Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Atul Malhotra, MD
Assistant Professor of Medicine, Harvard Medical School
Associate Physician, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Administrative Title(s)
Medical Director, Brigham and Women's Hospital Sleep Disorders Program
Other Affiliation(s)
Beth Israel Deaconess Medical Center
Massachusetts General Hospital
Massachusetts General Hospital
Inter-office Mail Address
BWH Sleep Disorders ProgramBeth Israel Deaconess Medical Center
Stoneman 8, 330 Brookline Avenue
Boston, MA 02215
Fax 617-732-7337
Society Memberships
American Academy of Sleep MedicineSleep Research Society
American Thoracic Society
American College of Chest Physicians
Society of Critical Care Medicine
Research Unit(s)
Medical Chronobiology Group, Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women's Hospital
Research Interests
My two major research foci are the pathogenesis of sleep apnea and the metabolic/cardiovascular complications of sleep disorders. The pathogenesis studies include anatomical ones using imaging, upper airway physiology, and control of breathing. These studies are ultimately designed to define the various contributors to apnea in different individuals. We have developed multivariate statistical models, computational finite element computational models, and an intact rat model to assess the various factors that are important in apnea pathogenesis. The ultimate goal is to define specific therapeutic targets for OSA patients of varying phenotypes. The rat studies are exploring the neurochemistry of the various components of upper airway reflexes with an eventual goal of defining potential pharmacological targets for OSA therapy. The metabolic/cardiovascular studies seek to separate obesity effects from OSA influences by assessing a host of autonomic, microcirculatory, inflammatory, hemostatic, metabolic, and hemodynamic variables. These studies include a cross sectional study comparing OSA patients with weight matched controls, an interventional study to assess the changes in the various biomarkers with OSA therapy, and the impact of weight loss on these biomarkers following gastric bypass surgery. The ultimate goal of these studies is to improve our understanding of apnea complications and to lay the groundwork for a multicenter clinical trial to determine the impact of treatment on OSA outcome. We also participate in industry-related science focused on the development of new diagnostic and therapeutic strategies in OSA.
Trainees
S. Crowley, 1998-99
S. Lazic, 1998-00
E. Ruffing, 1999-01
M. Stanchina, 1999-01
S. Patel, 2002-04
A. Jordan, 2002-05
A. Nguyen, 2005-06
K. Steiner, 2005-06
M. Eikermann, 2005-07
Y. Lo, 2005-07
S. Yim Yeh, 2006-Present
S. Rahangdale, 2006-Present
D. Eckert, 2006-Present
S. Bertisch, 2006-Present
P. Fassbender, 2006-07
S. Zaremba, 2007
J. Saboisky, 2007-Present
L. Campana, 2007-Present
R. Owens, 2008-Present
S. Lazic, 1998-00
E. Ruffing, 1999-01
M. Stanchina, 1999-01
S. Patel, 2002-04
A. Jordan, 2002-05
A. Nguyen, 2005-06
K. Steiner, 2005-06
M. Eikermann, 2005-07
Y. Lo, 2005-07
S. Yim Yeh, 2006-Present
S. Rahangdale, 2006-Present
D. Eckert, 2006-Present
S. Bertisch, 2006-Present
P. Fassbender, 2006-07
S. Zaremba, 2007
J. Saboisky, 2007-Present
L. Campana, 2007-Present
R. Owens, 2008-Present
Research Funding
PI R01 HL085188-01A2 Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea Pathogenesis (2008-2012)
Established Investigator Award, American Heart Association 2007
PI NIH RO1 Cardiovascular complications of OSA
PI NIH NHLBI SCOR Project 1 - pathogenesis of OSA
PI NIA Beeson Award - aging influences on the development of apnea
Established Investigator Award, American Heart Association 2007
PI NIH RO1 Cardiovascular complications of OSA
PI NIH NHLBI SCOR Project 1 - pathogenesis of OSA
PI NIA Beeson Award - aging influences on the development of apnea
Teaching
Co-director of HST 100 (Respiratory Physiology and Pathophysiology)
Weekly teaching conference for Pulmonary and Critical Care fellowship in the Harvard-wide program
Frequent lectures to house staff at all Harvard hospitals and to participants at Harvard CME courses
Chairman of the Education Committee for the American Thoracic Society (2006-Present)
Program Chair for the Respiratory Neurobiology and Sleep Assembly at the American Thoracic Society
Director of the National Sleep Medicine Course for the AASM (2005-Present)
Weekly teaching conference for Pulmonary and Critical Care fellowship in the Harvard-wide program
Frequent lectures to house staff at all Harvard hospitals and to participants at Harvard CME courses
Chairman of the Education Committee for the American Thoracic Society (2006-Present)
Program Chair for the Respiratory Neurobiology and Sleep Assembly at the American Thoracic Society
Director of the National Sleep Medicine Course for the AASM (2005-Present)
Selected Publications
Talmor D, Sarge T, Malhotra A, O'donnell C, Ritz R, Loring SH. Mechanical ventilated guided by esophageal pressure in acute lung injury.
New England Journal of Medicine, in press
Owens R, Hess D, Venegas J, Malhotra A, Harris RS. Effect of the chest wall on pressure-volume curve analysis of ARDS lungs.
Critical Care Medicine, in press
Segal Y, Malhotra A, Pillar G. Upper Airway Length may be Associated with the Severity of Obstructive Sleep Apnea Syndrome.
Sleep and Breathing, in press. [PMID: 18516636]
Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin, NL. Neostigmine but not Sugaammadex impairs Upper Airway Dilator Muscle Activity and Breathing.
British Journal of Anesthesia, in press. [PMID:18559352]
Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP.
Effect of oxygen in obstructive sleep apnea: Role of loop gain.
Respir Physiol Neurobiol. 2008;31(162):144-151. [PMID:18577470]
Elinoff J, Talmor D, Subramanian B, Karmpaliotis D, Goldberger A, Malhotra A.
Effects of Mechanical Ventilation on the Electrocardiogram in Healthy Adults.
Lung. 2008;186:219-223. [PMID:18478291]
Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, White DP, Chamberlin N. Differential Effects of Isoflurane and Propofol on Upper Airway Dilator Muscle Activity and Breathing.
Anesthesiology. 2008;108:897-906. [PMID:18431126]
Jia S, Malhotra A, Saeed M, Mark R, Talmor D. Risk Factors for ARDS in Patients Receiving Mechanical Ventilation for > 48 h.
Chest. 2008 Apr;133(4):853-61. Epub 2008 Feb 8. [PMID: 18263691]
Heinzer R, White DP, Dover L, Stevenson K, Malhotra A, Jordan A. Effect of Expiratory Positive Airway Pressure on Sleep Disordered Breathing.
Sleep. 2008 Mar 1;31(3):429-32. [PMID: 18363320]
Heinzer R, White DP, Jordan AS, Lo Y, Dover L, Stevenson K, Malhotra A. Trazodone increases Arousal Threshold in Obstructive Sleep Apnea.
Eur Respir J. 2008 Feb 6 [Epub ahead of print] [PMID: 18256066]
Macdonald M, Fang J, Pittman S, White DP, Malhotra A. The Current Prevalence of Sleep Disordered Breathing in Congestive Heart Failure Patients Treated with Beta Blockers.
J Clin Sleep Med. 2008 Feb 15;4(1):38-42. [PMID: 18350960]
Caramez MP, Kacmarek R, Harris RS, Malhotra A. Gas exchange impairment induced by open suctioning in ARDS: Impact of permissive hypercapnia.
