Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Robert W. McCarley, MD
Professor of Psychiatry, Harvard Medical School
Professor, Department of Psychiatry, VA Boston Healthcare System
Administrative Title(s)
Head of the Harvard Department of Psychiatry, and Head of the Laboratory of Neuroscience, VA Boston Healthcare System
Address
Department of Psychiatry at VA Boston Healthcare System940 Belmont St (116a)
Brockton, MA 02301
USA
Phone 774-826-2479
Phone 774-826-2485
Fax 508-586-0894
Email marie_fairbanks@hms.harvard.edu
Society Memberships
Sleep Research SocietyAmerican Academy of Sleep Medicine
Society of Neuroscience
American College Neuropsychopharmacology
American Psychiatric Association
Society of Biological Psychiatry
American Physiology Society
Research Unit(s)
Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System
Research Interests
Work in basic research has focused on how the brain controls behavior, especially that of sleep and wakefulness. The rapid eye movement (REM) sleep phase is present in all mammals and is of special interest to psychology and psychiatry because of its relationship to dreaming and to mood disorder. Research has examined REM sleep brainstem control mechanisms, both REM promotion by the reticular and cholinergic activity and its inhibition by aminergic activity, as well as recent studies of GABAergic influences on REM. Another line of investigation has indicated that adenosine acting in the basal forebrain is a key nonREM sleep factor, controlling the sleepiness that occurs after prolonged wakefulness by means of an inhibition of wakefulness-active neurons. The second messenger and molecular consequences of elevated adenosine may be useful in explaining "sleep debt", the long-term consequences of sleep restriction/deprivation. An intracellular cascade, triggered by adenosine acting at the A1 receptor, leads to increased adenosine A1 receptor production, further enhancing adenosine's sleep promoting effects. Recent work has been in animal models of the consequences of obstructive sleep apnea, examining the effects of sleep interruption and hypoxia. Another line of recent work is describing how the neuropeptide orexin acts in the control of sleep and wakefulness, and how interference with orexin production and receptor actions by siRNA and antisense increases REM sleep and causes behavioral cataplexy in animals.
Trainees
Jennifer I. Luebke, PhD (1988 - 1992)
Dean Salisbury, PhD (1990 – 1997)
Donald Rainnie, PhD (1993 –2000)
Chandlee Dickey, MD (1994 – 2001)
Geoffrey F. Potts, PhD (1994 – 1998)
Yoshio Hirayasu, MD, PhD (1995 – 1999)
Tarja Porkka-Heiskanen, MD PHD (1995 – 1997)
Melissa Frumin, MD, MS (1998 – 2000)
Chang Uk Lee, MD, PhD (1999 – 2000)
Vijay Ramesh, PhD (1999 – 2005)
Kiyoto Kasai, MD, PhD (2000 – 2002)
Toshiaki Onitsuka, MD, PhD (2000 – 2002)
Madhvi Patil, MD (2000 – 2001)
Kevin M. Spencer, PhD (2000 – 2003)
Marek Kubicki, MD, PhD (2001 – 2002)
James T. McKenna, PhD (2001 – 2006)
Hae-Jeong Park, PhD (2001 – 2003)
Ritchie Brown, PhD (2002 – 2004)
Noriomi Kuroki, MD (2002 – 2004)
Jaime Tartar, PhD (2004 - 2006)
Takeshi Yoshida, MD, PhD (2004 - 2005)
Motoaki Nakamura, MD, PhD (2003 – Present)
Lichao Chen, MD, PhD (2004 – Present)
Ryuichiro Hashimoto PhD (2004 – Present)
Tsuyoshi Araki, MD (2005 – Present)
Toshiro Kawashima, MD, PhD (2005 – Present)
Joel S. Snyder, PhD (2005 – Present)
Dean Salisbury, PhD (1990 – 1997)
Donald Rainnie, PhD (1993 –2000)
Chandlee Dickey, MD (1994 – 2001)
Geoffrey F. Potts, PhD (1994 – 1998)
Yoshio Hirayasu, MD, PhD (1995 – 1999)
Tarja Porkka-Heiskanen, MD PHD (1995 – 1997)
Melissa Frumin, MD, MS (1998 – 2000)
Chang Uk Lee, MD, PhD (1999 – 2000)
Vijay Ramesh, PhD (1999 – 2005)
Kiyoto Kasai, MD, PhD (2000 – 2002)
Toshiaki Onitsuka, MD, PhD (2000 – 2002)
Madhvi Patil, MD (2000 – 2001)
Kevin M. Spencer, PhD (2000 – 2003)
Marek Kubicki, MD, PhD (2001 – 2002)
James T. McKenna, PhD (2001 – 2006)
Hae-Jeong Park, PhD (2001 – 2003)
Ritchie Brown, PhD (2002 – 2004)
Noriomi Kuroki, MD (2002 – 2004)
Jaime Tartar, PhD (2004 - 2006)
Takeshi Yoshida, MD, PhD (2004 - 2005)
Motoaki Nakamura, MD, PhD (2003 – Present)
Lichao Chen, MD, PhD (2004 – Present)
Ryuichiro Hashimoto PhD (2004 – Present)
Tsuyoshi Araki, MD (2005 – Present)
Toshiro Kawashima, MD, PhD (2005 – Present)
Joel S. Snyder, PhD (2005 – Present)
Research Funding
NIH/NIMH MERIT AWARD, Synaptic basis of sleep cycle control. PI: McCarley. Brainstem and basal forebrain control of REM and nonREM sleep. NIH/NIMH, Orexin and the Control of Sleep and Wakefulness. PI: McCarley. VA, Research Enhancement Award. PI: McCarley. NIH/NIHLB. Behavioral & Neurobiological Consequences of Obstructive Sleep Apnea. PI: McCarley, Project 2, Program Project PI, Clif Saper.
This research has been very much of a laboratory team effort, as shown by the coauthors on the publications. This team's superb effort has been recognized by the lab chief's having received the Distinguished Scientist Award from the Sleep Research Society, the William C. Dement Award for Academic Achievement by the Amer. Academy of Sleep Medicine (to be given in June, 2006), the top research prize, the Middleton Award, from the Dept. of Veterans Affairs Medical Research Service, and the top research Award of the American Psychiatric Association.
Selected Publications
Kubicki M, McCarley RW, Westin CF, Park HJ, Maier SE, Kikinis R, Jolesz FA, Shenton ME: Review of Diffusion Tensor Imaging Studies in Schizophrenia.
Journal of Psychiatry Research (In Press).
