Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Jun Lu, MD, PhD
Assistant Professor of Neurology, Harvard Medical School
Physician, Assistant Professor, Department of Neurology, Beth Israel Deaconess Medical Center
Inter-office Mail Address
HIM #819Society Memberships
Society for NeuroscienceResearch Unit(s)
Systems Neurobiology
Research Interests
My approach to understand sleep-wake behaviors is to dissect out anatomically and physiologically the neuronal groups responsible for spectrum of sleep-wake behaviors in rodent model. Once the key neuronal groups and their connections are identified, we can further fill up the details of the identified neural circuitry. One example of this approach is our recent work identifying flip-flop switch control of REM sleep.
Trainees
Research Funding
NIH, PI: Jun Lu. Dopaminergic control of arousal
Selected Publications
Fuller PM, Lu J, Saper CB. Standards of evidence in chronobiology: A response.
J Circadian Rhythms. 2009 Jul 22;7:9. [PMID: 19624818]
Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia.
J Neurosci. 2009 Jul 22;29(29):9361-9. [PMID: 19625526]
Pedersen NP, Fuller PM, Lu J, Saper CB. In the flicker of an eye.
J Physiol. 2008 Jul 15;586(14):3305-6. [PMID: 18625803]
Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia.
J Comp Neurol. 2008 Jun 1;508(4):648-62. [PMID: 18383504]
Fuller PM, Lu J, Saper CB. Differential rescue of light- and food-entrainable circadian rhythms. Science. 2008 May 23;320(5879):1074-7. [PMID: 18497298]
Lu J, Lian G, Lenkinski R, De Grand A, Vaid RR, Bryce T, Stasenko M, Boskey A, Walsh C, Sheen V. Filamin B mutations cause chondrocyte defects in skeletal development.
Hum Mol Genet. 2007 Jul 15;16(14):1661-75. Epub 2007 May 17. [PMID: 17510210]
Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
J Cell Biol. 2006 Oct 23;175(2):209-15. [PMID: 17060494]
Lu J, Sherman D, Devor M, Saper CB. A putative flip-flop switch for control of REM sleep.
Nature. 2006 Jun 1;441(7093):589-94. Epub 2006 May 10. [PMID: 16688184]
Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V. Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.
J Comp Neurol. 2006 Jan 20;494(3):476-84. [PMID: 16320251]
Lu J, Jhou TC, Saper CB. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter.
J Neurosci. 2006 Jan 4;26(1):193-202. [PMID: 16399687]
Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.
J Neurosci. 2003 Nov 19;23(33):10691-702. [PMID: 14627654]
Zhang YH, Lu J, Elmquist JK, Saper CB. Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain.
J Comp Neurol. 2003 Aug 11;463(1):3-12. [PMID: 12811798]
Gooley JJ, Lu J, Fischer D, Saper CB. A broad role for melanopsin in nonvisual photoreception.
J Neurosci. 2003 Aug 6;23(18):7093-106. [PMID: 12904470]
Lu J, Bjorkum AA, Xu M, Gaus SE, Shiromani PJ, Saper CB. Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep.
J Neurosci. 2002 Jun 1;22(11):4568-76. [PMID: 12040064]
Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB. Afferents to the ventrolateral preoptic nucleus.
J Neurosci. 2002 Feb 1;22(3):977-90. [PMID: 11826126]
Gooley JJ, Lu J, Chou TC, Scammell TE, Saper CB. Melanopsin in cells of origin of the retinohypothalamic tract.
Nat Neurosci. 2001 Dec;4(12):1165. [PMID: 11713469]
Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
EMBO J. 2001 Nov 1;20(21):5840-52. [PMID: 11689425]
Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation.
J Neurosci. 2001 Jul 1;21(13):4864-74. [PMID: 11425913]
Zhang YH, Lu J, Elmquist JK, Saper CB. Lipopolysaccharide activates specific populations of hypothalamic and brainstem neurons that project to the spinal cord.
J Neurosci. 2000 Sep 1;20(17):6578-86. [PMID: 10964963]
Lu J, Greco MA, Shiromani P, Saper CB. Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep.
J Neurosci. 2000 May 15;20(10):3830-42. [PMID: 10804223]
Lu J, Shiromani P, Saper CB. Retinal input to the sleep-active ventrolateral preoptic nucleus in the rat.
Neuroscience. 1999;93(1):209-14. [PMID: 10430484]
Silveira DC, Liu Z, de LaCalle S, Lu J, Klein P, Holmes GL, Herzog AG. Activation of the locus coeruleus after amygdaloid kindling.
Epilepsia. 1998 Dec;39(12):1261-4. [PMID: 9860060]
Reviews
Fuller PM, Saper CB, Lu J. The pontine REM switch: past and present.
J Physiol. 2007 Nov 1;584(Pt 3):735-41. Epub 2007 Sep 20. Review. [PMID: 17884926]
Lu J, Greco MA. Sleep circuitry and the hypnotic mechanism of GABAA drugs.
J Clin Sleep Med. 2006 Apr 15;2(2):S19-26. Review. [PMID: 17557503]
Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms.
