Faculty Profile

Jun Lu, MD, PhD


Assistant Professor of Neurology, Harvard Medical School
Physician, Assistant Professor, Department of Neurology, Beth Israel Deaconess Medical Center

See publications


Inter-office Mail Address

HIM #819

Society Memberships

Society for Neuroscience

Research Unit(s)

Systems Neurobiology

Research Interests

My approach to understand sleep-wake behaviors is to dissect out anatomically and physiologically the neuronal groups responsible for spectrum of sleep-wake behaviors in rodent model. Once the key neuronal groups and their connections are identified, we can further fill up the details of the identified neural circuitry. One example of this approach is our recent work identifying flip-flop switch control of REM sleep.

Trainees

Laura Nelson, PhD 2002
Vanessa Vogel, PhD 2003
David Sherman 2005-present
Vetrivelan Ramalingam, PhD

Research Funding

NIH, PI: Jun Lu. Dopaminergic control of arousal

Selected Publications

Lu J, Sherman D, Devor M, Saper CB. A putative flip-flop switch for control of REM sleep.
Nature. 2006 Jun 1;441(7093):589-94 [PMID: 16688184]

Lu J, Jhou TC, Saper CB. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter.
J Neurosci. 2006 Jan 4;26(1):193-202. [PMID: 16399687]

Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.
J Neurosci. 2003 Nov 19;23(33):10691-702. [PMID: 14627654]

Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation.
J Neurosci. 2001 Jul 1;21(13):4864-74. [PMID: 11425913]

Lu J, Greco MA, Shiromani P, Saper CB.J Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep.
Neurosci. 2000 May 15;20(10):3830-42. [PMID: 10804223]

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