Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Steven A. Shea, PhD
Associate Professor of Medicine, Harvard Medical School
Associate Physiologist, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Administrative Title(s)
Director, Sleep Disorders Research Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Address
Medical Chronobiology Program, Division of Sleep Medicine, BWH221 Longwood Avenue (BLI-044)
Boston, MA 02115
USA
Inter-office Mail Address
BLI-044Phone 617-732-5788
Fax 617-278-0683
Email steven_shea@hms.harvard.edu
Society Memberships
Sleep Research SocietyAmerican Academy of Sleep Medicine
Committee Memberships
Division of Sleep Medicine Fellowship Selection Committee, Brigham & Women’s Hospital and Harvard Medical School, Member (2000-Present)
Sleep Grand Rounds Organizing Committee, Brigham & Women’s Hospital and Harvard Medical School, Member (2001-Present)
Research Committee, American Academy of Sleep Medicine, Member (2002-Present)
Research Committee, American Academy of Sleep Medicine, Vice-Chair (2004-Present)
Sleep Research Society Representative, Program Committee SLEEP APSS International Conferences 2006-2009, Member (2006-Present)
Sub-Committee for Selection of Trainees, Training Program in Sleep, Circadian and Respiratory Neurobiology, Brigham & Women’s Hospital and Harvard Medical School, Chair (2007-Present)
Executive Board, American Sleep Medicine Foundation, Member (2008-Present)
Research Committee, American Academy of Sleep Medicine, Chair (2008-Present)
Circadian Rhythms Section, American Academy of Sleep Medicine, Chair (2008-Present)
Division of Sleep Medicine Fellowship Selection Committee, Brigham & Women’s Hospital and Harvard Medical School, Member (2000-Present)
Sleep Grand Rounds Organizing Committee, Brigham & Women’s Hospital and Harvard Medical School, Member (2001-Present)
Research Committee, American Academy of Sleep Medicine, Member (2002-Present)
Research Committee, American Academy of Sleep Medicine, Vice-Chair (2004-Present)
Sleep Research Society Representative, Program Committee SLEEP APSS International Conferences 2006-2009, Member (2006-Present)
Sub-Committee for Selection of Trainees, Training Program in Sleep, Circadian and Respiratory Neurobiology, Brigham & Women’s Hospital and Harvard Medical School, Chair (2007-Present)
Executive Board, American Sleep Medicine Foundation, Member (2008-Present)
Research Committee, American Academy of Sleep Medicine, Chair (2008-Present)
Circadian Rhythms Section, American Academy of Sleep Medicine, Chair (2008-Present)
Research Unit(s)
Medical Chronobiology Program
Sleep Disorders Research Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Sleep Disorders Research Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Research Interests
Sleep Disorders Research Program at Brigham and Women's Hospital: The goal of this research program is to understand the pathophysiology and improve the therapy for all sleep disorders, and to understand the interaction between sleep and other medical problems. There are approximately 10 current faculty performing research in areas including mechanistic physiology in healthy humans, clinical research, epidemiology, animal models and mathematical models. These approaches are used to understand the pathophysiology and therapy for obstructive sleep apnea and insomnia, and to understand the relationship of sleep with other disorders, including periodic limb movements of sleep, hypertension, other cardiovascular diseases and cardiovascular biomarkers, seizures and 'nocturnal' asthma. There is also research on the effect of aging and gender on sleep disorders, and the influence of sleep deprivation on metabolic function.
Medical Chronobiology Program at Brigham and Women's Hospital: The severity of many diseases varies across the 24-hour period. For example, heart attacks occur most frequently in the morning a few hours after waking up, epileptic seizures of the brain's temporal lobe usually occur in the late afternoon or early evening, and asthma is generally worst at night. The goal of the Medical Chronobiology Program at Brigham and Women's Hospital is to understand the biological basis behind these time-variant changes in disease severity. We aim to determine whether or not these changes are caused by the body clock (the endogenous circadian pacemaker) or attributable to behaviors that occur on a regular daily basis, including the sleep/wake cycle. Understanding the biological basis of these changes across the day and night may provide an insight into the underlying cause of the disease and could lead to better therapy (e.g. appropriately timed medication to target specific phases of the body clock or to coincide with specific behaviors that cause vulnerability, such as exercise).
Medical Chronobiology Program at Brigham and Women's Hospital: The severity of many diseases varies across the 24-hour period. For example, heart attacks occur most frequently in the morning a few hours after waking up, epileptic seizures of the brain's temporal lobe usually occur in the late afternoon or early evening, and asthma is generally worst at night. The goal of the Medical Chronobiology Program at Brigham and Women's Hospital is to understand the biological basis behind these time-variant changes in disease severity. We aim to determine whether or not these changes are caused by the body clock (the endogenous circadian pacemaker) or attributable to behaviors that occur on a regular daily basis, including the sleep/wake cycle. Understanding the biological basis of these changes across the day and night may provide an insight into the underlying cause of the disease and could lead to better therapy (e.g. appropriately timed medication to target specific phases of the body clock or to coincide with specific behaviors that cause vulnerability, such as exercise).