McKenna JT, Tartar, JL, Ward, CP, Thakkar, MM, Ling, L, McGuire, M, McCarley, RW, Strecker, RE. Sleep fragmentation elevates basal forebrain adenosine and NREM EEG delta activity: implications for modeling the consequences of obstructive sleep apnea.
Submitted to press.
Salisbury DF, Kuroki N, Kasai K, Shenton ME, McCarley RW. Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia.
Arch Gen Psychiatry. 2007 May;64(5):521-9. [PMID: 17485604]
Gurrera RJ, Nakamura M, Kubicki M, Dickey CC, Niznikiewicz MA, Voglmaier MM, McCarley RW, Shenton ME, Westin CF, Maier SE, Seidman LJ. The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging study.
Schizophr Res. 2007 Feb;90(1-3):360-2. Epub 2006 Nov 28. [PMID: 17126532]
Dickey CC, McCarley RW, Xu ML, Seidman LJ, Voglmaier MM, Niznikiewicz MA, Connor E, Shenton ME. MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder.
Schizophr Res. 2007 Jan;89(1-3):49-58. Epub 2006 Oct 5. [PMID: 17027236]
Nestor PG, Kubicki M, Kuroki N, Gurrera, RJ, Niznikiewicz M, Sheton ME, McCarley RW. Episodic Memory and Neuroimaging in Hippocampus and Fornix in Chronic Schizphrenia.
Psychiatry Res. 2007 May 15;155(1):21-8. [PMID: 17395435]
McCoy JG, Tartar JL, Bebis AC, Ward CP, McKenna JT, Baxter MG, McGaughy J, McCarley RW, Strecker RE. Experimental sleep fragmentation impairs attentional set-shifting in rats.
SLEEP 2007;30(1):52-60. [PMID: 17310865]
Nakamura M, Salisbury D. F, Hirayasu Y, Bouix S, Pohl K. M, Yoshida T, Koo M. S, Shenton M. E, and McCarley R. W. Neocortical gray matter volume in first episode schizophrenia and first episode affective psychosis: a cross-sectional and longitudinal MRI study.
Biol Psychiatry. 2007 Jun 22; Epub ahead of print [PMID: 17586477]
Nakamura M, Nestor PG, McCarley RW, Levitt JJ, Hsu L, Kawashima T, et al. Altered orbitofrontal sulcogyral pattern in schizophrenia.
Brain 2007; 130: 693-707. [PMID: 17347256]
Nestor PG, Kubicki M, Spencer KM, Niznikiewicz M, McCarley RW, Shenton ME. Attentional networks and cingulum bundle in chronic schizophrenia.
Schizophr Res 2007;90:308-315 [PMID: 17150337]
Onitsuka T, McCarley RW, Kuroki N, Dickey CC, Kubicki M, Demeo SS, Frumin M, Kikinis R, Jolesz FA, Shenton ME: Occipital lobe gray matter volume in male patients with chronic schizophrenia: A quantitative MRI study.
Schizophr Res 2007 [PMID: 17350226]
Nestor PG, Onitsuka T, Gurrera RJ, Niznikiewicz MA, Frumin M, Shenton ME, McCarley RW. Dissociable contributions of MRI reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia.
Schizophr Res. 2007 Mar;91(1-3):103-6. PMID: [17229550]
Ramesh V, Thatte H, McCarley RW and Basheer R. Adenosine and Sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain.
J Neurochem, 100 (2007):1351-1363. [PMID: 17316404]
McKenna JT, Tartar JL, Ward CP, Thakkar MM, Ling L, McGuire M, White D, McCarley RW, and Strecker RE. Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness.
Neuroscience. 2007 Jun 8;146(4):1462-73. Epub 2007 Apr 18. [PMID: 17442498]
Brown RE, McCarley RW. Neuroanatomical and neurochemical basis of wakefulness and REM sleep systems.
In: Sinton, Monti (Eds.), 2006, Cambridge University Press. In press.
Min-seong Koo, Chandlee C. Kickey, Hae-Jeong Park, Marek Kubicki, Na Young Ji, Sylvain Bouix, Kilian M. Pohl, james J. Levitt, Motoaki Nakamura, Martha E. Shenton, Robert W. McCarley, Smaller Neocortical Gray Matter and Larger Sulcal Cerebrospinal Fluid Volumes in Neuroleptic-Naive Women With Schizotypal Personality Disorder.
Arch Gen Psychiatry, 63(10), 1090-1100, 2006. [PMID: 17015811]
Tao R, Ma Z, McKenna JT, Thakkar MM, Winston S, Strecker RE, McCarley RW. Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats.
Neuroscience 2006; 141: 1101-1105. [PMID: 16820265]
Strecker R, Basheer R, McKenna JT, McCarley R. Another Chapter in the Adenosine Story.
Invited Editorial, Sleep 2006; 29: 426-428. [PMID: 16676774]
Wible C, Han D, Spencer M, Kubicki M, Niznikiewicz M, Jolesz F, McCarley RW, Nestor P: Connectivity Among Semantic Associates: An fMRI Study of Semantic Priming.
Brain and Language 2006 Jun;97(3):294-305. [PMID: 16413049]
M Koo, Dickey CC, Park H, Kubicki M, Ji NY, Bouix S, Pohl KM, Levitt JJ, Nakamura M, Shenton ME, McCarley RW (2006): Smaller Neocortical Gray Matter and Larger Sulcal CSF Volumes in Neuroleptic-Naive Females with Schizotypal Personality Disorder.
Arch Gen Psych 63; 1090-1100 [PMID: 17015811]
Spencer KM, McCarley RW. Neuropsychiatric abnormalities: a new vista from studies on fundamental properties of neural communication.
Psychiatric Times 2006;23:34ff.
Nestor, PG, Valdman O, Niznikiewicz M, Spencer K, McCarley RW, Shenton ME. Word priming in schizophrenia: associational and semantic influences.
Schizophr Res 2006;82:139-142 [PMID: 16325376]
Brown RE, Winston S, Basheer R, Thakkar MM, McCarley RW. Electrophysiological characterization of neurons in the dorsolateral pontine REM sleep induction zone of the rat: intrinsic membrane properties and response to carbachol and orexins.
Neuroscience 2006; 143(3): 739-755. [PMID: 17008019]
Onitsuka T, Niznikiewicz MA, Spencer KM, Fruman M, Kuroki N, Lucia LC, Shenton ME, McCarley RW. Functional and structural deficits in brain regions subserving face perception in schizophrenia.
Am J Psychiatry. 2006;163(3):455-62. [PMID: 16513867]
Tartar JL, Ward CP, McKenna JT, Thakkar MM, Arrigoni E, McCarley RW, Brown RE, and Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation.
