Faculty Profile

Division of Sleep Medicine, Sleep Disorders Program

My primary interest is to understand the pathophysiology of obstructive sleep apnea with an aim towards developing newer treatments.  Sleep apnea is a multifactorial disorder.  By identifying the relative importance of these factors in different individuals, we may be able to develop more tolerable therapies for patients.

American Heart Association

Owens R, Wellman A, Malhotra A. The chicken-or-egg debate in OSA pathogenesis.
Sleep. 2009 Oct 1;32(10):1255-6. [PMID: 19848354]

Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea.
Sleep. 2009 Mar 1;32(3):361-8. [PMID: 19294956]

Malhotra A, Bertisch S, Wellman A. Complex sleep apnea: it isn't really a disease.
J Clin Sleep Med. 2008 Oct 15;4(5):406-8. PMID: 18853695]

Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP. Effect of  oxygen in obstructive sleep apnea: role of loop gain.
Respir Physiol Neurobiol. 2008 Jul 31;162(2):144-51. Epub 2008 Jun 3. [PMID: 18577470]

Jordan AS, Wellman A, Heinzer RC, Lo YL, Schory K, Dover L, Gautam S, Malhotra A, White DP. Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans.
Thorax. 2007 Oct;62(10):861-7. Epub 2007 Apr 5.  [PMID: 17412778]

Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikermann M, Schory K, Dover L, White DP. Influence of wakefulness on pharyngeal airway muscle activity. Thorax. 2007 Sep;62(9):799-805. Epub 2007 Mar 27. [PMID: 17389755]

Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP, Malhotra A. The influence of aging on pharyngeal collapsibility during sleep.
Chest. 2007 Jun;131(6):1702-9. Epub 2007 Apr 5. [PMID: 17413053]

Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol 2007; 581(Pt 1):291-298. [PMID: 17317747]

Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]

Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]

Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol. 2005 Nov;99(5):2020-7. Epub 2005 Jun 30.  [PMID: 15994243]

Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32. Epub 2004 Aug 18. [PMID: 15317668]

Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
J Appl Physiol. 2003 Jan;94(1):205-12. Epub 2002 Sep 20. [PMID: 12391042]

Wellman A, Malhotra A, White DP. Atrial pacing in sleep apnea syndrome.
N Engl J Med. 2002 Aug 8;347(6):445-6; author reply 445-6. [PMID: 12167690]

Kuhn WF, Wellman A. The use of melatonin as a potential treatment for shiftwork sleep disorder.
Acad Emerg Med. 1998 Aug;5(8):842-3. [PMID: 9715249]