Trainees
C Spengler 1994-1996
L Bloch 1996-1999
Najib Ayas 1997-1998
D Slamowitz 1997-1999
T Akahoshi 1997-2000
T Stentz 1998-1999
Michael Hilton 1999-2003
Milena K. Pavlova, MD 2002-2004
Frank AJL Scheer, PhD 2003-present
Kun Hu 2005-present
Eliza Van Reen, PhD 2007-present
Mikhail Litinski, MD 2008-present
L Bloch 1996-1999
Najib Ayas 1997-1998
D Slamowitz 1997-1999
T Akahoshi 1997-2000
T Stentz 1998-1999
Michael Hilton 1999-2003
Milena K. Pavlova, MD 2002-2004
Frank AJL Scheer, PhD 2003-present
Kun Hu 2005-present
Eliza Van Reen, PhD 2007-present
Mikhail Litinski, MD 2008-present
Research Funding
CIRCADIAN AND SLEEP/WAKE ASPECTS OF NOCTURNAL ASTHMA
NIH/NHLBI R01 HL64815
Principal Investigator: Steven A. Shea, PhD
The major goal of this project is to test the hypothesis that asthma severity is affected by separate circadian influences (independent of sleep) and sleep/wake cycle influences (independent of circadian rhythm).
CHRONOBIOLOGY OF CARDIOVASCULAR AND PULMONARY DISEASE
NIH/NHLBI K24 HL076446
Principal Investigator: Steven A. Shea, PhD
This is a "mid-career" award with a primary aim to develop a group of outstanding clinical investigators of medical chronobiology - and to help understand the independent roles of the internal body clock (circadian pacemaker) and behavioral day/night patterns (including the sleep/wake cycle) causing the day/night pattern in the severity of a number of disorders.
CIRCADIAN AND BEHAVIORAL FACTORS OF CARDIOVASCULAR RISK
NIH/NHLBI R01 HL76409
Principal Investigator: Steven A. Shea, PhD
The major goal of this project is to assess whether the circadian system or the day/night pattern of behaviors including postural changes, activity and sleep state changes predispose the individual to increased cardiovascular risk at different times of day or night (i.e., the ultimate goal is to understand the morning peak in adverse cardiovascular events such as stroke and myocardial infarction).
TRAINING IN SLEEP, CIRCADIAN & RESPIRATORY NEUROBIOLOGY
NIH/NHLBI T32 HL07901
Principal Investigator: Charles A. Czeisler, PhD, MD
An institutional National Research Service Award Program for Training in Sleep, Circadian and Respiratory Neurobiology. It is designed to provide a structured, comprehensive program to train outstanding individuals for academic positions in the broad field of sleep disorders medicine with specific trainees in neuroscience, biology, physiology, applied sciences or statistics.
MELATONIN SUPPLEMENTATION IN HYPERTENSIVE PATIENTS
NIH/NCCAM R21 AT-002713
Principal Investigator: Frank A Scheer, PhD
The major goal of this project is to assess whether melatonin supplementation aids sleep in hypertensive patients receiving Atenolol (which disturbs sleep and inhibits endogenous melatonin release).
SLEEP, AGING AND CIRCADIAN RHYTHM DISORDERS
NIH/NIA P01 AG009975
Principal Investigator: Charles A. Czeisler, PhD, MD
The major goal of this project is to assess the whether the role of the circadian system in the disturbed sleep characteristic of elderly humans, and to determine the effect of aging upon the consequences of sleep restriction in terms of cognitive performance, vigilance and metabolic changes.
NIH/NHLBI R01 HL64815
Principal Investigator: Steven A. Shea, PhD
The major goal of this project is to test the hypothesis that asthma severity is affected by separate circadian influences (independent of sleep) and sleep/wake cycle influences (independent of circadian rhythm).
CHRONOBIOLOGY OF CARDIOVASCULAR AND PULMONARY DISEASE
NIH/NHLBI K24 HL076446
Principal Investigator: Steven A. Shea, PhD
This is a "mid-career" award with a primary aim to develop a group of outstanding clinical investigators of medical chronobiology - and to help understand the independent roles of the internal body clock (circadian pacemaker) and behavioral day/night patterns (including the sleep/wake cycle) causing the day/night pattern in the severity of a number of disorders.
CIRCADIAN AND BEHAVIORAL FACTORS OF CARDIOVASCULAR RISK
NIH/NHLBI R01 HL76409
Principal Investigator: Steven A. Shea, PhD
The major goal of this project is to assess whether the circadian system or the day/night pattern of behaviors including postural changes, activity and sleep state changes predispose the individual to increased cardiovascular risk at different times of day or night (i.e., the ultimate goal is to understand the morning peak in adverse cardiovascular events such as stroke and myocardial infarction).
