, R, Talmor, D, Chittock, D, Finfer, S, Intensive Insulin Therapy and Mortality in the Critically Ill: A Meta-Analysis Updated with the NICE-SUGAR Data
CMAJ, 2009, 180:821-7. [PMID: 19318387]
Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep.
Chest. 2009 Apr;135(4):957-64. [PMID: 19118266]
Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS, A comparison of methods to identify open-lung PEEP
Intensive Care Medicine 2009, 35: 740-7. [PMID: 19183951]
Jordan, AS, White, DP, Lo, Y, Wellman, A, Eckert, DJ, Yim-Yeh, S, Eikermann, M, Smith, SA, Stevenson, KE, Malhotra, A, Airway Dilator Muscle Activity and Lung Volume During Stable Breathing in OSA
Sleep 2009, 32: 361-368. [PMID: 19294956]
Eckert, D, Malhotra, A, Lo, Y, White, DP, Jordan, AS, Genioglossus Muscle Activity During REM sleep on CPAP in Men and Women with and without Obstructive Sleep Apnea
Chest 2009, 135:957-64. [PMID: 19118266]
Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL. Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats.
Anesthesiology. 2009 Jun;110(6):1327-34. [PMID: 19417601]
Yim Yeh, S, Doupis, J, Rahangdale, S, Horr, S, Malhotra, A, Veves, A, Total serum bilirubin does not affect vascular reactivity in patients with diabetes
Vascular Medicine 2009, 14: 129-136. [PMID: 19366819]
Talmor, D, Sarge, T, Malhotra, A, O’donnell, C, Ritz, R, Loring, SH, Mechanical Ventilated guided by Esophageal Pressure in Acute Lung Injury
New England Journal of Medicine, 2008, 359: 2095-2104. [PMID: 19001507]
Wellman, A, Malhotra, A, Jordan, AS, Stevenson, KE, Gautam, S, White, DP, Effect of oxygen in obstructive sleep apnea: Role of loop gain
Respir. Physiol. Neurobiol. 2008, 31;162:144-51; [PMID: 18577470]
Owens, R, Hess, D, Venegas, J, Malhotra, A, Harris, RS, Effect of the chest wall on pressure-volume curve analysis of ARDS lungs
Critical Care Medicine 2008;36:2980-5 [PMID: 18824918]
Eikermann, M, Zaremba, S, Malhotra, A, Jordan, AS, Rosow, C, Chamberlin, NL, Neostigmine but not Sugaammadex impairs Upper Airway Dilator Muscle Activity and Breathing, British Journal of Anesthesia
Br J Anaesth. 2008;101:344-9 [PMID: 18559352]
Elinoff, J, Talmor, D, Subramanian, B, Karmpaliotis, D, Goldberger, A, Malhotra, A, Effects of Mechanical Ventilation on the Electrocardiogram in Adults
Lung 2008, 186: 219-223. [PMID: 18478291]
Segal, Y, Malhotra, A, Pillar, G, Upper Airway Length may be Associated with the Severity of Obstructive Sleep Apnea Syndrome
Sleep & Breathing 2008;12:311-6. [PMID: 18516636]
Heinzer, R, White, DP, Jordan, AS, Lo, Y, Dover, L, Stevenson, K, Malhotra A, Trazodone increases Arousal Threshold in Obstructive Sleep Apnoea
European Respiratory Journal 2008, 31: 1308-1312 [PMID: 18256066]
Jia, S, Malhotra A, Saeed, M, Mark, R, Talmor, D, Risk Factors for Acute Respiratory Distress Syndrome in Patients Mechanically
Chest. 2008;133: 853-61 [PMID: 18263691]
Wilkinson, V, Malhotra A, Nicholas, CL, Worsnop, C, Jordan, AS, Butler, JE, Saboisky, JP, Gandevia, SC, White, DP, Trinder, J, Discharge Patterns of Human Genioglossus Motor Units During Sleep Onset
SLEEP 2008, 31: 525-533. [PMID: 18457240]
Heinzer, R, White, DP, Dover, L, Stevenson, K, Malhotra A, Jordan, A, Effect of Expiratory Positive Airway Pressure on Sleep Disordered Breathing
SLEEP 2008;31:429-32. [PMID: 18363320]
Macdonald, M, Fang, J, Pittman, S, White, DP, Malhotra A, The Current Prevalence of Sleep Disordered Breathing in Congestive Heart Failure Patients Treated with Beta Blockers
Journal of Clinical Sleep Medicine, 2008, 4:38-42. [PMID: 18350960]
Eikermann, M, Malhotra A, Fassbender, P, Zaremba, S, Jordan, AS, White, DP, Chamberlin, N, Differential Effects of Isoflurane and Propofol on Upper Airway Dilator Muscle Activity and Breathing
Anesthesiology 2008, 108: 897-906. [PMID: 18431126]
Caramez, MP, Miyoski, E, Harris, RS, Kacmarek, R, Malhotra A, Gas exchange impairment induced by open suctioning in ARDS: Impact of permissive hypercapnia.
Critical Care Medicine 2008, 36: 560-564. [PMID: 18091534]
Talmor, D, Sarge, T, Legedza, DA, O’donnell, CR, Ritz, R, Loring, SH, Malhotra A, Cytokine Release Following Recruitment Maneuvers
Chest 2007, 132: 1434-1439. [PMID: 17925413]
Eikermann, M, Fassbender, P, Malhotra A Takahashi, M, Kubo, S, Jordan, AS, White, DP, and Chamberlin, NL, Unwarranted Administration of Acetylcholinesterase Inhibitors Can Impair Genioglossus and Diaphragm Muscle Function
Anesthesiology. 2007, 107:621-629. [PMID: 17893459]
Stanchina, ML, Ellison, K, Malhotra A, Anderson, M, Kirk, M, Benser, ME, Tosi, C, Carlisle, C, Millman, RP, Buxton, A, The Impact of Cardiac Resynchronization Therapy on Obstructive Sleep Apnea in Heart Failure Patients: A Pilot StudyC
hest 2007, 132:433-439. [PMID: 17573498]
Pierce, R, White, DP, Malhotra A, Edwards, J, Kleverlaan, D, Palmer, LJ, Trinder, J, Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea
European Respiratory Journal 2007, 30:345-53. [PMID: 17459896]
Jordan, AS, Wellman, DA, Heinzer, R, Lo, Y, Schory, K, Dover, L, Gautam, S, Malhotra A and White, DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans
Thorax 2007, 62: 861-867. [PMID: 17412778]
Lo, Y, Jordan, A., Malhotra A, Wellman, A, Heinzer, R, Eikermann, M, Schory, K, Dover, L, White, DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity
Thorax 2007, 62: 799-805. [PMID: 17389755]
Chamberlin, NL, Eikermann, M, Fassbender, P, White, DP, and Malhotra A. Genioglossus Premotoneurons and the Negative Pressure Reflex in Rats
J. Physiol. (London) 2007, 579: 515-526. [PMID: 17185342]
Huang, Y, White, DP, Malhotra A. Use of Computational Modeling to Predict Responses to Upper Airway Surgery in Obstructive Sleep Apnea
Laryngoscope 2007, 117: 648-653. [PMID: 17415135]
Eikermann, M, Jordan, AS, Chamberlin, NL, Gautam, S, Wellman, DA, Lo, Y, White, DP and Malhotra A. The Influence of Aging on Pharyngeal Collapsibility during Sleep
Chest 2007, 131: 1702-1709. [PMID: 17413053]
Ronen O, Malhotra A, Pillar G. Influence of gender and age on upper-airway length during development.