Crit Care Med. 2008 Feb;36(2):560-4. [PMID: 18091534]
Wilkinson, V, Malhotra A, Nicholas, CL, Worsnop, C, Jordan, AS, Butler,
JE, Saboisky, JP, Gandevia, SC, White, DP, Trinder, J, Discharge Patterns of Human Genioglossus Motor Units During Sleep Onset.
Sleep. 2008, 31: 525-533.
Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan
AS, White DP, and Chamberlin NL. Unwarranted Administration of Acetylcholinesterase Inhibitors Can Impair Genioglossus and Diaphragm Muscle Function.
Anesthesiology. 2007 Oct;107(4):621-9. [PMID: 17893459]
Talmor, D, Sarge, T, Legedza, DA, O’donnell, CR, Ritz, R, Loring, SH, Malhotra, A. Cytokine Release Following Recruitment Maneuvers.
Chest. 2007 Nov;132(5):1434-9. Epub 2007 Oct 9. [PMID: 17925413]
Ronen, O, Malhotra, A, Pillar, G. The influence of gender and age on upper airway length during development.
Pediatrics. 2007 Oct;120(4):e1028-34. [PMID: 17908723]
Jordan AS, Wellman A, Heinzer RC, Lo YL, Schory K, Dover L, Gautam S, Malhotra
A, White DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans.
Thorax. 2007 Oct;62(10):861-7. Epub 2007 Apr 5. [PMID: 17412778]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikerman M, Schory K,
Dover L, White DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity.
Thorax. 2007 Sep;62(9):799-805. Epub 2007 Mar 27. [PMID: 17389755]
Stanchina ML, Ellison K, Malhotra A, Anderson M, Kirk M, Benser ME, Tosi C, Carlisle C, Millman RP, Buxton A. The Impact of Cardiac Resynchronization Therapy on Obstructive Sleep Apnea in Heart Failure Patients: A Pilot Study.
Chest. 2007 Aug;132(2):433-9. Epub 2007 Jun 15. [PMID: 17573498]
Pierce R, White D, Malhotra A, Edwards JK, Kleverlaan D, Palmer L, Trinder J. Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea.
Eur Respir J. 2007 Aug;30(2):345-53. Epub 2007 Apr 25. [PMID: 17459896]
Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP,
Malhotra A. The influence of aging on pharyngeal collapsibility during sleep.
Chest. 2007 Jun;131(6):1702-9. Epub 2007 Apr 5. [PMID: 17413053]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea.
Laryngoscope. 2007 Apr;117(4):648-653. [PMID: 17415135]
Karmpaliotis D, Kirtane AJ, Ruisi CP, Polonsky T, Malhotra A, Talmor D et al. Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema.
Chest. 2007 Apr;131(4):964-71. [PMID: 17426196]
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol. 2007. Mar 1;579(Pt 2):515-526. Epub 2006 Dec 21. [PMID: 17185342]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between Reduced Sleep and Weight Gain in Women.
Am J Epidemiol. 2006 Nov 15;164(10):947-54. Epub 2006 Aug 16. [PMID: 16914506]
Pittman SD, Pillar G, Berry R, Malhotra A, MacDonald MM, White DP. Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.
Sleep and Breath. 2006 Sep;10(3):123-31. [PMID: 16586136]
Cho M, Malhotra A, Karmpoliotis D, Harris RS, Wain J, Patel SR. The impact of mechanical ventilation on bronchopleural fistula following lung biopsy.
Annals of Thoracic Surgery. 2006 Jul;82(1):261-6. [PMID: 16798226]
Patel SR, Malhotra A, Gottlieb D, White DP, Hu FB. Correlates of long sleep duration.
Sleep. 2006 Jul 1;29(7):881-9. [PMID: 16895254]
Heinzer R, Jordan A, Malhotra A, Wellman A, Lo Y, Patel S, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in sleep apnea patients.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung protective ventilation in acute respiratory distress syndrome.
Respir Care. 2006 May;51(5):497-502. [PMID: 16638159]
Talmor D, Sarge T, O’Donnell CR, Ritz R, Malhotra A, Lisbon A, Loring SH. Esophageal and transpulmonary pressures in acute respiratory failure.
Crit Care Med. 2006 May;34(5):1389-94. [PMID: 16540960]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Yinon D, Lowenstein L, Suraya S, Belooseski R, Zmora O, Malhotra A, Pillar G. Pre-eclamptic toxemia is associated with sleep disordered breathing and endothelial dysfunction.
Eur Respir J. 2006 Feb;27(2):328-33. [PMID: 16452588]
Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J of Med. 2006 Jan;119(1):72.e9-14. [PMID: 16431197]
Nguyen TN, Badjatia N, Malhotra A, Gibbons FK, Qureshi MM, Greenberg SA. Factors predicting extubation success in patients with Guillain-Barre syndrome.
Neurocrit Care. 2006;5(3):230-4. [PMID: 17290095]
Jordan AS, Wellman DA, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol. 2005 Nov;99(5):2020-7. Epub 2005 Jun 30. [PMID: 15994243]
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol. 2005 Sep;99(3):1138-48. Epub 2005 Apr 14. [PMID: 15831800]
Huang Y, White DP, Malhotra A. The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway.
Chest. 2005 Sep;128(3):1324-30. [PMID: 16162725]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan A, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med. 2005 Jul 1;172(1):114-7. Epub 2005 Apr 7. [PMID: 15817803]
Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CRR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB. Paradoxical responses to positive end-expiratory pressure in patients with airway obstructive during controlled ventilation.
Crit Care Med. 2005 Jul;33(7):1519-28. [PMID: 16003057]
Bajwa EK, Ayas NT, Schulzer M, Mak E, Ryu JH, Malhotra A. Interferon-gamma 1b therapy in idiopathic pulmonary fibrosis: a meta-analysis.
Chest. 2005 Jul;128(1):203-6. [PMID: 16002936]
Aloia MS, Stanchina M, Arndt JT, Malhotra A, Millman RP. Treatment adherence and outcomes in flexible versus standard continuous positive airway pressure therapy.
Chest. 2005 Jun;127(6):2085-93. [PMID: 15947324]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnea versus controls.
J Physiol. 2005 Apr 15;564(Pt 2):549-62. Epub 2005 Feb 3. [PMID: 15695240]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32. Epub 2004 Aug 18. [PMID: 15317668]
Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.
Sleep. 2004 Nov 1;27(7):1394-403. [PMID: 15586793]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans.
J Physiol (London). 2004 Aug 1;558(Pt 3):993-1004. Epub 2004 Jun 24.
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep. 2004 Sep 15;27(6):1105-12. [PMID: 15532204]
Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP. Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.
Sleep. 2004 Aug 1;27(5):923-33. [PMID: 15453551]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep. 2004 Mar 15;27(2):249-53. [PMID: 15124718]
Patel SR, Karmpaliotis D, Ayas NT, Mark EJ, Wain J, Thompson BT, Malhotra A. The role of open lung biopsy in the acute respiratory distress syndrome.
Chest. 2004 Jan;125(1):197-202. [PMID: 14718441]
Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol. 2003 Dec 1;553(Pt 2):533-44. Epub 2003 Sep 8. [PMID: 12963804]
Stanchina ML, Malhotra A, Fogel RB, Trinder J, Ayas N, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep. 2003 Nov 1;26(7):851-6. [PMID: 14655919]
Fogel RB, Trinder J, Malhotra A, Stanchina M, Edwards JK, Schory KE, White DP.
Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state. J Physiol. 2003 Aug 1;550(Pt 3):899-910. Epub 2003 Jun 13. [PMID: 12807995]
Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra A. Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.