TRAINING IN SLEEP, CIRCADIAN & RESPIRATORY NEUROBIOLOGY
NIH/NHLBI T32 HL07901
Principal Investigator: Charles A. Czeisler, PhD, MD
An institutional National Research Service Award Program for Training in Sleep, Circadian and Respiratory Neurobiology. It is designed to provide a structured, comprehensive program to train outstanding individuals for academic positions in the broad field of sleep disorders medicine with specific trainees in neuroscience, biology, physiology, applied sciences or statistics.
MELATONIN SUPPLEMENTATION IN HYPERTENSIVE PATIENTS
NIH/NCCAM R21 AT-002713
Principal Investigator: Frank A Scheer, PhD
The major goal of this project is to assess whether melatonin supplementation aids sleep in hypertensive patients receiving Atenolol (which disturbs sleep and inhibits endogenous melatonin release).
SLEEP, AGING AND CIRCADIAN RHYTHM DISORDERS
NIH/NIA P01 AG009975
Principal Investigator: Charles A. Czeisler, PhD, MD
The major goal of this project is to assess the whether the role of the circadian system in the disturbed sleep characteristic of elderly humans, and to determine the effect of aging upon the consequences of sleep restriction in terms of cognitive performance, vigilance and metabolic changes.
Teaching
BIOL E-180 The Physiology of Sleep
Harvard Extension School
Course Director: Steven A. Shea, Ph.D.
This seminar course addresses the basis of biological rhythms including circadian rhythms, and the technology, the neurophysiology, the physiology, the psychology, the pathology and the functions of sleep -- particularly in humans.
Harvard Extension School
Course Director: Steven A. Shea, Ph.D.
This seminar course addresses the basis of biological rhythms including circadian rhythms, and the technology, the neurophysiology, the physiology, the psychology, the pathology and the functions of sleep -- particularly in humans.
Related Websites
Medical Chronobiology
BWH Sleep Disorders Research Program
BIOL E-180 The Physiology of Sleep
Harvard Medical School/WGBH Healthy Sleep Website
Medical Chronobiology
BWH Sleep Disorders Research Program
BIOL E-180 The Physiology of Sleep
Harvard Medical School/WGBH Healthy Sleep Website
Selected Publications
Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
Epilepsy Behav. 2009 Sep 26. [Epub ahead of print] [PMID: 19786369]
Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment.
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4453-8. Epub 2009 Mar 2. [PMID: 19255424]
Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker.
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2490-4. Epub 2009 Feb 6. [PMID: 19202078]
Hu K, Scheer FA, Buijs RM, Shea SA. The Circadian Pacemaker Generates Similar Circadian Rhythms in the Fractal Structure of Heart Rate in Humans and Rats.
Cardiovascular Res 2008: Oct 1;80(1):62-8. [PMID: 18539630]
Scheer FA, Shea TJ, Hilton MF, Shea SA. A circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night.
J Biol Rhythm 2008: Aug;23(4):353-61.[PMID: 18663242]
Kun Hu, Scheer FA, Buijs RM, Shea SA. The Endogenous Circadian Pacemaker Imparts a Scale-Invariant Pattern of Heart Rate Fluctuations across Time Scales Spanning Minutes to 24 Hours.
J Biol Rhythms. 2008 Jun;23(3):265-73. [PMID: 18487418]
Pavlova MK, Duffy JF, Shea SA. Polysomnographic respiratory abnormalities in asymptomatic individuals.
Sleep. 2008 Feb 1;31(2):241-8. [PMID: 18274272]
Ivanov PCh, Hu K, Hilton MF, Shea SA, Stanley HE. Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics.
Proc Natl Acad Sci. 2007 Dec 26;104(52):20702-7. Epub 2007 Dec 19. [PMID: 18093917]
Hu K, Scheer, FAJL, Ivanov P Ch, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation.
Neurosci. 2007 Nov 9;149(3):508-17. Epub 2007 Oct 24. [PMID: 17920204]
Scheer, FAJL, Stone PH, Shea SA. Decreased sleep in heart failure: are medications to blame?
Arch. Int. Med. 2007 May 28;167(10):1098-9; author reply 1099-100. [PMID: 17533214]
Scheer FA, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SA. Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion.
Spinal Cord. 2006 Feb;44(2):78-81. [PMID: 16130027]
Shea SA, Hilton MF, Orlova C, Ayers RT, Mantzoros CS. Independent Circadian and Sleep/Wake Regulation of Adipokines and Glucose in Humans.
J Clin Endocrinol Metab. 2005 May;90(5):2537-44. Epub 2005 Feb 1. [PMID: 15687326]
Hu K, Ivanov PCh, Chen Z, Hilton MF, Stanley HE, Shea SA. Non-random fluctuations and multi-scale dynamics regulation of human activity.
Physica A. 2004 Jun;337(1-2):307-18. [PMID: 15759365]
Hu K, Ivanov PCh, Hilton MF, Chen Z, Ayers RT, Stanley HE, Shea SA. Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior.
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18223-7. Epub 2004 Dec 20. [PMID: 15611476]
Pavlova MK, Shea SA, Bromfield EB. Day/night patterns of focal seizures.