Pediatrics. 2007 Oct;120(4):e1028-34.[PMID: 17908723]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Karmpaliotis D, Kirtane AJ, Ruisi CP, Polonsky T, Malhotra A, Talmor D, Kosmidou I, Jarolim P, de Lemos JA, Sabatine MS, Gibson CM, Morrow D. Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema.
Chest. 2007 Apr;131(4):964-71. [PMID: 17426196]
Nguyen TN, Badjatia N, Malhotra A, Gibbons FK, Qureshi MM, Greenberg SA. Factors predicting extubation success in patients with Guillain-Barré syndrome. Neurocrit Care. 2006;5(3):230-4. [PMID: 17290095]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between reduced sleep and weight gain in women.
Am J Epidemiol. 2006 Nov 15;164(10):947-54. Epub 2006 Aug 16. [PMID: 16914506]
Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Correlates of long sleep duration.
Sleep. 2006 Jul 1;29(7):881-9. [PMID: 16895254]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Cho MH, Malhotra A, Donahue DM, Wain JC, Harris RS, Karmpaliotis D, Patel SR. Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome.
Ann Thorac Surg. 2006 Jul;82(1):261-6. [PMID: 16798226]
Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung protective ventilation in acute respiratory distress syndrome.
Respir Care 2006, 51:497-502. [PMID: 16638159]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Talmor D, Sarge T, O'Donnell CR, Ritz R, Malhotra A, Lisbon A, Loring SH. Esophageal and transpulmonary pressures in acute respiratory failure.
Crit Care Med. 2006 May;34(5):1389-94. [PMID: 16540960]
Pittman SD, Pillar G, Berry R, Malhotra A, MacDonald MM, White DP. Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.
Sleep Breath. 2006, 10: 123-131. [PMID: 16586136]
Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J of Med 2006, 119: 72 e9-14. [PMID: 16431197]
Yinon D, Lowenstein L, Suraya S, Belooseski R, Zmora O, Malhotra A, Pillar G. Pre-eclampsia is associated with sleep disordered breathing and endothelial dysfunction.
Eur Respir J 2006, 27:328-33. [PMID: 16452588]
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol 2005, 99:1138-48. [PMID: 15831800]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan A, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med 2005, 172:114-7. [PMID: 15817803]
Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CRR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB. Paradoxical responses to positive end-expiratory pressure in patients with airway obstructive during controlled ventilation.
Crit Care Med 2005, 33:1519-28. [PMID: 16003057]
Huang Y, White DP, Malhotra A. The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway.
Chest 2005, 128:1324-30. [PMID: 16162725]
Bajwa EK, Ayas NT, Schulzer M, Mak E, Ryu JH, Malhotra A. Interferon-gamma 1b therapy in idiopathic pulmonary fibrosis: a meta-analysis.
Chest 2005, 128:203-6. [PMID: 16002936]
Aloia MS, Stanchina M, Arnedt JT, Malhotra A, Millman RP. Treatment adherence and outcomes in flexible vs. standard continuous positive airway pressure therapy.
Chest. 2005, 127:2085-93. [PMID: 15947324]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls.
J Physiol 2005, 564:549-62. [PMID: 15695240]
Jordan AS, Wellman DA, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol 2005, 99:2020-7. [PMID: 15994243]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med 2004, 170:1225-32. [PMID: 15317668]
Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.
Sleep 2004, 27:1394-403. [PMID: 15586793]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans.
J Physiol (London) 2004, 558:993-1004. [PMID: 15218069]
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep 2004, 27:1105-12. [PMID: 15532204]
Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP. Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.
Sleep 2004, 27:923-33. [PMID: 15453551]
Patel SR, Karmpaliotis D, Ayas NT, Mark EJ, Wain J, Thompson BT, Malhotra A. The role of open-lung biopsy in ARDS.
Chest 2004, 125:197-202. [PMID: 14718441]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep 2004, 27:249-53. [PMID: 15124718]
Fogel R, White DP, Pierce R, Malhotra, A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol 2003, 553: 533-44. [PMID: 12963804]
Stanchina ML, Malhotra, A, Fogel RB, Trinder J, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep 2003, 26:851-6. [PMID: 14655919]
Fogel RB, Trinder J, Malhotra, A, Stanchina M, Edwards JK, Schory KE, White DP. Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.
J Physiol 2003, 550:899-910. [PMID: 12807995]
Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra, A. Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.
J Appl Physiol 2003, 94:1875-82. [PMID: 12533492]
Patel SR, White DP, Malhotra, A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.
Arch Intern Med 2003, 163:565-71. [PMID: 12622603]
Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N. Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus.
J Pediatr 2003, 142:163-8. [PMID: 12584538]
Ayas N, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women.
Arch Intern Med 2003, 163:205-9. [PMID: 12546611]
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
J Appl Physiol 2003 94:205-12. [PMID: 12391042]
Malhotra A, Huang Y, Fogel RB, Pillar G, Edwards, JK, Kikinis R, Loring SH, White DP. The male predisposition to pharyngeal collapse: importance of airway length.
Am J Respir Crit Care Med 2002, 166: 1388-95. [PMID: 12421747]
Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg Z, Pillar G. Severe hypersomnolence after pituitary/hypothalamic surgery in adolescents: clinical characteristics and potential mechanisms.
Pediatrics 2002, 110: e74. [PMID: 12456941]
Karmpaliotis D, Kosmidou I, Ingenito EP, Hong K, Malhotra A, Sunday ME, Haley KJ. Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.
Am J Physiol Lung Cell Mol Physiol 2002, 283: L585-95. [PMID: 12169578]
Stanchina M, Malhotra A, Fogel R, Ayas, N, Edwards JK, Schory K, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during non-rapid eye movement sleep.
Am J Respir Crit Care Med 2002, 165:945-9. [PMID: 11934719]
Fisher D, Pillar G, Malhotra A, Peled N, Lavie P. Long-term follow-up of untreated patients with sleep apnea syndrome.
Respir Med 2002, 96:337-43. [PMID: 12167690]
Malhotra A, Pillar G, Fogel R, Edwards J, Ayas N, Akahoshi, T, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med 2002, 165:71-7. [PMID: 11779733]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med 2001, 164:2025-30. [PMID: 11739130]
Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM. The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation.