J Appl Physiol. 2003 May;94(5):1875-82. Epub 2003 Jan 17. [PMID: 12533492]
Malhotra A, Muse V, Mark E. Clinical Pathological Case: An 82-year-old man with dyspnea and pulmonary abnormalities.
New Engl J Med. 2003 Apr 17;348(16):1574-85. [PMID: 12700378]
Fogel RB, Malhotra A, Dalagiorgou G, Robinson M, Jakab M, Kikinis R, Pittman SD, White DP. Anatomic and physiologic predictors of apnea severity in morbidly obese subjects.
Sleep. 2003 Mar 15;26(2):150-5. [PMID: 12683472]
Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.
Arch of Intern Med. 2003 Mar 10;163(5):565-71. [PMID: 12622603]
Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N. Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus.
J Pediatr. 2003 Feb;142(2):163-8. [PMID: 12584538]
Ayas N, White DP, Manson J, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women.
Arch of Intern Med. 2003 Jan 27;163(2):205-9. [PMID: 12546611]
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Respiratory system loop gain in normal men and women measured with proportional assist ventilation.
J Appl Physiol. 2003 Jan;94(1):205-12. Epub 2002 Sep 20. [PMID: 12391042]
Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg A, Pillar G. Severe hypersomnolence after pituitary/hypothalamic surgery in children: clinical characteristics and potential mechanisms.
Pediatrics. 2002 Dec;110(6):e74. [PMID: 12456941]
Malhotra A, Huang Y, Fogel R, Pillar G, Kikinis R, Loring SH, White DP. The male predisposition to pharyngeal collapse: importance of airway length.
Am J Respir Crit Care Med. 2002 Nov 15;166(10):1388-95. [PMID: 12421747]
Karmpaliotis D, Kosmidou I, Ingenito EP, Hong K, Malhotra A, Sunday ME, Haley KJ. Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L585-95. [PMID: 12169578]
Fisher D, Pillar G, Malhotra A, Peled N, Lavie P. Long-term follow-up of untreated patients with obstructive sleep apnea syndrome.
Respir Med. 2002 May;96(5):337-43. [PMID: 12113384]
Stanchina M, Malhotra A, Fogel R, Edwards JK, Schory K, Ayas N, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir Crit Care Med. 2002 Apr 1;165(7):945-9. [PMID: 11934719]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards J, Ayas N, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med. 2002 Jan 1;165(1):71-7. [PMID: 11779733]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med. 2001 Dec 1;164(11):2025-30. [PMID: 11739130]
Pillar G, Fogel R, Malhotra A, Edwards J, Beauregard J, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
Respiration Physiology. 2001 Aug;127(1):23-38. [PMID: 11445198]
Malhotra A, Pillar G, Edwards J, Beauregard J, Fogel R, Shea S, White DP. Upper airway collapsibility: measurement and sleep effects.
Chest. 2001 Jul;120(1):156-61. [PMID: 11451832]
Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM. The sleep apnea/hypopnea syndrome depresses waking vagal tone independent of sympathetic activation.
Eur Respir J. 2001 Jun;17(6):1258-66. [PMID: 11491174]
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endo Met. 2001 Mar;86(3):1175-80. [PMID: 11238505]
Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender.
Am J Resp Crit Care Med. 2000 Nov;162(5):1627-32. [PMID: 11069787]
Pillar G, Malhotra A, Edwards J, Beauregard J Fogel R, Shea S White DP. Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.
J Appl Phys. 2000 Oct;89(4):1275-82. [PMID: 11007559]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure.
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1058-62. [PMID: 10988130]
Malhotra A, Fogel R, Edwards J, Shea S, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000. May;161(5):1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol. 2000 Apr;88(4):1346-54. [PMID: 10749829]
Schwartz D, Maroo A, Malhotra A, Kesselman H. Negative pressure pulmonary hemorrhage.
Chest. 1999 Apr;115(4):1194-7. [PMID: 10208229]
Proceedings of Meetings:
Huang Y, Malhotra A, White DP. A computational model of upper airway collapsibility.
IEEE Conference 2003.
Malhotra A, Huang Y, White DP. Upper airway mechanics: influence of gender.
Proc Second Joint EMBS/BMES Conference 2002;1544-5.
Pittman SD, Tal N, Pillar G, Malhotra A, Hilton M, Fogel R, Ayas N, White DP. Automated detection of obstructive sleep-disordered breathing events using peripheral arterial tonometry and oximetry.
Computers in Cardiology 2000;27:485-8.
Pittman SD, Hill PD, Malhotra A, Ayas N, Fogel R, White DP. Stabilizing Cheyne Stokes respiration associated with congestive heart failure using computer-assisted positive airway pressure.
Computers in Cardiology 2000;27:201-4.
Reviews, Chapters and Editorials:
Malhotra A, Kacmarek R. Mechanical ventilation. Ranieri M, et. al., editors.
In: Anesthetic Principles in Critical Care, in press.
Stanchina M, Malhotra A, White DP. An evidenced-based review of the diagnosis and treatment of respiratory disorders of sleep.
In: Crapo and King, in press.
Goodwin A, Bajwa E, Malhotra A. Non-invasive determination of cardiac output.
In: Irwin and Rippe’s Intensive Care Medicine, 6th Edition, in press.
Nguyen A, Yim S, Malhotra A. Theories of OSA Pathogenesis.
In: Obstructive Sleep Apnea. (two volume textbook, Taylor and Francis), in press.
Malhotra A, Fogel R, White DP. Disorders of excessive sleepiness for neurological therapeutics: Burgess A, editor.
In: Principles and Practice. Martin Dunitz Publishers, in press.
Malhotra A, Hillman D. Pbesity and the lung: Obesity, respirations and intensive care. (Invited review)
Thorax, in press
Malhotra A, Bertisch S, Wellman DA. Complex apnea is not a disease. (Invited Pro/Con)
Journal of Clinical Sleep Medicine, in press.
Pillar G, White DP, Malhotra A. Age-related changes in the pharyngeal structure and function in sleep apnea and normal subjects.
IN: SR Pandi-Perumal, J.M. Monti, and A. Monjan Principles and Practice of Geriatric Sleep Medicine, Cambridge University Press, in press.
Eckert DJ, Malhotra A, Jordan AS. Obstructive Sleep Apnea Pathogenesis, Progress
In: Cardiovascular Diseases (A Malhotra Guest Editor), in press.
Owens R, Yeh S, Eckert D, Malhotra A. Upper Airway Function in the Pathogenesis of Obstructive Sleep Apnea: A review of the current literature, Current Opinion
In: Pulmonary Diseases, in press.
Yim Yeh S, Rahangdale S, Malhotra A. Metabolic Syndrome, OSA and CPAP: A Weighty Issue. (Invited editorial)
Chest, in press.
Owens R, Yim Yeh S, Malhotra A. CO Poisoning or CO Protection.
Chest, in press.
Rahangdale S, Campana L, Malhotra A. Not So Good Vibrations.
Sleep, in press.
Eckert, D and Malhotra, A. Pathophysiology of Obstructive Sleep Apnea.
Proceedings of the American Thoracic Society, in press.
Kacmarek R, Villar J, Malhotra A. Modes of Mechanical Ventilation. Ranieri M, et. al. editors,
Elsevier Publishers, in press.
Eikermann, M and Malhotra, A. Predictive value of stimulated muscle force assessment in critically ill patients. (Editorial).
Acta Anaesthesiol Scand. 2008 Jan;52(1):1-2. [PMID: 18173429]
Eikermann, M, Chamberlin, N, Gerber, H, Malhotra, A. Muscle weakness after administration of neuromuscular blocking agents: Don’t immobilize the diaphragm unnecessarily.
Critical Care Medicine. 2007 Jun;35(6):1634-5; author reply 1635.