Nature. 2005 Oct 27;437(7063):1257-63. Review. [PMID: 16251950]
Lu J, Sheen V. Periventricular heterotopia.
Epilepsy Behav. 2005 Sep;7(2):143-9. Review. [PMID: 15996530]
Saper CB, Lu J, Chou TC, Gooley J. The hypothalamic integrator for circadian rhythms.
Trends Neurosci. 2005 Mar;28(3):152-7. Review. [PMID: 15749169]
J Circadian Rhythms. 2009 Jul 22;7:9. [PMID: 19624818]
Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia.
J Neurosci. 2009 Jul 22;29(29):9361-9. [PMID: 19625526]
Pedersen NP, Fuller PM, Lu J, Saper CB. In the flicker of an eye.
J Physiol. 2008 Jul 15;586(14):3305-6. [PMID: 18625803]
Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia.
J Comp Neurol. 2008 Jun 1;508(4):648-62. [PMID: 18383504]
Fuller PM, Lu J, Saper CB. Differential rescue of light- and food-entrainable circadian rhythms. Science. 2008 May 23;320(5879):1074-7. [PMID: 18497298]
Lu J, Lian G, Lenkinski R, De Grand A, Vaid RR, Bryce T, Stasenko M, Boskey A, Walsh C, Sheen V. Filamin B mutations cause chondrocyte defects in skeletal development.
Hum Mol Genet. 2007 Jul 15;16(14):1661-75. Epub 2007 May 17. [PMID: 17510210]
Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
J Cell Biol. 2006 Oct 23;175(2):209-15. [PMID: 17060494]
Lu J, Sherman D, Devor M, Saper CB. A putative flip-flop switch for control of REM sleep.
Nature. 2006 Jun 1;441(7093):589-94. Epub 2006 May 10. [PMID: 16688184]
Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V. Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.
J Comp Neurol. 2006 Jan 20;494(3):476-84. [PMID: 16320251]
Lu J, Jhou TC, Saper CB. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter.
J Neurosci. 2006 Jan 4;26(1):193-202. [PMID: 16399687]
Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.
J Neurosci. 2003 Nov 19;23(33):10691-702. [PMID: 14627654]
Zhang YH, Lu J, Elmquist JK, Saper CB. Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain.
J Comp Neurol. 2003 Aug 11;463(1):3-12. [PMID: 12811798]
Gooley JJ, Lu J, Fischer D, Saper CB. A broad role for melanopsin in nonvisual photoreception.
J Neurosci. 2003 Aug 6;23(18):7093-106. [PMID: 12904470]
Lu J, Bjorkum AA, Xu M, Gaus SE, Shiromani PJ, Saper CB. Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep.
J Neurosci. 2002 Jun 1;22(11):4568-76. [PMID: 12040064]
Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB. Afferents to the ventrolateral preoptic nucleus.
J Neurosci. 2002 Feb 1;22(3):977-90. [PMID: 11826126]
Gooley JJ, Lu J, Chou TC, Scammell TE, Saper CB. Melanopsin in cells of origin of the retinohypothalamic tract.
Nat Neurosci. 2001 Dec;4(12):1165. [PMID: 11713469]
Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
EMBO J. 2001 Nov 1;20(21):5840-52. [PMID: 11689425]
Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation.
J Neurosci. 2001 Jul 1;21(13):4864-74. [PMID: 11425913]
Zhang YH, Lu J, Elmquist JK, Saper CB. Lipopolysaccharide activates specific populations of hypothalamic and brainstem neurons that project to the spinal cord.
J Neurosci. 2000 Sep 1;20(17):6578-86. [PMID: 10964963]
Lu J, Greco MA, Shiromani P, Saper CB. Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep.
J Neurosci. 2000 May 15;20(10):3830-42. [PMID: 10804223]
Lu J, Shiromani P, Saper CB. Retinal input to the sleep-active ventrolateral preoptic nucleus in the rat.
Neuroscience. 1999;93(1):209-14. [PMID: 10430484]
Silveira DC, Liu Z, de LaCalle S, Lu J, Klein P, Holmes GL, Herzog AG. Activation of the locus coeruleus after amygdaloid kindling.
Epilepsia. 1998 Dec;39(12):1261-4. [PMID: 9860060]
Reviews
Fuller PM, Saper CB, Lu J. The pontine REM switch: past and present.
J Physiol. 2007 Nov 1;584(Pt 3):735-41. Epub 2007 Sep 20. Review. [PMID: 17884926]
Lu J, Greco MA. Sleep circuitry and the hypnotic mechanism of GABAA drugs.
J Clin Sleep Med. 2006 Apr 15;2(2):S19-26. Review. [PMID: 17557503]
Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms.
Nature. 2005 Oct 27;437(7063):1257-63. Review. [PMID: 16251950]
Lu J, Sheen V. Periventricular heterotopia.
Epilepsy Behav. 2005 Sep;7(2):143-9. Review. [PMID: 15996530]
Saper CB, Lu J, Chou TC, Gooley J. The hypothalamic integrator for circadian rhythms.
Trends Neurosci. 2005 Mar;28(3):152-7. Review. [PMID: 15749169]
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