Eur Respir J 2001;17:1258-66. [PMID: 11491174]
Pillar G, Fogel R, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
Respir Physiol 2001, 127:23-38. [PMID: 11445198]
Malhotra A, Pillar G, Fogel, R, Beauregard J, Edwards, JK, White DP. Upper airway collapsibility: measurements and sleep effects.
Chest 2001;120:156-61. [PMID: 11451832]
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endocrinol Metab 2001;86:1175-80. [PMID: 11238505]
Pillar G, Malhotra A, Fogel, R, Beauregard J, Slamowitz, D, Shea SA and White DP. Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.
J Appl Phys 2000;89:1275-82. [PMID: 11007559]
Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender.
Am J Respir Crit Care Med 2000;162:1627-32. [PMID: 11069787]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000;162:1058-62. [PMID: 10988130]
Malhotra A, Fogel R, Edwards J, Shea SA, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000;161:1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol 2000;88:1346-54. [PMID: 10749829]
Reviews, Chapters and Editorials:
Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in
obstructive sleep apnoea.
Expert Opin Ther Targets. 2009 Jul;13(7):795-809. Review. [PMID: 19530985]
Loring SH, Garcia-Jacques M, Malhotra A. Pulmonary characteristics in COPD and mechanisms of increased work of breathing.
J Appl Physiol. 2009 Jul;107(1):309-14. Review. [PMID: 19359620]
Atkeson A, Yeh SY, Malhotra A, Jelic S. Endothelial function in obstructive sleep apnea.
Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):351-62. Review. [PMID: 19249441]
Rahangdale S, Yeh SY, Malhotra A, Veves A. Therapeutic interventions and oxidative stress in diabetes.
Front Biosci. 2009 Jan 1;14:192-209. Review. [PMID: 19273063]
Eckert, DJ, Malhotra, A, Jordan, AS, Mechanisms of Apnea.
Progress in Cardiovascular Diseases (A Malhotra Guest Editor), 2009 Jan-Feb; 51:313-23. [PMID 19110133]
Malhotra A, Loscalzo J. Sleep and cardiovascular disease: an overview.
Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):279-84. [PMID: 19110129]
Rahangdale, S, Campana, L, Malhotra, A, Not So Good Vibrations
Sleep 2008, 31: 1204-05. [PMID: 18788644]
Owens, R, Yim Yeh, S, Malhotra, A, CO Poisoning or CO Protection, invited editorial
Chest 2008;134:895-6 [PMID 18988771]
Yim Yeh, S, Rahangdale, S, Malhotra, A, Metabolic Syndrome, OSA and CPAP: A Weighty Issue
Chest, invited editorial 2008, 134: 675-676. [PMID: 18842905]
Owens, R, Eckert, D, Yeh, S, Malhotra, A, Upper Airway Function in the Pathogenesis of Obstructive Sleep Apnea: A review of the current literature
Current Opinion in Pulmonary Diseases, invited review Curr Opin Pulm Med. 2008;14: 519-24 [PMID: 18812828]
Pillar, G, White, DP, Malhotra, A, Age-related changes in the pharyngeal structure and function in sleep apnea and normal subjects
in S.R. Pandi-Perumal, J.M. Monti, and A. Monjan Principles and Practice of Geriatric Sleep Medicine, Cambridge University Press, in press.
Malhotra, A, Bertisch, S, and Wellman, DA, Complex Apnea isn’t a Real Disease,
Journal of Clinical Sleep Medicine, invited Pro/Con 2008, 4: 406-408. [PMID: 18853695]
Malhotra, A and Hillman, D, Obesity and the lung: Obesity, Respiration and Intensive Care
Thorax, invited review, 2008, 63: 925-931. [PMID: 18820119]
Malhotra A, Fogel R, White DP. Disorders of excessive sleepiness for neurological therapeutics:
In Burgess A, Principles and Practice. London, UK, Martin Dunitz Publishers in press.
Stanchina M, Malhotra A, White DP. An evidenced-based review of the diagnosis and treatment of respiratory disorders of sleep.
In Crapo and King in press.
Nguyen A, Yim S, Malhotra A. Theories of OSA Pathogenesis.
In Obstructive Sleep Apnea. (two volume textbook, Taylor and Francis), in press.
Eckert, D and Malhotra, A, Pathophysiology of Adult Obstructive Sleep Apnea
Proceedings of the American Thoracic Society 2008;5:144-53.
Goodwin AJ, Bajwa EK, Malhotra A. Minimally Invasive Cardiology
in: Irwin RS, Cerra FB, Rippe JM, Irwin and Rippe’s Intensive Care Medicine, 6th Edition (Philadelphia, Lippincott Williams & Wilkins), 2008, 261-274.
Eikermann, M and Malhotra, A. Predictive value of stimulated muscle force assessment in critically ill patients
Editorial, Acta Anaesthesiol Scand. 2008; 52: 1-2. [PMID: 18173429]
Malhotra, A, Kacmarek RM. Mechanical ventilation.
In. Hagberg C (Ed) Benumof’s airway management: principles and practice. Philadelphia. Lippincott Publishing Co, 2007; 1079-1122.
Chiche, L, Forel, JM, Papazian, L, Asakura, Y, Komatsu, T, Busch, T, Bercker, S, Kaisers, U, Malhotra, A, Low Tidal Volume Ventilation
New England Journal of Medicine 2007, 357: 2518-2520.
Eckert, D, Saboisky, J, Jordan, A, Malhotra, A, Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea
Journal of Clinical Sleep Medicine 2007, 3: 570-573.
Malhotra, A., Low Tidal Volume Ventilation in the acute respiratory distress syndrome, New England Journal of Medicine
Clinical Therapeutics section, 2007, 357: 1113-1120. PMID: 17855672
Eikermann, M, Chamberlin, N, Gerber, H, Malhotra, A, Muscle weakness after administration of neuromuscular blocking agents: Don’t immobilize the diaphragm unnecessarily
Critical Care Medicine 2007, 35: 1634-1635.
Eikermann, M, Magder, S, Malhotra, A, Is brachial artery peak velocity variation ready for prime time?
Chest 2007, 131: 1279-1281
Yim, S, Fredberg, JJ, Malhotra, A, CPAP for asthma: not a big stretch?
European Respiratory Journal, 2007, 29:226-228.
Benson, A, Bajwa E, Malhotra A. Pulmonary Disease.
In: Sabatine MS, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia Lippincott Williams and Wilkins. 2007; third edition, pages 2:1-2:23.
Shochat, T, Pillar, G, Malhotra, A, Aging and Sleep, invited review
Int J Sleep Disorders 2007;1(3):92-101
Loring, SH and Malhotra, A, Inspiratory efforts during mechanical ventilation: is there risk of barotrauma?
Chest 2007; 131: 646-648.
Eckert, D, Jordan, A, Merchia, P, Malhotra, A, Central Sleep Apnea: Pathophysiology and Treatment
Chest 2007, 131: 595-607.