Malhotra A, Eikermann M, Magder S. Is brachial artery peak velocity variation ready for prime time?
Chest. 2007 May;131(5):1279-81. [PMID: 17494778]
Yim S, Fredberg JJ, Malhotra A. Continuous positive airway pressure for asthma: not a big stretch? (Invited editorial).
Eur Respir J. 2007 Feb;29(2):226-8. [PMID: 17264319]
Loring SH, Malhotra A. Inspiratory efforts during mechanical ventilation: is there risk of barotrauma?
Chest. 2007 Mar;131(3):646-8. [PMID: 17356075]
Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment.
Chest. 2007 Feb;131(2):595-607. [PMID: 17296668]
Malhotra, A. Low Tidal Volume Ventilation in ARDS. (Invited review).
New England Journal of Medicine. Clinical Therapeutics section, 2007, 357: 1113-1120.
Chiche, L, Forel, JM, Papazian, L, Asakura, Y, Komatsu, T, Busch, T, Bercker, S, Kaisers, U, Malhotra, A. Low Tidal Volume Ventilation.
New England Journal of Medicine. 2007, 357: 2518-2520.
Malhotra, A and Kacmarek, RM. Mechanical Ventilation. In:
Benomof's Airway Management. 2007 (Mosby), pp. 1079-1122.
Benson, A, Bajwa E, Malhotra A. Pulmonary Disease.
In: Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Sabatine MS, editor.
Lippincott Williams and Wilkins. 2007; third edition.
Eckert, D, Saboisky, J, Jordan, A, Malhotra, A. Upper airway myopathy is not important in obstructive sleep apnea.
Journal of Clinical Sleep Medicine. 2007, 3: 570-574.
Shochat T, Pillar G, Malhotra A. Sleep and Aging. (Invited review).
Int J Sleep Disorders 2007; 3(1):92-102.
Malhotra A, Patel S. Lung biopsy in ARDS: is it worth the risk?
Crit Care. 2006;10(4):160. [PMID: 16941755]
Yim, S, Malhotra, A, Veves, A. Anti-oxidants and CVD in Diabetes: Where do we stand now?
Current Diabetes Reports, in press.
Hammer L, Dessertaine G, Timset JF, Aberegg SK, Tamler R, Leroith D, Roth J, Van den Berghe G, Wilmer A, Boullon R, Malhotra A. Intensive Insulin in the Medical Intensive Care Unit.
New Eng J Med. 2006 May 11;354(19):2069-71. [PMID: 16687723]
Malhotra A. Intensive insulin in intensive care. Invited editorial.
New Engl J Med. 2006 Feb 2;354(5):516-8. [PMID: 16452564]
Malhotra A, Jordan AS. Did fat boy Joe need hormone replacement? Invited editorial.
Sleep. 2006 Jan 1;29(1):16-8.
Kacmarek RM, Malhotra A. Equipment required for home mechanical ventilation.
In: Tobin MJ (Ed) Principles and Practice of Mechanical Ventilation, 2nd Ed, McGraw Hill, New York (In Press). 2006.
Yim S, Jordan AS, Malhotra A. Obstructive sleep apnea, clinical presentation, diagnosis and treatment. In: Randerath WJ, Sanner BM, Somers VK, editors.
Sleep Apnea – Current diagnosis and treatment. 2006, Volume 35;118-36.
Heinzer, R., Jordan, AS, Malhotra, A. Sleep Apnea Syndrome,
Wiley Encyclopedia of Biomedical Engineering, John Wiley and Sons, 2006.
Pillar G, Harder L, Malhotra A. Trauma and post-traumatic stress disorder.
Encyclopedia of Sleep Medicine, 2006. p.857-66.
Jordan A, Malhotra A. Pharyngeal lumen: both length and size matter. Journal of Clinical Sleep Medicine. Invited editorial,
J Clin. Sleep Med. 2005 Jul 15;1(3):264-5. [PMID: 17566186]
Malhotra A, Berry R, White DP. Central sleep apnea.
In: Clinical Sleep Disorders.
Lippincott Williams and Wilkins. 2005;331-46.
Bajwa E, Malhotra A, Thompson T. Monitoring of the patient in septic shock.
Seminars in Respiratory and Critical Care Medicine 2004, 25: 629-644.
Malhotra A, Jordan AS. Surface tension and sleep apnea: a sticky business. Invited editorial.
Sleep. 2005 Apr 1;28(4):392-3. [PMID: 16171283]
Ting L, Malhotra A. Sleep: an overview.
In: Prim Care 2005 Jun;32(2):305-18.
Kacmarek R, Malhotra A. High frequency oscillatory ventilation: what large animal studies have taught us!
Crit Care Med. 2005 Mar;33(3 Suppl):S148-54. [PMID: 15753721]
Malhotra A, Berry R, White DP. Central sleep apnea.
In: Clinical Sleep Disorders.
Lippincott; 2005 p. 331-46.
Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T, Patel S, Wain J, Malhotra A. Surgical stress in ARDS open-lung biopsy.
In: Chest. 2004 Oct;126(4):1383-4. [PMID: 15486411]
Oddo M, Liaudet L, Patel SR, Wain J, Malhotra A. Open-lung biopsy for ARDS Patients.
In: Chest. 2004 Sep;126(3):1003. [PMID: 15364791]
Bajwa E, Mouded M, Systrom DM, Malhotra A. Pulmonary Disease.
In: Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Sabatine MS, editor.
Lippincott Williams and Wilkins. 2004; second edition.
Carden KA, Malhotra A. The debate about gender differences in obstructive sleep apnea.
In: Sleep Medicine. 2003 Nov; 4(6):485-7.
McCowen KC, Malhotra A. The correlation between obstructive sleep apnea and low gonadotropin secretion in men.
In: Sleep Medicine. 2003;4:83-4.
Malhotra A, White DP. Seminar: Obstructive sleep apnoea.
In: Lancet. 2002 Jul 20;360(9328):237-45. [PMID: 12133673]
Malhotra A, White DP. The pathogenesis of obstructive sleep apnea. In McNicholas W, Phillipson E, editors.
Breathing Disorders in Sleep, 2002; p. 44-64.
Malhotra A, Schwartz D. Lung Cancer. In: Hess D, MacIntyre N, Saposnick et al., editors.
Respiratory Care: Principles and Practice. 2002; p. 1151-67.
Malhotra A, Schwartz D, Ayas N, Stanchina M, White DP. The treatment of hyperoxic hypercarbia.
In: Lancet. 2001 Mar 17;357(9259):884-5. [PMID: 11265981]
McCowen K, Malhotra A, Bistrian B. Stress-induced hyperglycemia.
In: Critical Care Clinics. 2001. p. 107-24.
Sabatine M, Malhotra A, Systrom DM. Pulmonary Disease. In: Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Sabatine MS, editor.
Lippincott Williams and Wilkins; 2000. p. 2-1-21.
Schwartz DR, Malhotra A, Fink MP. Microcirculatory weak units – an alternative explanation.
In: Critical Care Medicine. 2000 Aug;28(8):3127-9. [PMID: 10966332]
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in septic shock.
In: Advances in Structural Biology. Jai Press; 2000 p. 65-82.
Pillar G, Malhotra A, Lavie P. Post traumatic stress disorder and sleep – what a nightmare!
Sleep Medicine Reviews. 2000. p. 183-200.
Malhotra A, Ayas N, Epstein L. The art and science of continuous positive airway pressure therapy in obstructive sleep apnea.
In: Current Opinion in Pulmonary Disease. 2000. p. 490-5.
Ayas N, Malhotra A, Epstein L. Alternative therapies for sleep apnea.