Epilepsy Behav. 2004 Feb;5(1):44-9. [PMID: 14751206]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control.
Am J Respir Crit Care Med. 2001 Dec 1;164(11):2025-30. [PMID: 11739130]
Pillar G, Fogel RB, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences.
Respir Physiol. 2001 Aug;127(1):23-38. [PMID: 11445198]
Elliott AR, Shea SA, Dijk DJ, Wyatt JK, Riel E, Neri DF, Czeisler CA, West JB, Prisk GK. Microgravity reduces sleep-disordered breathing in humans.
Am J Respir Crit Care Med. 2001 Aug 1;164(3):478-85. [PMID: 11500354]
Malhotra A, Pillar G, Fogel RB, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure.
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1058-62. [PMID: 10988130]
Pillar G, Malhotra A, Fogel RB, Beauregard J, Slamowitz DI, Shea SA, White DP. Upper airway muscle responsiveness to rising PCO(2) during NREM sleep.
J Appl Physiol. 2000 Oct;89(4):1275-82. [PMID: 11007559]
Ayas NT, Brown R, Shea SA. Hypercapnia can induce arousal from sleep in the absence of altered respiratory mechanoreception.
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1004-8. [PMID: 10988121]
Shea SA, Akahoshi T, Edwards JK, White DP. Influence of chemoreceptor stimuli on genioglossal response to negative pressure in humans.
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):559-65. [PMID: 10934087]
Spengler CM, Czeisler CA, Shea SA. An endogenous circadian rhythm of respiratory control in humans.
J Physiol. 2000 Aug 1;526 Pt 3:683-94. Erratum in: Am J Respir Crit Care Med 2002 Oct 1;166(7):1005. [PMID: 10922018]
Bloch-Salisbury E, Lansing R, Shea SA. Acute changes in carbon dioxide levels alter the electroencephalogram without affecting cognitive function.
Psychophysiology. 2000 Jul;37(4):418-26. [PMID: 10934900]
Zeitzer JM, Ayas NT, Shea SA, Brown R, Czeisler CA. Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia.
J Clin Endocrinol Metab. 2000 Jun;85(6):2189-96. [PMID: 10852451]
Hilton MF, Umali MU, Czeisler CA, Wyatt JK, Shea SA. Endogenous circadian control of the human autonomic nervous system.
Comput Cardiol. 2000;27:197-200. [PMID: 14632012]
Malhotra A, Fogel RB, Edwards JK, Shea SA, White DP. Local mechanisms drive genioglossus activation in obstructive sleep apnea.
Am J Respir Crit Care Med. 2000 May;161(5):1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol. 2000 Apr;88(4):1346-54. [PMID: 10749829]
Spengler CM, Shea SA. Sleep deprivation per se does not decrease the hypercapnic ventilatory response in humans.
Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1124-8. Erratum in: Am J Respir Crit Care Med 2002 Oct 1;166(7):1005. [PMID: 10764300]
White DP, Edwards JK, Shea SA. Local reflex mechanisms: influence on basal genioglossal muscle activation in normal subjects.
Sleep. 1998 Nov 1;21(7):719-28. [PMID: 11286348]
Shea SA, Edwards JK, White DP. Effect of wake-sleep transitions and rapid eye movement sleep on pharyngeal muscle response to negative pressure in humans.
J Physiol. 1999 Nov 1;520 Pt 3:897-908. [PMID: 10545152]
Evans KC, Shea SA, Saykin AJ. Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans.
J Physiol. 1999 Oct 15;520 Pt 2:383-92. [PMID: 10523407]
Banzett RB, Guz A, Paydarfar D, Shea SA, Schachter SC, Lansing RW. Cardiorespiratory variables and sensation during stimulation of the left vagus in patients with epilepsy.
Epilepsy Res. 1999 May;35(1):1-11. [PMID: 10232789]
Spengler CM, Banzett RB, Systrom DM, Shannon DC, Shea SA. Respiratory sensations during heavy exercise in subjects without respiratory chemosensitivity.
Respir Physiol. 1998 Oct;114(1):65-74. [PMID: 9858052]
Shea SA, Hoit JD, Banzett RB. Competition between gas exchange and speech production in ventilated subjects.
Biol Psychol. 1998 Sep;49(1-2):9-27. [PMID: 9792482]
Banzett RB, Shea SA, Brown R, Schwartzstein R, Lansing R, Guz A. Perception of inflation of a single lung lobe in humans.
Respir Physiol. 1997 Feb;107(2):125-36. [PMID: 9108626]
Bloch-Salisbury E, Shea SA, Brown R, Evans K, Banzett RB. Air hunger induced by acute increase in PCO2 adapts to chronic elevation of PCO2 in ventilated humans.
J Appl Physiol. 1996 Aug;81(2):949-56. [PMID: 8872667]
Shea SA, Harty HR, Banzett RB. Self-control of level of mechanical ventilation to minimize CO2 induced air hunger.