Yim, S, Malhotra, A, Veves, A, Anti-oxidants and CVD in Diabetes: Where do we stand now?
Current Diabetes Reports 2007, 7: 8-13.
Malhotra, A and Patel, SR, Lung Biopsy in ARDS: Is it Worth the Risk?
Critical Care, 2006, 10: 160.
Hammer L, Dessertaine G, Timset JF, Aberegg SK, Tamler R, Leroith D, Roth J, Van den Berghe G, Wilmer A, Boullon R, Malhotra A.
Intensive Insulin in the Medical Intensive Care Unit, New Engl J Med. 2006; 354:2069-71.
Yim S, Jordan AS, Malhotra A. Obstructive sleep apnea, clinical presentation, diagnosis and treatment. In: Randerath WJ, Sanner BM, Somers VK, editors.
Sleep Apnea – Current diagnosis and treatment. Basel, Karger, 2006, 35:118-136.
Heinzer, R., Jordan, AS, Malhotra A, Sleep Apnea Syndrome, in Khoo, M., Wiley
Encyclopedia of Biomedical Engineering, New York, John Wiley and Sons, 2006, pp. 18-34.
Kacmarek RM, Malhotra A. Equipment required for home mechanical ventilation. In Tobin MJ (Ed)
Principles and Practice of Mechanical Ventilation, 2nd Ed, New York McGraw Hill, 2006; pages 97-128
Kacmarek RM., Villar J, Malhotra A Modes of Mechanical ventilation. In Albert RK, Slutsky A, Ranieri M, Takala J, Torres A. (Eds).
Clinical Critical Care Medicine, Philadelphia, Elsevier Pub Co., 2006; pages 109-120.
Malhotra A. Intensive insulin in intensive care.
New Engl J Med, Invited editorial 2006;354:516-8.
Malhotra A, Jordan AS. Did fat boy Joe need hormone replacement?
Sleep 2006, 29:16-8.
Pillar G, Harder L, Malhotra A. Trauma and post-traumatic stress disorder. In Chang T, Vihtelic CM, Gold C, Lydic R, and Baghdoyan HA
Encyclopedia of Sleep Medicine, New York, John Wiley & Sons, 2006. p.857-66.
Jordan A, Malhotra A. Pharyngeal lumen: both length and size matter.
Journal of Clinical Sleep Medicine. 2005, 1:264-265.
Kacmarek R and Malhotra A High frequency oscillatory ventilation: what large animal studies have taught us!
Crit Care Med 2005, 33:S148-54.
Malhotra A, Jordan AS. Surface tension and sleep apnea: a sticky business.
SLEEP 2005, 28:392-3.
Ting L, Malhotra A. Disorders of Sleep: an overview.
Prim Care 2005, 32:305-18.
Malhotra A, Berry R, White DP. Central sleep apnea. In Carney, PR, Berry, RB, Geyer
J, Clinical Sleep Disorders. Philadelphia, Lippincott; 2005 p. 331-46.
Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T, Patel S, Wain J, Malhotra A. Surgical stress in ARDS open-lung biopsy.
Chest 2004 Oct;126:1383-4
Fogel, RB, Malhotra A, White, DP, Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome
Thorax 2004, 59: 159-163.
Oddo M, Liaudet L, Patel SR, Wain J, Malhotra A Open-lung biopsy for ARDS Patients.
Chest 2004;126:1003-4.
Bajwa E, Mouded M, Systrom DM, Malhotra A. Pulmonary Disease.
In: Sabatine MS, Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia: Lippincott Williams and Wilkins. 2004; second edition, pages 2:1 to 2:22
Bajwa E, Malhotra A, Thompson T. Monitoring of the patient in septic shock.
Seminars in Respiratory and Critical Care Medicine 2004, 25: 629-644.
Carden K and Malhotra A. The debate about gender differences in obstructive sleep apnea
Sleep Med 2003, 4:485-7.
McCowen KC, Malhotra, A. The correlation between obstructive sleep apnea and low gonadotropin secretion in men.
Sleep Medicine 2003;4:83-4.
Malhotra A, White DP. Obstructive sleep apnoea.
Lancet 2002, 360:237-45.
Malhotra A, White DP. The pathogenesis of obstructive sleep apnea. In McNicholas W, Phillipson E, editors.
Breathing Disorders in Sleep, London: W B Saunders, 2002; p. 44-64.
Malhotra A, Schwartz D. Lung Cancer. In: Hess D, MacIntyre N, Mishoe, S, Galvin, WF, Adams, AB, Saposnick, AB
Respiratory Care: Principles and Practice. Philadelphia, PA, WB Saunders, 2002 1151-67
Malhotra A, Schwartz DR, Ayas N, Stanchina M, White DP. The treatment of oxygen-induced hypercarbia.
Lancet 2001;357:884-5.
McCowen K, Malhotra A, Bistrian B. Stress-induced hyperglycemia
Critical Care Clinics. 2001, 17:107-24.
Sabatine M, Malhotra A, Systrom DM. Pulmonary Disease. In: Sabatine, MD, Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia, PA
Lippincott Williams and Wilkins; 2000. p. 2-1-21.
Schwartz DR, Malhotra A, Fink MP. Microcirculatory weak units – an alternative explanation.
Critical Care Medicine 2000;28:3127-8.
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in septic shock. In: Malhotra, SK and Tuszynski, J.
Advances in Structural Biology., Stamford, CT, Jai Press; 2000 p. 65-82.
Pillar G, Malhotra A, Lavie P. Post-traumatic stress disorder and sleep – what a nightmare!
Sleep Med Rev 2000, 4: 183-200.
Malhotra A, Ayas N, Epstein L. The art and science of continuous positive airway pressure therapy in obstructive sleep apnea.
Curr Opin Pulm Med 2000 6: 490-495.
Ayas N, Malhotra A, Epstein L. Alternative therapies for sleep apnea.
Drugs Today (Barc) 1999, 35: 811-21.
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in sepsis: an overview.
Sepsis 1999, 1:279-89.
Malhotra A, Kradin R. The pulmonary immune response to asbestos. In Peters GA, Peters BJ, editors.
Asbestos and Cancer; Salem, NH: Butterworth Legal, 1997, 1-23.
Kezirian EJ, White DP, Malhotra A, Ma W, McCulloch CE, Goldberg AN. Inter-rater reliability of drug-induced sleep endoscopy.
Arch Otol Head Neck Surg in press.
Owens R, Wellman A, Malhotra A. The chicken-or-egg debate in OSA pathogenesis.
Sleep. 2009 Oct 1;32(10):1255-6. [PMID: 19848354]
Fassbender P, Geldner G, Blobner M, Hofmockel R, Rex C, Gautam S, Malhotra A, Eikermann M. Clinical predictors of duration of action of cisatracurium and rocuronium administered long-term.