In: Drugs Today. 1999. p. 811-21.
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in sepsis: an overview.
In: Sepsis; 1999. p. 279-89.
Malhotra A, Kradin R. The pulmonary immune response to asbestos. In Peters GA, Peters BJ, editors.
Asbestos and Cancer; 1997.
Clinical Communications:
Patel SR, Harris RS, Malhotra A. Pulmonary dead space and survival.
New Engl J Med. 2002 Sep 12;347(11):850-2. [PMID: 12227367]
Malhotra A, Ayas N, Kacmarek R. Prone positioning of patients in acute respiratory failure.
New Engl J Med. 2002 Jan 24;346(4):295-7. [PMID: 11811184]
Wellman DA, Malhotra A, White DP. Atrial pacing in sleep apnea syndrome.
New Engl J Med. 2002 Aug 8;347(6):445-6. [PMID: 12167690]
Books:
Lavie P, Pillar G, Malhotra A. Sleep disorders: diagnosis, management and treatment.
Martin Dunitz Publishers; 2002. Co-author and co-editor.
Non-Print Materials:
Nguyen A, Malhotra A. Comment on short-term and long-term effects of nasal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome.
Journal Club of the Assembly on Critical Care of the American Thoracic Society, November 2005.
Sharma S, Malhotra A. Comment on risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation.
Journal Club of the Assembly on Critical Care of the American Thoracic Society, April 2005.
Malhotra A. Pathophysiology of cardiovascular disease.
Audio-Digest Otolaryngology, 2005 38: ISSN 0271-1354.
Murthy A, Malhotra A. Invited Commentaries for Journal Club of the Assembly on Critical Care of the American Thoracic Society, April 2002 – present, approximately 2-3 per year.
Stanchina M, Patel S, Malhotra A. The Answer Page. Web-based learning tool. Wrote 20 sections on various respiratory and critical care physiology topics, 2001.
Schwartz D, Malhotra A, Kacmarek R. Prone Positioning in Acute Respiratory Distress Syndrome for Up-To-Date 2000.
Malhotra A, Fogel R, Pillar G, Winkelman J. Non-pulmonary Aspects of Sleep Medicine for Pulmonary and Critical Care Update (PCCU).
American College of Chest Physicians 1999.
Schwartz D, Malhotra A, Weinberger S. Pulmonary Embolus in Pregnancy for Up-To-Date 1999.
Malhotra A, Schwartz D Schwartzstein, R. Oxygen Toxicity for Up-To-Date 1998.
New England Journal of Medicine, in press
Owens R, Hess D, Venegas J, Malhotra A, Harris RS. Effect of the chest wall on pressure-volume curve analysis of ARDS lungs.
Critical Care Medicine, in press
Segal Y, Malhotra A, Pillar G. Upper Airway Length may be Associated with the Severity of Obstructive Sleep Apnea Syndrome.
Sleep and Breathing, in press. [PMID: 18516636]
Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin, NL. Neostigmine but not Sugaammadex impairs Upper Airway Dilator Muscle Activity and Breathing.
British Journal of Anesthesia, in press. [PMID:18559352]
Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP.
Effect of oxygen in obstructive sleep apnea: Role of loop gain.
Respir Physiol Neurobiol. 2008;31(162):144-151. [PMID:18577470]
Elinoff J, Talmor D, Subramanian B, Karmpaliotis D, Goldberger A, Malhotra A.
Effects of Mechanical Ventilation on the Electrocardiogram in Healthy Adults.
Lung. 2008;186:219-223. [PMID:18478291]
Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, White DP, Chamberlin N. Differential Effects of Isoflurane and Propofol on Upper Airway Dilator Muscle Activity and Breathing.
Anesthesiology. 2008;108:897-906. [PMID:18431126]
Jia S, Malhotra A, Saeed M, Mark R, Talmor D. Risk Factors for ARDS in Patients Receiving Mechanical Ventilation for > 48 h.
Chest. 2008 Apr;133(4):853-61. Epub 2008 Feb 8. [PMID: 18263691]
Heinzer R, White DP, Dover L, Stevenson K, Malhotra A, Jordan A. Effect of Expiratory Positive Airway Pressure on Sleep Disordered Breathing.
Sleep. 2008 Mar 1;31(3):429-32. [PMID: 18363320]
Heinzer R, White DP, Jordan AS, Lo Y, Dover L, Stevenson K, Malhotra A. Trazodone increases Arousal Threshold in Obstructive Sleep Apnea.
Eur Respir J. 2008 Feb 6 [Epub ahead of print] [PMID: 18256066]
Macdonald M, Fang J, Pittman S, White DP, Malhotra A. The Current Prevalence of Sleep Disordered Breathing in Congestive Heart Failure Patients Treated with Beta Blockers.
J Clin Sleep Med. 2008 Feb 15;4(1):38-42. [PMID: 18350960]
Caramez MP, Kacmarek R, Harris RS, Malhotra A. Gas exchange impairment induced by open suctioning in ARDS: Impact of permissive hypercapnia.
Crit Care Med. 2008 Feb;36(2):560-4. [PMID: 18091534]
Wilkinson, V, Malhotra A, Nicholas, CL, Worsnop, C, Jordan, AS, Butler,
JE, Saboisky, JP, Gandevia, SC, White, DP, Trinder, J, Discharge Patterns of Human Genioglossus Motor Units During Sleep Onset.
Sleep. 2008, 31: 525-533.
Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan
AS, White DP, and Chamberlin NL. Unwarranted Administration of Acetylcholinesterase Inhibitors Can Impair Genioglossus and Diaphragm Muscle Function.
Anesthesiology. 2007 Oct;107(4):621-9. [PMID: 17893459]
Talmor, D, Sarge, T, Legedza, DA, O’donnell, CR, Ritz, R, Loring, SH, Malhotra, A. Cytokine Release Following Recruitment Maneuvers.
Chest. 2007 Nov;132(5):1434-9. Epub 2007 Oct 9. [PMID: 17925413]
Ronen, O, Malhotra, A, Pillar, G. The influence of gender and age on upper airway length during development.
Pediatrics. 2007 Oct;120(4):e1028-34. [PMID: 17908723]
Jordan AS, Wellman A, Heinzer RC, Lo YL, Schory K, Dover L, Gautam S, Malhotra
A, White DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans.
Thorax. 2007 Oct;62(10):861-7. Epub 2007 Apr 5. [PMID: 17412778]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikerman M, Schory K,
Dover L, White DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity.
Thorax. 2007 Sep;62(9):799-805. Epub 2007 Mar 27. [PMID: 17389755]
Stanchina ML, Ellison K, Malhotra A, Anderson M, Kirk M, Benser ME, Tosi C, Carlisle C, Millman RP, Buxton A. The Impact of Cardiac Resynchronization Therapy on Obstructive Sleep Apnea in Heart Failure Patients: A Pilot Study.
Chest. 2007 Aug;132(2):433-9. Epub 2007 Jun 15. [PMID: 17573498]
Pierce R, White D, Malhotra A, Edwards JK, Kleverlaan D, Palmer L, Trinder J. Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea.
Eur Respir J. 2007 Aug;30(2):345-53. Epub 2007 Apr 25. [PMID: 17459896]
Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP,
Malhotra A. The influence of aging on pharyngeal collapsibility during sleep.
Chest. 2007 Jun;131(6):1702-9. Epub 2007 Apr 5. [PMID: 17413053]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea.
Laryngoscope. 2007 Apr;117(4):648-653. [PMID: 17415135]
Karmpaliotis D, Kirtane AJ, Ruisi CP, Polonsky T, Malhotra A, Talmor D et al. Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema.