Respir Physiol. 1996 Feb;103(2):113-25. [PMID: 8833543]
Banzett RB, Lansing RW, Evans KC, Shea SA. Stimulus-response characteristics of CO2-induced air hunger in normal subjects.
Respir Physiol. 1996 Jan;103(1):19-31. [PMID: 8822220]
Horner RL, Innes JA, Morrell MJ, Shea SA, Guz A. The effect of sleep on reflex genioglossus muscle activation by stimuli of negative airway pressure in humans.
J Physiol. 1994 Apr 1;476(1):141-51. [PMID: 8046629]
Hoit JD, Shea SA, Banzett RB. Speech production during mechanical ventilation in tracheostomized individuals.
J Speech Hear Res. 1994 Feb;37(1):53-63. [PMID: 8170131]
Shea SA, Andres LP, Paydarfar D, Banzett RB, Shannon DC. Effect of mental activity on breathing in congenital central hypoventilation syndrome.
Respir Physiol. 1993 Dec;94(3):251-63. [PMID: 8108605]
Shea SA, Andres LP, Shannon DC, Banzett RB. Ventilatory responses to exercise in humans lacking ventilatory chemosensitivity.
J Physiol. 1993 Aug;468:623-40. [PMID: 8254528]
Shea SA, Andres LP, Shannon DC, Guz A, Banzett RB. Respiratory sensations in subjects who lack a ventilatory response to CO2.
Respir Physiol. 1993 Aug;93(2):203-19. [PMID: 8210759]
Morrell MJ, Shea SA, Adams L, Guz A. Effects of inspiratory support upon breathing in humans during wakefulness and sleep.
Respir Physiol. 1993 Jul;93(1):57-70. [PMID: 8367617]
Shea SA, Dinh TP, Hamilton RD, Guz A, Benchetrit G. Breathing patterns of monozygous twins during behavioural tasks.
Acta Genet Med Gemellol (Roma). 1993;42(2):171-84. [PMID: 7976112]
Manning HL, Shea SA, Schwartzstein RM, Lansing RW, Brown R, Banzett RB. Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics.
Respir Physiol. 1992 Oct;90(1):19-30. [PMID: 1455095]
Sullivan TY, Muzzin S, Hamilton RD, Adams L, Shea SA, Horner RL, Guz A. Volume detection during voluntary and passive breathing.
Respir Physiol. 1991 Jun;84(3):323-35. [PMID: 1925111]
Datta AK, Shea SA, Horner RL, Guz A. The influence of induced hypocapnia and sleep on the endogenous respiratory rhythm in humans.
J Physiol. 1991;440:17-33. Erratum in: J Physiol (Lond) 1991 Dec;444:778. [PMID: 1804960]
Shea SA, Horner RL, Benchetrit G, Guz A. The persistence of a respiratory 'personality' into stage IV sleep in man.
Respir Physiol. 1990 Apr;80(1):33-44. [PMID: 2367750]
Horner RL, Shea SA, McIvor J, Guz A. Pharyngeal size and shape during wakefulness and sleep in patients with obstructive sleep apnoea.
Q J Med. 1989 Aug;72(268):719-35. [PMID: 2602554]
Horner RL, Mohiaddin RH, Lowell DG, Shea SA, Burman ED, Longmore DB, Guz A. Sites and sizes of fat deposits around the pharynx in obese patients with obstructive sleep apnoea and weight matched controls.
Eur Respir J. 1989 Jul;2(7):613-22. [PMID: 2776867]
Shea SA, Winning AJ, McKenzie E, Guz A. Does the abnormal pattern of breathing in patients with interstitial lung disease persist in deep, non-rapid eye movement sleep?
Am Rev Respir Dis. 1989 Mar;139(3):653-8. [PMID: 2923365]
Shea SA, Benchetrit G, Pham Dinh T, Hamilton RD, Guz A. The breathing patterns of identical twins.
Respir Physiol. 1989 Feb;75(2):211-23. [PMID: 2711052]
Benchetrit G, Shea SA, Dinh TP, Bodocco S, Baconnier P, Guz A. Individuality of breathing patterns in adults assessed over time.
Respir Physiol. 1989 Feb;75(2):199-209. [PMID: 2711051]
Shea SA, Horner RL, Banner NR, McKenzie E, Heaton R, Yacoub MH, Guz A. The effect of human heart-lung transplantation upon breathing at rest and during sleep.
Respir Physiol. 1988 May;72(2):131-49. [PMID: 3131860]
Shea SA, Walter J, Pelley C, Murphy K, Guz A. The effect of visual and auditory stimuli upon resting ventilation in man.
Respir Physiol. 1987 Jun;68(3):345-57. [PMID: 3616180]
Shea SA, Walter J, Murphy K, Guz A. Evidence for individuality of breathing patterns in resting healthy man.
Respir Physiol. 1987 Jun;68(3):331-44. [PMID: 3616179]
Winning AJ, Hamilton RD, Shea SA, Guz A. Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: evidence for pulmonary chemosensitivity.