Eur. J. Neurosci. 2006; 23(10): 2739-2748. [PMID: 16817877]
Koo MS, Levitt JJ, McCarley RW, Seidman LJ, Dickey CC, Niznikiewicz MA, Voglmaier MM, Zamani P, Long KR, Kim SS, Shenton ME. Reduction of caudate nucleus volumes in neuroleptic-naive female subjects with schizotypal personality disorder.
Biol Psychiatry. 2006 Jul 1;60(1):40-8. Epub 2006 Feb 7. [PMID: 16460694]
Noriomi Kuroki, Marek Kubicki, Paul G. Nestor, Dean F. Salisbury, Hae-Jeong Park, James J. Levitt, Sophie Woolston, Melissa Frumin, Margaret Niznikiewicz, Carl-Fredrik Westin, Stephan E. Maier, Robert W. McCarley and Martha E. Shenton. Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients.
Biol Psychiatry, 60(1), 22-31, 2006. [PMID: 16406249]
Kuroki N, Shenton ME, Salisbury DF, Hirayasu Y, Onitsuka T, Ersner-Hershfield H, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW. Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study.
Am J Psychiatry. 2006 Dec;163(12):2103-10. [PMID: 17151161]
Arrigoni E, Chamberlin NL, Saper CB, McCarley RW. Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.
Neuroscience. 2006 Jun 30;140(2):403-13. Epub 2006 Mar 20 [PMID: 16542780]
Cordova CA, Said BO, McCarley RW, Baxter MG, Chiba AA, Strecker RE. Sleep deprivation in rats produces attentional impairments on a 5-choice serial reaction time task.
Sleep. 2006 Jan 1;29(1):69-76. [PMID: 16453983]
Basheer R, Brown R, Ramesh V, Begum S, McCarley RW. Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity.
J Neurosci Res. 2005 Dec 1;82(5):650-8. [PMID: 16273548]
Ma Z, Strecker RE, McKenna JT, Thakkar MM, McCarley RW, Tao R. Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats.
Neuroscience. 2005;135(3):949-58. Epub 2005 Sep 8. [PMID: 16154286]
McCarley RW. Mechanisms and models of REM sleep control.
Arch Ital Biol. 2004 Jul;142(4):429-67. Review. [PMID: 15493547]
Sinton CM, McCarley RW. Neurophysiological mechanisms of sleep and wakefulness: a question of balance.
Semin Neurol. 2004 Sep;24(3):211-23. Review. [PMID: 15449215]
Basheer R, Strecker RE, Thakkar MM, McCarley RW. Adenosine and sleep-wake regulation.
Prog Neurobiol. 2004 Aug;73(6):379-96. Review. [PMID: 15313333]
Thakkar MM, Delgiacco RA, Strecker RE, McCarley RW. Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats.
Neuroscience. 2003;122(4):1107-13. [PMID: 14643776]
Thakkar MM, Winston S, McCarley RW. A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain.
J Neurosci. 2003 May 15;23(10):4278-87. [PMID: 12764116]
Ito K, Yanagihara M, Imon H, Dauphin L, McCarley RW. Intracellular recordings of pontine medial gigantocellular tegmental field neurons in the naturally sleeping cat: behavioral state-related activity and soma size difference in order of recruitment.
Neuroscience. 2002;114(1):23-37. [PMID: 12207952]
Basheer R, Arrigoni E, Thatte HS, Greene RW, Ambudkar IS, McCarley RW. Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons.
J Neurosci. 2002 Sep 1;22(17):7680-6. [PMID: 12196591]
Strecker RE, Nalwalk J, Dauphin LJ, Thakkar MM, Chen Y, Ramesh V, Hough LB, McCarley RW. Extracellular histamine levels in the feline preoptic/anterior hypothalamic
area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study.
Neuroscience. 2002;113(3):663-70. [PMID: 12150786]
Thakkar MM, Strecker RE, McCarley RW. Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons.
Brain Res. 2002 Aug 2;945(2):276-80. [PMID: 12126890]
Thakkar MM, Winston S, McCarley RW. Orexin neurons of the hypothalamus express adenosine A1 receptors.
Brain Res. 2002 Jul 19;944(1-2):190-4. [PMID: 12106679]
Basheer R, Rainnie DG, Porkka-Heiskanen T, Ramesh V, McCarley RW. Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat.
Neuroscience. 2001;104(3):731-9. [PMID: 11440805]
Strecker RE, Thakkar MM, Porkka-Heiskanen T, Dauphin LJ, Bjorkum AA, McCarley RW. Behavioral state-related changes of extracellular serotonin concentration in the pedunculopontine tegmental nucleus: a microdialysis study in freely moving animals.
Sleep Res Online. 1999;2(2):21-7. [PMID: 11421239]
Basheer R, Halldner L, Alanko L, McCarley RW, Fredholm BB, Porkka-Heiskanen T. Opposite changes in adenosine A1 and A2A receptor mRNA in the rat following sleep deprivation.
Neuroreport. 2001 Jun 13;12(8):1577-80. [PMID: 11409719]
Thakkar MM, Ramesh V, Strecker RE, McCarley RW. Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.
Arch Ital Biol. 2001 Apr;139(3):313-28. [PMID: 11330208]
Arrigoni E, Rainnie DG, McCarley RW, Greene RW. Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum.
J Neurosci. 2001 Feb 1;21(3):1076-85. [PMID: 11157094]
Porkka-Heiskanen T, Strecker RE, McCarley RW. Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study.
Neuroscience. 2000;99(3):507-17. [PMID: 11029542]
Basheer R, Porkka-Heiskanen T, Strecker RE, Thakkar MM, McCarley RW. Adenosine as a biological signal mediating sleepiness following prolonged wakefulness.
Biol Signals Recept. 2000 Nov-Dec;9(6):319-27. Review. [PMID: 11025338]
Strecker RE, Morairty S, Thakkar MM, Porkka-Heiskanen T, Basheer R, Dauphin LJ, Rainnie DG, Portas CM, Greene RW, McCarley RW. Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state.
Behav Brain Res. 2000 Nov;115(2):183-204. [PMID: 11000420]
Basheer R, Porkka-Heiskanen T, Stenberg D, McCarley RW. Adenosine and behavioral state control: adenosine increases c-Fos protein and AP1 binding in basal forebrain of rats.
Brain Res Mol Brain Res. 1999 Nov 10;73(1-2):1-10. [PMID: 10581392]
McCarley RW. Dreams: disguise of forbidden wishes or transparent reflections of a distinct brain state?