Chest. 2007 Apr;131(4):964-71. [PMID: 17426196]
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol. 2007. Mar 1;579(Pt 2):515-526. Epub 2006 Dec 21. [PMID: 17185342]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between Reduced Sleep and Weight Gain in Women.
Am J Epidemiol. 2006 Nov 15;164(10):947-54. Epub 2006 Aug 16. [PMID: 16914506]
Pittman SD, Pillar G, Berry R, Malhotra A, MacDonald MM, White DP. Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.
Sleep and Breath. 2006 Sep;10(3):123-31. [PMID: 16586136]
Cho M, Malhotra A, Karmpoliotis D, Harris RS, Wain J, Patel SR. The impact of mechanical ventilation on bronchopleural fistula following lung biopsy.
Annals of Thoracic Surgery. 2006 Jul;82(1):261-6. [PMID: 16798226]
Patel SR, Malhotra A, Gottlieb D, White DP, Hu FB. Correlates of long sleep duration.
Sleep. 2006 Jul 1;29(7):881-9. [PMID: 16895254]
Heinzer R, Jordan A, Malhotra A, Wellman A, Lo Y, Patel S, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in sleep apnea patients.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung protective ventilation in acute respiratory distress syndrome.
Respir Care. 2006 May;51(5):497-502. [PMID: 16638159]
Talmor D, Sarge T, O’Donnell CR, Ritz R, Malhotra A, Lisbon A, Loring SH. Esophageal and transpulmonary pressures in acute respiratory failure.
Crit Care Med. 2006 May;34(5):1389-94. [PMID: 16540960]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Yinon D, Lowenstein L, Suraya S, Belooseski R, Zmora O, Malhotra A, Pillar G. Pre-eclamptic toxemia is associated with sleep disordered breathing and endothelial dysfunction.
Eur Respir J. 2006 Feb;27(2):328-33. [PMID: 16452588]
Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J of Med. 2006 Jan;119(1):72.e9-14. [PMID: 16431197]
Nguyen TN, Badjatia N, Malhotra A, Gibbons FK, Qureshi MM, Greenberg SA. Factors predicting extubation success in patients with Guillain-Barre syndrome.
Neurocrit Care. 2006;5(3):230-4. [PMID: 17290095]
Jordan AS, Wellman DA, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol. 2005 Nov;99(5):2020-7. Epub 2005 Jun 30. [PMID: 15994243]
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol. 2005 Sep;99(3):1138-48. Epub 2005 Apr 14. [PMID: 15831800]
Huang Y, White DP, Malhotra A. The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway.
Chest. 2005 Sep;128(3):1324-30. [PMID: 16162725]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan A, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med. 2005 Jul 1;172(1):114-7. Epub 2005 Apr 7. [PMID: 15817803]
Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CRR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB. Paradoxical responses to positive end-expiratory pressure in patients with airway obstructive during controlled ventilation.
Crit Care Med. 2005 Jul;33(7):1519-28. [PMID: 16003057]
Bajwa EK, Ayas NT, Schulzer M, Mak E, Ryu JH, Malhotra A. Interferon-gamma 1b therapy in idiopathic pulmonary fibrosis: a meta-analysis.
Chest. 2005 Jul;128(1):203-6. [PMID: 16002936]
Aloia MS, Stanchina M, Arndt JT, Malhotra A, Millman RP. Treatment adherence and outcomes in flexible versus standard continuous positive airway pressure therapy.
Chest. 2005 Jun;127(6):2085-93. [PMID: 15947324]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnea versus controls.
J Physiol. 2005 Apr 15;564(Pt 2):549-62. Epub 2005 Feb 3. [PMID: 15695240]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32. Epub 2004 Aug 18. [PMID: 15317668]
Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.
Sleep. 2004 Nov 1;27(7):1394-403. [PMID: 15586793]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans.
J Physiol (London). 2004 Aug 1;558(Pt 3):993-1004. Epub 2004 Jun 24.
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep. 2004 Sep 15;27(6):1105-12. [PMID: 15532204]
Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP. Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.
Sleep. 2004 Aug 1;27(5):923-33. [PMID: 15453551]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep. 2004 Mar 15;27(2):249-53. [PMID: 15124718]
Patel SR, Karmpaliotis D, Ayas NT, Mark EJ, Wain J, Thompson BT, Malhotra A. The role of open lung biopsy in the acute respiratory distress syndrome.
Chest. 2004 Jan;125(1):197-202. [PMID: 14718441]
Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol. 2003 Dec 1;553(Pt 2):533-44. Epub 2003 Sep 8. [PMID: 12963804]
Stanchina ML, Malhotra A, Fogel RB, Trinder J, Ayas N, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep. 2003 Nov 1;26(7):851-6. [PMID: 14655919]
Fogel RB, Trinder J, Malhotra A, Stanchina M, Edwards JK, Schory KE, White DP.
Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state. J Physiol. 2003 Aug 1;550(Pt 3):899-910. Epub 2003 Jun 13. [PMID: 12807995]
Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra A. Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.
J Appl Physiol. 2003 May;94(5):1875-82. Epub 2003 Jan 17. [PMID: 12533492]
Malhotra A, Muse V, Mark E. Clinical Pathological Case: An 82-year-old man with dyspnea and pulmonary abnormalities.
New Engl J Med. 2003 Apr 17;348(16):1574-85. [PMID: 12700378]
Fogel RB, Malhotra A, Dalagiorgou G, Robinson M, Jakab M, Kikinis R, Pittman SD, White DP. Anatomic and physiologic predictors of apnea severity in morbidly obese subjects.
Sleep. 2003 Mar 15;26(2):150-5. [PMID: 12683472]
Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.
Arch of Intern Med. 2003 Mar 10;163(5):565-71. [PMID: 12622603]
Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N. Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus.
J Pediatr. 2003 Feb;142(2):163-8. [PMID: 12584538]
Ayas N, White DP, Manson J, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women.
Arch of Intern Med. 2003 Jan 27;163(2):205-9. [PMID: 12546611]
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Respiratory system loop gain in normal men and women measured with proportional assist ventilation.
J Appl Physiol. 2003 Jan;94(1):205-12. Epub 2002 Sep 20. [PMID: 12391042]
Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg A, Pillar G. Severe hypersomnolence after pituitary/hypothalamic surgery in children: clinical characteristics and potential mechanisms.
Pediatrics. 2002 Dec;110(6):e74. [PMID: 12456941]
Malhotra A, Huang Y, Fogel R, Pillar G, Kikinis R, Loring SH, White DP. The male predisposition to pharyngeal collapse: importance of airway length.
Am J Respir Crit Care Med. 2002 Nov 15;166(10):1388-95. [PMID: 12421747]
Karmpaliotis D, Kosmidou I, Ingenito EP, Hong K, Malhotra A, Sunday ME, Haley KJ. Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L585-95. [PMID: 12169578]
Fisher D, Pillar G, Malhotra A, Peled N, Lavie P. Long-term follow-up of untreated patients with obstructive sleep apnea syndrome.
Respir Med. 2002 May;96(5):337-43. [PMID: 12113384]
Stanchina M, Malhotra A, Fogel R, Edwards JK, Schory K, Ayas N, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir Crit Care Med. 2002 Apr 1;165(7):945-9. [PMID: 11934719]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards J, Ayas N, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med. 2002 Jan 1;165(1):71-7. [PMID: 11779733]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med. 2001 Dec 1;164(11):2025-30. [PMID: 11739130]
Pillar G, Fogel R, Malhotra A, Edwards J, Beauregard J, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
Respiration Physiology. 2001 Aug;127(1):23-38. [PMID: 11445198]
Malhotra A, Pillar G, Edwards J, Beauregard J, Fogel R, Shea S, White DP. Upper airway collapsibility: measurement and sleep effects.