Clin Sci (Lond). 1986 Nov;71(5):519-26. [PMID: 3769402]
Adams L, Lane R, Shea SA, Cockcroft A, Guz A. Breathlessness during different forms of ventilatory stimulation: a study of mechanisms in normal subjects and respiratory patients.
Clin Sci (Lond). 1985 Dec;69(6):663-72. [PMID: 3933895]
Winning AJ, Hamilton RD, Shea SA, Knott C, Guz A. The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man.
Clin Sci (Lond). 1985 Feb;68(2):215-25. [PMID: 3917883]
Reviews
Ross SD, Sheinhait IA, Harrison KJ, Kvasz M, Connelly JE, Shea SA, Allen IE. Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea.
Sleep. 2000 Jun 15;23(4):519-32. [PMID: 10875559]
Book Chapters
Shea SA, Hilton MF, Muller JE. Day/Night Patterns of Myocardial Infarction and Sudden Cardiac Death: Interacting Roles of the Endogenous Circadian System and Behavioral Triggers.
In "Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics", Humana Press. 2007; Chapter 11, pp 251-289.
Epilepsy Behav. 2009 Sep 26. [Epub ahead of print] [PMID: 19786369]
Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment.
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4453-8. Epub 2009 Mar 2. [PMID: 19255424]
Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker.
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2490-4. Epub 2009 Feb 6. [PMID: 19202078]
Hu K, Scheer FA, Buijs RM, Shea SA. The Circadian Pacemaker Generates Similar Circadian Rhythms in the Fractal Structure of Heart Rate in Humans and Rats.
Cardiovascular Res 2008: Oct 1;80(1):62-8. [PMID: 18539630]
Scheer FA, Shea TJ, Hilton MF, Shea SA. A circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night.
J Biol Rhythm 2008: Aug;23(4):353-61.[PMID: 18663242]
Kun Hu, Scheer FA, Buijs RM, Shea SA. The Endogenous Circadian Pacemaker Imparts a Scale-Invariant Pattern of Heart Rate Fluctuations across Time Scales Spanning Minutes to 24 Hours.
J Biol Rhythms. 2008 Jun;23(3):265-73. [PMID: 18487418]
Pavlova MK, Duffy JF, Shea SA. Polysomnographic respiratory abnormalities in asymptomatic individuals.
Sleep. 2008 Feb 1;31(2):241-8. [PMID: 18274272]
Ivanov PCh, Hu K, Hilton MF, Shea SA, Stanley HE. Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics.
Proc Natl Acad Sci. 2007 Dec 26;104(52):20702-7. Epub 2007 Dec 19. [PMID: 18093917]
Hu K, Scheer, FAJL, Ivanov P Ch, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation.
Neurosci. 2007 Nov 9;149(3):508-17. Epub 2007 Oct 24. [PMID: 17920204]
Scheer, FAJL, Stone PH, Shea SA. Decreased sleep in heart failure: are medications to blame?
Arch. Int. Med. 2007 May 28;167(10):1098-9; author reply 1099-100. [PMID: 17533214]
Scheer FA, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SA. Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion.
Spinal Cord. 2006 Feb;44(2):78-81. [PMID: 16130027]
Shea SA, Hilton MF, Orlova C, Ayers RT, Mantzoros CS. Independent Circadian and Sleep/Wake Regulation of Adipokines and Glucose in Humans.
J Clin Endocrinol Metab. 2005 May;90(5):2537-44. Epub 2005 Feb 1. [PMID: 15687326]
Hu K, Ivanov PCh, Chen Z, Hilton MF, Stanley HE, Shea SA. Non-random fluctuations and multi-scale dynamics regulation of human activity.
Physica A. 2004 Jun;337(1-2):307-18. [PMID: 15759365]
Hu K, Ivanov PCh, Hilton MF, Chen Z, Ayers RT, Stanley HE, Shea SA. Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior.
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18223-7. Epub 2004 Dec 20. [PMID: 15611476]
Pavlova MK, Shea SA, Bromfield EB. Day/night patterns of focal seizures.
Epilepsy Behav. 2004 Feb;5(1):44-9. [PMID: 14751206]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control.
Am J Respir Crit Care Med. 2001 Dec 1;164(11):2025-30. [PMID: 11739130]
Pillar G, Fogel RB, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences.
Respir Physiol. 2001 Aug;127(1):23-38. [PMID: 11445198]
Elliott AR, Shea SA, Dijk DJ, Wyatt JK, Riel E, Neri DF, Czeisler CA, West JB, Prisk GK. Microgravity reduces sleep-disordered breathing in humans.
Am J Respir Crit Care Med. 2001 Aug 1;164(3):478-85. [PMID: 11500354]
Malhotra A, Pillar G, Fogel RB, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure.
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1058-62. [PMID: 10988130]
Pillar G, Malhotra A, Fogel RB, Beauregard J, Slamowitz DI, Shea SA, White DP. Upper airway muscle responsiveness to rising PCO(2) during NREM sleep.
J Appl Physiol. 2000 Oct;89(4):1275-82. [PMID: 11007559]
Ayas NT, Brown R, Shea SA. Hypercapnia can induce arousal from sleep in the absence of altered respiratory mechanoreception.
