Faculty Profile

Laboratory to Study the Consequences of Sleep Disordered Breathing, Department of Medicine, Beth Israel Deaconess Medical Center

Dr. Gilmartin and his collaborators have designed and are implementing both animal and human studies to evaluate the vascular, metabolic and sympathetic nervous system responses to hypoxia in patients with OSA and normal volunteers.  The current protocols involve exposures to human subjects of 8 hours of hypoxia during a single exposure as well as two weeks of an 8-hour exposure to hypoxia overnight, every night.  Variables measured include MSNA (muscle sympathetic nerve activity), forearm blood flow (measured by venous occlusion plethysmography) and hypoxic ventilatory responses both before an after the exposures. In addition, ongoing clinical invetigations into the mechanisms of and response to treatment in central sleep apnea are a significant focus of his research. 

Tustin Ennacheril, MD 2007-08

Human Physiology-Pulmonary Pathophysiology-Lecturer-HMS

Roberts DH, Gilmartin GS, Neeman N, Schulze JE, Cannistraro S, Ngo LH, Aronson MD, Weiss JW. Design and measurement of quality improvement indicators in ambulatory pulmonary care: creating a "culture of quality" in an academic pulmonary division.
Chest. 2009 Oct;136(4):1134-40. [PMID: 19809055]

Weiss MD, Tamisier R, Boucher J, Lynch M, Gilmartin G, Weiss JW, Thomas RJ. A  pilot study of sleep, cognition, and respiration under 4 weeks of intermittent nocturnal hypoxia in adult humans.
Sleep Med. 2009 Aug;10(7):739-45. Epub 2009 Mar 17. [PMID: 19282237]

Hunt BE, Tamisier R, Gilmartin GS, Curley M, Anand A, Weiss JW. Baroreflex responsiveness during ventilatory acclimatization in humans.
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1794-801. Epub 2008 Aug 29. [PMID: 18757487]

Gilmartin GS, Tamisier R, Curley M, Weiss JW. Ventilatory, hemodynamic, sympathetic nervous system, and vascular reactivity changes after recurrent nocturnal sustained hypoxia in humans.
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H778-85. Epub 2008 Jun 6. [PMID: 18539753]

Thomas RJ, Mietus JE, Peng CK, Gilmartin G, Daly RW, Goldberger AL, Gottlieb DJ. Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based method.
Sleep. 2007 Dec 1;30(12):1756-69. [PMID: 18246985]

Tamisier R, Hunt BE, Gilmartin GS, Curley M, Anand A, Weiss JW. Hemodynamics and muscle sympathetic nerve activity after 8 h of sustained hypoxia in healthy humans.
Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3027-35. Epub 2007 Sep  14. [PMID: 17873026]

Thomas RJ, Tamisier R, Boucher J, Kotlar Y, Vigneault K, Weiss JW, Gilmartin G. Nocturnal hypoxia exposure with simulated altitude for 14 days does not significantly alter working memory or vigilance in humans. Sleep. 2007 Sep 1;30(9):1195-203. [PMID: 17910391]

Gilmartin G, Tamisier R, Anand A, Cunnington D, Weiss JW. Evidence of impaired hypoxic vasodilation after intermediate-duration hypoxic exposure in humans.
Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2173-80. Epub 2006 Apr 28. [PMID: 16648184]

Gilmartin G, Ernst A. Metastatic Ovarian Carcinoma to the Airway.
Journal of Bronchology. 2002;9(1):25-26.

Reviews/Chapters/Editorials

Gilmartin GS, Daly R, Thomas RJ. Recognition and management of complex sleep-disordered breathing. 
Current Opinion in Pulmonary Medicine. 2005;11(6):485-93.

Gilmartin GS, Thomas RJ. Mechanisms of Arousal from Sleep and Their Consequences.
In: Current Opinion in Pulmonary Medicine. Lippincott Williams and Wilkins; 2004. p. 468-74.

Gilmartin G, Koziel H.  Pneumocystis Carinii Pneumonia in Adult Non-HIV Disorders.
In: Journal of Intensive Care Medicine. Thousand Oaks (CA): Sage Publications; 2002. p. 283-301.

Abstracts

Lynch ME, Gilmartin GS, Curley MJ, Tamisier R, Prabakar C, Weiss JW. Changes in Flow-Mediated Vasodilation after 2 weeks of Continuous vs. Cyclic Nocturnal Hypoxia in Humans.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A196.

Gilmartin GS, Prabakar C, Curley M, Tamisier R, Weiss JW. Changes in Insulin Sensitivity in Human Subjects Exposed to 14 Nights of Hypoxia.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A195.

Curley MJ, Gilmartin GS, Prabakar C, Lynch ME, Tamisier R, Weiss JW. Changes in Sympathetic Nervous System Activity and Hemodynamics after 4 weeks of Cyclic, Nocturnal Hypoxia in Normal Volunteers.
Proceddings of the American Thoracic Society. 2006;3(Abstracts):A195.

R Tamisier, GS Gilmartin, M Curley, AN Anand, JW Weiss.  8-Hour Poikilocapnic Hypoxia Causes Decreases in Muscle Sympathetic Nerve Activity (MSNA) and Blunted Vagal Baroreflex in Normal Human Volunteers.
American Journal of Critical Care Medicine. 2005;2(Abstract Issue): A878.

R Tamisier, GS Gilmartin, AN Anand, MJ Curley, JW Weiss.  Fourteen Days of Nocturnal Sustained Hypoxia Induces Increases in Muscle Sympathetic Nerve Activity (MSNA) and Arterial Blood Pressure in Normal Human Volunteers. 
American Journal of Respiratory and Critical Care Medicine. 2005;2(Abstract Issue): A877.

Ingenito EP, Tsai L, Gilmartin G.  Bronchoscopic Volume Reduction (BVR) Using Biopolymers Which Target Fibroblast, Machrophage, and Epithelial Cell Responses.
American Journal of Respiratory and Critical Care Medicine. 2001:163(5).

GS Gilmartin, R Tamisier, AN Anand, D Cunnington, JW Weiss.  Evidence of Impaired Hypoxic Vasodilation after Intermediate Duration Hypoxic Exposure.
American Journal of Respiratory and Critical Care Medicine. 2005;2(Abstract Issue): A235.