Ann N Y Acad Sci. 1998 May 15;843:116-33. No abstract available. [PMID: 9668654]
Thakkar MM, Strecker RE, McCarley RW. Behavioral state control through differential serotonergic inhibition in the
mesopontine cholinergic nuclei: a simultaneous unit recording and microdialysis study.
J Neurosci. 1998 Jul 15;18(14):5490-7. [PMID: 9651229]
Li X, Rainnie DG, McCarley RW, Greene RW. Presynaptic nicotinic receptors facilitate monoaminergic transmission.
J Neurosci. 1998 Mar 1;18(5):1904-12. [PMID: 9465015]
Basheer R, Sherin JE, Saper CB, Morgan JI, McCarley RW, Shiromani PJ. Effects of sleep on wake-induced c-fos expression.
J Neurosci. 1997 Dec 15;17(24):9746-50. [PMID: 9391027]
Portas CM, Thakkar M, Rainnie DG, Greene RW, McCarley RW. Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat.
Neuroscience. 1997 Jul;79(1):225-35. [PMID: 9178878]
Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA, Greene RW, McCarley RW. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness.
Science. 1997 May 23;276(5316):1265-8. [PMID: 9157887]
Portas CM, Thakkar M, Rainnie D, McCarley RW. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat.
J Neurosci. 1996 Apr 15;16(8):2820-8. [PMID: 8786456]
Sherin JE, Shiromani PJ, McCarley RW, Saper CB. Activation of ventrolateral preoptic neurons during sleep.
Science. 1996 Jan 12;271(5246):216-9. [PMID: 8539624]
Shiromani PJ, Malik M, Winston S, McCarley RW. Time course of Fos-like immunoreactivity associated with cholinergically induced REM sleep.
J Neurosci. 1995 May;15(5 Pt 1):3500-8. [PMID: 7751925]
Stevens DR, McCarley RW, Greene RW. The mechanism of noradrenergic alpha 1 excitatory modulation of pontine reticular formation neurons.
J Neurosci. 1994 Nov;14(11 Pt 1):6481-7. [PMID: 7965052]
Rainnie DG, Grunze HC, McCarley RW, Greene RW. Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal.
Science. 1994 Feb 4;263(5147):689-92. Erratum in: Science 1994 Jul 1;265(5168):16. [PMID: 8303279]
Luebke JI, McCarley RW, Greene RW. Inhibitory action of muscarinic agonists on neurons in the rat laterodorsal tegmental nucleus in vitro.
J Neurophysiol. 1993 Nov;70(5):2128-35. [PMID: 8294974]
Stevens DR, Birnstiel S, Gerber U, McCarley RW, Greene RW. Nicotinic depolarizations of rat medial pontine reticular formation neurons studied in vitro.
Neuroscience. 1993 Nov;57(2):419-24. [PMID: 8115046]
Stevens DR, McCarley RW, Greene RW. Excitatory amino acid-mediated responses and synaptic potentials in medial pontine reticular formation neurons of the rat in vitro.
J Neurosci. 1992 Nov;12(11):4188-94. [PMID: 1279137]
Massaquoi SG, McCarley RW. Extension of the Limit Cycle Reciprocal Interaction Model of REM cycle control. An integrated sleep control model.
J Sleep Res. 1992 Jun;1(2):138-143. [PMID: 10607042]
McCarley RW, Massaquoi SG. Neurobiological structure of the revised limit cycle reciprocal interaction model of REM cycle control.
J Sleep Res. 1992 Jun;1(2):132-137. [PMID: 10607041]
Luebke JI, Greene RW, Semba K, Kamondi A, McCarley
RW, Reiner PB. Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro.
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):743-7. [PMID: 1731349]
Gerber U, Stevens DR, McCarley RW, Greene RW. Muscarinic agonists activate an inwardly rectifying potassium conductance in medial pontine reticular formation neurons of the rat in vitro.
J Neurosci. 1991 Dec;11(12):3861-7. [PMID: 1744694]
Gerber U, Greene RW, McCarley RW. Repetitive firing properties of medial pontine reticular formation neurones of the rat recorded in vitro.
J Physiol. 1989 Mar;410:533-60. [PMID: 2795489]
Greene RW, Gerber U, McCarley RW. Cholinergic activation of medial pontine reticular formation neurons in vitro.
Brain Res. 1989 Jan 2;476(1):154-9. [PMID: 2914210]
Mitani A, Ito K, Mitani Y, McCarley RW. Morphological and electrophysiological identification of gigantocellular tegmental field neurons with descending projections in the cat: II. Bulb.
J Comp Neurol. 1988 Aug 15;274(3):371-86. [PMID: 2464618]
Mitani A, Ito K, Hallanger AE, Wainer BH, Kataoka K, McCarley RW. Cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei to the pontine gigantocellular tegmental field in the cat.
Brain Res. 1988 Jun 7;451(1-2):397-402. [PMID: 3251602]
Mitani A, Ito K, Mitani Y, McCarley RW. Morphological and electrophysiological identification of gigantocellular tegmental field neurons with descending projections in the cat: I. Pons.
J Comp Neurol. 1988 Feb 22;268(4):527-45. [PMID: 3356804]
Mitani A, Ito K, Mitani Y, McCarley RW. Descending projections from the gigantocellular tegmental field in the cat: cells of origin and their brainstem and spinal cord trajectories.
J Comp Neurol. 1988 Feb 22;268(4):546-66. [PMID: 2451685]
Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. I. Long term recordings of dorsal raphe discharge frequency and PGO waves.
Arch Ital Biol. 1987 Oct;125(4):317-43. [PMID: 3439827]
Baghdoyan HA, Rodrigo-Angulo ML, McCarley RW, Hobson JA. A neuroanatomical gradient in the pontine tegmentum for the cholinoceptive induction of desynchronized sleep signs.
Brain Res. 1987 Jun 30;414(2):245-61. [PMID: 3620930]
McCarley RW, Massaquoi SG. Further discussion of a model of the REM sleep oscillator.
Am J Physiol. 1986 Dec;251(6 Pt 2):R1033-6. [PMID: 3789190]
McCarley RW, Massaquoi SG. A limit cycle mathematical model of the REM sleep oscillator system.
Am J Physiol. 1986 Dec;251(6 Pt 2):R1011-29. [PMID: 3789188]
Greene RW, Haas HL, McCarley RW. A low threshold calcium spike mediates firing pattern alterations in pontine reticular neurons.
Science. 1986 Nov 7;234(4777):738-40. [PMID: 3775364]
Baghdoyan HA, Monaco AP, Rodrigo-Angulo ML, Assens F, McCarley RW, Hobson JA. Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs.