Am J Crit Care. 2009 Sep;18(5):439-45.[PMID: 19723864]
Buckley JD, Addrizzo-Harris DJ, Clay AS, Curtis JR, Kotloff RM, Lorin SM, Murin S, Sessler CN, Rogers PL, Rosen MJ, Spevetz A, King TE Jr, Malhotra A, Parsons PE. Multisociety task force recommendations of competencies in Pulmonary and Critical Care Medicine.
Am J Respir Crit Care Med. 2009 Aug 15;180(4):290-5. [PMID: 19661252]
Wiznitzer A, Mayer A, Novack V, Sheiner E, Gilutz H, Malhotra A, Novack L. Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.
Am J Obstet Gynecol. 2009 Jul 23. [PMID: 1963192]
Griesdale, D, de Souza, R, van Dam, R, Heyland, DK, Cook, D, Malhotra, A, Dhaliwal, R, Talmor, D, Chittock, D, Finfer, S, Intensive Insulin Therapy and Mortality in the Critically Ill: A Meta-Analysis Updated with the NICE-SUGAR Data
CMAJ, 2009, 180:821-7. [PMID: 19318387]
Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep.
Chest. 2009 Apr;135(4):957-64. [PMID: 19118266]
Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS, A comparison of methods to identify open-lung PEEP
Intensive Care Medicine 2009, 35: 740-7. [PMID: 19183951]
Jordan, AS, White, DP, Lo, Y, Wellman, A, Eckert, DJ, Yim-Yeh, S, Eikermann, M, Smith, SA, Stevenson, KE, Malhotra, A, Airway Dilator Muscle Activity and Lung Volume During Stable Breathing in OSA
Sleep 2009, 32: 361-368. [PMID: 19294956]
Eckert, D, Malhotra, A, Lo, Y, White, DP, Jordan, AS, Genioglossus Muscle Activity During REM sleep on CPAP in Men and Women with and without Obstructive Sleep Apnea
Chest 2009, 135:957-64. [PMID: 19118266]
Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL. Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats.
Anesthesiology. 2009 Jun;110(6):1327-34. [PMID: 19417601]
Yim Yeh, S, Doupis, J, Rahangdale, S, Horr, S, Malhotra, A, Veves, A, Total serum bilirubin does not affect vascular reactivity in patients with diabetes
Vascular Medicine 2009, 14: 129-136. [PMID: 19366819]
Talmor, D, Sarge, T, Malhotra, A, O’donnell, C, Ritz, R, Loring, SH, Mechanical Ventilated guided by Esophageal Pressure in Acute Lung Injury
New England Journal of Medicine, 2008, 359: 2095-2104. [PMID: 19001507]
Wellman, A, Malhotra, A, Jordan, AS, Stevenson, KE, Gautam, S, White, DP, Effect of oxygen in obstructive sleep apnea: Role of loop gain
Respir. Physiol. Neurobiol. 2008, 31;162:144-51; [PMID: 18577470]
Owens, R, Hess, D, Venegas, J, Malhotra, A, Harris, RS, Effect of the chest wall on pressure-volume curve analysis of ARDS lungs
Critical Care Medicine 2008;36:2980-5 [PMID: 18824918]
Eikermann, M, Zaremba, S, Malhotra, A, Jordan, AS, Rosow, C, Chamberlin, NL, Neostigmine but not Sugaammadex impairs Upper Airway Dilator Muscle Activity and Breathing, British Journal of Anesthesia
Br J Anaesth. 2008;101:344-9 [PMID: 18559352]
Elinoff, J, Talmor, D, Subramanian, B, Karmpaliotis, D, Goldberger, A, Malhotra, A, Effects of Mechanical Ventilation on the Electrocardiogram in Adults
Lung 2008, 186: 219-223. [PMID: 18478291]
Segal, Y, Malhotra, A, Pillar, G, Upper Airway Length may be Associated with the Severity of Obstructive Sleep Apnea Syndrome
Sleep & Breathing 2008;12:311-6. [PMID: 18516636]
Heinzer, R, White, DP, Jordan, AS, Lo, Y, Dover, L, Stevenson, K, Malhotra A, Trazodone increases Arousal Threshold in Obstructive Sleep Apnoea
European Respiratory Journal 2008, 31: 1308-1312 [PMID: 18256066]
Jia, S, Malhotra A, Saeed, M, Mark, R, Talmor, D, Risk Factors for Acute Respiratory Distress Syndrome in Patients Mechanically
Chest. 2008;133: 853-61 [PMID: 18263691]
Wilkinson, V, Malhotra A, Nicholas, CL, Worsnop, C, Jordan, AS, Butler, JE, Saboisky, JP, Gandevia, SC, White, DP, Trinder, J, Discharge Patterns of Human Genioglossus Motor Units During Sleep Onset
SLEEP 2008, 31: 525-533. [PMID: 18457240]
Heinzer, R, White, DP, Dover, L, Stevenson, K, Malhotra A, Jordan, A, Effect of Expiratory Positive Airway Pressure on Sleep Disordered Breathing
SLEEP 2008;31:429-32. [PMID: 18363320]
Macdonald, M, Fang, J, Pittman, S, White, DP, Malhotra A, The Current Prevalence of Sleep Disordered Breathing in Congestive Heart Failure Patients Treated with Beta Blockers
Journal of Clinical Sleep Medicine, 2008, 4:38-42. [PMID: 18350960]
Eikermann, M, Malhotra A, Fassbender, P, Zaremba, S, Jordan, AS, White, DP, Chamberlin, N, Differential Effects of Isoflurane and Propofol on Upper Airway Dilator Muscle Activity and Breathing
Anesthesiology 2008, 108: 897-906. [PMID: 18431126]
Caramez, MP, Miyoski, E, Harris, RS, Kacmarek, R, Malhotra A, Gas exchange impairment induced by open suctioning in ARDS: Impact of permissive hypercapnia.