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1004-8. [PMID: 10988121]
Shea SA, Akahoshi T, Edwards JK, White DP. Influence of chemoreceptor stimuli on genioglossal response to negative pressure in humans.
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):559-65. [PMID: 10934087]
Spengler CM, Czeisler CA, Shea SA. An endogenous circadian rhythm of respiratory control in humans.
J Physiol. 2000 Aug 1;526 Pt 3:683-94. Erratum in: Am J Respir Crit Care Med 2002 Oct 1;166(7):1005. [PMID: 10922018]
Bloch-Salisbury E, Lansing R, Shea SA. Acute changes in carbon dioxide levels alter the electroencephalogram without affecting cognitive function.
Psychophysiology. 2000 Jul;37(4):418-26. [PMID: 10934900]
Zeitzer JM, Ayas NT, Shea SA, Brown R, Czeisler CA. Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia.
J Clin Endocrinol Metab. 2000 Jun;85(6):2189-96. [PMID: 10852451]
Hilton MF, Umali MU, Czeisler CA, Wyatt JK, Shea SA. Endogenous circadian control of the human autonomic nervous system.
Comput Cardiol. 2000;27:197-200. [PMID: 14632012]
Malhotra A, Fogel RB, Edwards JK, Shea SA, White DP. Local mechanisms drive genioglossus activation in obstructive sleep apnea.
Am J Respir Crit Care Med. 2000 May;161(5):1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol. 2000 Apr;88(4):1346-54. [PMID: 10749829]
Spengler CM, Shea SA. Sleep deprivation per se does not decrease the hypercapnic ventilatory response in humans.
Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1124-8. Erratum in: Am J Respir Crit Care Med 2002 Oct 1;166(7):1005. [PMID: 10764300]
White DP, Edwards JK, Shea SA. Local reflex mechanisms: influence on basal genioglossal muscle activation in normal subjects.
Sleep. 1998 Nov 1;21(7):719-28. [PMID: 11286348]
Shea SA, Edwards JK, White DP. Effect of wake-sleep transitions and rapid eye movement sleep on pharyngeal muscle response to negative pressure in humans.
J Physiol. 1999 Nov 1;520 Pt 3:897-908. [PMID: 10545152]
Evans KC, Shea SA, Saykin AJ. Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans.
J Physiol. 1999 Oct 15;520 Pt 2:383-92. [PMID: 10523407]
Banzett RB, Guz A, Paydarfar D, Shea SA, Schachter SC, Lansing RW. Cardiorespiratory variables and sensation during stimulation of the left vagus in patients with epilepsy.
Epilepsy Res. 1999 May;35(1):1-11. [PMID: 10232789]
Spengler CM, Banzett RB, Systrom DM, Shannon DC, Shea SA. Respiratory sensations during heavy exercise in subjects without respiratory chemosensitivity.
Respir Physiol. 1998 Oct;114(1):65-74. [PMID: 9858052]
Shea SA, Hoit JD, Banzett RB. Competition between gas exchange and speech production in ventilated subjects.
Biol Psychol. 1998 Sep;49(1-2):9-27. [PMID: 9792482]
Banzett RB, Shea SA, Brown R, Schwartzstein R, Lansing R, Guz A. Perception of inflation of a single lung lobe in humans.
Respir Physiol. 1997 Feb;107(2):125-36. [PMID: 9108626]
Bloch-Salisbury E, Shea SA, Brown R, Evans K, Banzett RB. Air hunger induced by acute increase in PCO2 adapts to chronic elevation of PCO2 in ventilated humans.
J Appl Physiol. 1996 Aug;81(2):949-56. [PMID: 8872667]
Shea SA, Harty HR, Banzett RB. Self-control of level of mechanical ventilation to minimize CO2 induced air hunger.
Respir Physiol. 1996 Feb;103(2):113-25. [PMID: 8833543]
Banzett RB, Lansing RW, Evans KC, Shea SA. Stimulus-response characteristics of CO2-induced air hunger in normal subjects.
Respir Physiol. 1996 Jan;103(1):19-31. [PMID: 8822220]
Horner RL, Innes JA, Morrell MJ, Shea SA, Guz A. The effect of sleep on reflex genioglossus muscle activation by stimuli of negative airway pressure in humans.
J Physiol. 1994 Apr 1;476(1):141-51. [PMID: 8046629]
Hoit JD, Shea SA, Banzett RB. Speech production during mechanical ventilation in tracheostomized individuals.
J Speech Hear Res. 1994 Feb;37(1):53-63. [PMID: 8170131]
Shea SA, Andres LP, Paydarfar D, Banzett RB, Shannon DC. Effect of mental activity on breathing in congenital central hypoventilation syndrome.
Respir Physiol. 1993 Dec;94(3):251-63. [PMID: 8108605]
Shea SA, Andres LP, Shannon DC, Banzett RB. Ventilatory responses to exercise in humans lacking ventilatory chemosensitivity.