J Pharmacol Exp Ther. 1984 Oct;231(1):173-80. [PMID: 6491973]
Lydic R, McCarley RW, Hobson JA. Forced activity alters sleep cycle periodicity and dorsal raphe discharge rhythm.
Am J Physiol. 1984 Jul;247(1 Pt 2):R135-45. [PMID: 6331207]
McCarley RW, Benoit O, Barrionuevo G. Lateral geniculate nucleus unitary discharge in sleep and waking: state- and rate-specific aspects.
J Neurophysiol. 1983 Oct;50(4):798-818. PMID: [6631464]
Nelson JP, McCarley RW, Hobson JA. REM sleep burst neurons, PGO waves, and eye movement information.
J Neurophysiol. 1983 Oct;50(4):784-97. [PMID: 6631463]
McCarley RW. REM sleep and depression: common neurobiological control mechanisms.
Am J Psychiatry. 1982 May;139(5):565-70. [PMID: 6122380]
McCarley RW, Hoffman E. REM sleep dreams and the activation-synthesis hypothesis.
Am J Psychiatry. 1981 Jul;138(7):904-12. [PMID: 7258349]
McCarley RW, Nelson JP, Hobson JA. Ponto-geniculo-occipital (PGO) burst neurons: correlative evidence for neuronal generators of PGO waves.
Science. 1978 Jul 21;201(4352):269-72. [PMID: 663656]
Wyzinski PW, McCarley RW, Hobson JA. Discharge properties of pontine reticulospinal neurons during sleep-waking cycle.
J Neurophysiol. 1978 May;41(3):821-34. [PMID: 660232]
Hobson JA, McCarley RW. The brain as a dream state generator: an activation-synthesis hypothesis of the dream process.
Am J Psychiatry. 1977 Dec;134(12):1335-48. [PMID: 21570]
McCarley RW, Hobson JA. The neurobiological origins of psychoanalytic dream theory.
Am J Psychiatry. 1977 Nov;134(11):1211-21. [PMID: 333951]
McCarley RW, Hobson JA. Discharge patterns of cat pontine brain stem neurons during desynchronized sleep.
J Neurophysiol. 1975 Jul;38(4):751-66. [PMID: 1159463]
McCarley RW, Hobson JA. Neuronal excitability modulation over the sleep cycle: a structural and mathematical model.
Science. 1975 Jun 4;189(4196):58-60. [PMID: 1135627]
Hobson JA, McCarley RW, Wyzinski PW. Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups.
Science. 1975 Jun 4;189(4196):55-8. [PMID: 1094539]
Hobson JA, McCarley RW, Freedman R, Pivik RT. Time course of discharge rate changes by cat pontine brain stem neurons during sleep cycle.
J Neurophysiol. 1974 Nov;37(6):1297-309. No abstract available. [PMID: 4436702]
McCarley RW, Hobson JA. Single neuron activity in cat gigantocellular tegmental field: selectivity of discharge in desynchronized sleep.
Science. 1971 Dec 17;174(15):1250-2. No abstract available. [PMID: 5133450]
McCarley RW, Hobson JA. Cortical unit activity in desynchronized sleep.
Science. 1970 Feb 6;167(919):901-3. No abstract available. [PMID: 4312290]
Journal of Psychiatry Research (In Press).
McKenna JT, Tartar, JL, Ward, CP, Thakkar, MM, Ling, L, McGuire, M, McCarley, RW, Strecker, RE. Sleep fragmentation elevates basal forebrain adenosine and NREM EEG delta activity: implications for modeling the consequences of obstructive sleep apnea.
Submitted to press.
Salisbury DF, Kuroki N, Kasai K, Shenton ME, McCarley RW. Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia.
Arch Gen Psychiatry. 2007 May;64(5):521-9. [PMID: 17485604]
Gurrera RJ, Nakamura M, Kubicki M, Dickey CC, Niznikiewicz MA, Voglmaier MM, McCarley RW, Shenton ME, Westin CF, Maier SE, Seidman LJ. The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging study.
Schizophr Res. 2007 Feb;90(1-3):360-2. Epub 2006 Nov 28. [PMID: 17126532]
Dickey CC, McCarley RW, Xu ML, Seidman LJ, Voglmaier MM, Niznikiewicz MA, Connor E, Shenton ME. MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder.
Schizophr Res. 2007 Jan;89(1-3):49-58. Epub 2006 Oct 5. [PMID: 17027236]
Nestor PG, Kubicki M, Kuroki N, Gurrera, RJ, Niznikiewicz M, Sheton ME, McCarley RW. Episodic Memory and Neuroimaging in Hippocampus and Fornix in Chronic Schizphrenia.
Psychiatry Res. 2007 May 15;155(1):21-8. [PMID: 17395435]
McCoy JG, Tartar JL, Bebis AC, Ward CP, McKenna JT, Baxter MG, McGaughy J, McCarley RW, Strecker RE. Experimental sleep fragmentation impairs attentional set-shifting in rats.
SLEEP 2007;30(1):52-60. [PMID: 17310865]
Nakamura M, Salisbury D. F, Hirayasu Y, Bouix S, Pohl K. M, Yoshida T, Koo M. S, Shenton M. E, and McCarley R. W. Neocortical gray matter volume in first episode schizophrenia and first episode affective psychosis: a cross-sectional and longitudinal MRI study.
Biol Psychiatry. 2007 Jun 22; Epub ahead of print [PMID: 17586477]
Nakamura M, Nestor PG, McCarley RW, Levitt JJ, Hsu L, Kawashima T, et al. Altered orbitofrontal sulcogyral pattern in schizophrenia.
Brain 2007; 130: 693-707. [PMID: 17347256]
Nestor PG, Kubicki M, Spencer KM, Niznikiewicz M, McCarley RW, Shenton ME. Attentional networks and cingulum bundle in chronic schizophrenia.
Schizophr Res 2007;90:308-315 [PMID: 17150337]
Onitsuka T, McCarley RW, Kuroki N, Dickey CC, Kubicki M, Demeo SS, Frumin M, Kikinis R, Jolesz FA, Shenton ME: Occipital lobe gray matter volume in male patients with chronic schizophrenia: A quantitative MRI study.
Schizophr Res 2007 [PMID: 17350226]
Nestor PG, Onitsuka T, Gurrera RJ, Niznikiewicz MA, Frumin M, Shenton ME, McCarley RW. Dissociable contributions of MRI reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia.
Schizophr Res. 2007 Mar;91(1-3):103-6. PMID: [17229550]
Ramesh V, Thatte H, McCarley RW and Basheer R. Adenosine and Sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain.