Critical Care Medicine 2008, 36: 560-564. [PMID: 18091534]
Talmor, D, Sarge, T, Legedza, DA, O’donnell, CR, Ritz, R, Loring, SH, Malhotra A, Cytokine Release Following Recruitment Maneuvers
Chest 2007, 132: 1434-1439. [PMID: 17925413]
Eikermann, M, Fassbender, P, Malhotra A Takahashi, M, Kubo, S, Jordan, AS, White, DP, and Chamberlin, NL, Unwarranted Administration of Acetylcholinesterase Inhibitors Can Impair Genioglossus and Diaphragm Muscle Function
Anesthesiology. 2007, 107:621-629. [PMID: 17893459]
Stanchina, ML, Ellison, K, Malhotra A, Anderson, M, Kirk, M, Benser, ME, Tosi, C, Carlisle, C, Millman, RP, Buxton, A, The Impact of Cardiac Resynchronization Therapy on Obstructive Sleep Apnea in Heart Failure Patients: A Pilot StudyC
hest 2007, 132:433-439. [PMID: 17573498]
Pierce, R, White, DP, Malhotra A, Edwards, J, Kleverlaan, D, Palmer, LJ, Trinder, J, Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea
European Respiratory Journal 2007, 30:345-53. [PMID: 17459896]
Jordan, AS, Wellman, DA, Heinzer, R, Lo, Y, Schory, K, Dover, L, Gautam, S, Malhotra A and White, DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans
Thorax 2007, 62: 861-867. [PMID: 17412778]
Lo, Y, Jordan, A., Malhotra A, Wellman, A, Heinzer, R, Eikermann, M, Schory, K, Dover, L, White, DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity
Thorax 2007, 62: 799-805. [PMID: 17389755]
Chamberlin, NL, Eikermann, M, Fassbender, P, White, DP, and Malhotra A. Genioglossus Premotoneurons and the Negative Pressure Reflex in Rats
J. Physiol. (London) 2007, 579: 515-526. [PMID: 17185342]
Huang, Y, White, DP, Malhotra A. Use of Computational Modeling to Predict Responses to Upper Airway Surgery in Obstructive Sleep Apnea
Laryngoscope 2007, 117: 648-653. [PMID: 17415135]
Eikermann, M, Jordan, AS, Chamberlin, NL, Gautam, S, Wellman, DA, Lo, Y, White, DP and Malhotra A. The Influence of Aging on Pharyngeal Collapsibility during Sleep
Chest 2007, 131: 1702-1709. [PMID: 17413053]
Ronen O, Malhotra A, Pillar G. Influence of gender and age on upper-airway length during development.
Pediatrics. 2007 Oct;120(4):e1028-34.[PMID: 17908723]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Karmpaliotis D, Kirtane AJ, Ruisi CP, Polonsky T, Malhotra A, Talmor D, Kosmidou I, Jarolim P, de Lemos JA, Sabatine MS, Gibson CM, Morrow D. Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema.
Chest. 2007 Apr;131(4):964-71. [PMID: 17426196]
Nguyen TN, Badjatia N, Malhotra A, Gibbons FK, Qureshi MM, Greenberg SA. Factors predicting extubation success in patients with Guillain-Barré syndrome. Neurocrit Care. 2006;5(3):230-4. [PMID: 17290095]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between reduced sleep and weight gain in women.
Am J Epidemiol. 2006 Nov 15;164(10):947-54. Epub 2006 Aug 16. [PMID: 16914506]
Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Correlates of long sleep duration.
Sleep. 2006 Jul 1;29(7):881-9. [PMID: 16895254]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Cho MH, Malhotra A, Donahue DM, Wain JC, Harris RS, Karmpaliotis D, Patel SR. Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome.
Ann Thorac Surg. 2006 Jul;82(1):261-6. [PMID: 16798226]
Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung protective ventilation in acute respiratory distress syndrome.
Respir Care 2006, 51:497-502. [PMID: 16638159]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Talmor D, Sarge T, O'Donnell CR, Ritz R, Malhotra A, Lisbon A, Loring SH. Esophageal and transpulmonary pressures in acute respiratory failure.
Crit Care Med. 2006 May;34(5):1389-94. [PMID: 16540960]
Pittman SD, Pillar G, Berry R, Malhotra A, MacDonald MM, White DP. Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.
Sleep Breath. 2006, 10: 123-131. [PMID: 16586136]
Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J of Med 2006, 119: 72 e9-14. [PMID: 16431197]
Yinon D, Lowenstein L, Suraya S, Belooseski R, Zmora O, Malhotra A, Pillar G. Pre-eclampsia is associated with sleep disordered breathing and endothelial dysfunction.
Eur Respir J 2006, 27:328-33. [PMID: 16452588]
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol 2005, 99:1138-48. [PMID: 15831800]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan A, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med 2005, 172:114-7. [PMID: 15817803]
Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CRR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB. Paradoxical responses to positive end-expiratory pressure in patients with airway obstructive during controlled ventilation.
Crit Care Med 2005, 33:1519-28. [PMID: 16003057]
Huang Y, White DP, Malhotra A. The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway.
Chest 2005, 128:1324-30. [PMID: 16162725]
Bajwa EK, Ayas NT, Schulzer M, Mak E, Ryu JH, Malhotra A. Interferon-gamma 1b therapy in idiopathic pulmonary fibrosis: a meta-analysis.
Chest 2005, 128:203-6. [PMID: 16002936]
Aloia MS, Stanchina M, Arnedt JT, Malhotra A, Millman RP. Treatment adherence and outcomes in flexible vs. standard continuous positive airway pressure therapy.
Chest. 2005, 127:2085-93. [PMID: 15947324]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls.
J Physiol 2005, 564:549-62. [PMID: 15695240]
Jordan AS, Wellman DA, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol 2005, 99:2020-7. [PMID: 15994243]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med 2004, 170:1225-32. [PMID: 15317668]
Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.
Sleep 2004, 27:1394-403. [PMID: 15586793]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans.
J Physiol (London) 2004, 558:993-1004. [PMID: 15218069]
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep 2004, 27:1105-12. [PMID: 15532204]
Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP. Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.
Sleep 2004, 27:923-33. [PMID: 15453551]
Patel SR, Karmpaliotis D, Ayas NT, Mark EJ, Wain J, Thompson BT, Malhotra A. The role of open-lung biopsy in ARDS.
Chest 2004, 125:197-202. [PMID: 14718441]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep 2004, 27:249-53. [PMID: 15124718]
Fogel R, White DP, Pierce R, Malhotra, A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol 2003, 553: 533-44. [PMID: 12963804]
Stanchina ML, Malhotra, A, Fogel RB, Trinder J, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep 2003, 26:851-6. [PMID: 14655919]
Fogel RB, Trinder J, Malhotra, A, Stanchina M, Edwards JK, Schory KE, White DP. Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.
J Physiol 2003, 550:899-910. [PMID: 12807995]
Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra, A. Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.
J Appl Physiol 2003, 94:1875-82. [PMID: 12533492]
Patel SR, White DP, Malhotra, A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.
Arch Intern Med 2003, 163:565-71. [PMID: 12622603]
Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N. Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus.
J Pediatr 2003, 142:163-8. [PMID: 12584538]
Ayas N, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women.
Arch Intern Med 2003, 163:205-9. [PMID: 12546611]
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
J Appl Physiol 2003 94:205-12. [PMID: 12391042]
Malhotra A, Huang Y, Fogel RB, Pillar G, Edwards, JK, Kikinis R, Loring SH, White DP. The male predisposition to pharyngeal collapse: importance of airway length.
Am J Respir Crit Care Med 2002, 166: 1388-95. [PMID: 12421747]
Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg Z, Pillar G. Severe hypersomnolence after pituitary/hypothalamic surgery in adolescents: clinical characteristics and potential mechanisms.
Pediatrics 2002, 110: e74. [PMID: 12456941]
Karmpaliotis D, Kosmidou I, Ingenito EP, Hong K, Malhotra A, Sunday ME, Haley KJ. Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.