J Physiol. 1993 Aug;468:623-40. [PMID: 8254528]
Shea SA, Andres LP, Shannon DC, Guz A, Banzett RB. Respiratory sensations in subjects who lack a ventilatory response to CO2.
Respir Physiol. 1993 Aug;93(2):203-19. [PMID: 8210759]
Morrell MJ, Shea SA, Adams L, Guz A. Effects of inspiratory support upon breathing in humans during wakefulness and sleep.
Respir Physiol. 1993 Jul;93(1):57-70. [PMID: 8367617]
Shea SA, Dinh TP, Hamilton RD, Guz A, Benchetrit G. Breathing patterns of monozygous twins during behavioural tasks.
Acta Genet Med Gemellol (Roma). 1993;42(2):171-84. [PMID: 7976112]
Manning HL, Shea SA, Schwartzstein RM, Lansing RW, Brown R, Banzett RB. Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics.
Respir Physiol. 1992 Oct;90(1):19-30. [PMID: 1455095]
Sullivan TY, Muzzin S, Hamilton RD, Adams L, Shea SA, Horner RL, Guz A. Volume detection during voluntary and passive breathing.
Respir Physiol. 1991 Jun;84(3):323-35. [PMID: 1925111]
Datta AK, Shea SA, Horner RL, Guz A. The influence of induced hypocapnia and sleep on the endogenous respiratory rhythm in humans.
J Physiol. 1991;440:17-33. Erratum in: J Physiol (Lond) 1991 Dec;444:778. [PMID: 1804960]
Shea SA, Horner RL, Benchetrit G, Guz A. The persistence of a respiratory 'personality' into stage IV sleep in man.
Respir Physiol. 1990 Apr;80(1):33-44. [PMID: 2367750]
Horner RL, Shea SA, McIvor J, Guz A. Pharyngeal size and shape during wakefulness and sleep in patients with obstructive sleep apnoea.
Q J Med. 1989 Aug;72(268):719-35. [PMID: 2602554]
Horner RL, Mohiaddin RH, Lowell DG, Shea SA, Burman ED, Longmore DB, Guz A. Sites and sizes of fat deposits around the pharynx in obese patients with obstructive sleep apnoea and weight matched controls.
Eur Respir J. 1989 Jul;2(7):613-22. [PMID: 2776867]
Shea SA, Winning AJ, McKenzie E, Guz A. Does the abnormal pattern of breathing in patients with interstitial lung disease persist in deep, non-rapid eye movement sleep?
Am Rev Respir Dis. 1989 Mar;139(3):653-8. [PMID: 2923365]
Shea SA, Benchetrit G, Pham Dinh T, Hamilton RD, Guz A. The breathing patterns of identical twins.
Respir Physiol. 1989 Feb;75(2):211-23. [PMID: 2711052]
Benchetrit G, Shea SA, Dinh TP, Bodocco S, Baconnier P, Guz A. Individuality of breathing patterns in adults assessed over time.
Respir Physiol. 1989 Feb;75(2):199-209. [PMID: 2711051]
Shea SA, Horner RL, Banner NR, McKenzie E, Heaton R, Yacoub MH, Guz A. The effect of human heart-lung transplantation upon breathing at rest and during sleep.
Respir Physiol. 1988 May;72(2):131-49. [PMID: 3131860]
Shea SA, Walter J, Pelley C, Murphy K, Guz A. The effect of visual and auditory stimuli upon resting ventilation in man.
Respir Physiol. 1987 Jun;68(3):345-57. [PMID: 3616180]
Shea SA, Walter J, Murphy K, Guz A. Evidence for individuality of breathing patterns in resting healthy man.
Respir Physiol. 1987 Jun;68(3):331-44. [PMID: 3616179]
Winning AJ, Hamilton RD, Shea SA, Guz A. Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: evidence for pulmonary chemosensitivity.
Clin Sci (Lond). 1986 Nov;71(5):519-26. [PMID: 3769402]
Adams L, Lane R, Shea SA, Cockcroft A, Guz A. Breathlessness during different forms of ventilatory stimulation: a study of mechanisms in normal subjects and respiratory patients.
Clin Sci (Lond). 1985 Dec;69(6):663-72. [PMID: 3933895]
Winning AJ, Hamilton RD, Shea SA, Knott C, Guz A. The effect of airway anaesthesia on the control of breathing and the sensation of breathlessness in man.
Clin Sci (Lond). 1985 Feb;68(2):215-25. [PMID: 3917883]
Reviews
Ross SD, Sheinhait IA, Harrison KJ, Kvasz M, Connelly JE, Shea SA, Allen IE. Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea.
Sleep. 2000 Jun 15;23(4):519-32. [PMID: 10875559]
Book Chapters
Shea SA, Hilton MF, Muller JE. Day/Night Patterns of Myocardial Infarction and Sudden Cardiac Death: Interacting Roles of the Endogenous Circadian System and Behavioral Triggers.
In "Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics", Humana Press. 2007; Chapter 11, pp 251-289.
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