Chest. 2001 Jul;120(1):156-61. [PMID: 11451832]
Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM. The sleep apnea/hypopnea syndrome depresses waking vagal tone independent of sympathetic activation.
Eur Respir J. 2001 Jun;17(6):1258-66. [PMID: 11491174]
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endo Met. 2001 Mar;86(3):1175-80. [PMID: 11238505]
Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender.
Am J Resp Crit Care Med. 2000 Nov;162(5):1627-32. [PMID: 11069787]
Pillar G, Malhotra A, Edwards J, Beauregard J Fogel R, Shea S White DP. Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.
J Appl Phys. 2000 Oct;89(4):1275-82. [PMID: 11007559]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure.
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1058-62. [PMID: 10988130]
Malhotra A, Fogel R, Edwards J, Shea S, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000. May;161(5):1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol. 2000 Apr;88(4):1346-54. [PMID: 10749829]
Schwartz D, Maroo A, Malhotra A, Kesselman H. Negative pressure pulmonary hemorrhage.
Chest. 1999 Apr;115(4):1194-7. [PMID: 10208229]
Proceedings of Meetings:
Huang Y, Malhotra A, White DP. A computational model of upper airway collapsibility.
IEEE Conference 2003.
Malhotra A, Huang Y, White DP. Upper airway mechanics: influence of gender.
Proc Second Joint EMBS/BMES Conference 2002;1544-5.
Pittman SD, Tal N, Pillar G, Malhotra A, Hilton M, Fogel R, Ayas N, White DP. Automated detection of obstructive sleep-disordered breathing events using peripheral arterial tonometry and oximetry.
Computers in Cardiology 2000;27:485-8.
Pittman SD, Hill PD, Malhotra A, Ayas N, Fogel R, White DP. Stabilizing Cheyne Stokes respiration associated with congestive heart failure using computer-assisted positive airway pressure.
Computers in Cardiology 2000;27:201-4.
Reviews, Chapters and Editorials:
Malhotra A, Kacmarek R. Mechanical ventilation. Ranieri M, et. al., editors.
In: Anesthetic Principles in Critical Care, in press.
Stanchina M, Malhotra A, White DP. An evidenced-based review of the diagnosis and treatment of respiratory disorders of sleep.
In: Crapo and King, in press.
Goodwin A, Bajwa E, Malhotra A. Non-invasive determination of cardiac output.
In: Irwin and Rippe’s Intensive Care Medicine, 6th Edition, in press.
Nguyen A, Yim S, Malhotra A. Theories of OSA Pathogenesis.
In: Obstructive Sleep Apnea. (two volume textbook, Taylor and Francis), in press.
Malhotra A, Fogel R, White DP. Disorders of excessive sleepiness for neurological therapeutics: Burgess A, editor.
In: Principles and Practice. Martin Dunitz Publishers, in press.
Malhotra A, Hillman D. Pbesity and the lung: Obesity, respirations and intensive care. (Invited review)
Thorax, in press
Malhotra A, Bertisch S, Wellman DA. Complex apnea is not a disease. (Invited Pro/Con)
Journal of Clinical Sleep Medicine, in press.
Pillar G, White DP, Malhotra A. Age-related changes in the pharyngeal structure and function in sleep apnea and normal subjects.
IN: SR Pandi-Perumal, J.M. Monti, and A. Monjan Principles and Practice of Geriatric Sleep Medicine, Cambridge University Press, in press.
Eckert DJ, Malhotra A, Jordan AS. Obstructive Sleep Apnea Pathogenesis, Progress
In: Cardiovascular Diseases (A Malhotra Guest Editor), in press.
Owens R, Yeh S, Eckert D, Malhotra A. Upper Airway Function in the Pathogenesis of Obstructive Sleep Apnea: A review of the current literature, Current Opinion
In: Pulmonary Diseases, in press.
Yim Yeh S, Rahangdale S, Malhotra A. Metabolic Syndrome, OSA and CPAP: A Weighty Issue. (Invited editorial)
Chest, in press.
Owens R, Yim Yeh S, Malhotra A. CO Poisoning or CO Protection.
Chest, in press.
Rahangdale S, Campana L, Malhotra A. Not So Good Vibrations.
Sleep, in press.
Eckert, D and Malhotra, A. Pathophysiology of Obstructive Sleep Apnea.
Proceedings of the American Thoracic Society, in press.
Kacmarek R, Villar J, Malhotra A. Modes of Mechanical Ventilation. Ranieri M, et. al. editors,
Elsevier Publishers, in press.
Eikermann, M and Malhotra, A. Predictive value of stimulated muscle force assessment in critically ill patients. (Editorial).
Acta Anaesthesiol Scand. 2008 Jan;52(1):1-2. [PMID: 18173429]
Eikermann, M, Chamberlin, N, Gerber, H, Malhotra, A. Muscle weakness after administration of neuromuscular blocking agents: Don’t immobilize the diaphragm unnecessarily.
Critical Care Medicine. 2007 Jun;35(6):1634-5; author reply 1635.
Malhotra A, Eikermann M, Magder S. Is brachial artery peak velocity variation ready for prime time?
Chest. 2007 May;131(5):1279-81. [PMID: 17494778]
Yim S, Fredberg JJ, Malhotra A. Continuous positive airway pressure for asthma: not a big stretch? (Invited editorial).
Eur Respir J. 2007 Feb;29(2):226-8. [PMID: 17264319]
Loring SH, Malhotra A. Inspiratory efforts during mechanical ventilation: is there risk of barotrauma?
Chest. 2007 Mar;131(3):646-8. [PMID: 17356075]
Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment.
Chest. 2007 Feb;131(2):595-607. [PMID: 17296668]
Malhotra, A. Low Tidal Volume Ventilation in ARDS. (Invited review).
New England Journal of Medicine. Clinical Therapeutics section, 2007, 357: 1113-1120.
Chiche, L, Forel, JM, Papazian, L, Asakura, Y, Komatsu, T, Busch, T, Bercker, S, Kaisers, U, Malhotra, A. Low Tidal Volume Ventilation.
New England Journal of Medicine. 2007, 357: 2518-2520.
Malhotra, A and Kacmarek, RM. Mechanical Ventilation. In:
Benomof's Airway Management. 2007 (Mosby), pp. 1079-1122.
Benson, A, Bajwa E, Malhotra A. Pulmonary Disease.
In: Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Sabatine MS, editor.
Lippincott Williams and Wilkins. 2007; third edition.
Eckert, D, Saboisky, J, Jordan, A, Malhotra, A. Upper airway myopathy is not important in obstructive sleep apnea.
Journal of Clinical Sleep Medicine. 2007, 3: 570-574.
Shochat T, Pillar G, Malhotra A. Sleep and Aging. (Invited review).
Int J Sleep Disorders 2007; 3(1):92-102.
Malhotra A, Patel S. Lung biopsy in ARDS: is it worth the risk?
Crit Care. 2006;10(4):160. [PMID: 16941755]
Yim, S, Malhotra, A, Veves, A. Anti-oxidants and CVD in Diabetes: Where do we stand now?
Current Diabetes Reports, in press.
Hammer L, Dessertaine G, Timset JF, Aberegg SK, Tamler R, Leroith D, Roth J, Van den Berghe G, Wilmer A, Boullon R, Malhotra A. Intensive Insulin in the Medical Intensive Care Unit.
New Eng J Med. 2006 May 11;354(19):2069-71. [PMID: 16687723]
Malhotra A. Intensive insulin in intensive care. Invited editorial.