Am J Physiol Lung Cell Mol Physiol 2002, 283: L585-95. [PMID: 12169578]
Stanchina M, Malhotra A, Fogel R, Ayas, N, Edwards JK, Schory K, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during non-rapid eye movement sleep.
Am J Respir Crit Care Med 2002, 165:945-9. [PMID: 11934719]
Fisher D, Pillar G, Malhotra A, Peled N, Lavie P. Long-term follow-up of untreated patients with sleep apnea syndrome.
Respir Med 2002, 96:337-43. [PMID: 12167690]
Malhotra A, Pillar G, Fogel R, Edwards J, Ayas N, Akahoshi, T, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med 2002, 165:71-7. [PMID: 11779733]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med 2001, 164:2025-30. [PMID: 11739130]
Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM. The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation.
Eur Respir J 2001;17:1258-66. [PMID: 11491174]
Pillar G, Fogel R, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
Respir Physiol 2001, 127:23-38. [PMID: 11445198]
Malhotra A, Pillar G, Fogel, R, Beauregard J, Edwards, JK, White DP. Upper airway collapsibility: measurements and sleep effects.
Chest 2001;120:156-61. [PMID: 11451832]
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endocrinol Metab 2001;86:1175-80. [PMID: 11238505]
Pillar G, Malhotra A, Fogel, R, Beauregard J, Slamowitz, D, Shea SA and White DP. Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.
J Appl Phys 2000;89:1275-82. [PMID: 11007559]
Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender.
Am J Respir Crit Care Med 2000;162:1627-32. [PMID: 11069787]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000;162:1058-62. [PMID: 10988130]
Malhotra A, Fogel R, Edwards J, Shea SA, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000;161:1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol 2000;88:1346-54. [PMID: 10749829]
Reviews, Chapters and Editorials:
Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in
obstructive sleep apnoea.
Expert Opin Ther Targets. 2009 Jul;13(7):795-809. Review. [PMID: 19530985]
Loring SH, Garcia-Jacques M, Malhotra A. Pulmonary characteristics in COPD and mechanisms of increased work of breathing.
J Appl Physiol. 2009 Jul;107(1):309-14. Review. [PMID: 19359620]
Atkeson A, Yeh SY, Malhotra A, Jelic S. Endothelial function in obstructive sleep apnea.
Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):351-62. Review. [PMID: 19249441]
Rahangdale S, Yeh SY, Malhotra A, Veves A. Therapeutic interventions and oxidative stress in diabetes.
Front Biosci. 2009 Jan 1;14:192-209. Review. [PMID: 19273063]
Eckert, DJ, Malhotra, A, Jordan, AS, Mechanisms of Apnea.
Progress in Cardiovascular Diseases (A Malhotra Guest Editor), 2009 Jan-Feb; 51:313-23. [PMID 19110133]
Malhotra A, Loscalzo J. Sleep and cardiovascular disease: an overview.
Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):279-84. [PMID: 19110129]
Rahangdale, S, Campana, L, Malhotra, A, Not So Good Vibrations
Sleep 2008, 31: 1204-05. [PMID: 18788644]
Owens, R, Yim Yeh, S, Malhotra, A, CO Poisoning or CO Protection, invited editorial
Chest 2008;134:895-6 [PMID 18988771]
Yim Yeh, S, Rahangdale, S, Malhotra, A, Metabolic Syndrome, OSA and CPAP: A Weighty Issue
Chest, invited editorial 2008, 134: 675-676. [PMID: 18842905]
Owens, R, Eckert, D, Yeh, S, Malhotra, A, Upper Airway Function in the Pathogenesis of Obstructive Sleep Apnea: A review of the current literature
Current Opinion in Pulmonary Diseases, invited review Curr Opin Pulm Med. 2008;14: 519-24 [PMID: 18812828]
Pillar, G, White, DP, Malhotra, A, Age-related changes in the pharyngeal structure and function in sleep apnea and normal subjects
in S.R. Pandi-Perumal, J.M. Monti, and A. Monjan Principles and Practice of Geriatric Sleep Medicine, Cambridge University Press, in press.
Malhotra, A, Bertisch, S, and Wellman, DA, Complex Apnea isn’t a Real Disease,
Journal of Clinical Sleep Medicine, invited Pro/Con 2008, 4: 406-408. [PMID: 18853695]
Malhotra, A and Hillman, D, Obesity and the lung: Obesity, Respiration and Intensive Care
Thorax, invited review, 2008, 63: 925-931. [PMID: 18820119]
Malhotra A, Fogel R, White DP. Disorders of excessive sleepiness for neurological therapeutics:
In Burgess A, Principles and Practice. London, UK, Martin Dunitz Publishers in press.
Stanchina M, Malhotra A, White DP. An evidenced-based review of the diagnosis and treatment of respiratory disorders of sleep.
In Crapo and King in press.
Nguyen A, Yim S, Malhotra A. Theories of OSA Pathogenesis.
In Obstructive Sleep Apnea. (two volume textbook, Taylor and Francis), in press.
Eckert, D and Malhotra, A, Pathophysiology of Adult Obstructive Sleep Apnea
Proceedings of the American Thoracic Society 2008;5:144-53.
Goodwin AJ, Bajwa EK, Malhotra A. Minimally Invasive Cardiology
in: Irwin RS, Cerra FB, Rippe JM, Irwin and Rippe’s Intensive Care Medicine, 6th Edition (Philadelphia, Lippincott Williams & Wilkins), 2008, 261-274.
Eikermann, M and Malhotra, A. Predictive value of stimulated muscle force assessment in critically ill patients
Editorial, Acta Anaesthesiol Scand. 2008; 52: 1-2. [PMID: 18173429]
Malhotra, A, Kacmarek RM. Mechanical ventilation.
In. Hagberg C (Ed) Benumof’s airway management: principles and practice. Philadelphia. Lippincott Publishing Co, 2007; 1079-1122.
Chiche, L, Forel, JM, Papazian, L, Asakura, Y, Komatsu, T, Busch, T, Bercker, S, Kaisers, U, Malhotra, A, Low Tidal Volume Ventilation
New England Journal of Medicine 2007, 357: 2518-2520.
Eckert, D, Saboisky, J, Jordan, A, Malhotra, A, Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea
Journal of Clinical Sleep Medicine 2007, 3: 570-573.
Malhotra, A., Low Tidal Volume Ventilation in the acute respiratory distress syndrome, New England Journal of Medicine
Clinical Therapeutics section, 2007, 357: 1113-1120. PMID: 17855672
Eikermann, M, Chamberlin, N, Gerber, H, Malhotra, A, Muscle weakness after administration of neuromuscular blocking agents: Don’t immobilize the diaphragm unnecessarily
Critical Care Medicine 2007, 35: 1634-1635.
Eikermann, M, Magder, S, Malhotra, A, Is brachial artery peak velocity variation ready for prime time?
Chest 2007, 131: 1279-1281
Yim, S, Fredberg, JJ, Malhotra, A, CPAP for asthma: not a big stretch?