J Neurochem, 100 (2007):1351-1363. [PMID: 17316404]
McKenna JT, Tartar JL, Ward CP, Thakkar MM, Ling L, McGuire M, White D, McCarley RW, and Strecker RE. Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness.
Neuroscience. 2007 Jun 8;146(4):1462-73. Epub 2007 Apr 18. [PMID: 17442498]
Brown RE, McCarley RW. Neuroanatomical and neurochemical basis of wakefulness and REM sleep systems.
In: Sinton, Monti (Eds.), 2006, Cambridge University Press. In press.
Min-seong Koo, Chandlee C. Kickey, Hae-Jeong Park, Marek Kubicki, Na Young Ji, Sylvain Bouix, Kilian M. Pohl, james J. Levitt, Motoaki Nakamura, Martha E. Shenton, Robert W. McCarley, Smaller Neocortical Gray Matter and Larger Sulcal Cerebrospinal Fluid Volumes in Neuroleptic-Naive Women With Schizotypal Personality Disorder.
Arch Gen Psychiatry, 63(10), 1090-1100, 2006. [PMID: 17015811]
Tao R, Ma Z, McKenna JT, Thakkar MM, Winston S, Strecker RE, McCarley RW. Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats.
Neuroscience 2006; 141: 1101-1105. [PMID: 16820265]
Strecker R, Basheer R, McKenna JT, McCarley R. Another Chapter in the Adenosine Story.
Invited Editorial, Sleep 2006; 29: 426-428. [PMID: 16676774]
Wible C, Han D, Spencer M, Kubicki M, Niznikiewicz M, Jolesz F, McCarley RW, Nestor P: Connectivity Among Semantic Associates: An fMRI Study of Semantic Priming.
Brain and Language 2006 Jun;97(3):294-305. [PMID: 16413049]
M Koo, Dickey CC, Park H, Kubicki M, Ji NY, Bouix S, Pohl KM, Levitt JJ, Nakamura M, Shenton ME, McCarley RW (2006): Smaller Neocortical Gray Matter and Larger Sulcal CSF Volumes in Neuroleptic-Naive Females with Schizotypal Personality Disorder.
Arch Gen Psych 63; 1090-1100 [PMID: 17015811]
Spencer KM, McCarley RW. Neuropsychiatric abnormalities: a new vista from studies on fundamental properties of neural communication.
Psychiatric Times 2006;23:34ff.
Nestor, PG, Valdman O, Niznikiewicz M, Spencer K, McCarley RW, Shenton ME. Word priming in schizophrenia: associational and semantic influences.
Schizophr Res 2006;82:139-142 [PMID: 16325376]
Brown RE, Winston S, Basheer R, Thakkar MM, McCarley RW. Electrophysiological characterization of neurons in the dorsolateral pontine REM sleep induction zone of the rat: intrinsic membrane properties and response to carbachol and orexins.
Neuroscience 2006; 143(3): 739-755. [PMID: 17008019]
Onitsuka T, Niznikiewicz MA, Spencer KM, Fruman M, Kuroki N, Lucia LC, Shenton ME, McCarley RW. Functional and structural deficits in brain regions subserving face perception in schizophrenia.
Am J Psychiatry. 2006;163(3):455-62. [PMID: 16513867]
Tartar JL, Ward CP, McKenna JT, Thakkar MM, Arrigoni E, McCarley RW, Brown RE, and Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation.
Eur. J. Neurosci. 2006; 23(10): 2739-2748. [PMID: 16817877]
Koo MS, Levitt JJ, McCarley RW, Seidman LJ, Dickey CC, Niznikiewicz MA, Voglmaier MM, Zamani P, Long KR, Kim SS, Shenton ME. Reduction of caudate nucleus volumes in neuroleptic-naive female subjects with schizotypal personality disorder.
Biol Psychiatry. 2006 Jul 1;60(1):40-8. Epub 2006 Feb 7. [PMID: 16460694]
Noriomi Kuroki, Marek Kubicki, Paul G. Nestor, Dean F. Salisbury, Hae-Jeong Park, James J. Levitt, Sophie Woolston, Melissa Frumin, Margaret Niznikiewicz, Carl-Fredrik Westin, Stephan E. Maier, Robert W. McCarley and Martha E. Shenton. Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients.
Biol Psychiatry, 60(1), 22-31, 2006. [PMID: 16406249]
Kuroki N, Shenton ME, Salisbury DF, Hirayasu Y, Onitsuka T, Ersner-Hershfield H, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW. Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study.
Am J Psychiatry. 2006 Dec;163(12):2103-10. [PMID: 17151161]
Arrigoni E, Chamberlin NL, Saper CB, McCarley RW. Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.
Neuroscience. 2006 Jun 30;140(2):403-13. Epub 2006 Mar 20 [PMID: 16542780]
Cordova CA, Said BO, McCarley RW, Baxter MG, Chiba AA, Strecker RE. Sleep deprivation in rats produces attentional impairments on a 5-choice serial reaction time task.
Sleep. 2006 Jan 1;29(1):69-76. [PMID: 16453983]
Basheer R, Brown R, Ramesh V, Begum S, McCarley RW. Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity.
J Neurosci Res. 2005 Dec 1;82(5):650-8. [PMID: 16273548]
Ma Z, Strecker RE, McKenna JT, Thakkar MM, McCarley RW, Tao R. Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats.
Neuroscience. 2005;135(3):949-58. Epub 2005 Sep 8. [PMID: 16154286]
McCarley RW. Mechanisms and models of REM sleep control.
Arch Ital Biol. 2004 Jul;142(4):429-67. Review. [PMID: 15493547]
Sinton CM, McCarley RW. Neurophysiological mechanisms of sleep and wakefulness: a question of balance.
Semin Neurol. 2004 Sep;24(3):211-23. Review. [PMID: 15449215]
Basheer R, Strecker RE, Thakkar MM, McCarley RW. Adenosine and sleep-wake regulation.
Prog Neurobiol. 2004 Aug;73(6):379-96. Review. [PMID: 15313333]
Thakkar MM, Delgiacco RA, Strecker RE, McCarley RW. Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats.
Neuroscience. 2003;122(4):1107-13. [PMID: 14643776]
Thakkar MM, Winston S, McCarley RW. A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain.
J Neurosci. 2003 May 15;23(10):4278-87. [PMID: 12764116]
Ito K, Yanagihara M, Imon H, Dauphin L, McCarley RW. Intracellular recordings of pontine medial gigantocellular tegmental field neurons in the naturally sleeping cat: behavioral state-related activity and soma size difference in order of recruitment.