New Engl J Med. 2006 Feb 2;354(5):516-8. [PMID: 16452564]
Malhotra A, Jordan AS. Did fat boy Joe need hormone replacement? Invited editorial.
Sleep. 2006 Jan 1;29(1):16-8.
Kacmarek RM, Malhotra A. Equipment required for home mechanical ventilation.
In: Tobin MJ (Ed) Principles and Practice of Mechanical Ventilation, 2nd Ed, McGraw Hill, New York (In Press). 2006.
Yim S, Jordan AS, Malhotra A. Obstructive sleep apnea, clinical presentation, diagnosis and treatment. In: Randerath WJ, Sanner BM, Somers VK, editors.
Sleep Apnea – Current diagnosis and treatment. 2006, Volume 35;118-36.
Heinzer, R., Jordan, AS, Malhotra, A. Sleep Apnea Syndrome,
Wiley Encyclopedia of Biomedical Engineering, John Wiley and Sons, 2006.
Pillar G, Harder L, Malhotra A. Trauma and post-traumatic stress disorder.
Encyclopedia of Sleep Medicine, 2006. p.857-66.
Jordan A, Malhotra A. Pharyngeal lumen: both length and size matter. Journal of Clinical Sleep Medicine. Invited editorial,
J Clin. Sleep Med. 2005 Jul 15;1(3):264-5. [PMID: 17566186]
Malhotra A, Berry R, White DP. Central sleep apnea.
In: Clinical Sleep Disorders.
Lippincott Williams and Wilkins. 2005;331-46.
Bajwa E, Malhotra A, Thompson T. Monitoring of the patient in septic shock.
Seminars in Respiratory and Critical Care Medicine 2004, 25: 629-644.
Malhotra A, Jordan AS. Surface tension and sleep apnea: a sticky business. Invited editorial.
Sleep. 2005 Apr 1;28(4):392-3. [PMID: 16171283]
Ting L, Malhotra A. Sleep: an overview.
In: Prim Care 2005 Jun;32(2):305-18.
Kacmarek R, Malhotra A. High frequency oscillatory ventilation: what large animal studies have taught us!
Crit Care Med. 2005 Mar;33(3 Suppl):S148-54. [PMID: 15753721]
Malhotra A, Berry R, White DP. Central sleep apnea.
In: Clinical Sleep Disorders.
Lippincott; 2005 p. 331-46.
Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T, Patel S, Wain J, Malhotra A. Surgical stress in ARDS open-lung biopsy.
In: Chest. 2004 Oct;126(4):1383-4. [PMID: 15486411]
Oddo M, Liaudet L, Patel SR, Wain J, Malhotra A. Open-lung biopsy for ARDS Patients.
In: Chest. 2004 Sep;126(3):1003. [PMID: 15364791]
Bajwa E, Mouded M, Systrom DM, Malhotra A. Pulmonary Disease.
In: Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Sabatine MS, editor.
Lippincott Williams and Wilkins. 2004; second edition.
Carden KA, Malhotra A. The debate about gender differences in obstructive sleep apnea.
In: Sleep Medicine. 2003 Nov; 4(6):485-7.
McCowen KC, Malhotra A. The correlation between obstructive sleep apnea and low gonadotropin secretion in men.
In: Sleep Medicine. 2003;4:83-4.
Malhotra A, White DP. Seminar: Obstructive sleep apnoea.
In: Lancet. 2002 Jul 20;360(9328):237-45. [PMID: 12133673]
Malhotra A, White DP. The pathogenesis of obstructive sleep apnea. In McNicholas W, Phillipson E, editors.
Breathing Disorders in Sleep, 2002; p. 44-64.
Malhotra A, Schwartz D. Lung Cancer. In: Hess D, MacIntyre N, Saposnick et al., editors.
Respiratory Care: Principles and Practice. 2002; p. 1151-67.
Malhotra A, Schwartz D, Ayas N, Stanchina M, White DP. The treatment of hyperoxic hypercarbia.
In: Lancet. 2001 Mar 17;357(9259):884-5. [PMID: 11265981]
McCowen K, Malhotra A, Bistrian B. Stress-induced hyperglycemia.
In: Critical Care Clinics. 2001. p. 107-24.
Sabatine M, Malhotra A, Systrom DM. Pulmonary Disease. In: Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Sabatine MS, editor.
Lippincott Williams and Wilkins; 2000. p. 2-1-21.
Schwartz DR, Malhotra A, Fink MP. Microcirculatory weak units – an alternative explanation.
In: Critical Care Medicine. 2000 Aug;28(8):3127-9. [PMID: 10966332]
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in septic shock.
In: Advances in Structural Biology. Jai Press; 2000 p. 65-82.
Pillar G, Malhotra A, Lavie P. Post traumatic stress disorder and sleep – what a nightmare!
Sleep Medicine Reviews. 2000. p. 183-200.
Malhotra A, Ayas N, Epstein L. The art and science of continuous positive airway pressure therapy in obstructive sleep apnea.
In: Current Opinion in Pulmonary Disease. 2000. p. 490-5.
Ayas N, Malhotra A, Epstein L. Alternative therapies for sleep apnea.
In: Drugs Today. 1999. p. 811-21.
Schwartz D, Malhotra A, Fink M. Cytopathic hypoxia in sepsis: an overview.
In: Sepsis; 1999. p. 279-89.
Malhotra A, Kradin R. The pulmonary immune response to asbestos. In Peters GA, Peters BJ, editors.
Asbestos and Cancer; 1997.
Clinical Communications:
Patel SR, Harris RS, Malhotra A. Pulmonary dead space and survival.
New Engl J Med. 2002 Sep 12;347(11):850-2. [PMID: 12227367]
Malhotra A, Ayas N, Kacmarek R. Prone positioning of patients in acute respiratory failure.
New Engl J Med. 2002 Jan 24;346(4):295-7. [PMID: 11811184]
Wellman DA, Malhotra A, White DP. Atrial pacing in sleep apnea syndrome.
New Engl J Med. 2002 Aug 8;347(6):445-6. [PMID: 12167690]
Books:
Lavie P, Pillar G, Malhotra A. Sleep disorders: diagnosis, management and treatment.
Martin Dunitz Publishers; 2002. Co-author and co-editor.
Non-Print Materials:
Nguyen A, Malhotra A. Comment on short-term and long-term effects of nasal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome.
Journal Club of the Assembly on Critical Care of the American Thoracic Society, November 2005.
Sharma S, Malhotra A. Comment on risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation.
Journal Club of the Assembly on Critical Care of the American Thoracic Society, April 2005.
Malhotra A. Pathophysiology of cardiovascular disease.
Audio-Digest Otolaryngology, 2005 38: ISSN 0271-1354.
Murthy A, Malhotra A. Invited Commentaries for Journal Club of the Assembly on Critical Care of the American Thoracic Society, April 2002 – present, approximately 2-3 per year.
Stanchina M, Patel S, Malhotra A. The Answer Page. Web-based learning tool. Wrote 20 sections on various respiratory and critical care physiology topics, 2001.
Schwartz D, Malhotra A, Kacmarek R. Prone Positioning in Acute Respiratory Distress Syndrome for Up-To-Date 2000.
Malhotra A, Fogel R, Pillar G, Winkelman J. Non-pulmonary Aspects of Sleep Medicine for Pulmonary and Critical Care Update (PCCU).
American College of Chest Physicians 1999.
Schwartz D, Malhotra A, Weinberger S. Pulmonary Embolus in Pregnancy for Up-To-Date 1999.
Malhotra A, Schwartz D Schwartzstein, R. Oxygen Toxicity for Up-To-Date 1998.
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