European Respiratory Journal, 2007, 29:226-228.
Benson, A, Bajwa E, Malhotra A. Pulmonary Disease.
In: Sabatine MS, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia Lippincott Williams and Wilkins. 2007; third edition, pages 2:1-2:23.
Shochat, T, Pillar, G, Malhotra, A, Aging and Sleep, invited review
Int J Sleep Disorders 2007;1(3):92-101
Loring, SH and Malhotra, A, Inspiratory efforts during mechanical ventilation: is there risk of barotrauma?
Chest 2007; 131: 646-648.
Eckert, D, Jordan, A, Merchia, P, Malhotra, A, Central Sleep Apnea: Pathophysiology and Treatment
Chest 2007, 131: 595-607.
Yim, S, Malhotra, A, Veves, A, Anti-oxidants and CVD in Diabetes: Where do we stand now?
Current Diabetes Reports 2007, 7: 8-13.
Malhotra, A and Patel, SR, Lung Biopsy in ARDS: Is it Worth the Risk?
Critical Care, 2006, 10: 160.
Hammer L, Dessertaine G, Timset JF, Aberegg SK, Tamler R, Leroith D, Roth J, Van den Berghe G, Wilmer A, Boullon R, Malhotra A.
Intensive Insulin in the Medical Intensive Care Unit, New Engl J Med. 2006; 354:2069-71.
Yim S, Jordan AS, Malhotra A. Obstructive sleep apnea, clinical presentation, diagnosis and treatment. In: Randerath WJ, Sanner BM, Somers VK, editors.
Sleep Apnea – Current diagnosis and treatment. Basel, Karger, 2006, 35:118-136.
Heinzer, R., Jordan, AS, Malhotra A, Sleep Apnea Syndrome, in Khoo, M., Wiley
Encyclopedia of Biomedical Engineering, New York, John Wiley and Sons, 2006, pp. 18-34.
Kacmarek RM, Malhotra A. Equipment required for home mechanical ventilation. In Tobin MJ (Ed)
Principles and Practice of Mechanical Ventilation, 2nd Ed, New York McGraw Hill, 2006; pages 97-128
Kacmarek RM., Villar J, Malhotra A Modes of Mechanical ventilation. In Albert RK, Slutsky A, Ranieri M, Takala J, Torres A. (Eds).
Clinical Critical Care Medicine, Philadelphia, Elsevier Pub Co., 2006; pages 109-120.
Malhotra A. Intensive insulin in intensive care.
New Engl J Med, Invited editorial 2006;354:516-8.
Malhotra A, Jordan AS. Did fat boy Joe need hormone replacement?
Sleep 2006, 29:16-8.
Pillar G, Harder L, Malhotra A. Trauma and post-traumatic stress disorder. In Chang T, Vihtelic CM, Gold C, Lydic R, and Baghdoyan HA
Encyclopedia of Sleep Medicine, New York, John Wiley & Sons, 2006. p.857-66.
Jordan A, Malhotra A. Pharyngeal lumen: both length and size matter.
Journal of Clinical Sleep Medicine. 2005, 1:264-265.
Kacmarek R and Malhotra A High frequency oscillatory ventilation: what large animal studies have taught us!
Crit Care Med 2005, 33:S148-54.
Malhotra A, Jordan AS. Surface tension and sleep apnea: a sticky business.
SLEEP 2005, 28:392-3.
Ting L, Malhotra A. Disorders of Sleep: an overview.
Prim Care 2005, 32:305-18.
Malhotra A, Berry R, White DP. Central sleep apnea. In Carney, PR, Berry, RB, Geyer
J, Clinical Sleep Disorders. Philadelphia, Lippincott; 2005 p. 331-46.
Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T, Patel S, Wain J, Malhotra A. Surgical stress in ARDS open-lung biopsy.
Chest 2004 Oct;126:1383-4
Fogel, RB, Malhotra A, White, DP, Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome
Thorax 2004, 59: 159-163.
Oddo M, Liaudet L, Patel SR, Wain J, Malhotra A Open-lung biopsy for ARDS Patients.
Chest 2004;126:1003-4.
Bajwa E, Mouded M, Systrom DM, Malhotra A. Pulmonary Disease.
In: Sabatine MS, Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia: Lippincott Williams and Wilkins. 2004; second edition, pages 2:1 to 2:22
Bajwa E, Malhotra A, Thompson T. Monitoring of the patient in septic shock.
Seminars in Respiratory and Critical Care Medicine 2004, 25: 629-644.
Carden K and Malhotra A. The debate about gender differences in obstructive sleep apnea
Sleep Med 2003, 4:485-7.
McCowen KC, Malhotra, A. The correlation between obstructive sleep apnea and low gonadotropin secretion in men.
Sleep Medicine 2003;4:83-4.
Malhotra A, White DP. Obstructive sleep apnoea.
Lancet 2002, 360:237-45.
Malhotra A, White DP. The pathogenesis of obstructive sleep apnea. In McNicholas W, Phillipson E, editors.
Breathing Disorders in Sleep, London: W B Saunders, 2002; p. 44-64.
Malhotra A, Schwartz D. Lung Cancer. In: Hess D, MacIntyre N, Mishoe, S, Galvin, WF, Adams, AB, Saposnick, AB
Respiratory Care: Principles and Practice. Philadelphia, PA, WB Saunders, 2002 1151-67
Malhotra A, Schwartz DR, Ayas N, Stanchina M, White DP. The treatment of oxygen-induced hypercarbia.
Lancet 2001;357:884-5.
McCowen K, Malhotra A, Bistrian B. Stress-induced hyperglycemia
Critical Care Clinics. 2001, 17:107-24.
Sabatine M, Malhotra A, Systrom DM. Pulmonary Disease. In: Sabatine, MD, Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia, PA
Lippincott Williams and Wilkins; 2000. p. 2-1-21.
Schwartz DR, Malhotra A, Fink MP. Microcirculatory weak units – an alternative explanation.
Critical Care Medicine 2000;28:3127-8.
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in septic shock. In: Malhotra, SK and Tuszynski, J.
Advances in Structural Biology., Stamford, CT, Jai Press; 2000 p. 65-82.
Pillar G, Malhotra A, Lavie P. Post-traumatic stress disorder and sleep – what a nightmare!
Sleep Med Rev 2000, 4: 183-200.
Malhotra A, Ayas N, Epstein L. The art and science of continuous positive airway pressure therapy in obstructive sleep apnea.
Curr Opin Pulm Med 2000 6: 490-495.
Ayas N, Malhotra A, Epstein L. Alternative therapies for sleep apnea.
Drugs Today (Barc) 1999, 35: 811-21.
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in sepsis: an overview.
Sepsis 1999, 1:279-89.
Malhotra A, Kradin R. The pulmonary immune response to asbestos. In Peters GA, Peters BJ, editors.
Asbestos and Cancer; Salem, NH: Butterworth Legal, 1997, 1-23.
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