Neuroscience. 2002;114(1):23-37. [PMID: 12207952]
Basheer R, Arrigoni E, Thatte HS, Greene RW, Ambudkar IS, McCarley RW. Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons.
J Neurosci. 2002 Sep 1;22(17):7680-6. [PMID: 12196591]
Strecker RE, Nalwalk J, Dauphin LJ, Thakkar MM, Chen Y, Ramesh V, Hough LB, McCarley RW. Extracellular histamine levels in the feline preoptic/anterior hypothalamic
area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study.
Neuroscience. 2002;113(3):663-70. [PMID: 12150786]
Thakkar MM, Strecker RE, McCarley RW. Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons.
Brain Res. 2002 Aug 2;945(2):276-80. [PMID: 12126890]
Thakkar MM, Winston S, McCarley RW. Orexin neurons of the hypothalamus express adenosine A1 receptors.
Brain Res. 2002 Jul 19;944(1-2):190-4. [PMID: 12106679]
Basheer R, Rainnie DG, Porkka-Heiskanen T, Ramesh V, McCarley RW. Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat.
Neuroscience. 2001;104(3):731-9. [PMID: 11440805]
Strecker RE, Thakkar MM, Porkka-Heiskanen T, Dauphin LJ, Bjorkum AA, McCarley RW. Behavioral state-related changes of extracellular serotonin concentration in the pedunculopontine tegmental nucleus: a microdialysis study in freely moving animals.
Sleep Res Online. 1999;2(2):21-7. [PMID: 11421239]
Basheer R, Halldner L, Alanko L, McCarley RW, Fredholm BB, Porkka-Heiskanen T. Opposite changes in adenosine A1 and A2A receptor mRNA in the rat following sleep deprivation.
Neuroreport. 2001 Jun 13;12(8):1577-80. [PMID: 11409719]
Thakkar MM, Ramesh V, Strecker RE, McCarley RW. Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.
Arch Ital Biol. 2001 Apr;139(3):313-28. [PMID: 11330208]
Arrigoni E, Rainnie DG, McCarley RW, Greene RW. Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum.
J Neurosci. 2001 Feb 1;21(3):1076-85. [PMID: 11157094]
Porkka-Heiskanen T, Strecker RE, McCarley RW. Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study.
Neuroscience. 2000;99(3):507-17. [PMID: 11029542]
Basheer R, Porkka-Heiskanen T, Strecker RE, Thakkar MM, McCarley RW. Adenosine as a biological signal mediating sleepiness following prolonged wakefulness.
Biol Signals Recept. 2000 Nov-Dec;9(6):319-27. Review. [PMID: 11025338]
Strecker RE, Morairty S, Thakkar MM, Porkka-Heiskanen T, Basheer R, Dauphin LJ, Rainnie DG, Portas CM, Greene RW, McCarley RW. Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state.
Behav Brain Res. 2000 Nov;115(2):183-204. [PMID: 11000420]
Basheer R, Porkka-Heiskanen T, Stenberg D, McCarley RW. Adenosine and behavioral state control: adenosine increases c-Fos protein and AP1 binding in basal forebrain of rats.
Brain Res Mol Brain Res. 1999 Nov 10;73(1-2):1-10. [PMID: 10581392]
McCarley RW. Dreams: disguise of forbidden wishes or transparent reflections of a distinct brain state?
Ann N Y Acad Sci. 1998 May 15;843:116-33. No abstract available. [PMID: 9668654]
Thakkar MM, Strecker RE, McCarley RW. Behavioral state control through differential serotonergic inhibition in the
mesopontine cholinergic nuclei: a simultaneous unit recording and microdialysis study.
J Neurosci. 1998 Jul 15;18(14):5490-7. [PMID: 9651229]
Li X, Rainnie DG, McCarley RW, Greene RW. Presynaptic nicotinic receptors facilitate monoaminergic transmission.
J Neurosci. 1998 Mar 1;18(5):1904-12. [PMID: 9465015]
Basheer R, Sherin JE, Saper CB, Morgan JI, McCarley RW, Shiromani PJ. Effects of sleep on wake-induced c-fos expression.
J Neurosci. 1997 Dec 15;17(24):9746-50. [PMID: 9391027]
Portas CM, Thakkar M, Rainnie DG, Greene RW, McCarley RW. Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat.
Neuroscience. 1997 Jul;79(1):225-35. [PMID: 9178878]
Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA, Greene RW, McCarley RW. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness.
Science. 1997 May 23;276(5316):1265-8. [PMID: 9157887]
Portas CM, Thakkar M, Rainnie D, McCarley RW. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat.
J Neurosci. 1996 Apr 15;16(8):2820-8. [PMID: 8786456]
Sherin JE, Shiromani PJ, McCarley RW, Saper CB. Activation of ventrolateral preoptic neurons during sleep.
Science. 1996 Jan 12;271(5246):216-9. [PMID: 8539624]
Shiromani PJ, Malik M, Winston S, McCarley RW. Time course of Fos-like immunoreactivity associated with cholinergically induced REM sleep.
J Neurosci. 1995 May;15(5 Pt 1):3500-8. [PMID: 7751925]
Stevens DR, McCarley RW, Greene RW. The mechanism of noradrenergic alpha 1 excitatory modulation of pontine reticular formation neurons.
J Neurosci. 1994 Nov;14(11 Pt 1):6481-7. [PMID: 7965052]
Rainnie DG, Grunze HC, McCarley RW, Greene RW. Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal.
Science. 1994 Feb 4;263(5147):689-92. Erratum in: Science 1994 Jul 1;265(5168):16. [PMID: 8303279]
Luebke JI, McCarley RW, Greene RW. Inhibitory action of muscarinic agonists on neurons in the rat laterodorsal tegmental nucleus in vitro.
J Neurophysiol. 1993 Nov;70(5):2128-35. [PMID: 8294974]
Stevens DR, Birnstiel S, Gerber U, McCarley RW, Greene RW. Nicotinic depolarizations of rat medial pontine reticular formation neurons studied in vitro.
Neuroscience. 1993 Nov;57(2):419-24. [PMID: 8115046]
Stevens DR, McCarley RW, Greene RW. Excitatory amino acid-mediated responses and synaptic potentials in medial pontine reticular formation neurons of the rat in vitro.
J Neurosci. 1992 Nov;12(11):4188-94. [PMID: 1279137]
Massaquoi SG, McCarley RW. Extension of the Limit Cycle Reciprocal Interaction Model of REM cycle control. An integrated sleep control model.
J Sleep Res. 1992 Jun;1(2):138-143. [PMID: 10607042]
McCarley RW, Massaquoi SG. Neurobiological structure of the revised limit cycle reciprocal interaction model of REM cycle control.
J Sleep Res. 1992 Jun;1(2):132-137. [PMID: 10607041]
Luebke JI, Greene RW, Semba K, Kamondi A, McCarley
RW, Reiner PB. Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro.
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):743-7. [PMID: 1731349]
Gerber U, Stevens DR, McCarley RW, Greene RW. Muscarinic agonists activate an inwardly rectifying potassium conductance in medial pontine reticular formation neurons of the rat in vitro.
J Neurosci. 1991 Dec;11(12):3861-7. [PMID: 1744694]
Gerber U, Greene RW, McCarley RW. Repetitive firing properties of medial pontine reticular formation neurones of the rat recorded in vitro.
J Physiol. 1989 Mar;410:533-60. [PMID: 2795489]
Greene RW, Gerber U, McCarley RW. Cholinergic activation of medial pontine reticular formation neurons in vitro.
Brain Res. 1989 Jan 2;476(1):154-9. [PMID: 2914210]
Mitani A, Ito K, Mitani Y, McCarley RW. Morphological and electrophysiological identification of gigantocellular tegmental field neurons with descending projections in the cat: II. Bulb.
J Comp Neurol. 1988 Aug 15;274(3):371-86. [PMID: 2464618]
Mitani A, Ito K, Hallanger AE, Wainer BH, Kataoka K, McCarley RW. Cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei to the pontine gigantocellular tegmental field in the cat.
Brain Res. 1988 Jun 7;451(1-2):397-402. [PMID: 3251602]
Mitani A, Ito K, Mitani Y, McCarley RW. Morphological and electrophysiological identification of gigantocellular tegmental field neurons with descending projections in the cat: I. Pons.
J Comp Neurol. 1988 Feb 22;268(4):527-45. [PMID: 3356804]
Mitani A, Ito K, Mitani Y, McCarley RW. Descending projections from the gigantocellular tegmental field in the cat: cells of origin and their brainstem and spinal cord trajectories.
J Comp Neurol. 1988 Feb 22;268(4):546-66. [PMID: 2451685]
Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep. I. Long term recordings of dorsal raphe discharge frequency and PGO waves.
Arch Ital Biol. 1987 Oct;125(4):317-43. [PMID: 3439827]
Baghdoyan HA, Rodrigo-Angulo ML, McCarley RW, Hobson JA. A neuroanatomical gradient in the pontine tegmentum for the cholinoceptive induction of desynchronized sleep signs.
Brain Res. 1987 Jun 30;414(2):245-61. [PMID: 3620930]
McCarley RW, Massaquoi SG. Further discussion of a model of the REM sleep oscillator.
Am J Physiol. 1986 Dec;251(6 Pt 2):R1033-6. [PMID: 3789190]
McCarley RW, Massaquoi SG. A limit cycle mathematical model of the REM sleep oscillator system.
Am J Physiol. 1986 Dec;251(6 Pt 2):R1011-29. [PMID: 3789188]
Greene RW, Haas HL, McCarley RW. A low threshold calcium spike mediates firing pattern alterations in pontine reticular neurons.
Science. 1986 Nov 7;234(4777):738-40. [PMID: 3775364]
Baghdoyan HA, Monaco AP, Rodrigo-Angulo ML, Assens F, McCarley RW, Hobson JA. Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs.
J Pharmacol Exp Ther. 1984 Oct;231(1):173-80. [PMID: 6491973]
Lydic R, McCarley RW, Hobson JA. Forced activity alters sleep cycle periodicity and dorsal raphe discharge rhythm.
Am J Physiol. 1984 Jul;247(1 Pt 2):R135-45. [PMID: 6331207]
McCarley RW, Benoit O, Barrionuevo G. Lateral geniculate nucleus unitary discharge in sleep and waking: state- and rate-specific aspects.
J Neurophysiol. 1983 Oct;50(4):798-818. PMID: [6631464]
Nelson JP, McCarley RW, Hobson JA. REM sleep burst neurons, PGO waves, and eye movement information.
J Neurophysiol. 1983 Oct;50(4):784-97. [PMID: 6631463]
McCarley RW. REM sleep and depression: common neurobiological control mechanisms.
Am J Psychiatry. 1982 May;139(5):565-70. [PMID: 6122380]
McCarley RW, Hoffman E. REM sleep dreams and the activation-synthesis hypothesis.
Am J Psychiatry. 1981 Jul;138(7):904-12. [PMID: 7258349]
McCarley RW, Nelson JP, Hobson JA. Ponto-geniculo-occipital (PGO) burst neurons: correlative evidence for neuronal generators of PGO waves.
Science. 1978 Jul 21;201(4352):269-72. [PMID: 663656]
Wyzinski PW, McCarley RW, Hobson JA. Discharge properties of pontine reticulospinal neurons during sleep-waking cycle.
J Neurophysiol. 1978 May;41(3):821-34. [PMID: 660232]
Hobson JA, McCarley RW. The brain as a dream state generator: an activation-synthesis hypothesis of the dream process.
Am J Psychiatry. 1977 Dec;134(12):1335-48. [PMID: 21570]
McCarley RW, Hobson JA. The neurobiological origins of psychoanalytic dream theory.
Am J Psychiatry. 1977 Nov;134(11):1211-21. [PMID: 333951]
McCarley RW, Hobson JA. Discharge patterns of cat pontine brain stem neurons during desynchronized sleep.
J Neurophysiol. 1975 Jul;38(4):751-66. [PMID: 1159463]
McCarley RW, Hobson JA. Neuronal excitability modulation over the sleep cycle: a structural and mathematical model.
Science. 1975 Jun 4;189(4196):58-60. [PMID: 1135627]
Hobson JA, McCarley RW, Wyzinski PW. Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups.
Science. 1975 Jun 4;189(4196):55-8. [PMID: 1094539]
Hobson JA, McCarley RW, Freedman R, Pivik RT. Time course of discharge rate changes by cat pontine brain stem neurons during sleep cycle.
J Neurophysiol. 1974 Nov;37(6):1297-309. No abstract available. [PMID: 4436702]
McCarley RW, Hobson JA. Single neuron activity in cat gigantocellular tegmental field: selectivity of discharge in desynchronized sleep.
Science. 1971 Dec 17;174(15):1250-2. No abstract available. [PMID: 5133450]
McCarley RW, Hobson JA. Cortical unit activity in desynchronized sleep.
Science. 1970 Feb 6;167(919):901-3. No abstract available. [PMID: 4312290]
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